Details of the Target

General Information of Target

Target ID LDTP11012
Target Name 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1)
Gene Name AGPAT1
Gene ID 10554
Synonyms
G15; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha; EC 2.3.1.51; 1-acylglycerol-3-phosphate O-acyltransferase 1; 1-AGP acyltransferase 1; 1-AGPAT 1; Lysophosphatidic acid acyltransferase alpha; LPAAT-alpha; Protein G15
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MAAAEEEDGGPEGPNRERGGAGATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPE
RQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPESRGGFQPFGDTGGF
HFSFGVGAFPFGFFTTVFNAHEPFRRGTGVDLGQGHPASSWQDSLFLFLAIFFFFWLLSI
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
Subcellular location
Endoplasmic reticulum membrane
Function
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
TTD ID
T05739
Uniprot ID
Q99943
DrugMap ID
TTPL1TK
Ensemble ID
ENST00000336984.6
HGNC ID
HGNC:324
ChEMBL ID
CHEMBL3583

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.10  LDD0402  [1]
HDSF-alk
 Probe Info  		2.80  LDD0197  [2]
STPyne
 Probe Info  		K191(2.84); K277(9.72)  LDD0277  [3]
BTD
 Probe Info  		C229(2.24)  LDD1700  [4]
HPAP
 Probe Info  		3.04  LDD0062  [5]
Acrolein
 Probe Info  		N.A.  LDD0230  [6]
DBIA
 Probe Info  		C229(1.13)  LDD0531  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
IPM
 Probe Info  		C229(0.00); C121(0.00)  LDD0005  [10]
VSF
 Probe Info  		N.A.  LDD0007  [10]
AOyne
 Probe Info  		12.60  LDD0443  [11]
NAIA_5
 Probe Info  		N.A.  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C094
 Probe Info  		25.46  LDD1785  [13]
C426
 Probe Info  		17.03  LDD2081  [13]
FFF probe14
 Probe Info  		20.00  LDD0477  [14]
FFF probe3
 Probe Info  		18.18  LDD0464  [14]
Alk-rapa
 Probe Info  		10.77  LDD0213  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C229(0.88)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C229(1.11)  LDD2152  [4]
 LDCM0214  AC1 HCT 116 C229(1.13)  LDD0531  [7]
 LDCM0215  AC10 HEK-293T C218(0.90); C229(0.92)  LDD0813  [7]
 LDCM0216  AC100 HCT 116 C229(0.87)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C229(1.00)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C229(1.08)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C229(0.80)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C229(0.77)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C229(0.96)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C229(0.77)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C229(0.72)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C229(0.92)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C229(0.96)  LDD0542  [7]
 LDCM0226  AC11 HEK-293T C218(1.06); C229(0.62)  LDD0824  [7]
 LDCM0227  AC110 HCT 116 C229(0.77)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C229(0.79)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C229(0.96)  LDD0546  [7]
 LDCM0230  AC113 HEK-293T C229(1.08)  LDD0828  [7]
 LDCM0231  AC114 HEK-293T C229(0.86)  LDD0829  [7]
 LDCM0232  AC115 HEK-293T C229(0.95)  LDD0830  [7]
 LDCM0233  AC116 HEK-293T C229(0.87)  LDD0831  [7]
 LDCM0234  AC117 HEK-293T C229(0.87)  LDD0832  [7]
 LDCM0235  AC118 HEK-293T C229(0.91)  LDD0833  [7]
 LDCM0236  AC119 HEK-293T C229(0.88)  LDD0834  [7]
 LDCM0237  AC12 HEK-293T C218(0.93); C229(0.74)  LDD0835  [7]
 LDCM0238  AC120 HEK-293T C229(1.03)  LDD0836  [7]
 LDCM0239  AC121 HEK-293T C229(0.79)  LDD0837  [7]
 LDCM0240  AC122 HEK-293T C229(0.75)  LDD0838  [7]
 LDCM0241  AC123 HEK-293T C229(0.69)  LDD0839  [7]
 LDCM0242  AC124 HEK-293T C229(0.83)  LDD0840  [7]
 LDCM0243  AC125 HEK-293T C229(0.76)  LDD0841  [7]
 LDCM0244  AC126 HEK-293T C229(0.94)  LDD0842  [7]
 LDCM0245  AC127 HEK-293T C229(1.03)  LDD0843  [7]
 LDCM0246  AC128 HCT 116 C229(0.83)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C229(1.27)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C229(0.85)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C229(1.17)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C229(1.46)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C229(1.06)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C229(1.01)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C229(1.06)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C229(1.01)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C229(1.04)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C229(1.10)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C229(1.00)  LDD0575  [7]
