Details of the Target

General Information of Target

Target ID LDTP14199
Target Name Nuclear receptor corepressor 2 (NCOR2)
Gene Name NCOR2
Gene ID 9612
Synonyms
CTG26; Nuclear receptor corepressor 2; N-CoR2; CTG repeat protein 26; SMAP270; Silencing mediator of retinoic acid and thyroid hormone receptor; SMRT; T3 receptor-associating factor; TRAC; Thyroid-, retinoic-acid-receptor-associated corepressor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDAPRQVVNFGPGPAKLPHSVLLEIQKELLDYKGVGISVLEMSHRSSDFAKIINNTENLV
RELLAVPDNYKVIFLQGGGCGQFSAVPLNLIGLKAGRCADYVVTGAWSAKAAEEAKKFGT
INIVHPKLGSYTKIPDPSTWNLNPDASYVYYCANETVHGVEFDFIPDVKGAVLVCDMSSN
FLSKPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFALRECPSVLEYKVQAGNSSLY
NTPPCFSIYVMGLVLEWIKNNGGAAAMEKLSSIKSQTIYEIIDNSQGFYVCPVEPQNRSK
MNIPFRIGNAKGDDALEKRFLDKALELNMLSLKGHRSVGGIRASLYNAVTIEDVQKLAAF
MKKFLEMHQL
Target Bioclass
Transcription factor
Family
N-CoR nuclear receptor corepressors family
Subcellular location
Nucleus
Function
Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation.
Uniprot ID
Q9Y618
Ensemble ID
ENST00000405201.6
HGNC ID
HGNC:7673
ChEMBL ID
CHEMBL2111363

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.E1571G .
CALU6 SNV: p.Q1693K .
CFPAC1 Deletion: p.S1844AfsTer37 DBIA    Probe Info 
COLO800 SNV: p.R2146L; p.H2148Y DBIA    Probe Info 
EFO27 Deletion: p.H155TfsTer18
SNV: p.P154Q		 DBIA    Probe Info 
FTC133 SNV: p.P7T .
HCT15 SNV: p.A2328T .
HDQP1 SNV: p.S2432L DBIA    Probe Info 
HEC1 SNV: p.R632H .
HEC1B SNV: p.R632H .
HT115 SNV: p.V1145A .
ICC108 SNV: p.E522K DBIA    Probe Info 
IPC298 Substitution: p.P785T .
Ishikawa (Heraklio) 02 ER Deletion: p.A847RfsTer117 DBIA    Probe Info 
JURKAT Deletion: p.P2416RfsTer49
SNV: p.V1057M		 .
KARPAS422 SNV: p.L1761P .
LNCaP clone FGC SNV: p.L167P .
MCC26 SNV: p.E1191K; p.P2265S DBIA    Probe Info 
MFE319 SNV: p.A241E; p.N2207I .
MM1S Deletion: p.G1052AfsTer11 .
MOLT4 SNV: p.A903T; p.L2321F .
NB1 SNV: p.R1706P .
NCIH1155 SNV: p.A2400P DBIA    Probe Info 
NCIH2172 SNV: p.V1418L .
NCIH446 SNV: p.D180E DBIA    Probe Info 
NUGC3 Insertion: p.I976HfsTer8 .
OSRC2 SNV: p.L2391I .
PF382 SNV: p.L379P .
RKO Insertion: p.G781RfsTer15
SNV: p.L124V		 DBIA    Probe Info 
RL952 SNV: p.M431T .
SW1271 SNV: p.D914Y .
