Details of the Target

General Information of Target

Target ID LDTP09845
Target Name Geranylgeranyl transferase type-2 subunit alpha (RABGGTA)
Gene Name RABGGTA
Gene ID 5875
Synonyms
Geranylgeranyl transferase type-2 subunit alpha; EC 2.5.1.60; Geranylgeranyl transferase type II subunit alpha; Rab geranyl-geranyltransferase subunit alpha; Rab GG transferase alpha; Rab GGTase alpha; Rab geranylgeranyltransferase subunit alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARAAALLPSRSPPTPLLWPLLLLLLLETGAQDVRVQVLPEVRGQLGGTVELPCHLLPPV
PGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAEL
QDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTV
ALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKV
EHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTS
GTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGG
IIGGIIAAIIATAVAATGILICRQQRKEQTLQGAEEDEDLEGPPSYKPPTPKAKLEAQEM
PSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEERSGPLHPGATSLGSPIPV
PPGPPAVEDVSLDLEDEEGEEEEEYLDKINPIYDALSYSSPSDSYQGKGFVMSRAMYV
Target Bioclass
Enzyme
Family
Protein prenyltransferase subunit alpha family
Function
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.
Uniprot ID
Q92696
Ensemble ID
ENST00000216840.11
HGNC ID
HGNC:9795
ChEMBL ID
CHEMBL5249

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C532(0.62)  LDD2089  [2]
DBIA
 Probe Info  		C354(5.71)  LDD0209  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C99(0.00); C132(0.00); C516(0.00); C532(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C99(0.00); C354(0.00); C256(0.00); C457(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C99(0.00); C354(0.00); C487(0.00); C256(0.00)  LDD0037  [4]
NAIA_4
 Probe Info  		C68(0.00); C99(0.00)  LDD2226  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
IPM
 Probe Info  		N.A.  LDD0147  [7]
TFBX
 Probe Info  		C132(0.00); C99(0.00)  LDD0148  [7]
Acrolein
 Probe Info  		C516(0.00); C99(0.00)  LDD0217  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
W1
 Probe Info  		C516(0.00); C371(0.00); C99(0.00); C132(0.00)  LDD0236  [9]
AOyne
 Probe Info  		9.60  LDD0443  [10]
NAIA_5
 Probe Info  		C99(0.00); C487(0.00); C516(0.00); C145(0.00)  LDD2223  [5]
HHS-482
 Probe Info  		Y107(1.36)  LDD2239  [11]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		10.27  LDD1838  [12]
C201
 Probe Info  		29.65  LDD1877  [12]
C426
 Probe Info  		15.56  LDD2081  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C532(0.89); C186(1.93)  LDD2117  [2]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C532(0.58)  LDD2132  [2]
 LDCM0214  AC1 HCT 116 C145(0.64); C516(0.95); C532(1.70); C99(1.51)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C371(1.15); C532(1.14)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C371(0.89); C516(0.82); C532(1.10); C99(0.86)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C371(0.76); C516(0.80); C532(1.06); C99(0.74)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C371(1.12); C516(0.82); C532(0.99); C99(0.67)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C371(0.60); C516(0.73); C532(0.93); C99(0.54)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C371(1.06); C516(0.93); C532(1.01); C99(0.55)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C371(0.71); C516(0.79); C532(1.06); C99(0.47)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C371(0.74); C516(0.79); C532(1.07); C99(0.53)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C371(0.86); C516(0.67); C532(1.13); C99(0.48)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C371(0.70); C516(0.73); C532(1.07); C99(0.56)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C371(0.86); C516(0.90); C532(1.35); C99(0.44)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C371(1.16); C532(1.49)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C371(0.70); C516(0.68); C532(0.95); C99(0.51)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C371(0.67); C516(0.65); C532(0.97); C99(0.54)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C371(0.80); C516(0.67); C532(1.07); C99(0.59)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C145(1.10); C186(0.97); C354(0.97); C516(1.18)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C145(1.19); C186(0.86); C354(1.21); C516(0.97)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C145(1.07); C186(0.73); C354(1.26); C516(0.94)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C145(1.11); C186(0.90); C354(1.12); C516(1.12)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C145(1.22); C186(1.77); C354(1.00); C516(1.00)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C145(1.09); C186(1.14); C354(1.11); C516(1.17)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C145(1.06); C186(0.98); C354(1.14); C516(1.06)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C371(1.45); C532(1.97)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C145(0.73); C186(0.83); C354(1.18); C516(1.16)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C145(1.25); C186(2.04); C354(0.96); C516(0.97)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C145(1.05); C186(0.86); C354(1.15); C516(1.00)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C145(0.95); C186(1.11); C354(1.01); C516(1.05)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C145(1.13); C186(1.29); C354(0.95); C516(1.05)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C145(1.30); C186(0.84); C354