Details of the Target

General Information of Target

Target ID LDTP07213
Target Name Regulation of nuclear pre-mRNA domain-containing protein 2 (RPRD2)
Gene Name RPRD2
Gene ID 23248
Synonyms
KIAA0460; Regulation of nuclear pre-mRNA domain-containing protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGGGGGSSKASSSSASSAGALESSLDRKFQSVTNTMESIQGLSSWCIENKKHHSTIVY
HWMKWLRRSAYPHRLNLFYLANDVIQNCKRKNAIIFRESFADVLPEAAALVKDPSVSKSV
ERIFKIWEDRNVYPEEMIVALREALSTTFKTQKQLKENLNKQPNKQWKKSQTSTNPKAAL
KSKIVAEFRSQALIEELLLYKRSEDQIELKEKQLSTMRVDVCSTETLKCLKDKTGGKKFS
KEFEEASSKLEEFVNGLDKQVKNGPSLTEALENAGIFYEAQYKEVKVVANAYKTFANRVN
NLKKKLDQLKSTLPDPEESPVPSPSMDAPSPTGSESPFQGMGGEESQSPTMESEKSATPE
PVTDNRDVEDMELSDVEDDGSKIIVEDRKEKPAEKSAVSTSVPTKPTENISKASSCTPVP
VTMTATPPLPKPVNTSLSPSPALALPNLANVDLAKISSILSSLTSVMKNTGVSPASRPSP
GTPTSPSNLTSGLKTPAPATTTSHNPLANILSKVEITPESILSALSKTQTQSAPALQGLS
SLLQSVTGNPVPASEAASQSTSASPANTTVSTIKGRNLPSSAQPFIPKSFNYSPNSSTSE
VSSTSASKASIGQSPGLPSTTFKLPSNSLGFTATHNTSPAAPPTEVTICQSSEVSKPKLE
SESTSPSLEMKIHNFLKGNPGFSGLNLNIPILSSLGSSAPSESHPSDFQRGPTSTSIDNI
DGTPVRDERSGTPTQDEMMDKPTSSSVDTMSLLSKIISPGSSTPSSTRSPPPGRDESYPR
ELSNSVSTYRPFGLGSESPYKQPSDGMERPSSLMDSSQEKFYPDTSFQEDEDYRDFEYSG
PPPSAMMNLEKKPAKSILKSSKLSDTTEYQPILSSYSHRAQEFGVKSAFPPSVRALLDSS
ENCDRLSSSPGLFGAFSVRGNEPGSDRSPSPSKNDSFFTPDSNHNSLSQSTTGHLSLPQK
QYPDSPHPVPHRSLFSPQNTLAAPTGHPPTSGVEKVLASTISTTSTIEFKNMLKNASRKP
SDDKHFGQAPSKGTPSDGVSLSNLTQPSLTATDQQQQEEHYRIETRVSSSCLDLPDSTEE
KGAPIETLGYHSASNRRMSGEPIQTVESIRVPGKGNRGHGREASRVGWFDLSTSGSSFDN
GPSSASELASLGGGGSGGLTGFKTAPYKERAPQFQESVGSFRSNSFNSTFEHHLPPSPLE
HGTPFQREPVGPSSAPPVPPKDHGGIFSRDAPTHLPSVDLSNPFTKEAALAHAAPPPPPG
EHSGIPFPTPPPPPPPGEHSSSGGSGVPFSTPPPPPPPVDHSGVVPFPAPPLAEHGVAGA
VAVFPKDHSSLLQGTLAEHFGVLPGPRDHGGPTQRDLNGPGLSRVRESLTLPSHSLEHLG
PPHGGGGGGGSNSSSGPPLGPSHRDTISRSGIILRSPRPDFRPREPFLSRDPFHSLKRPR
PPFARGPPFFAPKRPFFPPRY
Target Bioclass
Other
Uniprot ID
Q5VT52
Ensemble ID
ENST00000369067.7
HGNC ID
HGNC:29039

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.P329L DBIA    Probe Info 
HCT15 SNV: p.V103I .
HDQP1 SNV: p.G1161D DBIA    Probe Info 
HEC1 SNV: p.A1249T DBIA    Probe Info 
HEC1B SNV: p.A1249T .