 LDCM0259  AC14 HEK-293T C218(0.90); C229(1.09)  LDD0857  [7]
 LDCM0260  AC140 HCT 116 C229(1.11)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C229(1.18)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C229(1.31)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C229(1.38)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C229(0.78)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C229(0.88)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C229(1.17)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C229(1.18)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C229(2.65)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C229(2.03)  LDD0586  [7]
 LDCM0270  AC15 HEK-293T C218(0.93); C229(0.71)  LDD0868  [7]
 LDCM0271  AC150 HCT 116 C229(1.08)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C229(1.27)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C229(1.18)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C229(1.56)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C229(1.01)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C229(1.20)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C229(1.00)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C229(1.12)  LDD2161  [7]
 LDCM0276  AC17 HEK-293T C218(0.92); C229(1.05)  LDD0874  [7]
 LDCM0277  AC18 HEK-293T C218(1.17); C229(0.92)  LDD0875  [7]
 LDCM0278  AC19 HEK-293T C218(0.84); C229(1.04)  LDD0876  [7]
 LDCM0279  AC2 HCT 116 C229(1.13)  LDD0596  [7]
 LDCM0280  AC20 HEK-293T C218(1.02); C229(1.14)  LDD0878  [7]
 LDCM0281  AC21 HEK-293T C218(1.04); C229(1.07)  LDD0879  [7]
 LDCM0282  AC22 HEK-293T C218(1.16); C229(0.91)  LDD0880  [7]
 LDCM0283  AC23 HEK-293T C218(1.22); C229(0.85)  LDD0881  [7]
 LDCM0284  AC24 HEK-293T C218(1.03); C229(1.14)  LDD0882  [7]
 LDCM0285  AC25 HEK-293T C218(1.01); C229(0.76)  LDD0883  [7]
 LDCM0286  AC26 HEK-293T C218(0.99); C229(0.73)  LDD0884  [7]
 LDCM0287  AC27 HEK-293T C218(0.96); C229(0.97)  LDD0885  [7]
 LDCM0288  AC28 HEK-293T C218(0.90); C229(0.82)  LDD0886  [7]
 LDCM0289  AC29 HEK-293T C218(1.00); C229(0.75)  LDD0887  [7]
 LDCM0290  AC3 HCT 116 C229(1.24)  LDD0607  [7]
 LDCM0291  AC30 HEK-293T C218(0.95); C229(0.77)  LDD0889  [7]
 LDCM0292  AC31 HEK-293T C218(0.95); C229(0.88)  LDD0890  [7]
 LDCM0293  AC32 HEK-293T C218(1.08); C229(0.82)  LDD0891  [7]
 LDCM0294  AC33 HEK-293T C218(1.09); C229(0.84)  LDD0892  [7]
 LDCM0295  AC34 HEK-293T C218(1.16); C229(0.75)  LDD0893  [7]
 LDCM0296  AC35 HEK-293T C218(1.11); C229(1.03)  LDD1535  [16]
 LDCM0297  AC36 HEK-293T C218(0.94); C229(1.01)  LDD1536  [16]
 LDCM0298  AC37 HEK-293T C218(0.90)  LDD1537  [16]
 LDCM0299  AC38 HEK-293T C218(0.99); C229(1.07)  LDD1538  [16]
 LDCM0300  AC39 HEK-293T C218(1.01)  LDD1539  [16]
 LDCM0301  AC4 HCT 116 C229(1.35)  LDD0618  [7]
 LDCM0302  AC40 HEK-293T C218(0.93); C229(0.99)  LDD1541  [16]
 LDCM0303  AC41 HEK-293T C218(1.00)  LDD1542  [16]
 LDCM0304  AC42 HEK-293T C218(1.06); C229(0.97)  LDD1543  [16]
 LDCM0305  AC43 HEK-293T C218(1.14); C229(1.02)  LDD1544  [16]
 LDCM0306  AC44 HEK-293T C218(0.90); C229(1.12)  LDD1545  [16]
 LDCM0307  AC45 HEK-293T C218(0.88)  LDD1546  [16]
 LDCM0308  AC46 HCT 116 C229(1.15)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C229(1.30)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C229(1.29)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C229(1.22)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C229(1.11)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C229(1.27)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C229(1.05)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C229(1.09)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C229(0.97)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C229(1.10)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C229(1.09)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C229(1.12)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C229(1.41)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C229(1.20)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C229(1.42)  LDD0639  [7]
 LDCM0323  AC6 HEK-293T C218(0.95); C229(0.66)  LDD0921  [7]
 LDCM0324  AC60 HCT 116 C229(1.56)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C229(1.33)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C229(1.32)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C229(1.31)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C229(1.62)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C229(1.48)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C229(1.19)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C229(1.81)  LDD0648  [7]
