Details of the Target

General Information of Target

Target ID LDTP04590
Target Name Smoothelin (SMTN)
Gene Name SMTN
Gene ID 6525
Synonyms
SMSMO; Smoothelin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADEALAGLDEGALRKLLEVTADLAERRRIRSAIRELQRQELEREEEALASKRFRAERQD
NKENWLHSQQREAEQRAALARLAGQLESMNDVEELTALLRSAGEYEERKLIRAAIRRVRA
QEIEAATLAGRLYSGRPNSGSREDSKGLAAHRLEQCEVPEREEQEQQAEVSKPTPTPEGT
SQDVTTVTLLLRAPPGSTSSSPASPSSSPTPASPEPPLEPAEAQCLTAEVPGSPEPPPSP
PKTTSPEPQESPTLPSTEGQVVNKLLSGPKETPAAQSPTRGPSDTKRADVAGPRPCQRSL
SVLSPRQPAQNRESTPLASGPSSFQRAGSVRDRVHKFTSDSPMAARLQDGTPQAALSPLT
PARLLGPSLTSTTPASSSSGSSSRGPSDTSSRFSKEQRGVAQPLAQLRSCPQEEGPRGRG
LAARPLENRAGGPVARSEEPGAPLPVAVGTAEPGGSMKTTFTIEIKDGRGQASTGRVLLP
TGNQRAELTLGLRAPPTLLSTSSGGKSTITRVNSPGTLARLGSVTHVTSFSHAPPSSRGG
CSIKMEAEPAEPLAAAVEAANGAEQTRVNKAPEGRSPLSAEELMTIEDEGVLDKMLDQST
DFEERKLIRAALRELRQRKRDQRDKERERRLQEARGRPGEGRGNTATETTTRHSQRAADG
SAVSTVTKTERLVHSNDGTRTARTTTVESSFVRRSENGSGSTMMQTKTFSSSSSSKKMGS
IFDREDQASPRAGSLAALEKRQAEKKKELMKAQSLPKTSASQARKAMIEKLEKEGAAGSP
GGPRAAVQRSTSFGVPNANSIKQMLLDWCRAKTRGYEHVDIQNFSSSWSDGMAFCALVHN
FFPEAFDYGQLSPQNRRQNFEVAFSSAEMLVDCVPLVEVDDMMIMGKKPDPKCVFTYVQS
LYNHLRRHELRLRGKNV
Target Bioclass
Other
Family
Smoothelin family
Subcellular location
Cytoplasm, cytoskeleton
Function Structural protein of the cytoskeleton.
Uniprot ID
P53814
Ensemble ID
ENST00000333137.12
HGNC ID
HGNC:11126

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C296(0.61)  LDD1700  [2]
EA-probe
 Probe Info  		N.A.  LDD0440  [3]
DBIA
 Probe Info  		C410(7.74)  LDD0209  [4]
IA-alkyne
 Probe Info  		C296(8.39)  LDD1704  [5]
IPM
 Probe Info  		C410(0.00); C296(0.00)  LDD0147  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		12.50  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C296(0.90)  LDD2142  [2]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C296(0.98)  LDD2112  [2]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C296(0.83)  LDD2095  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C296(0.54)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C296(1.27)  LDD2152  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C296(0.94)  LDD2103  [2]
 LDCM0214  AC1 HEK-293T C296(1.02)  LDD1507  [9]
 LDCM0215  AC10 HEK-293T C296(0.99)  LDD1508  [9]
 LDCM0237  AC12 HEK-293T C156(1.04)  LDD1510  [9]
 LDCM0270  AC15 HEK-293T C156(1.03); C296(0.99)  LDD1513  [9]
 LDCM0276  AC17 HEK-293T C296(0.99)  LDD1515  [9]
 LDCM0277  AC18 HEK-293T C296(1.09)  LDD1516  [9]
 LDCM0279  AC2 HEK-293T C296(1.02)  LDD1518  [9]
 LDCM0280  AC20 HEK-293T C156(0.92)  LDD1519  [9]
 LDCM0281  AC21 HEK-293T C156(1.04); C296(0.96)  LDD1520  [9]
 LDCM0283  AC23 HEK-293T C156(1.03); C296(0.92)  LDD1522  [9]
 LDCM0285  AC25 HEK-293T C296(0.97)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C296(1.09)  LDD1525  [9]
 LDCM0288  AC28 HEK-293T C156(1.13)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C156(1.26); C296(1.00)  LDD1528  [9]
 LDCM0292  AC31 HEK-293T C156(0.85); C296(0.98)  LDD1531  [9]
 LDCM0294  AC33 HEK-293T C296(1.08)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C296(1.06)  LDD1534  [9]
 LDCM0297  AC36 HEK-293T C156(1.00)  LDD1536  [9]
 LDCM0298  AC37 HEK-293T C156(1.04); C296(1.14)  LDD1537  [9]
 LDCM0300  AC39 HEK-293T C156(1.11); C296(1.07)  LDD1539  [9]
 LDCM0301  AC4 HEK-293T C156(0.99)  LDD1540  [9]
 LDCM0303  AC41 HEK-293T C296(1.06)  LDD1542  [9]
 LDCM0304  AC42 HEK-293T C296(1.06)  LDD1543  [9]
 LDCM0306  AC44 HEK-293T C156(1.06)  LDD1545  [9]
 LDCM0307  AC45 HEK-293T C156(1.24); C296(1.05)  LDD1546  [9]
 LDCM0309  AC47 HEK-293T C156(0.91); C296(1.10)  LDD1548  [9]
 LDCM0311  AC49 HEK-293T C296(1.05)  LDD1550  [9]
 LDCM0312  AC5 HEK-293T C156(1.50); C296(1.04)  LDD1551  [9]
 LDCM0313  AC50 HEK-293T C296(1.06)  LDD1552  [9]
 LDCM0315  AC52 HEK-293T C156(1.05)  LDD1554  [9]
