Details of the Target

General Information of Target

Target ID LDTP12554
Target Name Latent-transforming growth factor beta-binding protein 3 (LTBP3)
Gene Name LTBP3
Gene ID 4054
Synonyms
Latent-transforming growth factor beta-binding protein 3; LTBP-3
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASKSWLNFLTFLCGSAIGFLLCSQLFSILLGEKVDTQPNVLHNDPHARHSDDNGQNHLE
GQMNFNADSSQHKDENTDIAENLYQKVRILCWVMTGPQNLEKKAKHVKATWAQRCNKVLF
MSSEENKDFPAVGLKTKEGRDQLYWKTIKAFQYVHEHYLEDADWFLKADDDTYVILDNLR
WLLSKYDPEEPIYFGRRFKPYVKQGYMSGGAGYVLSKEALKRFVDAFKTDKCTHSSSIED
LALGRCMEIMNVEAGDSRDTIGKETFHPFVPEHHLIKGYLPRTFWYWNYNYYPPVEGPGC
CSDLAVSFHYVDSTTMYELEYLVYHLRPYGYLYRYQPTLPERILKEISQANKNEDTKVKL
GNP
Target Bioclass
Other
Family
LTBP family
Subcellular location
Secreted
Function
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.
Uniprot ID
Q9NS15
Ensemble ID
ENST00000301873.11
HGNC ID
HGNC:6716

