Details of the Target

General Information of Target

Target ID LDTP09872
Target Name Zinc finger protein ubi-d4 (DPF2)
Gene Name DPF2
Gene ID 5977
Synonyms
BAF45D; REQ; UBID4; Zinc finger protein ubi-d4; Apoptosis response zinc finger protein; BRG1-associated factor 45D; BAF45D; D4, zinc and double PHD fingers family 2; Protein requiem
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATVIHNPLKALGDQFYKEAIEHCRSYNSRLCAERSVRLPFLDSQTGVAQNNCYIWMEKR
HRGPGLAPGQLYTYPARCWRKKRRLHPPEDPKLRLLEIKPEVELPLKKDGFTSESTTLEA
LLRGEGVEKKVDAREEESIQEIQRVLENDENVEEGNEEEDLEEDIPKRKNRTRGRARGSA
GGRRRHDAASQEDHDKPYVCDICGKRYKNRPGLSYHYAHTHLASEEGDEAQDQETRSPPN
HRNENHRPQKGPDGTVIPNNYCDFCLGGSNMNKKSGRPEELVSCADCGRSGHPTCLQFTL
NMTEAVKTYKWQCIECKSCILCGTSENDDQLLFCDDCDRGYHMYCLNPPVAEPPEGSWSC
HLCWELLKEKASAFGCQA
Target Bioclass
Other
Family
Requiem/DPF family
Subcellular location
Nucleus
Function
Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells. Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF-kappa-B pathway.
Uniprot ID
Q92785
Ensemble ID
ENST00000415073.6
HGNC ID
HGNC:9964

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FTC133 SNV: p.T286M DBIA    Probe Info 
HCT15 SNV: p.V8E DBIA    Probe Info 
NUGC3 Deletion: p.L128WfsTer21 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [2]
TH211
 Probe Info  		Y27(20.00)  LDD0257  [3]
BTD
 Probe Info  		C24(0.40)  LDD2104  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
DBIA
 Probe Info  		C53(2.95); C374(1.14); C295(2.07); C298(2.07)  LDD0080  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C24(0.00); C306(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C24(0.00); C306(0.00); C53(0.00)  LDD0036  [7]
IPIAA_L
 Probe Info  		C273(0.00); C295(0.00)  LDD0031  [8]
Lodoacetamide azide
 Probe Info  		C306(0.00); C24(0.00); C53(0.00)  LDD0037  [7]
NAIA_4
 Probe Info  		C24(0.00); C53(0.00)  LDD2226  [9]
IPM
 Probe Info  		N.A.  LDD0147  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Phosphinate-6
 Probe Info  		C24(0.00); C276(0.00); C298(0.00); C324(0.00)  LDD0018  [11]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C298(1.29)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C273(0.94); C276(0.94); C295(0.85); C298(0.85)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C24(0.66); C273(0.70); C276(0.70); C295(0.72)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C24(0.83); C273(0.71); C276(0.71); C295(0.69)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C24(0.66); C273(0.79); C276(0.79); C295(0.75)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C24(0.85); C273(0.83); C276(0.83); C295(0.94)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C24(0.80); C273(0.90); C276(0.90); C295(0.77)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C24(0.89); C273(0.98); C276(0.98); C295(1.15)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C24(0.95); C273(0.91); C276(0.91); C295(0.85)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C24(0.80); C273(0.88); C276(0.88); C295(0.84)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C24(0.64); C273(0.71); C276(0.71); C295(0.71)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C24(0.73); C273(0.75); C276(0.75); C295(0.73)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C273(0.88); C276(0.88); C295(0.97); C298(0.97)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C24(0.71); C273(0.94); C276(0.94); C295(0.70)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C24(0.82); C273(0.73); C276(0.73); C295(0.77)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C24(0.73); C273(0.86); C276(0.86); C295(0.71)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C24(0.65); C295(0.86); C298(0.86); C53(1.02)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C24(0.60); C295(0.79); C298(1.20); C53(1.20)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C24(0.66); C295(0.78); C298(1.33); C53(1.24)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C24(0.72); C295(0.69); C298(0.94); C53(1.17)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C24(0.51); C295(0.80); C298(1.05); C53(1.09)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C24(0.49); C295(0.80); C298(1.15); C53(1.03)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C24(0.47); C295(0.80); C298(0.87); C53(1.09)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C273(0.85); C276(0.85); C295(0.86); C298(0.86)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C24(0.58); C295(0.78); C298(0.81); C53(1.16)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C24(0.83); C295(0.84); C298(0.71); C53(0.84)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C24(0.65); C295(0.78); C298(0.88); C53(0.90)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C24(0.51); C295(0.68); C298(0.75); C53(1.17)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C24(0.65); C295(0.97); C298(0.72); C53(1.13)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C24(0.71); C295(0.71); C298(0.80); C53(0.99)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C24(0.78); C295(0.77); C298(0.78); C53(1.38)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C24(0.82); C295(0.72); C298(0.72); C53(1.28)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C273(0.48); C276(0.48); C295(0.89); C298(0.89)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C273(0.39); C276(0.39); C295(0.63); C298(0.63)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C273(0.42); C276(0.42); C295(0.82); C298(0.82)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C273(0.41); C276(0.41); C295(0.68); C298(0.68)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C273(0.37); C276(0.37); C295(0.61); C298(0.61)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C273(0.41); C276(0.41); C295(0.68); C298(0.68)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C273(0.37); C276(0.37); C295(0.85); C298(0.85