Details of the Target

General Information of Target

Target ID LDTP14268
Target Name NF-kappa-B essential modulator (IKBKG)
Gene Name IKBKG
Gene ID 8517
Synonyms
FIP3; NEMO; NF-kappa-B essential modulator; NEMO; FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifier
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNTNDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFV
SQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAELIE
EYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKW
SLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICTPDLV
VFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDA
DRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNV
FGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESE
RSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDP
QLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHK
INAEGTPEDVFLQLCTAIDSIF
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways. Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin . Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.; (Microbial infection) Also considered to be a mediator for HTLV-1 Tax oncoprotein activation of NF-kappa-B.
Uniprot ID
Q9Y6K9
Ensemble ID
ENST00000422680.6
HGNC ID
HGNC:5961
ChEMBL ID
CHEMBL4967

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K111(10.00); K309(5.00); K344(10.00)  LDD0277  [2]
BTD
 Probe Info  		C167(2.96)  LDD1699  [3]
DBIA
 Probe Info  		C415(1.73)  LDD3311  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
5E-2FA
 Probe Info  		H81(0.00); H235(0.00); H40(0.00)  LDD2235  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C347(0.00); C131(0.00); C167(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C131(0.00); C167(0.00); C347(0.00); C76(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C167(0.00); C347(0.00); C131(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		C11(0.00); C54(0.00); C76(0.00); C95(0.00)  LDD2226  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [10]
IPM
 Probe Info  		N.A.  LDD0005  [11]
SF
 Probe Info  		N.A.  LDD0028  [12]
TFBX
 Probe Info  		C347(0.00); C131(0.00)  LDD0148  [13]
VSF
 Probe Info  		N.A.  LDD0007  [11]
1c-yne
 Probe Info  		K326(0.00); K143(0.00)  LDD0228  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
Methacrolein
 Probe Info  		C347(0.00); C167(0.00)  LDD0218  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		C347(0.00); C76(0.00); C131(0.00)  LDD2223  [9]
HHS-465
 Probe Info  		K309(0.00); Y308(0.00)  LDD2240  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C347(1.14)  LDD2117  [3]
 LDCM0214  AC1 HEK-293T C54(1.04); C76(0.96); C347(1.03); C167(0.87)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C54(0.92); C76(1.05); C347(0.97); C131(1.07)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C54(0.97); C76(1.20); C347(0.98); C167(1.00)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C54(0.97); C76(1.16); C347(1.06); C417(0.90)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C54(0.96); C76(1.19); C347(1.00); C131(1.23)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C54(0.91); C76(1.03); C347(1.09); C167(1.03)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C54(1.02); C76(0.98); C347(1.03); C167(0.79)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C54(1.07); C76(0.99); C347(1.00); C131(0.98)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C54(1.20); C76(1.55); C347(1.26); C167(1.03)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C54(0.98); C76(1.04); C347(0.99); C131(1.00)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C54(1.00); C76(1.12); C347(1.04); C417(0.81)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C54(0.97); C76(1.07); C347(0.94); C131(1.05)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C54(0.99); C76(1.06); C347(1.01); C131(1.00)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C54(0.96); C76(1.09); C347(1.07); C167(0.96)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C54(0.97); C76(1.19); C131(1.13)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C54(1.02); C76(0.98); C347(0.99); C167(0.93)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C54(1.03); C76(1.08); C347(0.97); C131(1.09)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C54(0.96); C76(1.00); C347(0.90); C167(1.36)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C54(0.98); C76(1.03); C347(1.00); C417(0.78)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C54(0.98); C76(1.02); C347(1.01); C131(1.11)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C54(0.89); C76(1.06); C347(0.82); C167(1.06)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C54(0.98); C76(1.04); C347(0.98); C131(1.19)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C54(0.90); C76(0.99); C347(1.05); C167(1.02)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C54(0.90); C76(1.05); C131(1.02)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C54(1.03); C76(1.09); C347(1.11); C167(0.90)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C54(1.03); C76(1.17); C347(0.96); C131(1.12)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C54(0.92); C76(1.17); C347(0.84); C167(1.24)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C54(1.04); C76(1.10); C347(1.11); C417(1.09)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C54(1.02); C76(1.14); C347(0.92); C131(1.03)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