Details of the Target

General Information of Target

Target ID LDTP11626
Target Name Protein YIPF3 (YIPF3)
Gene Name YIPF3
Gene ID 25844
Synonyms
C6orf109; KLIP1; Protein YIPF3; Killer lineage protein 1; Natural killer cell-specific antigen KLIP1; YIP1 family member 3) [Cleaved into: Protein YIPF3, 36 kDa form III]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQLQTRFYTDNKKYAVDDVPFSIPAASEIADLSNIINKLLKDKNEFHKHVEFDFLIKGQ
FLRMPLDKHMEMENISSEEVVEIEYVEKYTAPQPEQCMFHDDWISSIKGAEEWILTGSYD
KTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVK
ALHCCRGHAGSVDSIAVDGSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTNRPRKKQKT
EQLGLTRTPIVTLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSLKSTLTGNKVF
NCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLIS
GSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSPTTSH
VGA
Target Bioclass
Transporter and channel
Family
YIP1 family
Subcellular location
Cell membrane
Function Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.
Uniprot ID
Q9GZM5
Ensemble ID
ENST00000372422.7
HGNC ID
HGNC:21023

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K102(3.55)  LDD0277  [1]
EA-probe
 Probe Info  		N.A.  LDD0440  [2]
AOyne
 Probe Info  		15.00  LDD0443  [3]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C153
 Probe Info  		18.77  LDD1834  [4]
C178
 Probe Info  		27.47  LDD1857  [4]
C218
 Probe Info  		25.63  LDD1892  [4]
C219
 Probe Info  		6.11  LDD1893  [4]
C220
 Probe Info  		19.43  LDD1894  [4]
C264
 Probe Info  		19.43  LDD1935  [4]
C270
 Probe Info  		6.77  LDD1940  [4]
C285
 Probe Info  		26.72  LDD1955  [4]
C287
 Probe Info  		17.27  LDD1957  [4]
C288
 Probe Info  		8.51  LDD1958  [4]
C289
 Probe Info  		82.71  LDD1959  [4]
C290
 Probe Info  		4.92  LDD1960  [4]
C310
 Probe Info  		13.18  LDD1977  [4]
C362
 Probe Info  		65.80  LDD2023  [4]
C363
 Probe Info  		20.39  LDD2024  [4]
C364
 Probe Info  		23.59  LDD2025  [4]
C366
 Probe Info  		7.52  LDD2027  [4]
C367
 Probe Info  		5.31  LDD2028  [4]
OEA-DA
 Probe Info  		20.00  LDD0046  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tripartite motif-containing protein 42 (TRIM42) TRIM/RBCC family Q8IWZ5
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Keratin-associated protein 3-2 (KRTAP3-2) KRTAP type 3 family Q9BYR7
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Keratin-associated protein 9-4 (KRTAP9-4) KRTAP type 9 family Q9BYQ2
Keratin-associated protein 9-8 (KRTAP9-8) KRTAP type 9 family Q9BYQ0
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Protein YIPF4 (YIPF4) YIP1 family Q9BSR8

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570