)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C273(0.42); C276(0.42); C295(0.79); C298(0.79)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C273(0.40); C276(0.40); C295(0.58); C298(0.58)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C273(0.42); C276(0.42); C295(0.63); C298(0.63)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C273(0.33); C276(0.33); C295(0.79); C298(0.79)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C273(0.37); C276(0.37); C295(0.63); C298(0.63)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C273(0.90); C276(0.90); C295(0.92); C298(0.92)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C273(0.37); C276(0.37); C295(0.70); C298(0.70)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C273(0.42); C276(0.42); C295(0.69); C298(0.69)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C273(0.41); C276(0.41); C295(0.70); C298(0.70)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C295(0.95); C298(0.95); C53(1.02)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C295(1.35); C298(1.35); C53(1.60)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C295(1.08); C298(1.08); C53(1.16)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C295(1.20); C298(1.20); C53(1.22)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C295(1.13); C298(1.13); C53(1.55)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C295(1.34); C298(1.34); C53(1.86)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C295(1.31); C298(1.31); C53(1.46)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C273(0.81); C276(0.81); C53(0.88); C295(0.92)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C295(1.00); C298(1.00); C53(1.10)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C295(1.08); C298(1.08); C53(1.16)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C295(1.06); C298(1.06); C53(1.67)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C295(1.87); C298(1.87); C53(2.34)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C295(1.19); C298(1.19); C53(1.70)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C295(1.33); C298(1.33); C53(1.55)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C295(1.09); C298(1.09); C53(1.46)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C295(1.19); C298(1.19); C53(2.00)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C53(0.82); C24(0.99)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C24(0.92); C53(1.34)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C24(1.18); C53(1.29)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C298(1.05)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C24(1.02); C53(1.70)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C24(1.02); C53(1.25)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C24(0.90); C53(0.93)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C53(0.90); C24(1.14)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C53(0.83); C24(1.02)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C24(0.71)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C24(0.79)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C24(1.03)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C24(0.84)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C24(0.72)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C298(1.15)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C24(0.71)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C24(0.77)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C24(0.71)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C24(0.73)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C24(0.64)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C24(0.82); C295(1.03); C298(1.03); C53(1.18)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C53(0.64); C24(0.93); C295(1.16); C298(1.16)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C53(0.70); C24(0.92); C295(1.49); C298(1.49)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C295(0.83); C298(0.83); C53(0.91); C24(1.13)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C53(0.78); C24(0.90); C295(0.93); C298(0.93)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C298(1.27)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C53(0.93); C24(1.04); C295(1.15); C298(1.15)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C53(0.68); C24(0.86); C295(1.19); C298(1.19)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C53(0.73); C24(0.95); C295(1.14); C298(1.14)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C53(0.73); C24(0.90); C295(1.18); C298(1.18)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C53(0.80); C24(0.87); C295(1.53); C298(1.53)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C53(0.97); C295(0.97); C298(0.97); C24(1.08)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C53(0.95)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C53(0.93)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C53(0.96)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C53(1.19)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C298(1.09)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C53(1.16)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C53(0.96)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C53(0.87)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C53(1.10)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C53(1.15)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C53(1.43)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C53(1.88)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C53(1.61)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C53(1.45)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C53(1.57)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C53(0.86); C273(0.89); C276(0.89); C295(0.94)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C53(1.69)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C53(1.30)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C53(0.96)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C53(1.17)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C53(1.52)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C53(0.75)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C53(1.06)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C53(0.92)  LDD0648  [6]