C54(0.96); C76(1.11); C347(0.98); C131(1.23)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C54(0.94); C76(1.04); C347(1.04); C167(1.02)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C54(1.01); C76(1.02); C347(1.02); C417(0.93)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C54(0.91); C76(1.13); C131(0.93)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C54(1.06); C76(1.12); C347(1.00); C167(0.86)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C54(1.00); C76(1.14); C347(1.01); C131(1.07)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C54(0.97); C76(1.15); C347(0.92); C167(1.12)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C54(1.01); C76(1.09); C347(1.05); C417(0.99)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C54(1.06); C76(1.16); C347(0.96); C131(1.08)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C54(0.91); C76(1.14); C347(0.98); C131(0.96)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C54(0.89); C76(1.10); C347(0.93); C167(1.03)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C54(1.00); C76(1.22); C131(1.04)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C54(1.08); C76(1.09); C347(1.03); C167(0.96)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C54(1.01); C76(1.02); C347(0.98); C131(0.99)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C54(1.03); C76(1.11); C347(1.02); C131(1.06)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C54(0.99); C76(1.26); C347(0.94); C167(1.07)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C54(1.00); C76(1.07); C347(1.05); C417(0.98)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C54(1.03); C76(1.14); C347(0.96); C131(1.02)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C54(0.90); C76(1.18); C347(0.99); C131(1.20)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C54(0.91); C76(1.09); C347(0.98); C167(0.93)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C54(0.95); C76(1.29); C131(0.92)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C54(1.06); C76(1.00); C347(1.01); C167(1.14)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C54(1.00); C76(1.08); C347(1.02); C131(0.92)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C54(0.96); C76(1.19); C347(1.07); C167(0.98)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C54(1.01); C76(1.06); C347(1.10); C131(1.02)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C54(1.02); C76(0.96); C347(1.03); C417(0.97)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C54(1.08); C76(1.08); C347(1.00); C131(0.94)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C54(0.94); C76(1.14); C347(1.01); C131(1.04)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C54(0.86); C76(0.98); C347(1.04); C167(1.02)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C54(0.92); C76(1.08); C131(1.00)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C54(0.96); C76(0.96); C347(1.02); C167(1.05)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C54(0.96); C76(1.19); C131(0.96)  LDD1569  [18]
 LDCM0520  AKOS000195272 MDA-MB-231 C347(1.07)  LDD2113  [3]
 LDCM0248  AKOS034007472 HEK-293T C54(1.07); C76(1.14); C347(0.98); C131(1.06)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C54(1.09); C76(1.01); C347(1.03); C167(1.00)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C54(0.95); C76(1.31); C131(1.11)  LDD1514  [18]
 LDCM0156  Aniline NCI-H1299 12.40  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C54(20.00); C76(20.00); C131(2.51); C76(1.54)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C54(0.94); C76(1.02)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C54(1.04); C76(1.15); C347(0.75); C131(1.12)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C54(1.01); C76(0.96); C347(0.95); C167(1.03)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C54(1.01); C76(1.16)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C54(1.02); C76(1.08); C347(0.92); C167(0.78)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C54(0.99); C76(1.14); C347(1.08); C131(1.11)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C54(0.94); C76(1.02); C347(0.93); C167(0.88)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C54(1.00); C76(1.06)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C54(0.93); C76(1.08); C347(0.96); C167(0.87)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C54(1.07); C76(1.15); C347(1.06); C131(1.09)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C54(0.98); C76(1.09); C347(1.04); C167(1.12)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C54(1.00); C76(1.07)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C54(0.87); C76(1.22); C347(0.97); C167(1.01)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C54(1.02); C76(1.05); C347(0.98); C167(0.76)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C54(0.99); C76(1.07); C347(1.09); C131(0.99)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C54(0.98); C76(1.02); C347(0.78); C167(0.95)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C54(1.07); C76(1.03)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C54(1.05); C76(1.08); C347(0.88); C167(0.93)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C54(1.04); C76(1.15); C347(0.96); C131(1.26)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C54(0.90); C76(1.14); C347(0.98); C167(1.08)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C54(1.09); C76(1.17)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C54(1.09); C76(1.25); C347(1.05); C167(0.79)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C54(0.92); C76(1.15); C347(1.01); C131(1.03)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C54(0.97); C76(1.38); C131(1.19)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C54(0.96); C76(1.07); C347(1.01); C167(0.78)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C54(1.10); C76(1.07)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C54(0.92); C76(1.21); C347(0.97); C167(0.84)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C54(0.92); C76(1.11); C347(1.06); C131(0.90)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C54(1.05); C76(1.20); C347(1.01); C167(0.75)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C54(0.98); C76(0.94)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C54(1.05); C76(0.91); C347(0.92); C167(0.95)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C54(0.94); C76(1.08); C347(0.98); C131(0.77)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C54(0.98); C76(1.07); C347(0.94); C167(1.01)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C54(1.11); C76(1.25)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C54(0.94); C76(1.08); C347(0.88); C167(1.00)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C54(0.90); C76(1.25); C347(0.99); C131(1.17)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C54(1.04); C76(1.21); C347(0.82); C167(1.13)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C54(1.05); C76(1.10); C347(1.07); C167(1.21)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C54(0.97); C76(1.32); C347(0.92); C131(1.13)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C54(0.93); C76(1.60); C347(0.93); C167(0.99)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C54(0.89); C76(1.06); C347(0.90); C167(0.92)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C54(0.94); C76(1.33); C347(0.97); C417(0.94)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C54(1.02); C76(1.53); C347(0.80); C131(1.14)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C54(1.00); C76(1.55); C347(0.88); C131(1.55)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C54(0.86); C76(1.56); C347(1.17); C167(0.95)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C54(0.99); C76(1.54); C131(1.32)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C54(0.88); C76(1.10)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C54(1.06); C76(1.18); C347(1.09); C167(0.82)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C54(0.85); C76(1.12); C347(1.03); C131(0.99)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C54(1.06); C76(1.12); C347(0.77); C167(1.11)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C54(0.98); C76(1.11); C347(1.09); C167(0.88)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C54(0.86); C76(1.06); C347(0.95); C131(1.12)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C54(0.96); C76(1.24); C347(0.99); C131(1.11)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C54(1.06); C76(1.30); C347(0.93); C167(1.19)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C54(0.95); C76(1.40); C347(0.96); C417(0.76)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C54(1.02); C76(1.50); C347(0.88); C131(0.97)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C54(0.95); C76(1.48); C347(0.92); C131(1.14)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C54(0.97); C76(1.41); C347(0.96); C167(1.02)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C54(0.96); C76(1.58); C131(1.48)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C54(0.95); C76(1.07)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C54(1.01); C76(1.01); C347(0.91); C131(0.98)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C54(0.92); C76(1.05); C347(0.87); C167(1.13)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C54(1.07); C76(1.16); C347(1.04); C167(1.09)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C54(1.03); C76(0.98); C347(0.94); C167(0.73)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C54(1.02); C76(1.12); C347(1.02); C131(0.98)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C54(1.00); C76(1.44); C347(0.88); C167(1.15)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C54(1.00); C76(1.15); C347(0.99); C417(0.77)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C54(1.16); C76(1.42); C347(0.84); C131(1.17)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C54(0.92); C76(1.33); C347(1.00); C131(1.19)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C54(0.98); C76(1.38); C347(0.98); C167(1.23)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C54(1.01); C76(1.41); C131(1.55)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C54(0.95); C76(1.02)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C54(1.14); C76(0.96); C347(1.09); C167(1.22)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C54(0.96); C76(1.08); C347(0.88); C167(1.04)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C54(0.88); C76(1.14); C347(0.97); C167(1.59)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C54(1.11); C76(1.02); C347(0.96); C167(0.88)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C54(0.97); C76(1.16); C347(0.99); C131(0.99)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C54(0.89); C76(1.46); C347(0.80); C167(1.06)