Details of the Target

General Information of Target

Target ID LDTP12745
Target Name Uridine-cytidine kinase-like 1 (UCKL1)
Gene Name UCKL1
Gene ID 54963
Synonyms
URKL1; Uridine-cytidine kinase-like 1; EC 2.7.1.48
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Target Bioclass
Enzyme
Family
Uridine kinase family
Subcellular location
Cytoplasm
Function May contribute to UTP accumulation needed for blast transformation and proliferation.
Uniprot ID
Q9NWZ5
Ensemble ID
ENST00000354216.11
HGNC ID
HGNC:15938

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KYSE410 SNV: p.D248Y .
LS180 Deletion: p.T228RfsTer16 .
SBC5 SNV: p.M117I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K179(7.14)  LDD0277  [2]
BTD
 Probe Info  		C65(0.94)  LDD2107  [3]
AHL-Pu-1
 Probe Info  		C35(2.66)  LDD0169  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
Acrolein
 Probe Info  		N.A.  LDD0232  [6]
DBIA
 Probe Info  		C35(1.14)  LDD0078  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C374(0.00); C317(0.00); C35(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C317(0.00); C374(0.00); C35(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C374(0.00); C317(0.00); C35(0.00)  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
NAIA_5
 Probe Info  		N.A.  LDD2225  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
W1
 Probe Info  		N.A.  LDD0236  [12]
AOyne
 Probe Info  		14.60  LDD0443  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C65(1.01)  LDD2117  [3]
 LDCM0025  4SU-RNA DM93 C35(2.64)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C35(2.66)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C35(1.43)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C35(0.81)  LDD0532  [7]
 LDCM0226  AC11 HCT 116 C35(0.81)  LDD0543  [7]
 LDCM0230  AC113 HCT 116 C35(1.16)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C35(1.23)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C35(1.11)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C35(1.24)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C35(1.03)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C35(1.32)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C35(1.29)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C35(0.64)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C35(1.06)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C35(1.29)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C35(1.16)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C35(1.46)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C35(1.15)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C35(1.17)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C35(1.37)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C35(1.65)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C35(1.15)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C35(0.65)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C35(0.96)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C35(0.79)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C35(0.97)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C35(1.02)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C35(0.92)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C35(1.16)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C35(1.02)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C35(0.74)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C35(0.76)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C35(0.83)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C35(0.63)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C35(1.06)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C35(0.81)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C35(0.72)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C35(1.24)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C35(0.94)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C35(0.85)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C35(1.09)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C35(1.07)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C35(1.04)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C35(0.86)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C35(0.64)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C35(0.96)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C35(0.94)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C35(0.89)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C35(1.01)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C35(1.09)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C35(0.90)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C35(1.41)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C35(1.21)  LDD2161  [7]
 LDCM0276  AC17 PaTu 8988t C35(1.03)  LDD1155  [7]
 LDCM0277  AC18 PaTu 8988t C35(1.14)  LDD1156  [7]
 LDCM0278  AC19 PaTu 8988t C35(0.97)  LDD1157  [7]
 LDCM0279  AC2 HCT 116 C35(1.91)  LDD0596  [7]
 LDCM0280  AC20 PaTu 8988t C35(1.30)  LDD1159  [7]
 LDCM0281  AC21 PaTu 8988t C35(1.05)  LDD1160  [7]
 LDCM0282  AC22 PaTu 8988t C35(1.02)  LDD1161  [7]
 LDCM0283  AC23 PaTu 8988t C35(1.56)  LDD1162  [7]
 LDCM0284  AC24 PaTu 8988t C35(1.48)  LDD1163  [7]
 LDCM0285  AC25 PaTu 8988t C35(1.51)  LDD1164  [7]
 LDCM0286  AC26 PaTu 8988t C35(1.60)  LDD1165  [7]
 LDCM0287  AC27 PaTu 8988t C35(1.19)  LDD1166  [7]
 LDCM0288  AC28 PaTu 8988t C35(1.85)  LDD1167  [7]
 LDCM0289  AC29 PaTu 8988t C35(0.96)  LDD1168  [7]
 LDCM0290  AC3 HCT 116 C35(1.26)  LDD0607  [7]
 LDCM0291  AC30 PaTu 8988t C35(1.50)  LDD1170  [7]
 LDCM0292  AC31 PaTu 8988t C35(2.34)  LDD1171  [7]
 LDCM0293  AC32 PaTu 8988t C35(1.21)  LDD1172  [7]
 LDCM0294  AC33 PaTu 8988t C35(1.54)  LDD1173  [7]
 LDCM0295  AC34 PaTu 8988t C35(1.11)  LDD1174  [7]