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.H234R .
COLO320 SNV: p.N644T .
HT Deletion: p.R656AfsTer6 .
JURKAT Deletion: p.R656AfsTer6
SNV: p.C370Y;p.Q525Ter;p.C625F		 .
KARPAS422 SNV: p.H483Y .
LNCaP clone FGC SNV: p.N746S .
MELHO Substitution: p.P195N .
MFE319 SNV: p.E175D .
MOLT4 SNV: p.G152C .
NCIH716 SNV: p.G652V; p.A653S .
SNU1 SNV: p.H600Q .
U937 SNV: p.D282Y .
WM1552C SNV: p.H317Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
EA-probe
 Probe Info  		N.A.  LDD0440  [1]
DBIA
 Probe Info  		C614(1.01); C620(1.01); C379(0.96); C381(0.96)  LDD0078  [2]
TFBX
 Probe Info  		C319(0.00); C71(0.00); C1297(0.00); C279(0.00)  LDD0148  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C394(1.17)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C394(0.99); C319(1.21)  LDD1508  [5]
 LDCM0216  AC100 HCT 116 C117(0.79); C123(0.79)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C117(0.93); C123(0.93)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C117(1.05); C123(1.05)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C117(1.01); C123(1.01)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C117(1.11); C123(1.11)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C117(0.97); C123(0.97)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C117(0.92); C123(0.92)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C117(1.07); C123(1.27)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C117(0.90); C123(0.98)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C117(0.79); C123(0.85)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C394(1.17); C319(1.12); C727(1.01)  LDD1509  [5]
 LDCM0227  AC110 HCT 116 C117(0.73); C123(1.06)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C117(0.78); C123(0.90)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C117(1.12); C123(0.75)  LDD0546  [2]
 LDCM0237  AC12 HEK-293T C319(1.09)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C394(0.98); C319(1.49); C727(1.09)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C319(1.02)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C394(1.06)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C394(1.04); C319(1.06)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C394(1.66); C319(1.07); C727(1.36)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C394(0.94); C319(1.14)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C319(0.95)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C319(0.93)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C394(1.04); C319(1.36); C727(1.21)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C319(0.95)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C394(0.92)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C394(0.99)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C394(1.13); C319(0.94)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C394(1.09); C319(1.05); C727(1.05)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C319(0.98)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C319(1.02)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C394(1.30); C319(1.09); C727(0.89)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C394(1.14); C319(1.13); C727(1.12)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C319(1.01)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C394(0.88)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C394(1.28)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C394(0.95); C319(1.14)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C394(1.23); C319(1.04); C727(1.03)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C319(1.09)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C319(0.99)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C394(1.12); C319(1.06); C727(1.02)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C319(1.14)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C319(1.05)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C394(1.00)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C394(1.05)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C394(1.04); C319(1.12)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C394(0.97); C319(1.12); C727(1.26)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C319(1.13)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C319(0.97)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C394(1.14); C319(1.36); C727(1.13)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C319(1.13)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C394(1.19)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C394(1.63)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C319(0.96)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C394(0.98); C319(1.20)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C394(1.02); C319(0.94); C727(1.12)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C319(1.19)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C319(1.05)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C394(1.17); C319(1.50); C727(1.04)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C319(1.05)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C394(1.09)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C394(1.01)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C394(1.01); C319(1.17)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C394(1.17); C319(1.06); C727(1.05)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C394(1.15); C319(1.07); C727(0.95)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C319(1.08)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C319(0.98)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C394(1.15); C319(1.04); C727(1.11)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C319(0.99)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C394(1.06)  LDD1567  [5]
 LDCM0332  AC68 HCT 116 C117(1.33); C123(1.33)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C117(1.22); C123(1.22)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C319(0.95)  LDD1568  [5]
 LDCM0335  AC70 HCT 116 C117(1.46); C123(1.46)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C117(1.26); C123(1.26)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C117(1.23); C123(1.23)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C117(1.74); C123(1.74)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C117(1.93); C123(1.93)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C117(2.62); C123(2.62)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C117(1.22); C123(1.22)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C117(1.39); C123(1.39)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C117(1.34); C123(1.34)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C117(1.25); C123(1.25)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C394(1.10)  LDD1569  [5]
 LDCM0346  AC80 HCT 116 C117(1.42); C123(1.42)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C117(1.05); C123(1.05)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C117(1.52); C123(1.52)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C117(1.26); C123(1.26)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C117(1.12); C123(1.12)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C117(1.44); C123(1.44)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C117(1.18); C123(1.18)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C117(1.44); C123(1.44)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C117(1.25); C123(1.25)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C117(1.24); C123(1.24)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C117(1.33); C123(1.33)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C117(1.38); C123(1.38)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C117(1.33); C123(1.33)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C117(1.28); C123(1.28)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C117(1.14); C123(1.14)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C117(1.47); C123(1.47)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C117(1.26); C123(1.26)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C117(1.23); C123(1.23)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C117(1.71); C123(1.71)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C117(0.85); C123(0.85)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C319(1.05)  LDD1511  [5]