 LDCM0332  AC68 HEK-293T C218(0.98); C229(0.94)  LDD0930  [7]
 LDCM0333  AC69 HEK-293T C218(0.91); C229(0.93)  LDD0931  [7]
 LDCM0334  AC7 HEK-293T C218(0.92); C229(0.57)  LDD0932  [7]
 LDCM0335  AC70 HEK-293T C218(0.85); C229(0.79)  LDD0933  [7]
 LDCM0336  AC71 HEK-293T C218(1.03); C229(1.01)  LDD0934  [7]
 LDCM0337  AC72 HEK-293T C218(0.96); C229(1.05)  LDD0935  [7]
 LDCM0338  AC73 HEK-293T C218(0.94); C229(1.03)  LDD0936  [7]
 LDCM0339  AC74 HEK-293T C218(0.97); C229(1.28)  LDD0937  [7]
 LDCM0340  AC75 HEK-293T C218(0.95); C229(0.80)  LDD0938  [7]
 LDCM0341  AC76 HEK-293T C218(0.93); C229(1.15)  LDD0939  [7]
 LDCM0342  AC77 HEK-293T C218(0.92); C229(0.97)  LDD0940  [7]
 LDCM0343  AC78 HEK-293T C218(0.83); C229(0.80)  LDD0941  [7]
 LDCM0344  AC79 HEK-293T C218(1.01); C229(0.95)  LDD0942  [7]
 LDCM0345  AC8 HEK-293T C218(0.97); C229(0.74)  LDD0943  [7]
 LDCM0346  AC80 HEK-293T C218(1.13); C229(1.10)  LDD0944  [7]
 LDCM0347  AC81 HEK-293T C218(0.92); C229(0.88)  LDD0945  [7]
 LDCM0348  AC82 HEK-293T C218(0.94); C229(0.96)  LDD0946  [7]
 LDCM0349  AC83 HCT 116 C229(0.95)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C229(0.89)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C229(0.90)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C229(1.09)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C229(0.97)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C229(0.84)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C229(0.89)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C229(0.97)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C229(1.07)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C229(0.95)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C229(0.94)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C229(1.05)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C229(1.05)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C229(1.19)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C229(1.09)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C229(0.87)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C229(0.98)  LDD0683  [7]
 LDCM0248  AKOS034007472 HEK-293T C218(0.92); C229(1.17)  LDD0846  [7]
 LDCM0356  AKOS034007680 HEK-293T C218(0.90); C229(1.08)  LDD0954  [7]
 LDCM0275  AKOS034007705 HEK-293T C218(0.86); C229(0.73)  LDD0873  [7]
 LDCM0156  Aniline NCI-H1299 11.67  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C229(1.36)  LDD2171  [7]
 LDCM0367  CL1 HCT 116 C229(1.32)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C229(1.16)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C229(1.21)  LDD0686  [7]
 LDCM0370  CL101 HEK-293T C218(0.98); C229(0.81)  LDD0968  [7]
 LDCM0371  CL102 HEK-293T C218(0.82); C229(0.87)  LDD0969  [7]
 LDCM0372  CL103 HEK-293T C218(0.88); C229(0.76)  LDD0970  [7]
 LDCM0373  CL104 HEK-293T C218(0.98); C229(0.70)  LDD0971  [7]
 LDCM0374  CL105 HEK-293T C218(1.24); C229(0.98)  LDD0972  [7]
 LDCM0375  CL106 HEK-293T C218(1.14); C229(1.27)  LDD0973  [7]
 LDCM0376  CL107 HEK-293T C218(1.01); C229(0.92)  LDD0974  [7]
 LDCM0377  CL108 HEK-293T C218(1.16); C229(0.99)  LDD0975  [7]
 LDCM0378  CL109 HEK-293T C218(1.19); C229(1.05)  LDD0976  [7]
 LDCM0379  CL11 HCT 116 C229(0.97)  LDD0696  [7]
 LDCM0380  CL110 HEK-293T C218(1.20); C229(1.02)  LDD0978  [7]
 LDCM0381  CL111 HEK-293T C218(1.09); C229(0.89)  LDD0979  [7]
 LDCM0382  CL112 HEK-293T C218(0.91); C229(0.66)  LDD0980  [7]
 LDCM0383  CL113 HEK-293T C218(1.26); C229(0.82)  LDD0981  [7]
 LDCM0384  CL114 HEK-293T C218(1.08); C229(0.56)  LDD0982  [7]
 LDCM0385  CL115 HEK-293T C218(0.98); C229(0.75)  LDD0983  [7]
 LDCM0386  CL116 HEK-293T C218(1.00); C229(0.76)  LDD0984  [7]
 LDCM0387  CL117 HEK-293T C218(1.00)  LDD1591  [16]
 LDCM0388  CL118 HEK-293T C218(0.99); C229(0.96)  LDD1592  [16]
 LDCM0389  CL119 HEK-293T C218(1.06); C229(1.05)  LDD1593  [16]
 LDCM0390  CL12 HCT 116 C229(1.44)  LDD0707  [7]
 LDCM0391  CL120 HEK-293T C218(1.00)  LDD1595  [16]
