Details of the Target

General Information of Target

Target ID LDTP06322
Target Name [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (PDK3)
Gene Name PDK3
Gene ID 5165
Synonyms
PDHK3; [Pyruvate dehydrogenase; acetyl-transferring)] kinase isozyme 3, mitochondrial; EC 2.7.11.2; Pyruvate dehydrogenase kinase isoform 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANT
MREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNRHN
DVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVH
PKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSH
LFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRL
FNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKA
LSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQ
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
PDK/BCKDK protein kinase family
Subcellular location
Mitochondrion matrix
Function
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.
TTD ID
T99029
Uniprot ID
Q15120
DrugMap ID
TTDEQIP
Ensemble ID
ENST00000379162.9
HGNC ID
HGNC:8811
ChEMBL ID
CHEMBL3893

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
Ishikawa (Heraklio) 02 ER SNV: p.P75H DBIA    Probe Info 
MEWO SNV: p.K9N DBIA    Probe Info 
MOLT4 SNV: p.R299H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH216
 Probe Info  		Y326(20.00)  LDD0259  [1]
STPyne
 Probe Info  		K374(8.70)  LDD0277  [2]
Probe 1
 Probe Info  		Y337(17.60)  LDD3495  [3]
DBIA
 Probe Info  		C41(1.04)  LDD3313  [4]
AHL-Pu-1
 Probe Info  		C41(5.34)  LDD0168  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C191(0.00); C208(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C191(0.00); C208(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C191(0.00); C208(0.00)  LDD0037  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
IPM
 Probe Info  		N.A.  LDD0005  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C165
 Probe Info  		13.45  LDD1845  [11]
C231
 Probe Info  		11.47  LDD1904  [11]
C232
 Probe Info  		96.34  LDD1905  [11]
C235
 Probe Info  		19.70  LDD1908  [11]
C278
 Probe Info  		74.03  LDD1948  [11]
C338
 Probe Info  		10.70  LDD2001  [11]
C353
 Probe Info  		5.74  LDD2014  [11]
C426
 Probe Info  		19.70  LDD2081  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C41(5.34)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C41(3.80)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C191(1.00); C208(0.97)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C191(1.07); C208(1.02)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C191(0.98); C208(1.06)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C191(0.93); C208(1.02)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C191(1.08); C208(1.05)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C191(0.97); C208(0.99)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C191(1.01); C208(0.94)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C191(1.04); C208(0.97)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C191(0.82); C208(0.87)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C191(1.03); C208(1.03)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C191(1.06); C208(0.95)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C191(0.91); C208(1.00)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C191(1.08); C208(1.01)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C191(1.03); C208(1.03)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C191(1.04); C208(1.02)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C191(1.00); C208(0.91)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C191(1.00); C208(1.06)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C191(0.96); C208(1.02)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C191(0.95); C208(1.00)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C191(0.99); C208(0.96)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C191(0.96); C208(1.03)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C191(1.05); C208(1.04)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C191(0.99); C208(1.02)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C191(1.03); C208(0.99)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C191(0.95); C208(0.93)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C191(0.98); C208(1.09)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C191(0.93); C208(0.95)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C191(0.91); C208(0.94)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C191(0.92); C208(1.02)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C191(0.95); C208(0.97)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C191(1.04); C208(1.06)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C191(1.03); C208(1.02)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C191(1.02); C208(0.92)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C191(1.01); C208(0.96)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C191(0.97); C208(1.04)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C191(0.92); C208(1.05)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C191(0.91); C208(0.96)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C191(0.96); C208(0.99)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C191(1.00); C208(1.07)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C191(0.86); C208(1.10)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C191(1.06); C208(1.04)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C191(0.98); C208(0.92)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C191(0.96); C208(0.99)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C191(1.02); C208(1.03)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C191(0.97); C208(1.10)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C191(0.97); C208(0.99)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C191(1.01); C208(0.99)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C191(0.97); C208(1.13)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C191(0.98); C208(1.03)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C191(1.03); C208(1.05)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C191(0.95); C208(0.89)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C191(0.95); C208(1.04)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C191(0.90); C208(1.11)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C191(1.01); C208(1.01)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C191(0.97); C208(0.99)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C191(0.91); C208(1.01)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C191(0.92); C208(1.02)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C191(0.92); C208(1.00)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C191(0.92); C208(1.00)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C191(0.99); C208(1.09)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C191(0.99); C208(1.02)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C191(0.94); C208(0.97)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C191(0.99); C208(0.94)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C191(1.02); C208(1.00)  LDD1514  [12]
 LDCM0367  CL1 HEK-293T C191(1.01); C208(0.98)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C191(1.88); C208(1.02)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C191(1.06); C208(0.93)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C191(1.01); C208(0.96)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C191(1.11); C208(0.91)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C191(0.96); C208(0.94)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C191(0.98); C208(0.95)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C191(0.93); C208(0.96)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C191(1.03); C208(0.93)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C191(0.97); C208(1.03)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C191(0.94); C208(1.06)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C191(0.98); C208(0.92)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C191(1.15); C208(0.99)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C191(1.04); C208(0.94)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C191(1.04); C208(1.01)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C191(0.96); C208(0.92)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C191(0.86); C208(0.91)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C191(1.16); C208(0.83)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C191(0.88); C208(0.94)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C191(0.92); C208(0.99)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C191(0.94); C208(0.97)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C191(0.87); C208(