JURKAT SNV: p.S9N Compound 10    Probe Info 
MCC13 SNV: p.S323F; p.S942F; p.P1288L DBIA    Probe Info 
MCC26 SNV: p.S1002F DBIA    Probe Info 
OVK18 SNV: p.A274V .
SKMEL3 SNV: p.K177T .
SNGM SNV: p.A20T DBIA    Probe Info 
SW403 SNV: p.Q213H .
TGBC1TKB SNV: p.E702K DBIA    Probe Info 
TOV21G SNV: p.S619N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
ONAyne
 Probe Info  		K855(0.54)  LDD0274  [2]
STPyne
 Probe Info  		K91(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y292(6.70); Y592(24.25)  LDD3495  [3]
AHL-Pu-1
 Probe Info  		C649(3.41); C222(3.53)  LDD0169  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
DBIA
 Probe Info  		C903(1.12)  LDD0078  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C88(0.00); C222(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		C222(0.00); C1071(0.00)  LDD0037  [8]
NAIA_5
 Probe Info  		C903(0.00); C88(0.00); C649(0.00); C1071(0.00)  LDD2224  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
Compound 10
 Probe Info  		C1071(0.00); C903(0.00)  LDD2216  [12]
Compound 11
 Probe Info  		C1071(0.00); C903(0.00)  LDD2213  [12]
ENE
 Probe Info  		C1071(0.00); C903(0.00)  LDD0006  [13]
IPM
 Probe Info  		N.A.  LDD0005  [13]
VSF
 Probe Info  		C222(0.00); C1071(0.00)  LDD0007  [13]
Phosphinate-6
 Probe Info  		C903(0.00); C222(0.00); C1071(0.00); C88(0.00)  LDD0018  [14]
Acrolein
 Probe Info  		C1071(0.00); C903(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		C1071(0.00); C903(0.00)  LDD0219  [15]
Methacrolein
 Probe Info  		C1071(0.00); C903(0.00)  LDD0218  [15]
W1
 Probe Info  		D83(0.00); Y79(0.00); N82(0.00)  LDD0236  [16]
AOyne
 Probe Info  		12.50  LDD0443  [17]
HHS-465
 Probe Info  		K1168(0.00); Y1167(0.00); Y869(0.00); Y876(0.00)  LDD2240  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C222(3.02)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C649(3.41); C222(3.53)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C222(0.94); C416(0.89)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C222(1.12)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C222(0.99)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C222(1.14)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C222(1.01)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C222(1.01)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C222(0.96)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C222(1.13)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C222(1.20)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C222(0.99)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C222(1.08)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C222(1.11)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C222(1.21)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C222(1.31)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C222(0.97)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C222(0.98)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C222(1.09); C903(1.12)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C222(0.96); C903(1.49)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C222(1.02); C903(0.88)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C222(0.98); C903(1.80)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C222(1.40); C903(0.97)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C222(1.15); C903(1.73)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C222(1.51); C903(1.52)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C222(0.95)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C222(1.10); C903(1.39)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C222(1.02); C903(1.23)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C222(1.09); C903(1.09)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C222(1.06); C903(1.11)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C222(1.08); C903(1.10)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C222(1.01); C903(1.40)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C222(1.00); C903(1.48)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C222(1.06); C903(1.44)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C903(0.44)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C903(0.43)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C903(0.63)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C903(0.50)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C903(0.55)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C903(0.49)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C903(0.57)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C903(0.66)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C903(0.55)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C903(0.53)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C903(0.60)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C903(0.60)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C222(1.02)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C903(0.58)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C903(0.60)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C903(0.55)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C903(0.93)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C903(1.31)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C903(0.98)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C903(1.08)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C903(1.46)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C903(1.46)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C903(1.28)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C222(1.00)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C903(0.91)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C903(1.15)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C903(1.47)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C903(2.32)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C903(1.35)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C903(1.26)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C903(1.24)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C903(0.99)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C222(1.03); C416(1.08)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C222(0.85); C416(0.99)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C222(0.94); C416(0.98)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C222(0.89); C416(1.01)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C222(1.11); C416(1.29)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C222(0.95); C416(1.07)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C416(1.02); C222(1.07)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C222(0.97); C416(1.06)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C222(1.01); C416(1.12)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C222(1.03)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C222(1.07)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C222(1.12)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C222(1.05)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C222(1.01)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C222(0.88); C416(0.94)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C222(1.13)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C222(1.07)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C222(1.21)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C222(1.16)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C222(1.32)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C222(0.75)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C222(0.97)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C222(0.86)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C222(1.25)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C222(1.31)