Details of the Target

General Information of Target

Target ID LDTP10857
Target Name c-Myc-binding protein (MYCBP)
Gene Name MYCBP
Gene ID 26292
Synonyms
AMY1; c-Myc-binding protein; Associate of Myc 1; AMY-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEK
SRLVSAFKERQSSKNLLSCENSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEV
VDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGV
RTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWS
SKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAA
LGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIA
DICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKE
KGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQI
NKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAP
KIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL
Target Type
Clinical trial
Target Bioclass
Other
Family
AMY1 family
Subcellular location
Cytoplasm
Function May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.
TTD ID
T37298
Uniprot ID
Q99417
DrugMap ID
TTVW4XU
Ensemble ID
ENST00000397572.5
HGNC ID
HGNC:7554

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y35(0.21)  LDD0264  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
m-APA
 Probe Info  		H50(0.00); H51(0.00)  LDD2231  [3]
NHS
 Probe Info  		N.A.  LDD0010  [4]
STPyne
 Probe Info  		N.A.  LDD0009  [4]
1c-yne
 Probe Info  		K20(0.00); K40(0.00)  LDD0228  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
HHS-482
 Probe Info  		Y35(0.06)  LDD2239  [7]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C003
 Probe Info  		16.91  LDD1713  [8]
C052
 Probe Info  		6.87  LDD1750  [8]
C313
 Probe Info  		12.13  LDD1980  [8]
C356
 Probe Info  		8.94  LDD2017  [8]
C382
 Probe Info  		16.80  LDD2041  [8]
C391
 Probe Info  		13.74  LDD2050  [8]
C397
 Probe Info  		10.06  LDD2056  [8]
C424
 Probe Info  		8.63  LDD2079  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H50(0.00); H51(0.00)  LDD0222  [6]
 LDCM0116  HHS-0101 DM93 Y35(0.21)  LDD0264  [1]
 LDCM0118  HHS-0301 DM93 Y35(0.49)  LDD0266  [1]
 LDCM0119  HHS-0401 DM93 Y35(0.51)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y35(0.98)  LDD0268  [1]
 LDCM0107  IAA HeLa H51(0.00); H50(0.00)  LDD0221  [6]
 LDCM0109  NEM HeLa H50(0.00); H51(0.00)  LDD0223  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (ARFGEF1) . Q9Y6D6
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) . Q9Y6D5
MYCBP-associated protein (MYCBPAP) . Q8TBZ2

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dcr-myc siRNA drug D02OZT

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587