 LDCM0332  AC68 HEK-293T C273(1.25); C295(0.91); C298(0.91)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C273(1.07); C295(0.88); C298(0.88)  LDD0931  [6]
 LDCM0334  AC7 HCT 116 C53(0.71); C295(0.83); C298(0.83); C273(1.06)  LDD0651  [6]
 LDCM0335  AC70 HEK-293T C273(1.46); C295(0.68); C298(0.68)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C273(1.15); C295(0.75); C298(0.75)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C273(1.02); C295(0.73); C298(0.73)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C273(1.04); C295(0.75); C298(0.75)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C273(0.92); C295(0.92); C298(0.92)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C273(1.14); C295(0.74); C298(0.74)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C273(1.50); C295(1.00); C298(1.00)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C273(1.24); C295(0.91); C298(0.91)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C273(1.13); C295(1.06); C298(1.06)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C273(0.95); C295(1.03); C298(1.03)  LDD0942  [6]
 LDCM0345  AC8 HCT 116 C273(0.94); C276(0.94); C53(0.95); C295(1.17)  LDD0662  [6]
 LDCM0346  AC80 HEK-293T C273(1.60); C295(1.18); C298(1.18)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C273(1.51); C295(1.12); C298(1.12)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C273(1.82); C295(0.86); C298(0.86)  LDD0946  [6]
 LDCM0349  AC83 HCT 116 C24(1.12); C295(1.41); C298(1.41); C53(1.46)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C295(1.07); C298(1.07); C24(1.10); C53(1.58)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C295(0.90); C298(0.90); C24(0.98); C53(1.23)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C24(0.80); C53(1.06); C295(1.10); C298(1.10)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C24(0.80); C295(0.87); C298(0.87); C53(1.46)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C24(0.93); C295(1.10); C298(1.10); C53(1.62)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C24(1.19); C295(1.31); C298(1.31); C53(1.52)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C24(0.76); C53(0.84); C295(1.07); C298(1.07)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C24(1.11); C295(1.50); C298(1.50); C53(2.07)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C24(1.13); C295(1.44); C298(1.44); C53(2.03)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C295(1.04); C298(1.04); C24(1.10); C53(1.73)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C295(0.85); C298(0.85); C24(1.10); C53(1.79)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C295(1.03); C298(1.03); C53(1.38); C24(1.54)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C24(1.14); C295(1.19); C298(1.19); C53(1.61)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C24(1.02); C295(1.09); C298(1.09); C53(1.92)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C295(0.94); C298(0.94); C273(0.96); C276(0.96)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C295(0.62); C298(0.62); C24(0.68); C273(0.76)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C273(0.86); C276(0.86); C295(0.90); C298(0.90)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C53(0.80); C295(0.92); C298(0.92); C273(0.97)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C273(0.80); C276(0.80); C295(0.90); C298(0.90)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.11  LDD0403  [2]
 LDCM0020  ARS-1620 HCC44 C53(1.21); C295(1.32); C298(1.32); C374(1.09)  LDD2171  [6]
 LDCM0632  CL-Sc Hep-G2 C24(20.00); C53(20.00)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C273(0.90); C276(0.90); C53(0.94); C295(1.00)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C53(0.97); C273(1.43); C276(1.43); C295(1.72)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C298(1.14)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C295(0.60); C298(0.60); C273(0.67); C276(0.67)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C295(0.77); C298(0.77); C53(0.79); C273(0.81)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C295(0.92); C298(0.92); C53(1.03); C273(1.04)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C295(0.82); C298(0.82); C273(0.90); C276(0.90)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C53(0.82); C24(0.84)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C53(0.91); C24(0.98)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C53(0.75); C24(0.92)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C24(1.18); C53(1.23)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C24(0.98); C53(1.04)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C295(1.03); C298(1.03); C53(1.31); C273(1.81)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C24(0.99); C53(1.23)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C24(1.11); C53(1.66)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C24(0.69)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C24(0.70)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C24(0.63)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C24(0.81)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C24(0.67)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C295(0.92); C298(0.92); C53(1.06); C24(1.30)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C53(0.96); C24(0.99); C295(1.22); C298(1.22)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