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C416(0.90); C222(0.95)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C222(1.53)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C222(1.12)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C222(1.03)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C222(0.98)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C222(1.14)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C222(1.36)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C222(0.94)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C222(0.88)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C222(0.93)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C222(1.04)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C416(0.78); C222(1.03)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C222(1.21)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C222(0.79)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C222(0.99)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C222(0.93)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C222(0.99)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C222(1.12)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C222(1.37)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C222(1.28)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C222(1.37)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C222(1.54)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C222(1.06)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C222(1.22)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C222(1.18)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C222(1.44)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C222(1.33)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C222(1.57)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C222(1.46)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C222(1.40)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C222(1.65)  LDD0648  [6]
 LDCM0332  AC68 HEK-293T C222(1.05); C903(1.00)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C222(2.07); C903(0.98)  LDD0931  [6]
 LDCM0334  AC7 HCT 116 C222(1.05)  LDD0651  [6]
 LDCM0335  AC70 HEK-293T C222(1.01); C903(1.08)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C222(1.11); C903(1.19)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C222(1.14); C903(0.98)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C222(0.63); C903(1.03)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C222(0.88); C903(1.16)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C222(0.70); C903(1.13)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C222(1.00); C903(1.23)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C222(1.42); C903(1.11)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C222(1.56); C903(0.95)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C222(0.93); C903(1.15)  LDD0942  [6]
 LDCM0345  AC8 HCT 116 C222(0.97)  LDD0662  [6]
 LDCM0346  AC80 HEK-293T C222(0.85); C903(1.13)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C222(0.97); C903(1.04)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C222(1.64); C903(0.88)  LDD0946  [6]
 LDCM0349  AC83 HCT 116 C903(0.97)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C903(1.03)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C903(1.01)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C903(1.04)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C903(0.97)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C903(1.05)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C903(0.98)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C903(1.03)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C903(1.04)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C903(0.95)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C903(1.13)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C903(0.91)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C903(1.00)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C903(0.86)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C903(1.08)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C222(1.32)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C222(0.93)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C222(1.15)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C222(1.20)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C222(1.39)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 12.01  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C903(1.12)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa C1071(0.00); C903(0.00); C222(0.00)  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C222(0.93)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C416(0.84)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C416(0.99)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C222(0.92); C416(0.98)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C222(1.11)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C222(0.89)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C222(1.00)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C222(1.02)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C222(0.81); C416(0.88)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C222(0.64); C416(0.78)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C222(0.76); C416(0.82)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C222(0.88); C416(1.03)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C222(0.95); C416(1.23)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C416(0.92)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C222(0.85); C416(0.98)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C222(0.85); C416(1.19)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C222(0.96)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C222(1.14)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C222(1.02)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C222(1.13)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C222(1.07)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C222(1.47)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C222(1.45)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C222(1.05)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C416(0.86)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C222(1.27)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C222(0.77)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C222(0.85)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C222(1.48)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C222(1.08)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C222(0.96)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C222(0.96)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C222(1.06)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C222(1.36)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C416(0.94)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C416(0.92)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C416(0.88)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C222(1.21)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C222(0.82)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C222(1.07)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C222(0.82)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C416(0.82)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C222(1.02)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C222(0.88)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C222(0.91)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C222(1.08)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C222(1.13)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C222(1.20)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C222(1.30)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