0.99)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C191(0.83); C208(1.01)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C191(1.08); C208(1.14)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C191(0.94); C208(1.10)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C191(0.82); C208(0.91)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C191(0.84); C208(0.93)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C191(1.21); C208(0.96)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C191(0.89); C208(1.05)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C191(0.81); C208(0.97)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C191(0.84); C208(0.97)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C191(0.81); C208(0.97)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C191(0.87); C208(1.15)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C191(0.88); C208(0.93)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C191(0.86); C208(0.99)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C191(1.18); C208(1.02)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C191(0.87); C208(1.06)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C191(1.09); C208(0.92)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C191(0.97); C208(1.02)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C191(0.95); C208(1.06)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C191(0.89); C208(1.01)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C191(0.93); C208(1.03)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C191(1.23); C208(0.94)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C191(1.08); C208(1.10)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C191(1.01); C208(1.07)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C191(1.03); C208(1.06)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C191(0.92); C208(0.94)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C191(0.94); C208(0.95)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C191(0.95); C208(0.94)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C191(0.99); C208(0.98)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C191(0.97); C208(0.92)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C191(0.95); C208(0.98)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C191(1.02); C208(1.07)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C191(1.02); C208(0.98)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C191(1.05); C208(0.93)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C191(2.09); C208(0.86)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C191(1.28); C208(1.11)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C191(1.03); C208(1.06)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C191(1.15); C208(1.09)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C191(0.94); C208(0.98)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C191(1.12); C208(1.00)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C191(0.95); C208(1.01)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C191(1.02); C208(0.95)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C191(1.11); C208(0.97)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C191(0.94); C208(1.06)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C191(0.96); C208(1.00)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C191(0.97); C208(0.97)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C191(1.08); C208(0.85)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C191(1.05); C208(1.04)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C191(1.00); C208(1.09)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C191(1.03); C208(1.07)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C191(0.82); C208(0.90)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C191(0.92); C208(0.96)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C191(0.99); C208(1.00)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C191(1.05); C208(1.07)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C191(1.10); C208(0.97)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C191(1.40); C208(1.12)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C191(1.00); C208(1.20)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C191(0.93); C208(0.92)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C191(1.07); C208(0.91)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C191(0.95); C208(0.97)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C191(0.91); C208(0.98)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C191(1.06); C208(1.05)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C191(0.97); C208(1.11)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C191(0.84); C208(0.96)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C191(0.88); C208(1.00)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C191(0.91); C208(1.02)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C191(1.14); C208(1.02)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C191(0.99); C208(0.94)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C191(0.97); C208(1.05)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C191(1.04); C208(1.13)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C191(0.98); C208(0.92)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C191(1.07); C208(0.79)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C191(0.91); C208(1.05)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C191(1.06); C208(0.97)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C191(0.98); C208(1.02)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C191(0.98); C208(1.15)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C191(0.98); C208(1.06)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C191(0.90); C208(0.97)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C191(0.96); C208(1.07)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C191(1.13); C208(1.06)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C191(1.00); C208(1.04)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C191(0.91); C208(1.05)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C191(1.89); C208(1.01)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C191(0.92); C208(1.06)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C191(0.94); C208(0.92)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C191(0.99); C208(1.05)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C191(1.12); C208(1.05)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C191(1.14); C208(0.96)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C191(0.81); C208(0.93)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C191(0.75); C208(0.99)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C191(0.78); C208(1.10)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C191(0.84); C208(1.17)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C191(0.87); C208(0.98)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C191(0.92); C208(1.02)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C191(1.72); C208(1.00)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C191(0.84); C208(1.00)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C191(1.08); C208(0.97)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C191(1.21); C208(0.96)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C191(1.01); C208(1.08)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C191(1.19); C208(0.89)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C191(0.94); C208(0.96)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C191(1.05); C208(0.99)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C191(0.94); C208(0.99)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C191(0.91); C208(0.93)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C191(0.92); C208(0.97)  LDD1698  [12]
 LDCM0625  F8 Ramos C191(1.59)  LDD2187  [13]
 LDCM0573  Fragment11 Ramos C191(0.21)  LDD2190  [13]
 LDCM0576  Fragment14 Ramos C191(1.29)  LDD2193  [13]
 LDCM0586  Fragment28 Ramos C191(0.70)  LDD2198  [13]
 LDCM0468  Fragment33 HEK-293T C191(0.86); C208(1.02)  LDD1671  [12]
 LDCM0566  Fragment4 Ramos C191(0.61)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C191(0.99); C208(1.07)  LDD1631  [12]
 LDCM0569  Fragment7 Ramos C191(2.10)  LDD2186  [13]
 LDCM0022  KB02 HEK-293T C191(0.94); C208(0.96)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C191(0.94); C208(0.93)  LDD1497  [12]
 LDCM0024  KB05 Hs 936.T C41(1.04)  LDD3313  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT) 2-oxoacid dehydrogenase family P10515

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Radicicol Small molecular drug DB03758
Dihydrolipoic Acid . DB03760

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578