C53(0.94); C24(1.12); C295(1.35); C298(1.35)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C53(1.13); C295(1.48); C298(1.48); C273(1.84)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C53(0.72); C24(0.88); C295(0.90); C298(0.90)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C53(1.04)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C53(0.84)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C53(1.43)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C53(1.13)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C53(1.55)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C53(1.07)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C53(1.53)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C53(1.03)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C295(0.97); C298(0.97); C53(1.13); C273(1.51)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C53(1.01); C295(1.01); C298(1.01); C273(1.41)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C295(0.98); C298(0.98); C53(1.17); C273(1.87)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C53(0.92); C295(1.15); C298(1.15)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C295(0.74); C298(0.74); C53(0.78)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C53(0.94); C295(1.07); C298(1.07)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C295(1.02); C298(1.02); C53(1.20)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C53(0.84); C273(1.11); C276(1.11); C295(1.12)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C53(0.93); C295(1.18); C298(1.18)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C295(0.83); C298(0.83); C53(0.97)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C295(0.91); C298(0.91); C53(1.28)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C53(1.41); C295(1.44); C298(1.44)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C53(1.09); C295(1.33); C298(1.33)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C295(1.44); C298(1.44); C53(0.88)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C295(1.07); C298(1.07); C53(0.77)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C295(1.16); C298(1.16); C53(1.03)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C295(1.60); C298(1.60); C53(1.17)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C295(1.46); C298(1.46); C53(1.01)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C273(0.89); C276(0.89); C295(1.38); C298(1.38)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C295(1.44); C298(1.44); C53(0.98)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C53(1.30)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C295(0.93); C298(0.93); C53(1.24)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C295(0.84); C298(0.84); C53(1.13)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C295(1.03); C298(1.03); C53(1.19)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C295(1.10); C298(1.10); C53(1.17)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C295(0.73); C298(0.73); C53(1.18)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C295(0.87); C298(0.87); C53(1.31)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C295(1.00); C298(1.00); C53(1.17)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C273(1.49); C276(1.49); C295(0.95); C298(0.95)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C295(0.91); C298(0.91); C53(1.32)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C295(0.82); C298(0.82); C53(1.53)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C295(0.88); C298(0.88); C53(1.36)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C295(1.16); C298(1.16); C53(1.46)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C295(0.83); C298(0.83); C53(1.46)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C295(0.88); C298(0.88); C53(1.73)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C295(1.08); C298(1.08); C53(0.66)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C295(1.00); C298(1.00); C53(0.77)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C295(0.90); C298(0.90); C53(0.72)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C295(1.06); C298(1.06); C53(0.85)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C273(1.17); C276(1.17); C295(1.26); C298(1.26)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C295(1.07); C298(1.07); C53(0.91)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C295(1.09); C298(1.09); C53(0.78)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C295(0.94); C298(0.94); C53(0.63)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C295(0.97); C298(0.97); C53(0.74)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C295(1.07); C298(1.07); C53(1.01)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C295(1.06); C298(1.06); C53(1.28)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C295(1.11); C298(1.11); C53(0.81)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C295(0.97); C298(0.97); C53(0.70)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C295(1.28); C298(1.28); C53(1.09)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C295(1.33); C298(1.33); C53(0.85)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C273(0.83); C276(0.83); C295(0.74); C298(0.74)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C295(1.22); C298(1.22); C53(0.79)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C295(1.01); C298(1.01); C53(0.89)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C295(1.17); C298(1.17); C53(1.11)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C295(1.05); C298(1.05); C53(0.96)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C295(0.98); C298(0.98); C53(0.93)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C295(1.01); C298(1.01); C53(0.86)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C295(1.12); C298(1.12); C53(0.