 LDCM0316  AC53 HEK-293T C156(1.07); C296(0.93)  LDD1555  [9]
 LDCM0318  AC55 HEK-293T C156(0.94); C296(0.92)  LDD1557  [9]
 LDCM0320  AC57 HEK-293T C296(1.14)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C296(1.15)  LDD1560  [9]
 LDCM0324  AC60 HEK-293T C156(1.27)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C156(1.04); C296(1.03)  LDD1564  [9]
 LDCM0327  AC63 HEK-293T C156(1.10); C296(1.19)  LDD1566  [9]
 LDCM0334  AC7 HEK-293T C156(0.90); C296(1.08)  LDD1568  [9]
 LDCM0545  Acetamide MDA-MB-231 C296(0.21)  LDD2138  [2]
 LDCM0520  AKOS000195272 MDA-MB-231 C296(0.65)  LDD2113  [2]
 LDCM0248  AKOS034007472 HEK-293T C156(0.99); C296(1.04)  LDD1511  [9]
 LDCM0356  AKOS034007680 HEK-293T C296(0.99)  LDD1570  [9]
 LDCM0156  Aniline NCI-H1299 11.74  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C296(0.27)  LDD2091  [2]
 LDCM0372  CL103 HEK-293T C156(1.04)  LDD1576  [9]
 LDCM0376  CL107 HEK-293T C156(0.96)  LDD1580  [9]
 LDCM0379  CL11 HEK-293T C156(0.92); C296(0.77)  LDD1583  [9]
 LDCM0381  CL111 HEK-293T C156(1.14)  LDD1585  [9]
 LDCM0385  CL115 HEK-293T C156(1.10)  LDD1589  [9]
 LDCM0389  CL119 HEK-293T C156(0.99)  LDD1593  [9]
 LDCM0394  CL123 HEK-293T C156(0.92)  LDD1598  [9]
 LDCM0398  CL127 HEK-293T C156(1.50)  LDD1602  [9]
 LDCM0402  CL15 HEK-293T C156(0.80)  LDD1606  [9]
 LDCM0404  CL17 HEK-293T C296(1.24)  LDD1608  [9]
 LDCM0405  CL18 HEK-293T C296(0.92)  LDD1609  [9]
 LDCM0408  CL20 HEK-293T C156(1.13)  LDD1612  [9]
 LDCM0409  CL21 HEK-293T C156(1.01); C296(1.24)  LDD1613  [9]
 LDCM0411  CL23 HEK-293T C156(0.82); C296(0.77)  LDD1615  [9]
 LDCM0415  CL27 HEK-293T C156(0.92)  LDD1619  [9]
 LDCM0417  CL29 HEK-293T C296(0.93)  LDD1621  [9]
 LDCM0418  CL3 HEK-293T C156(1.01)  LDD1622  [9]
 LDCM0419  CL30 HEK-293T C296(0.89)  LDD1623  [9]
 LDCM0421  CL32 HEK-293T C156(1.43)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C156(0.71); C296(0.97)  LDD1626  [9]
 LDCM0424  CL35 HEK-293T C156(1.03); C296(0.89)  LDD1628  [9]
 LDCM0428  CL39 HEK-293T C156(1.23)  LDD1632  [9]
 LDCM0431  CL41 HEK-293T C296(1.08)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C296(1.13)  LDD1636  [9]
 LDCM0434  CL44 HEK-293T C156(1.06)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C156(1.15); C296(0.95)  LDD1639  [9]
 LDCM0437  CL47 HEK-293T C156(0.96); C296(0.76)  LDD1641  [9]
 LDCM0440  CL5 HEK-293T C296(0.96)  LDD1644  [9]
 LDCM0444  CL53 HEK-293T C296(1.03)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C296(0.96)  LDD1648  [9]
 LDCM0447  CL56 HEK-293T C156(1.04)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C156(0.81); C296(1.20)  LDD1651  [9]
 LDCM0450  CL59 HEK-293T C156(0.79); C296(0.91)  LDD1653  [9]
 LDCM0451  CL6 HEK-293T C296(1.07)  LDD1654  [9]
 LDCM0455  CL63 HEK-293T C156(1.02)  LDD1658  [9]
 LDCM0457  CL65 HEK-293T C296(1.01)  LDD1660  [9]
 LDCM0458  CL66 HEK-293T C296(1.08)  LDD1661  [9]
 LDCM0460  CL68 HEK-293T C156(1.15)  LDD1663  [9]
 LDCM0461  CL69 HEK-293T C156(0.88); C296(1.10)  LDD1664  [9]
 LDCM0464  CL71 HEK-293T C156(0.96); C296(0.88)  LDD1667  [9]
 LDCM0470  CL77 HEK-293T C296(1.09)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C296(1.06)  LDD1674  [9]
 LDCM0473  CL8 HEK-293T C156(0.77)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C156(1.06)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C156(0.88); C296(1.05)  LDD1678  [9]
 LDCM0477  CL83 HEK-293T C156(1.15); C296(0.88)  LDD1680  [9]
 LDCM0481  CL87 HEK-293T C156(1.07)  LDD1684  [9]
 LDCM0483  CL89 HEK-293T C296(0.96)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C156(1.04); C296(1.26)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C296(0.99)  LDD1688  [9]
 LDCM0487  CL92 HEK-293T C156(0.80)  LDD1690  [9]
 LDCM0488  CL93 HEK-293T C156(0.78); C296(1.04)  LDD1691  [9]
 LDCM0490  CL95 HEK-293T C156(0.91); C296(1.02)  LDD1693  [9]