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C54(0.99); C76(1.27); C347(0.99); C417(0.96)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C54(1.13); C76(1.55); C347(0.94); C131(1.14)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C54(0.94); C76(1.39); C347(0.92); C131(1.62)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C54(0.94); C76(1.52); C347(0.93); C167(1.04)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C54(0.95); C76(1.19); C347(0.87); C131(0.93)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C54(1.04); C76(1.50); C131(1.31)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C54(0.92); C76(1.05)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C54(1.02); C76(0.97); C347(1.01); C167(1.01)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C54(0.91); C76(1.17); C347(1.01); C131(1.05)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C54(0.96); C76(1.14); C347(0.83); C167(0.85)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C54(1.05); C76(1.09); C347(1.12); C167(0.87)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C54(0.98); C76(1.09); C347(0.92); C131(1.03)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C54(0.93); C76(1.40); C347(0.99); C167(1.04)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C54(1.00); C76(1.22); C347(1.03); C417(0.74)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C54(1.04); C76(1.46); C347(0.95); C131(1.09)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C54(0.88); C76(1.38); C347(0.85); C167(1.04)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C54(0.90); C76(1.27); C347(0.99); C131(1.07)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C54(0.99); C76(1.42); C347(0.97); C167(0.91)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C54(1.04); C76(1.58); C131(1.22)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C54(1.00); C76(1.06)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C54(1.07); C76(0.98); C347(0.99); C167(0.87)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C54(0.97); C76(1.14); C347(1.17); C167(0.81)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C54(1.08); C76(0.93); C347(0.98); C167(0.74)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C54(0.99); C76(1.11); C347(0.96); C131(1.05)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C54(1.05); C76(1.23); C347(0.94); C167(1.20)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C54(0.82); C76(1.03); C347(0.98); C417(0.78)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C54(0.96); C76(1.31); C347(0.98); C417(0.79)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C54(1.11); C76(1.38); C347(0.91); C131(1.31)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C54(0.99); C76(1.37); C347(0.95); C131(1.03)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C54(0.91); C76(1.25); C347(0.90); C167(0.94)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C54(0.94); C76(1.24); C131(1.18)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C54(0.97); C76(0.94)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C54(0.88); C76(0.88); C347(0.93); C167(0.86)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C54(1.08); C76(1.03); C347(0.91); C131(0.91)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C54(0.98); C76(1.05); C347(1.10); C167(1.02)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C54(1.05); C76(1.03); C347(1.03); C167(0.81)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C54(1.06); C76(1.25); C347(0.81); C131(1.05)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C54(0.93); C76(1.16); C347(0.88); C131(0.86)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C54(0.84); C76(1.25); C347(0.89); C167(1.07)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C54(0.96); C76(1.14); C347(1.01); C417(0.85)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C54(1.16); C76(1.41); C347(0.92); C131(1.07)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C54(1.02); C76(1.14); C347(0.91); C131(1.19)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C54(0.97); C76(1.15); C347(1.00); C167(0.80)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C54(0.89); C76(1.14); C131(0.92)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C54(1.03); C76(0.98)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C54(1.06); C76(1.13); C347(0.96); C167(0.64)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C54(0.96); C76(0.95); C347(0.91); C131(0.95)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C54(0.98); C76(1.03); C347(0.95); C131(0.98)  LDD1698  [18]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0625  F8 Ramos C347(1.00); C131(2.00)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C347(0.70); C131(1.29)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C347(4.26); C131(20.00)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C347(0.90); C131(1.66)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C347(0.90); C131(1.73)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C347(1.03); C131(0.74)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C347(0.78); C131(1.84)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C347(1.10); C131(1.11)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C347(0.69); C131(1.04)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C347(1.02); C131(1.35)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C347(0.57); C131(0.67)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C347(1.23); C131(2.04)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C347(1.02); C131(1.92)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C347(0.82); C131(2.25)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C54(0.96); C76(1.10); C347(1.00); C131(0.93)  LDD1671  [18]