C222(1.08)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C222(1.19)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C222(1.20)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C416(0.81)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C222(1.20)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C222(1.08)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C222(0.91)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C222(1.14)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C222(1.36)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C222(1.57)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C222(1.35)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C222(1.40)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C222(0.90)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C416(1.06)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C222(0.87)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C222(1.70)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C222(1.41)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C222(1.04)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C222(1.16)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C222(1.12)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C222(0.87); C903(0.99)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C222(0.87); C903(0.91)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C222(0.83); C903(0.94)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C222(0.91); C903(0.73)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C416(0.85)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C222(0.98); C903(0.88)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C222(1.09); C903(0.97)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C222(0.93); C903(0.92)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C222(0.93); C903(0.87)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C222(0.90); C903(0.99)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C222(0.87); C903(0.80)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C222(0.98); C903(1.05)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C222(0.79); C903(0.80)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C222(0.91); C903(0.89)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C222(1.05); C903(0.86)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C416(0.87)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C222(0.93); C903(0.97)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C416(1.26); C903(0.81)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C416(1.19); C903(0.83)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C416(1.36); C903(0.85)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C416(1.62); C903(0.63)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C416(1.18); C903(0.77)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C416(1.49); C903(0.92)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C416(2.21); C903(1.08)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C416(1.61); C903(0.78)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C416(1.26); C903(1.04)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C416(1.01)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C416(1.19); C903(0.91)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C416(1.21); C903(1.02)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C416(1.32); C903(0.93)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C416(1.70); C903(0.85)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C416(1.42); C903(0.87)  LDD0784  [6]
 LDCM0469  CL76 PaTu 8988t C48(1.29); C88(0.97)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C48(1.28); C88(1.13)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C48(1.33); C88(0.95)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C48(1.24); C88(1.07)  LDD1351  [6]
 LDCM0473  CL8 HCT 116 C416(0.97)  LDD0790  [6]
 LDCM0474  CL80 PaTu 8988t C48(1.34); C88(1.06)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C48(1.47); C88(1.07)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C48(1.74); C88(0.82)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C48(1.32); C88(1.01)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C48(1.18); C88(1.10)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C48(1.25); C88(1.08)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C48(1.17); C88(1.20)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C48(1.08); C88(1.14)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C48(1.24); C88(0.98)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C48(1.23); C88(1.22)  LDD1362  [6]
 LDCM0484  CL9 HCT 116 C416(0.98)  LDD0801  [6]
 LDCM0485  CL90 PaTu 8988t C48(1.26); C88(1.12)  LDD1364  [6]
 LDCM0486  CL91 HCT 116 C222(1.04); C416(0.99)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C222(0.77); C416(0.91)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C222(0.82); C416(0.85)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C222(0.88); C416(0.98)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C222(1.18); C416(0.91)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C222(0.94); C416(0.88)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C222(0.86); C416(0.95)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C222(1.03); C416(0.90)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C222(1.01); C416(0.79)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C1071(0.99); C649(1.01); C48(0.98); C88(0.79)  LDD1698  [19]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0625  F8 Ramos C222(1.49); C1071(1.71); C88(0.80); C649(3.92)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C222(1.24); C1071(0.90); C88(0.61)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C222(8.45); C1071(8.60); C88(20.00)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C222(1.08); C1071(0.73); C88(0.62)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C222(0.97); C1071(1.01); C88(0.54)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C222(1.55); C1071(0.84); C649(1.10)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C222(1.89); C1071(0.64)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C222(1.09); C1071(1.19); C88(0.72)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C222(1.38); C1071(1.15); C88(0.94)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C222(1.01); C1071(1.02); C88(0.70)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C222(0.83); C1071(0.71); C88(0.31)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C222(1.37); C1071(1.15); C88(0.73)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C222(1.20); C1071(1.01); C88(0.60)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C222(1.73); C1071(1.20); C88(0.75)  LDD2201  [20]
 LDCM0468  Fragment33 HCT 116 C416(1.57); C903(0.70)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C222(0.93); C1071(1.12); C88(2.30)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C222(1.53); C1071(1.51); C88(0.61); C649(0.94)  LDD2184  [20]
 LDCM0427  Fragment51 HCT 116 C222(2.33)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C222(1.27); C1071(1.27); C88(0.60)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C222(1.49); C1071(1.25); C88(0.90)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C222(1.15); C1071(0.93); C88(1.79)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C222(1.87); C1071(0.63)  LDD2188  [20]
 LDCM0022  KB02 HCT 116 C222(2.14)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C222(2.45)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C222(6.65)  LDD0082  [6]
 LDCM0131  RA190 MM1.R C903(1.64); C1071(0.78)  LDD0304  [21]
 LDCM0021  THZ1 HCT 116 C903(1.12)  LDD2173  [6]

References

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2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.