 LDCM0494  CL99 HEK-293T C156(1.15)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C156(1.28)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C296(1.30)  LDD1702  [2]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [3]
 LDCM0468  Fragment33 HEK-293T C156(0.82)  LDD1671  [9]
 LDCM0022  KB02 T cell-activated C296(8.39)  LDD1704  [5]
 LDCM0023  KB03 Jurkat C410(7.74)  LDD0209  [4]
 LDCM0024  KB05 WM115 C410(2.03)  LDD3327  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C296(0.99)  LDD2102  [2]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C296(0.29)  LDD2121  [2]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C296(0.29)  LDD2089  [2]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C296(1.17)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C296(0.95)  LDD2092  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C296(0.79)  LDD2093  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C296(0.97)  LDD2094  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C296(0.77)  LDD2096  [2]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C296(0.68)  LDD2097  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C296(0.94)  LDD2098  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C296(0.89)  LDD2100  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C296(1.28)  LDD2101  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C296(0.72)  LDD2104  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C296(1.35); C410(1.19)  LDD2105  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C296(0.89)  LDD2106  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C296(0.70)  LDD2107  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C296(1.26)  LDD2108  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C296(0.58)  LDD2109  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C296(1.04)  LDD2114  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C296(0.82)  LDD2115  [2]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C296(0.94)  LDD2116  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C296(0.89)  LDD2118  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C296(1.00)  LDD2120  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C296(0.98)  LDD2122  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C296(1.02)  LDD2124  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C296(0.47); C410(0.76)  LDD2125  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C296(1.08)  LDD2126  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C296(1.52)  LDD2128  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C296(0.55)  LDD2129  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C296(0.50)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C296(0.49)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C410(1.23)  LDD2136  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C296(0.61)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C296(0.36); C410(1.03)  LDD2140  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C296(0.55); C410(0.91)  LDD2141  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C296(1.35)  LDD2143  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C296(4.16)  LDD2144  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C296(3.06)  LDD2145  [2]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C296(0.88)  LDD2148  [2]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C296(1.25)  LDD2149  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C296(0.22)  LDD2150  [2]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C296(2.87)  LDD2151  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C296(1.89)  LDD2153  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wolframin (WFS1) . O76024

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840