TOV21G SNV: p.E1412Ter; p.R1993L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K2289(9.09)  LDD0277  [2]
Probe 1
 Probe Info  		Y1363(15.13); Y1370(6.81); Y1504(10.69); Y1673(10.37)  LDD3495  [3]
BTD
 Probe Info  		C649(0.97)  LDD2117  [4]
AHL-Pu-1
 Probe Info  		C649(3.30); C1056(2.37)  LDD0170  [5]
EA-probe
 Probe Info  		N.A.  LDD0440  [6]
HHS-475
 Probe Info  		Y1270(1.04)  LDD0264  [7]
DBIA
 Probe Info  		C1511(1.03)  LDD0078  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
IA-alkyne
 Probe Info  		C2168(0.00); C1503(0.00)  LDD0162  [10]
IPM
 Probe Info  		N.A.  LDD0025  [11]
NAIA_4
 Probe Info  		C2168(0.00); C2436(0.00)  LDD2226  [12]
NAIA_5
 Probe Info  		C1503(0.00); C1289(0.00); C2436(0.00)  LDD2224  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
WYneN
 Probe Info  		C2436(0.00); C1503(0.00)  LDD0021  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
HHS-465
 Probe Info  		N.A.  LDD2240  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C649(0.97)  LDD2117  [4]
 LDCM0025  4SU-RNA DM93 C649(3.30); C1056(2.37)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C649(3.19); C1297(2.32); C1056(7.51)  LDD0171  [5]
 LDCM0214  AC1 HEK-293T C866(0.91); C1503(0.99)  LDD1507  [18]
 LDCM0215  AC10 HCT 116 C1056(1.37)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C1511(0.83)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C1511(0.83)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C1511(0.75)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C1511(1.32)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C1511(1.21)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C1511(0.68)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C1511(1.33)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C1511(0.72)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C1511(1.07)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C1511(1.35)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C1056(1.43)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C1511(1.23)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C1511(1.33)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C1511(0.85)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C1511(1.07)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C1511(1.38)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C1511(1.32)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C1511(1.27)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C1511(1.26)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C1511(1.24)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C1511(1.35)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C1056(1.19)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C1511(1.40)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C1511(1.16)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C1511(1.36)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C1511(1.11)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C1511(1.20)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C1511(1.42)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C1511(1.78)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C1511(2.20)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C1056(1.65)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C1056(0.99)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C1056(1.48)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C1056(0.89)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C1056(0.99)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C1056(1.22)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C1056(1.32)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C1056(1.46)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C1056(1.23)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C1056(1.07)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C1056(1.33)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C1056(1.06)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C1056(1.13)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C1056(1.21)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C1056(1.14)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C1056(0.92)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C1056(1.11)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C1056(1.76)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C1056(1.25)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C1056(1.39)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C1056(1.75)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C1056(2.49)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C1056(1.76)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C1056(1.81)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C1056(1.19)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C1056(1.21)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C1056(1.85)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C1056(2.91)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C1056(1.49)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C1056(1.63)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C1056(1.22)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C1056(0.97)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C866(0.94); C1056(1.01)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C1056(1.10); C866(1.98)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C1056(1.16); C866(1.22)  LDD0595  [8]
 LDCM0279  AC2 HEK-293T C1289(1.31)  LDD1518  [18]