90)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C295(0.85); C298(0.85); C53(1.08)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C295(1.08); C298(1.08); C53(0.89)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C295(1.21); C298(1.21); C53(1.15)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C273(1.49); C276(1.49); C295(1.22); C298(1.22)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C295(1.12); C298(1.12); C53(1.44)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C295(1.03); C298(1.03); C53(0.98)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C295(1.10); C298(1.10); C53(1.04)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C295(1.23); C298(1.23); C53(0.93)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C295(1.13); C298(1.13); C53(1.05)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C295(0.77); C298(0.77)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C295(0.67); C298(0.67)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C295(0.88); C298(0.88)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C295(0.90); C298(0.90)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C273(2.01); C276(2.01); C295(1.10); C298(1.10)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C295(0.98); C298(0.98)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C295(0.76); C298(0.76)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C295(0.77); C298(0.77)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C295(0.87); C298(0.87)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C295(0.99); C298(0.99)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C295(0.94); C298(0.94)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C295(0.81); C298(0.81)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C295(0.81); C298(0.81)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C295(0.77); C298(0.77)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C295(1.04); C298(1.04)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C273(1.34); C276(1.34); C295(1.05); C298(1.05)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C295(0.68); C298(0.68)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C298(0.83)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C298(0.85)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C298(1.05)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C298(1.12)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C298(0.86)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C298(1.14)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C298(1.09)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C298(1.04)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C298(1.03)  LDD0811  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C24(2.09)  LDD1702  [4]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0625  F8 Ramos 1.49; C306(1.22); C24(1.30)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos 0.81; C306(0.63)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos 0.95; C306(0.32)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos 0.98; C306(0.75); C24(0.90)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos 1.16; C306(1.44)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos 0.64; C306(0.86); C24(0.96)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos 0.70; C306(0.59); C24(4.92)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos 0.98; C306(1.22); C24(1.49)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos 1.02; C306(1.04)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos 0.94; C306(0.80)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos 0.78; C306(0.84); C24(0.53)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos 1.10; C306(0.80); C24(0.90)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos 1.95; C306(1.59)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos 0.92; C306(0.57); C24(1.56)  LDD2201  [15]
 LDCM0468  Fragment33 HCT 116 C295(1.17); C298(1.17); C53(1.11)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos 0.86; C306(1.05); C24(0.64)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos 1.52; C306(0.77); C24(1.08)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C295(0.80); C298(0.80); C53(1.52)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos 1.67; C306(0.63)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos 1.65; C306(1.20)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos 0.89; C306(0.59); C24(1.28)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos 0.96; C306(0.53); C24(1.84)  LDD2188  [15]
 LDCM0022  KB02 HCT 116 C53(2.95); C374(1.14); C295(2.07); C298(2.07)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C53(2.46); C374(1.29); C295(1.49); C298(1.49)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C53(3.04); C374(2.24); C295(1.33); C298(1.33)  LDD0082  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C24(0.40)  LDD2104  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C24(0.64)  LDD2109  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C24(1.15)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C24(1.32)  LDD2127  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C24(1.20)  LDD2137  [4]
 LDCM0131  RA190 MM1.R C53(1.30)  LDD0304  [16]
 LDCM0021  THZ1 HCT 116 C53(1.21); C295(1.32); C298(1.32); C374(1.09)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Thioredoxin domain-containing protein 12 (TXNDC12) . O95881
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Protein LDOC1 (LDOC1) LDOC1 family O95751
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
Heat shock factor 2-binding protein (HSF2BP) . O75031
PRKCA-binding protein (PICK1) . Q9NRD5
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN) . Q92622
Tetratricopeptide repeat protein 23-like (TTC23L) . Q6PF05

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.