 LDCM0596  Fragment38 Ramos C347(0.96); C131(1.89)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C347(0.78); C131(1.20)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C54(1.08); C76(1.07); C347(0.98); C167(0.91)  LDD1631  [18]
 LDCM0610  Fragment52 Ramos C347(1.40); C131(2.62)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C347(1.74); C131(4.00)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C347(0.95); C131(1.06)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C347(0.93); C131(0.94)  LDD2188  [19]
 LDCM0022  KB02 HEK-293T C347(1.00); C54(1.02); C76(0.98); C11(0.95)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C347(1.04); C54(1.03); C76(1.09); C11(0.99)  LDD1497  [18]
 LDCM0024  KB05 G361 C415(1.73)  LDD3311  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C347(1.38)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C131(0.82)  LDD2104  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C347(0.92)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C347(0.57); C167(0.54)  LDD2115  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C347(1.00)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C347(1.01)  LDD2134  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C347(0.39)  LDD2144  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C347(0.49)  LDD2148  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 3 (COPS3) CSN3 family Q9UNS2
5'-deoxynucleotidase HDDC2 (HDDC2) HDDC2 family Q7Z4H3
Heat shock protein HSP 90-alpha (HSP90AA1) Heat shock protein 90 family P07900
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) Peptidase C14B family Q9UDY8
Sentrin-specific protease 2 (SENP2) Peptidase C48 family Q9HC62
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) Peptidase C64 family P21580
Proteasome subunit beta type-5 (PSMB5) Peptidase T1B family P28074
Serine-protein kinase ATM (ATM) PI3/PI4-kinase family Q13315
Serine/threonine-protein kinase ATR (ATR) PI3/PI4-kinase family Q13535
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) PPP phosphatase family P67775
Cyclin-dependent kinase 2 (CDK2) CMGC Ser/Thr protein kinase family P24941
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) Ser/Thr protein kinase family O15111
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) Ser/Thr protein kinase family O14920
Serine/threonine-protein kinase TBK1 (TBK1) Ser/Thr protein kinase family Q9UHD2
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) STE Ser/Thr protein kinase family Q99558
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) TKL Ser/Thr protein kinase family Q13546
Receptor-type tyrosine-protein kinase FLT3 (FLT3) Tyr protein kinase family P36888
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
E3 ubiquitin-protein ligase RNF31 (RNF31) RBR family Q96EP0
RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1) RBR family Q9BYM8
RING-box protein 2 (RNF7) RING-box family Q9UBF6
Ubiquitin-conjugating enzyme E2 D4 (UBE2D4) Ubiquitin-conjugating enzyme family Q9Y2X8
Endoribonuclease ZC3H12A (ZC3H12A) ZC3H12 family Q5D1E8
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A1 (ANXA1) Annexin family P04083
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Synaptotagmin-1 (SYT1) Synaptotagmin family P21579
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
NF-kappa-B inhibitor alpha (NFKBIA) NF-kappa-B inhibitor family P25963
Myc proto-oncogene protein (MYC) . P01106
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor (TNF) Tumor necrosis factor family P01375
Other
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiomotin (AMOT) Angiomotin family Q4VCS5
ADP-ribosylation factor-like protein 6-interacting protein 4 (ARL6IP4) ARL6IP4 family Q66PJ3
Calbindin (CALB1) Calbindin family P05937
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Keratin, type I cytoskeletal 18 (KRT18) Intermediate filament family P05783
Keratin, type II cytoskeletal 8 (KRT8) Intermediate filament family P05787
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
Oxidative stress-induced growth inhibitor 1 (OSGIN1) OKL38 family Q9UJX0
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
Pre-mRNA-splicing factor SLU7 (SLU7) SLU7 family O95391
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Polyubiquitin-C (UBC) Ubiquitin family P0CG48
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
ARF GTPase-activating protein GIT2 (GIT2) . Q14161
Arf-GAP with dual PH domain-containing protein 2 (ADAP2) . Q9NPF8
B-cell lymphoma/leukemia 10 (BCL10) . O95999
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Leukocyte receptor cluster member 8 (LENG8) . Q96PV6
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Sequestosome-1 (SQSTM1) . Q13501
Sharpin (SHARPIN) . Q9H0F6
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
TNFAIP3-interacting protein 2 (TNIP2) . Q8NFZ5
TRAF family member-associated NF-kappa-B activator (TANK) . Q92844

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tarenflurbil Small molecular drug DB05289
Agro100 . DB04998

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578