(1.19); C516(1.01)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C145(1.04); C186(0.98); C354(1.18); C516(1.10)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C145(1.07); C186(1.11); C354(1.03); C516(1.00)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C145(1.18); C186(1.23); C516(0.99); C99(1.26)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C145(1.31); C186(1.26); C516(1.11); C99(1.17)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C145(1.11); C186(1.16); C516(1.03); C99(1.06)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C145(1.31); C186(1.50); C516(1.13); C99(1.24)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C145(1.43); C186(1.16); C516(1.07); C99(1.08)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C145(1.29); C186(1.21); C516(1.10); C99(1.20)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C145(1.31); C186(1.19); C516(1.06); C99(1.13)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C145(1.33); C186(1.26); C516(1.05); C99(1.08)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C145(1.05); C186(1.28); C516(1.04); C99(1.05)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C145(1.14); C186(1.16); C516(1.00); C99(1.00)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C145(1.37); C186(0.92); C516(0.99); C99(0.83)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C145(1.47); C186(0.97); C516(1.10); C99(0.92)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C371(1.21); C532(1.41)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C145(1.62); C186(1.00); C516(1.02); C99(0.92)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C145(1.38); C186(0.95); C516(1.07); C99(0.99)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C145(1.19); C186(1.13); C516(1.12); C99(1.09)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C516(1.01); C354(1.12)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C516(0.91); C354(1.54)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C516(0.85); C354(1.27)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C516(1.02); C354(1.86)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C516(0.94); C354(1.66)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C516(0.79); C354(2.14)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C516(0.85); C354(1.91)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C532(1.18); C371(1.20)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C516(0.80); C354(1.22)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C516(0.84); C354(1.16)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C516(0.82); C354(1.50)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C516(0.96); C354(2.38)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C354(1.43); C516(0.93)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C354(1.38); C516(1.06)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C354(1.03); C516(0.95)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C354(1.04); C516(1.09)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C532(0.83); C186(1.05); C354(1.09); C516(1.11)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C532(0.43); C99(0.80); C516(0.97); C186(1.19)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C532(0.65); C99(0.92); C516(1.07); C354(1.17)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C145(0.92); C516(0.95); C532(0.98); C99(1.23)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C186(0.79); C99(0.83); C532(0.87); C516(1.09)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C532(0.58); C99(0.77); C186(1.01); C516(1.11)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C532(0.75); C186(0.91); C99(0.95); C516(1.13)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C532(0.59); C99(0.80); C186(0.97); C516(1.02)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C532(0.84); C186(1.05); C516(1.09); C354(1.12)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C99(0.79); C516(1.01); C186(1.48)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C99(0.65); C516(1.01); C186(1.31)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C99(0.70); C516(1.05); C186(1.55)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C99(0.68); C516(0.96); C186(1.67)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C99(0.68); C516(0.94); C186(1.33)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C145(0.86); C516(1.01); C532(1.26); C99(1.51)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C99(0.80); C516(1.00); C186(1.18)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C99(0.61); C516(1.00); C186(1.30)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C99(0.57); C516(0.98); C186(1.41)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C99(0.59); C516(1.00); C186(1.14)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C99(0.56); C186(0.82); C516(0.97)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C516(0.99); C371(1.05); C186(1.10)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C516(1.02); C186(1.14); C371(1.18)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C516(0.95); C371(1.13); C186(1.28)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C186(0.96); C516(1.01); C371(1.34)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C186(0.92); C516(1.08); C371(1.11)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C145(0.87); C516(1.02); C532(1.44); C99(1.61)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C