 LDCM0392  CL121 HCT 116 C229(0.96)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C229(0.93)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C229(1.32)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C229(0.87)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C229(1.57)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C229(1.20)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C229(1.41)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C229(1.38)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C229(1.36)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C229(1.34)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C229(1.22)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C229(0.88)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C229(0.79)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C229(0.90)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C229(1.03)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C229(1.00)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C229(0.94)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C229(0.92)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C229(1.02)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C229(1.14)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C229(1.00)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C229(0.93)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C229(1.23)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C229(1.23)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C229(1.02)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C229(1.22)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C229(1.21)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C229(1.09)  LDD0736  [7]
 LDCM0420  CL31 HEK-293T C218(1.09); C229(0.53)  LDD1018  [7]
 LDCM0421  CL32 HEK-293T C218(1.02); C229(0.72)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C218(1.03); C229(0.63)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C218(1.06); C229(0.94)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C218(1.02); C229(0.82)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C218(0.96); C229(0.93)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C218(0.97); C229(0.52)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C218(0.84); C229(0.74)  LDD1026  [7]
 LDCM0429  CL4 HCT 116 C229(1.43)  LDD0746  [7]
 LDCM0430  CL40 HEK-293T C218(1.05); C229(0.81)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C218(1.07); C229(0.78)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C218(0.97); C229(0.94)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C218(1.02); C229(0.98)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C218(1.05); C229(0.82)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C218(0.94); C229(0.82)  LDD1033  [7]
 LDCM0436  CL46 HCT 116 C229(1.04)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C229(1.50)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C229(0.87)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C229(0.97)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C229(1.41)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C229(1.30)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C229(2.17)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C229(1.17)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C229(1.06)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C229(1.04)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C229(0.96)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C229(0.92)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C229(1.14)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C229(1.06)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C229(0.95)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C229(1.22)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C229(0.89)  LDD0769  [7]
 LDCM0453  CL61 HEK-293T C229(0.74)  LDD1051  [7]
 LDCM0454  CL62 HEK-293T C229(0.98)  LDD1052  [7]
 LDCM0455  CL63 HEK-293T C229(0.75)  LDD1053  [7]
 LDCM0456  CL64 HEK-293T C229(0.73)  LDD1054  [7]
 LDCM0457  CL65 HEK-293T C229(0.87)  LDD1055  [7]
 LDCM0458  CL66 HEK-293T C229(0.94)  LDD1056  [7]
 LDCM0459  CL67 HEK-293T C229(1.04)  LDD1057  [7]
 LDCM0460  CL68 HEK-293T C229(1.17)  LDD1058  [7]
 LDCM0461  CL69 HEK-293T C229(0.88)  LDD1059  [7]
 LDCM0462  CL7 HCT 116 C229(1.40)  LDD0779  [7]
 LDCM0463  CL70 HEK-293T C229(1.03)  LDD1061  [7]
 LDCM0464  CL71 HEK-293T C229(1.00)  LDD1062  [7]
 LDCM0465  CL72 HEK-293T C229(0.90)  LDD1063  [7]
 LDCM0466  CL73 HEK-293T C229(1.19)  LDD1064  [7]
 LDCM0467  CL74 HEK-293T C229(0.88)  LDD1065  [7]
 LDCM0469  CL76 HEK-293T C218(1.54); C229(0.99)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C218(1.72); C229(0.84)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C218(1.65); C229(0.80)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C218(2.12); C229(0.94)  LDD1070  [7]