 LDCM0296  AC35 HEK-293T C35(1.04); C317(0.95)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C35(0.88)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C35(1.06)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C35(0.97); C317(1.00)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C35(1.04)  LDD1539  [14]
 LDCM0301  AC4 HCT 116 C35(0.96)  LDD0618  [7]
 LDCM0302  AC40 HEK-293T C35(1.02)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C35(1.07); C317(0.83)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C35(0.99)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C35(1.11); C317(0.94)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C35(1.01)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C35(1.17)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C35(0.93); C317(1.12)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C35(1.04)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C35(0.97)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C35(1.09); C317(0.83)  LDD1550  [14]
 LDCM0312  AC5 HCT 116 C35(1.15)  LDD0629  [7]
 LDCM0313  AC50 HEK-293T C35(0.95)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C35(0.97); C317(0.90)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C35(1.01)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C35(1.08)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C35(1.02); C317(0.93)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C35(1.04)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C35(1.03)  LDD1558  [14]
 LDCM0320  AC57 HCT 116 C35(0.93)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C35(0.69)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C35(0.86)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C35(0.70)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C35(0.81)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C35(0.67)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C35(0.77)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C35(0.89)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C35(0.82)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C35(0.84)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C35(0.86)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C35(0.86)  LDD0648  [7]
 LDCM0334  AC7 HCT 116 C35(0.86)  LDD0651  [7]
 LDCM0345  AC8 HCT 116 C35(0.73)  LDD0662  [7]
 LDCM0248  AKOS034007472 HCT 116 C35(0.68)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C35(1.18)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C35(0.67)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C35(1.14)  LDD0078  [7]
 LDCM0632  CL-Sc Hep-G2 C317(1.48)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C35(1.10)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C35(1.33)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C35(1.29)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C35(0.55)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C35(0.63)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C35(0.73)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C35(0.79)  LDD0690  [7]
 LDCM0374  CL105 PaTu 8988t C35(0.99)  LDD1253  [7]
 LDCM0375  CL106 PaTu 8988t C35(1.15)  LDD1254  [7]
 LDCM0376  CL107 PaTu 8988t C35(1.01)  LDD1255  [7]
 LDCM0377  CL108 PaTu 8988t C35(1.02)  LDD1256  [7]
 LDCM0378  CL109 PaTu 8988t C35(1.08)  LDD1257  [7]
 LDCM0379  CL11 HCT 116 C35(1.32)  LDD0696  [7]
 LDCM0380  CL110 PaTu 8988t C35(1.32)  LDD1259  [7]
 LDCM0381  CL111 PaTu 8988t C35(1.82)  LDD1260  [7]
 LDCM0382  CL112 PaTu 8988t C35(1.10)  LDD1261  [7]
 LDCM0383  CL113 PaTu 8988t C35(1.11)  LDD1262  [7]
 LDCM0384  CL114 PaTu 8988t C35(1.15)  LDD1263  [7]
 LDCM0385  CL115 PaTu 8988t C35(1.02)  LDD1264  [7]
 LDCM0386  CL116 PaTu 8988t C35(1.53)  LDD1265  [7]
 LDCM0387  CL117 HEK-293T C35(1.02); C317(0.90)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C35(1.10); C317(0.70)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C35(1.03)  LDD1593  [14]
 LDCM0390  CL12 HCT 116 C35(1.50)  LDD0707  [7]
 LDCM0391  CL120 HEK-293T C35(1.01); C317(0.84)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C35(0.96); C317(1.08)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C35(0.98); C317(0.90)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C35(0.97)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C35(0.94); C317(1.18)  LDD1599  [14]
 LDCM0396  CL125 HCT 116 C35(0.77)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C35(0.61)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C35(0.68)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C35(0.79)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C35(1.33)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C35(1.48)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C35(1.04)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C35(1.07)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C35(0.86)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C35(1.00)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C35(0.86)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C35(1.27)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C35(0.82)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C35(0.71)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C35(0.62)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C35(0.99)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C35(1.12)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C35(1.14)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C35(1.00)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C35(1.11)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C35(1.28)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C35(1.11)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C35(0.86)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C35(0.99)  LDD0736  [7]
 LDCM0420  CL31 HEK-293T C35(1.04); C317(0.87)  LDD1624  [14]