 LDCM0280  AC20 HCT 116 C1056(1.17); C866(1.31)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C1056(1.50); C866(2.19)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C1056(1.11); C866(1.46)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C866(1.44); C1056(1.49)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C1056(1.00); C866(1.30)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C1056(1.00)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C1056(1.31)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C1056(1.21)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C1056(1.30)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C1056(0.92)  LDD0606  [8]
 LDCM0290  AC3 HEK-293T C866(0.98); C1503(1.02); C1289(1.06)  LDD1529  [18]
 LDCM0291  AC30 HCT 116 C1056(1.05)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C1056(1.20)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C1056(1.28)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C1056(1.65)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C1056(1.30)  LDD0612  [8]
 LDCM0296  AC35 PaTu 8988t C1056(1.06)  LDD1175  [8]
 LDCM0297  AC36 PaTu 8988t C1056(1.35)  LDD1176  [8]
 LDCM0298  AC37 PaTu 8988t C1056(1.73)  LDD1177  [8]
 LDCM0299  AC38 PaTu 8988t C1056(1.58)  LDD1178  [8]
 LDCM0300  AC39 PaTu 8988t C1056(1.65)  LDD1179  [8]
 LDCM0301  AC4 HEK-293T C866(1.09); C1503(0.99); C1289(0.95)  LDD1540  [18]
 LDCM0302  AC40 PaTu 8988t C1056(1.88)  LDD1181  [8]
 LDCM0303  AC41 PaTu 8988t C1056(1.48)  LDD1182  [8]
 LDCM0304  AC42 PaTu 8988t C1056(1.76)  LDD1183  [8]
 LDCM0305  AC43 PaTu 8988t C1056(1.40)  LDD1184  [8]
 LDCM0306  AC44 PaTu 8988t C1056(2.50)  LDD1185  [8]
 LDCM0307  AC45 PaTu 8988t C1056(1.81)  LDD1186  [8]
 LDCM0308  AC46 HCT 116 C866(0.99)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C866(1.28)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C866(0.93)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C866(1.76)  LDD0628  [8]
 LDCM0312  AC5 HEK-293T C866(1.14); C1503(1.04)  LDD1551  [18]
 LDCM0313  AC50 HCT 116 C866(1.49)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C866(0.98)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C866(0.97)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C866(1.26)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C866(1.13)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C866(1.94)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C866(2.29)  LDD0636  [8]
 LDCM0320  AC57 PaTu 8988t C1056(1.55)  LDD1199  [8]
 LDCM0321  AC58 PaTu 8988t C1056(1.43)  LDD1200  [8]
 LDCM0322  AC59 PaTu 8988t C1056(1.55)  LDD1201  [8]
 LDCM0323  AC6 HCT 116 C1056(1.48)  LDD0640  [8]
 LDCM0324  AC60 PaTu 8988t C1056(1.43)  LDD1203  [8]
 LDCM0325  AC61 PaTu 8988t C1056(1.09)  LDD1204  [8]
 LDCM0326  AC62 PaTu 8988t C1056(1.36)  LDD1205  [8]
 LDCM0327  AC63 PaTu 8988t C1056(1.01)  LDD1206  [8]
 LDCM0328  AC64 PaTu 8988t C1056(1.32)  LDD1207  [8]
 LDCM0329  AC65 PaTu 8988t C1056(1.19)  LDD1208  [8]
 LDCM0330  AC66 PaTu 8988t C1056(1.36)  LDD1209  [8]
 LDCM0331  AC67 PaTu 8988t C1056(1.37)  LDD1210  [8]
 LDCM0332  AC68 HCT 116 C1056(1.06)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C1056(1.11)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C1056(1.20)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C1056(0.98)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C1056(1.08)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C1056(1.13)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C1056(1.98)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C1056(1.69)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C1056(2.08)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C1056(1.16)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C1056(1.40)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C1056(1.26)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C1056(1.35)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C1056(1.24)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C1056(1.41)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C1056(0.65)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C1056(2.02)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C866(1.06)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C866(1.04)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C866(1.08)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C866(1.02)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C866(0.95)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C866(1.12)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C866(0.96)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C866(1.08)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C866(1.16)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C866(1.10)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C866(1.03)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C866(1.36)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C866(1.05)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C866(1.02)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C866(1.17)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C1511(2.09)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C1511(0.72)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C1056(1.31)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C1056(1.30)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C1056(2.22)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.92  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C1511(1.03)  LDD0078  [8]
 LDCM0632  CL-Sc Hep-G2 C1503(2.87); C2436(1.79); C1289(1.31); C2436(0.58)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C1056(0.96); C1511(1.16)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C1056(1.92); C1511(2.12)  LDD0685  [8]