 LDCM0356  AKOS034007680 HEK-293T C394(1.17)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C394(1.14)  LDD1514  [5]
 LDCM0020  ARS-1620 HCC44 C614(1.01); C620(1.01); C379(0.96); C381(0.96)  LDD0078  [2]
 LDCM0368  CL10 HEK-293T C394(1.15); C319(1.25); C727(1.07)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C319(0.86); C289(1.06)  LDD1573  [5]
 LDCM0372  CL103 HEK-293T C394(1.21); C319(1.07)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C319(1.02); C289(1.13)  LDD1577  [5]
 LDCM0376  CL107 HEK-293T C394(0.92); C319(1.07)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C319(0.96); C289(0.87)  LDD1581  [5]
 LDCM0379  CL11 HEK-293T C319(1.22)  LDD1583  [5]
 LDCM0381  CL111 HEK-293T C394(0.91); C319(0.95)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C319(0.96); C289(0.99)  LDD1586  [5]
 LDCM0385  CL115 HEK-293T C394(1.21); C319(1.03)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C319(0.90); C289(0.88)  LDD1590  [5]
 LDCM0389  CL119 HEK-293T C394(1.09); C319(1.31)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C394(1.05)  LDD1594  [5]
 LDCM0391  CL120 HEK-293T C319(1.09); C289(0.96)  LDD1595  [5]
 LDCM0394  CL123 HEK-293T C394(1.11); C319(1.19)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C319(0.83); C289(1.04)  LDD1599  [5]
 LDCM0398  CL127 HEK-293T C394(1.31); C319(1.19)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C319(0.85); C289(1.10)  LDD1603  [5]
 LDCM0402  CL15 HEK-293T C394(1.17); C319(1.22)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C319(0.95); C289(0.97)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C394(1.24)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C394(0.95); C319(1.27)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C394(1.30); C319(1.09); C727(1.05)  LDD1610  [5]
 LDCM0408  CL20 HEK-293T C319(1.16)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C319(1.06)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C394(1.16); C319(1.21); C727(1.09)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C319(1.26)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C394(0.98)  LDD1616  [5]
 LDCM0415  CL27 HEK-293T C394(1.00); C319(0.97)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C319(0.93); C289(0.83)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C394(1.09)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C394(1.10); C319(1.00)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C394(0.91); C319(0.95)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C394(1.15); C319(0.99); C727(1.19)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C319(1.02)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C319(1.05)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C394(1.17); C319(1.97); C727(0.97)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C319(1.24)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C394(1.06)  LDD1629  [5]
 LDCM0428  CL39 HEK-293T C394(1.08); C319(1.03)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C319(0.84); C289(0.80)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C319(0.81); C289(0.77)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C394(1.16)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C394(0.90); C319(1.12)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C394(1.09); C319(1.07); C727(1.03)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C319(1.17)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C319(1.08)  LDD1639  [5]
 LDCM0436  CL46 HCT 116 C117(1.45); C123(1.45)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C117(1.36); C123(1.36)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C117(1.08); C123(1.08)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C117(1.21); C123(1.21)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C394(1.18)  LDD1644  [5]
 LDCM0441  CL50 HCT 116 C117(1.18); C123(1.18)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C117(1.50); C123(1.50)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C117(1.47); C123(1.47)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C117(1.27); C123(1.27)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C117(1.18); C123(1.18)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C117(1.06); C123(1.06)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C117(1.11); C123(1.11)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C117(1.04); C123(1.04)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C117(1.25); C123(1.25)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C117(1.44); C123(1.44)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C394(0.90); C319(1.46)  LDD1654  [5]
 LDCM0452  CL60 HCT 116 C117(1.21); C123(1.21)  LDD0769  [2]
 LDCM0455  CL63 HEK-293T C394(0.89); C319(1.24)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C319(0.97); C289(0.85)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C394(1.04)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C394(0.92); C319(1.18)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C394(1.20); C319(1.08); C727(1.09)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C319(1.05)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C319(1.05)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C394(1.16); C319(0.98); C727(1.02)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C394(1.07); C319(1.45); C727(1.18)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C319(1.35)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C394(0.97)  LDD1668  [5]
 LDCM0469  CL76 HEK-293T C319(0.96); C289(0.95)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C394(1.09)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C394(0.94); C319(1.03)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C394(1.16); C319(0.96); C727(1.24)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C319(1.21)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C319(1.26)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C319(1.21)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C394(1.24); C319(1.03); C727(1.22)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C319(1.35)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C394(0.90)  LDD1681  [5]
 LDCM0481  CL87 HEK-293T C394(1.23); C319(1.09)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C319(0.96); C289(1.27)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C394(1.38)  LDD1686  [5]
 LDCM0484  CL9 HEK-293T C319(1.17)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C394(0.82); C319(1.55)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C394(1.37); C319(1.04); C727(1.04)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C319(1.01)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C319(1.05)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C394(1.18); C319(1.17); C727(1.05)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C319(1.02)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C394(1.17)  LDD1694  [5]
 LDCM0494  CL99 HEK-293T C394(1.21); C319(1.02)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C394(1.12); C319(1.23)  LDD1698  [5]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [1]
 LDCM0468  Fragment33 HEK-293T C394(0.85); C319(1.04)  LDD1671  [5]
 LDCM0021  THZ1 HCT 116 C768(1.24); C770(1.24); C1010(1.08); C1021(1.08)  LDD2173  [2]

References

1 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402