 LDCM0421  CL32 HCT 116 C35(1.27)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C35(1.00)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C35(1.08)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C35(1.25)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C35(1.00)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C35(1.05)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C35(1.63)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C35(1.62)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C35(0.98)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C35(1.01)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C35(0.80)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C35(1.40)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C35(1.28)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C35(1.21)  LDD0752  [7]
 LDCM0436  CL46 PaTu 8988t C35(1.01)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C35(1.38)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C35(1.50)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C35(1.87)  LDD1318  [7]
 LDCM0440  CL5 HCT 116 C35(1.49)  LDD0757  [7]
 LDCM0441  CL50 PaTu 8988t C35(1.60)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C35(1.18)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C35(1.09)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C35(1.41)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C35(1.48)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C35(1.73)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C35(1.06)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C35(1.28)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C35(1.40)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C35(1.68)  LDD1329  [7]
 LDCM0451  CL6 HCT 116 C35(1.30)  LDD0768  [7]
 LDCM0452  CL60 PaTu 8988t C35(1.06)  LDD1331  [7]
 LDCM0453  CL61 HCT 116 C35(1.69)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C35(1.22)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C35(1.04)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C35(0.89)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C35(0.77)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C35(0.88)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C35(0.88)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C35(1.07)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C35(0.83)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C35(1.31)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C35(1.30)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C35(1.04)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C35(0.85)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C35(1.22)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C35(0.85)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C35(0.82)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C35(1.01)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C35(0.74)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C35(0.65)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C35(1.41)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C35(1.13)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C35(0.73)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C35(0.58)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C35(0.94)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C35(0.81)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C35(1.03)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C35(0.63)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C35(0.91)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C35(0.55)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C35(0.70)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C35(1.54)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C35(0.65)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C35(0.95)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C35(0.95)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C35(1.13)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C35(1.01)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C35(1.04)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C35(0.89)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C35(1.09)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C35(0.98)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C35(0.92)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C35(1.14)  LDD1698  [14]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0625  F8 Ramos C317(2.33)  LDD2187  [15]
 LDCM0573  Fragment11 Ramos C317(4.72)  LDD2190  [15]
 LDCM0576  Fragment14 Ramos C317(1.08)  LDD2193  [15]
 LDCM0586  Fragment28 Ramos C317(0.62)  LDD2198  [15]
 LDCM0468  Fragment33 HCT 116 C35(0.88)  LDD0785  [7]
 LDCM0566  Fragment4 Ramos C317(1.69)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C35(0.79)  LDD0744  [7]
 LDCM0569  Fragment7 Ramos C317(1.59)  LDD2186  [15]
 LDCM0022  KB02 HCT 116 C35(1.19)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C35(1.14)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C35(1.17)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0232  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C65(0.94)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C65(0.71)  LDD2109  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C65(1.51)  LDD2125  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C65(1.18)  LDD2140  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C65(1.44)  LDD2146  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase RNF19B (RNF19B) RBR family Q6ZMZ0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
5-o-phosphono-alpha-d-ribofuranosyl Diphosphate Small molecular drug DB01632
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Guanosine-5'-triphosphate Small molecular drug DB04137
Uracil Small molecular drug DB03419
Uridine Monophosphate Small molecular drug DB03685

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578