 LDCM0369  CL100 HEK-293T C866(0.97); C1503(0.97)  LDD1573  [18]
 LDCM0370  CL101 HCT 116 C1056(1.41)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C1056(1.13)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C1056(1.42)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C1056(1.18)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C866(1.31); C1056(1.98)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C1056(1.54); C866(2.71)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C1056(1.53); C866(1.59)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C866(1.70); C1056(1.89)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C1056(1.31); C866(1.61)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C1056(1.79); C1511(2.18)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C1056(1.91); C866(1.93)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C1056(1.22); C866(1.45)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C1056(1.05)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C1056(1.15)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C1056(1.08)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C1056(1.43)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C1056(1.20)  LDD0703  [8]
 LDCM0387  CL117 PaTu 8988t C1056(1.39)  LDD1266  [8]
 LDCM0388  CL118 PaTu 8988t C1056(1.33)  LDD1267  [8]
 LDCM0389  CL119 PaTu 8988t C1056(1.51)  LDD1268  [8]
 LDCM0390  CL12 HCT 116 C1056(1.85); C1511(3.06)  LDD0707  [8]
 LDCM0391  CL120 PaTu 8988t C1056(1.38)  LDD1270  [8]
 LDCM0392  CL121 HCT 116 C866(1.13)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C866(1.14)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C866(1.49)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C866(1.33)  LDD0712  [8]
 LDCM0396  CL125 PaTu 8988t C1056(1.18)  LDD1275  [8]
 LDCM0397  CL126 PaTu 8988t C1056(2.31)  LDD1276  [8]
 LDCM0398  CL127 PaTu 8988t C1056(1.70)  LDD1277  [8]
 LDCM0399  CL128 PaTu 8988t C1056(1.25)  LDD1278  [8]
 LDCM0400  CL13 HCT 116 C1511(1.04); C1056(1.64)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C1511(1.28); C1056(1.48)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C1511(0.85); C1056(1.50)  LDD0719  [8]
 LDCM0403  CL16 HEK-293T C866(1.10); C1503(1.04)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C866(0.93); C1503(1.03)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C1289(1.16)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C866(1.03); C1503(0.96); C1289(1.22)  LDD1610  [18]
 LDCM0407  CL2 HCT 116 C1056(0.89); C1511(1.20)  LDD0724  [8]
 LDCM0408  CL20 HEK-293T C866(1.13); C1503(1.05); C1289(1.11)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C866(0.86); C1503(0.94)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C866(1.01); C1503(1.09)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C866(1.05); C1503(1.01); C2168(0.89)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C866(1.21); C1503(1.07)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C866(0.95); C1503(1.07)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C866(0.75); C1503(0.91)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C1503(1.01)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C866(0.94); C1503(0.99)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C866(1.08); C1503(0.98)  LDD1621  [18]
 LDCM0418  CL3 HCT 116 C1056(1.00); C1511(1.32)  LDD0735  [8]
 LDCM0419  CL30 HEK-293T C1289(1.24)  LDD1623  [18]
 LDCM0420  CL31 HCT 116 C866(1.12)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C866(0.94)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C866(0.86)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C866(1.24)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C866(1.17)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C866(1.09)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C866(1.23)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C866(1.01)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C1056(0.99); C1511(2.35)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C866(1.02)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C866(1.20)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C866(1.74)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C866(1.46)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C866(1.03)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C866(1.32)  LDD0752  [8]
 LDCM0436  CL46 PaTu 8988t C1056(1.26)  LDD1315  [8]
 LDCM0437  CL47 PaTu 8988t C1056(1.44)  LDD1316  [8]
 LDCM0438  CL48 PaTu 8988t C1056(1.19)  LDD1317  [8]
 LDCM0439  CL49 PaTu 8988t C1056(1.17)  LDD1318  [8]
 LDCM0440  CL5 HCT 116 C1056(1.07); C1511(0.96)  LDD0757  [8]
 LDCM0441  CL50 PaTu 8988t C1056(1.31)  LDD1320  [8]
 LDCM0442  CL51 PaTu 8988t C1056(1.51)  LDD1321  [8]
 LDCM0443  CL52 PaTu 8988t C1056(1.22)  LDD1322  [8]
 LDCM0444  CL53 PaTu 8988t C1056(1.31)  LDD1323  [8]
 LDCM0445  CL54 PaTu 8988t C1056(1.61)  LDD1324  [8]
 LDCM0446  CL55 PaTu 8988t C1056(1.17)  LDD1325  [8]
 LDCM0447  CL56 PaTu 8988t C1056(0.55)  LDD1326  [8]
 LDCM0448  CL57 PaTu 8988t C1056(2.96)  LDD1327  [8]
 LDCM0449  CL58 PaTu 8988t C1056(1.44)  LDD1328  [8]
 LDCM0450  CL59 PaTu 8988t C1056(3.57)  LDD1329  [8]
 LDCM0451  CL6 HCT 116 C1056(1.37); C1511(1.25)  LDD0768  [8]
 LDCM0452  CL60 PaTu 8988t C1056(2.31)  LDD1331  [8]