516(1.01); C371(1.02); C186(1.05)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C516(0.96); C186(1.07); C371(1.24)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C186(1.01); C516(1.05); C371(1.15)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C186(0.90); C516(0.95); C371(1.20)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C516(1.06); C371(1.10); C186(1.28)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C371(0.99); C516(1.02); C186(1.31)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C532(0.63); C186(0.84); C516(0.93); C371(1.09)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C186(0.93); C516(0.95); C371(0.95); C532(0.96)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C532(0.73); C516(0.83); C371(1.03); C186(1.08)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C532(0.72); C186(0.82); C371(0.83); C516(0.87)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C145(0.90); C516(0.99); C532(1.21); C99(1.65)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C532(0.68); C186(0.76); C516(0.85); C371(0.86)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C532(0.73); C186(0.85); C354(0.86); C516(0.96)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C186(0.67); C532(0.71); C516(0.99); C371(1.15)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C516(0.93); C186(0.94); C371(0.98); C532(1.21)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C532(0.71); C186(0.82); C516(0.89); C371(1.02)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C371(0.79); C516(0.82); C186(0.94); C532(1.30)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C371(0.66); C516(0.69); C532(0.78); C186(0.84)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C145(0.88); C532(1.34); C354(1.80)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C145(0.74); C532(1.20); C354(1.97)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C532(1.00); C145(1.06); C354(2.32)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C532(0.75); C371(0.76)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C145(0.70); C532(1.02); C354(1.85)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C145(0.68); C532(1.00); C354(1.77)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C145(0.90); C532(0.90); C354(2.27)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C145(0.60); C532(0.99); C354(1.85)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C145(0.78); C532(1.11); C354(2.12)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C145(1.08); C532(1.15); C354(2.40)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C145(0.86); C532(1.44); C354(2.21)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C145(0.62); C532(0.89); C354(3.58)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C516(0.95); C145(1.16); C354(1.24)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C516(0.84); C145(1.11); C354(1.27)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C532(0.90); C371(0.94)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C516(0.87); C354(1.27); C145(3.23)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C516(1.02); C354(1.19); C145(1.37)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C516(0.96); C145(1.03); C354(1.18)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C516(0.85); C145(1.09); C354(1.95)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C516(0.76); C145(0.90); C354(1.97)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C516(0.69); C145(0.81); C354(2.46)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C516(0.96); C145(1.43); C354(1.51)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C516(1.00); C145(1.32); C354(1.44)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C516(0.86); C145(0.96); C354(1.14)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C516(1.11); C145(1.17); C354(1.23)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C532(0.90); C371(0.93)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C516(1.06); C145(1.22); C354(1.29)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C516(0.79); C145(0.86); C354(1.02)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C516(0.49); C145(0.52); C354(2.93)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C145(0.79); C99(0.98); C516(1.01); C354(1.98)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C145(0.68); C516(0.98); C99(1.00); C354(1.69)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C145(0.86); C99(0.97); C516(0.99); C354(1.33)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C99(0.84); C516(1.06); C145(1.39); C354(1.49)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C99(0.82); C145(0.95); C354(1.04); C516(1.07)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C99(0.82); C516(0.98); C145(1.16); C354(1.29)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C99(0.95); C516(1.01); C145(1.03); C354(1.61)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C99(0.78); C354(1.05); C516(1.07); C145(1.57)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C99(0.89); C145(1.03); C516(1.04); C354(2.17)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C99(0.93); C516(0.99); C145(1.03); C354(1.89)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C145(0.87); C99(0.92); C516(1.07); C354(1.15)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C145(0.84); C516(1.06); C99(1.11); C354(1.19)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C99(0.79); C145(0.79); C516(0.94); C354(1.21)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C145(0.86); C99(0.95); C516(0.99); C354(1.47)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C99(0.74); C145(0.84); C516(1.03); C354(1.44)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C99(0.14); C516(0.56); C371(0.64); C532(0.96)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C99(0.67); C371(0.71); C516(0.84); C532(1.00)  LDD0683  [13]