 LDCM0473  CL8 HCT 116 C229(1.12)  LDD0790  [7]
 LDCM0474  CL80 HEK-293T C218(1.86); C229(0.92)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C218(1.44); C229(0.94)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C218(1.12); C229(1.29)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C218(0.99); C229(0.99)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C218(3.03); C229(0.87)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C218(1.94); C229(0.83)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C218(2.45); C229(0.78)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C218(1.67); C229(0.84)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C218(1.21); C229(1.07)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C218(1.40); C229(0.98)  LDD1081  [7]
 LDCM0484  CL9 HCT 116 C229(1.43)  LDD0801  [7]
 LDCM0485  CL90 HEK-293T C218(1.40); C229(0.92)  LDD1083  [7]
 LDCM0486  CL91 HCT 116 C229(0.89)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C229(1.02)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C229(1.31)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C229(0.94)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C229(0.91)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C229(1.01)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C229(1.37)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C229(0.81)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C229(1.11)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C218(1.45); C229(1.00)  LDD1698  [16]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C229(3.58)  LDD1702  [4]
 LDCM0625  F8 Ramos C229(1.44)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C229(2.02)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C229(2.47)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C229(2.49)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C229(0.99)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C229(2.67)  LDD2193  [17]
 LDCM0580  Fragment21 Ramos C229(1.12)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C229(1.11)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C229(0.94)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C229(1.11)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C229(1.27)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C229(1.12)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C229(1.61)  LDD2201  [17]
 LDCM0468  Fragment33 HEK-293T C229(0.97)  LDD1066  [7]
 LDCM0596  Fragment38 Ramos C229(1.36)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C229(1.91)  LDD2184  [17]
 LDCM0427  Fragment51 HEK-293T C218(1.50); C229(1.18)  LDD1025  [7]
 LDCM0610  Fragment52 Ramos C229(1.23)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C229(1.28)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C229(3.12)  LDD2186  [17]
 LDCM0022  KB02 HEK-293T C229(1.08); C218(0.94)  LDD1492  [16]
 LDCM0023  KB03 HEK-293T C229(1.11); C218(0.99)  LDD1497  [16]
 LDCM0024  KB05 SKMEL2 C229(2.09)  LDD3322  [18]
 LDCM0109  NEM HeLa N.A.  LDD0230  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C229(1.05)  LDD2090  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C229(0.85)  LDD2093  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C229(1.04)  LDD2099  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C229(0.63)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C229(0.88)  LDD2111  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C229(0.34)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C229(0.88)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C229(0.81)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C229(1.05)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C229(0.99)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C229(1.28)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C229(1.44)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C229(1.07)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C229(0.91)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C229(2.24)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C229(0.82)  LDD2140  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C229(0.94)  LDD2146  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C218(0.68)  LDD2206  [19]
 LDCM0628  OTUB2-COV-1 HEK-293T C218(0.22)  LDD2207  [19]
 LDCM0014  Panhematin HEK-293T 3.04  LDD0062  [5]
 LDCM0090  Rapamycin JHH-7 10.77  LDD0213  [15]
 LDCM0021  THZ1 HCT 116 C229(1.36)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.