 LDCM0453  CL61 HCT 116 C1511(0.84)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C1511(0.90)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C1511(0.97)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C1511(0.70)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C1511(0.75)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C1511(0.92)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C1511(0.92)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C1511(0.76)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C1511(1.13)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C1056(1.41); C1511(1.99)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C1511(1.01)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C1511(0.90)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C1511(0.82)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C1511(0.89)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C1511(1.01)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C1056(1.37); C1511(1.52)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C1056(1.07); C1511(1.74)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C1056(1.23); C1511(1.61)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C1056(1.90); C1511(1.74)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C1056(1.99); C1511(1.16)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C1056(1.00); C1511(1.75)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C1056(1.29); C1511(1.67)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C1056(1.72); C1511(1.89)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C1056(1.56); C1511(1.13)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C1056(1.68); C1511(1.25)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C1056(1.35); C1511(1.15)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C1056(0.92); C1511(1.61)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C1056(1.47); C1511(1.22)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C1056(1.66); C1511(1.15)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C1056(2.26); C1511(1.69)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C1056(1.39); C1511(1.11)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C1056(1.25); C1511(1.34)  LDD0802  [8]
 LDCM0486  CL91 HEK-293T C866(0.93); C1503(0.92); C1289(0.95)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C866(0.94); C1503(1.08); C1289(1.07)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C866(0.93); C1503(1.09)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C866(0.85); C1503(1.18)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C866(0.81); C1503(1.00); C2168(1.02)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C866(0.91); C1503(0.98)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C866(1.00); C1503(1.07)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C866(0.84); C1503(0.99)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C1503(1.12)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C1503(0.99)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1503(1.78); C2436(1.16); C1289(0.94)  LDD1702  [4]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [6]
 LDCM0625  F8 Ramos C2436(1.56)  LDD2187  [19]
 LDCM0574  Fragment12 Ramos C2436(1.06)  LDD2191  [19]
 LDCM0576  Fragment14 Ramos C1503(1.07); C2436(1.19)  LDD2193  [19]
 LDCM0580  Fragment21 Ramos C1503(1.02); C2436(1.33)  LDD2195  [19]
 LDCM0578  Fragment27 Ramos C2436(1.90)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C1503(0.92); C2436(0.63)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C1503(1.89); C2436(0.91)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C1503(1.32)  LDD2200  [19]
 LDCM0468  Fragment33 HCT 116 C1511(0.77)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C1503(1.81)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C2436(0.83)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C866(1.72)  LDD0744  [8]
 LDCM0614  Fragment56 Ramos C1503(0.75); C2436(1.22)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C1503(0.97); C2436(1.02)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C2436(1.13)  LDD2188  [19]
 LDCM0116  HHS-0101 DM93 Y1270(1.04)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y1270(0.81)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y1270(1.15)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y1270(0.81)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y1270(1.25)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [15]
 LDCM0022  KB02 HCT 116 C1511(1.86); C1056(2.63)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C1511(1.41); C1056(1.27)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C1511(2.04); C1056(1.59)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0225  [15]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C866(0.96)  LDD2118  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C866(0.97)  LDD2122  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C866(0.68)  LDD2126  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1503(0.68)  LDD2141  [4]
 LDCM0021  THZ1 HCT 116 C1056(1.11); C1511(1.06)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone deacetylase 1 (HDAC1) Histone deacetylase family Q13547
Histone deacetylase 3 (HDAC3) Histone deacetylase family O15379
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Importin subunit alpha-3 (KPNA4) Importin alpha family O00629
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor E2F1 (E2F1) E2F/DP family Q01094
Retinoic acid receptor alpha (RARA) Nuclear hormone receptor family P10276
Msx2-interacting protein (SPEN) RRM Spen family Q96T58
Recombining binding protein suppressor of hairless (RBPJ) Su(H) family Q06330
Aryl hydrocarbon receptor (AHR) . P35869
Aryl hydrocarbon receptor nuclear translocator (ARNT) . P27540
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SNW domain-containing protein 1 (SNW1) SNW family Q13573

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578