 LDCM0248  AKOS034007472 HCT 116 C371(1.11); C532(1.29)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C371(1.08); C532(1.35)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C532(0.73); C371(0.86)  LDD0592  [13]
 LDCM0498  BS-3668 MDA-MB-231 C532(0.58)  LDD2091  [2]
 LDCM0108  Chloroacetamide HeLa C532(0.00); C99(0.00)  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C99(1.10)  LDD2227  [5]
 LDCM0367  CL1 HCT 116 C532(0.86); C516(0.93); C354(1.07)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C532(0.99); C516(1.00); C354(2.71)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C145(0.62); C516(0.96); C99(1.25); C532(1.31)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C532(0.94); C371(0.95)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C371(1.27); C532(1.36)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C371(1.16); C532(1.29)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C532(0.95); C371(0.99)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C532(0.52); C186(1.01); C516(1.12); C354(1.34)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C532(0.34); C99(1.04); C186(1.17); C516(1.23)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C532(0.64); C516(1.05); C99(1.07); C186(1.09)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C532(0.54); C516(1.20); C186(1.32); C354(1.51)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C99(0.63); C532(0.68); C186(0.92); C516(1.15)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C516(0.93); C532(1.09); C354(2.52)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C532(0.55); C99(1.07); C186(1.09); C516(1.13)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C532(0.57); C186(0.82); C99(0.92); C516(1.18)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C99(0.87); C516(0.90); C186(1.16)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C99(0.62); C516(0.93); C186(1.04)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C99(0.68); C516(0.90); C186(0.93)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C99(0.64); C186(0.92); C516(1.02)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C99(0.72); C186(0.86); C516(1.00)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C371(0.89); C516(0.90); C186(1.01)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C186(0.86); C516(1.07); C371(1.18)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C516(0.98); C186(1.04); C371(1.15)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C516(1.07); C532(1.12); C354(2.31)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C516(1.02); C186(1.07); C371(1.39)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C186(0.87); C371(0.89); C516(0.90); C532(0.90)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C532(0.75); C516(0.85); C371(0.97); C186(1.10)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C186(0.88); C516(0.98); C371(0.99); C532(1.03)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C186(0.69); C532(0.81); C371(0.87); C516(0.91)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C532(0.98); C145(1.04); C354(1.18)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C532(0.87); C145(0.93); C354(1.37)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C145(1.09); C354(1.14); C532(1.18)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C145(0.91); C532(1.02); C354(1.75)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C516(1.00); C532(1.14); C354(1.98)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C516(1.11); C532(1.26); C354(1.62)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C516(1.08); C532(1.10); C354(1.28)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C145(0.79); C516(0.94); C354(1.20); C186(1.23)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C145(0.75); C99(0.88); C186(0.89); C354(1.02)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C145(0.66); C354(0.95); C99(0.96); C186(1.12)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C145(0.81); C99(0.96); C186(1.01); C354(1.20)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C516(0.96); C532(1.03); C354(1.16)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C99(0.83); C354(1.04); C145(1.08); C186(1.39)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C145(0.86); C99(0.91); C354(1.02); C186(1.46)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C354(0.72); C145(0.72); C99(0.90); C186(1.08)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C354(0.78); C145(1.01); C186(1.08); C99(1.20)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C145(1.05); C186(1.62); C354(1.02); C99(1.02)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C145(0.91); C186(1.36); C354(1.12); C99(1.04)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C145(0.99); C186(1.38); C354(1.36); C99(1.12)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C145(1.10); C186(1.70); C354(1.35); C99(1.00)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C145(0.92); C186(1.53); C354(1.37); C99(0.96