General Information of Target

Target ID LDTP14683
Target Name Melanoma-associated antigen 10 (MAGEA10)
Gene Name MAGEA10
Gene ID 4109
Synonyms
MAGE10; Melanoma-associated antigen 10; Cancer/testis antigen 1.10; CT1.10; MAGE-10 antigen
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLLSFVVLALFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELS
DDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGYFNFTSATITYLAQEDGPV
VIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKRKYDTPKT
KKN
Target Type
Clinical trial
Target Bioclass
Other
Subcellular location
Nucleus
Function Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
TTD ID
T63178
Uniprot ID
P43363
DrugMap ID
TT1VNVM
Ensemble ID
ENST00000244096.7
HGNC ID
HGNC:6797

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info 
15.00  LDD0402  [1]
EA-probe
 Probe Info 
N.A.  LDD0440  [2]
Acrolein
 Probe Info 
N.A.  LDD0223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 12.83  LDD0403  [1]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.