)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C145(0.97); C186(1.88); C354(0.88); C99(0.86)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C354(1.24); C516(0.98); C532(1.52)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C145(0.77); C186(1.84); C354(0.80); C99(1.22)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C354(1.19); C532(0.90); C99(0.97)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C354(1.17); C516(0.85); C532(1.07)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C354(1.31); C516(0.94); C532(1.01)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C354(1.03); C516(0.92); C532(1.10)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C354(1.10); C516(0.93); C532(0.94)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C354(0.97); C516(0.96); C532(1.13)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C354(1.09); C516(1.13); C532(0.88)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C354(1.18); C516(0.94); C532(0.99)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C354(1.30); C516(1.12); C532(1.11)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C354(1.21); C516(0.90); C532(0.77)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C354(1.33); C516(0.85); C532(1.19)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C354(1.14); C516(1.21); C532(1.00)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C354(1.12); C516(0.94); C532(1.64)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C354(1.33); C516(1.12); C532(1.03)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C354(1.33); C516(1.02); C532(0.94)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C145(0.86); C186(1.40); C516(0.95); C99(0.97)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C145(0.84); C186(1.15); C516(1.08); C99(0.94)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C145(0.96); C186(1.14); C516(1.14); C99(1.03)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C145(0.98); C186(1.35); C516(1.03); C99(0.84)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C354(1.20); C516(0.99); C532(1.06)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C145(1.01); C186(1.20); C516(1.19); C99(1.03)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C145(1.15); C186(1.06); C516(1.06); C99(0.96)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C145(1.06); C186(1.09); C516(1.05); C99(0.99)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C145(1.00); C186(0.93); C516(1.08); C99(1.15)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C145(0.71); C186(1.21); C516(1.21); C99(1.00)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C145(0.93); C186(1.08); C516(1.12); C99(1.04)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C145(0.85); C186(1.10); C516(1.15); C99(0.96)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C145(0.98); C186(0.92); C516(1.10); C99(0.95)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C145(0.88); C186(1.27); C516(1.36); C99(0.92)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C145(0.99); C186(1.23); C516(1.28); C99(0.98)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C354(1.35); C516(1.00); C532(0.94)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C145(0.87); C186(1.26); C516(1.25); C99(1.01)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C186(0.88); C532(0.84)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C186(0.87); C532(0.95)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C186(0.69); C532(0.81)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C186(0.87); C532(0.94)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C186(1.06); C532(1.67)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C186(0.80); C532(0.99)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C186(0.86); C532(1.04)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C186(0.76); C532(0.90)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C186(0.75); C532(0.72)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C354(3.22); C516(0.99); C532(0.99)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C186(0.98); C532(1.18)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C186(0.83); C532(1.04)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C186(1.00); C532(0.96)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C186(0.93); C532(0.78)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C186(1.02); C532(0.87)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C516(0.93); C532(0.56)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C516(0.86); C532(0.71)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C516(0.92); C532(0.64)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C516(0.95); C532(0.69)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C354(0.87); C516(1.04); C532(1.06)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C516(0.84); C532(0.54)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C516(0.92); C532(0.63)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C516(0.85); C532(0.52)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C516(0.86); C532(0.48)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C516(0.75); C532(0.46)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C516(0.96); C532(0.61)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C516(0.98); C532(1.02)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C516(0.93); C532(0.80)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C516(0.85); C532(0.51)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C516(0.67); C532(0.31)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C354(1.34); C516(0.97); C532(0.84)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C516(0.80); C532(0.88)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C145(0.88); C516(1.05); C532(0.60); C99(0.83)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C145(0.57); C516(0.95); C532(0.81); C99(0.78)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C145(0.92); C516(0.96); C532(1.20); C99(0.94)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C145(0.70); C516(0.99); C532(1.75); C99(0.98)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C145(0.69); C516(1.01); C532(0.85); C99(0.96)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C145(0.81); C516(1.03); C532(0.83); C99(1.22)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C145(0.80); C516(0.99); C532(0.70); C99(1.11)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C145(0.74); C516(0.97); C532(1.09); C99(1.32)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C145(0.83); C516(0.91); C532(1.19); C99(1.46)  LDD0811  [13]
 LDCM0634  CY-0357 Hep-G2 C354(0.55)  LDD2228  [5]
 LDCM0495  E2913 HEK-293T C145(1.18); C354(0.98); C186(1.02); C371(1.02)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C532(6.58); C145(2.01); C342(1.18)  LDD1702  [2]
 LDCM0625  F8 Ramos C354(1.58); C342(5.32); C516(0.97); C532(0.69)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C354(1.75); C516(0.57); C532(0.46)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C354(0.85); C516(0.47); C532(0.09)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C354(1.52); C516(0.64); C532(0.46)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C354(1.07); C516(1.06); C532(0.98)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C354(0.90); C516(0.91); C532(0.82)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C354(1.90); C516(0.63); C532(0.38)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C354(1.27); C516(1.01); C532(0.79)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C354(0.90); C516(0.76); C532(0.81)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C354(1.21); C516(1.07); C532(1.05)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C354(0.78); C342(0.75); C516(0.92); C532(0.91)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C354(1.81); C516(0.96); C532(0.89)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C354(1.29); C516(1.33)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C354(1.77); C516(0.62); C532(0.47)  LDD2201  [15]
 LDCM0468  Fragment33 HCT 116 C186(0.86); C532(0.83)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C354(1.70); C516(0.92); C532(0.39)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C354(1.03); C342(1.17); C516(0.81); C532(0.40)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C354(1.08); C516(1.06); C532(0.64)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C354(1.63)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C354(1.64); C516(1.06); C532(1.41)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C354(1.35); C342(1.20); C516(0.79); C532(0.34)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C354(2.04); C516(0.57); C532(0.40)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C145(0.93); C354(0.87); C132(0.84); C186(1.04)  LDD1492  [14]
 LDCM0023  KB03 Jurkat C354(5.71)  LDD0209  [3]
 LDCM0024  KB05 COLO792 C132(1.40); C516(1.25); C532(1.71)  LDD3310  [16]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C532(0.62)  LDD2121  [2]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C532(0.62)  LDD2089  [2]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C532(1.13)  LDD2090  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C371(1.24)  LDD2096  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C186(1.10); C516(1.33)  LDD2099  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C532(0.98)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C532(1.03)  LDD2109  [2]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C186(0.69)  LDD2115  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C186(0.74)  LDD2124  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C532(1.15); C186(1.14); C516(1.03)  LDD2125  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C186(0.87); C371(0.93)  LDD2126  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C532(1.17); C186(1.15)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C532(1.35)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C532(0.87); C186(1.24); C516(1.36)  LDD2137  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C186(0.47)  LDD2143  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C516(1.75)  LDD2144  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C354(1.31)  LDD2207  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Geranylgeranyl transferase type-2 subunit beta (RABGGTB) Protein prenyltransferase subunit beta family P53611
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Rab proteins geranylgeranyltransferase component A 1 (CHM) Rab GDI family P24386

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Farnesyl Diphosphate Small molecular drug DB07780
Geranylgeranyl Diphosphate Small molecular drug DB07841
N-formylmethionine Small molecular drug DB04464

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.