Details of the Target

General Information of Target

Target ID LDTP13214
Target Name UPF0449 protein C19orf25 (C19orf25)
Gene Name C19orf25
Gene ID 148223
Synonyms
UPF0449 protein C19orf25
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAALVENSQVICEVWASNLEEEMRKIREIVLSYSYIAMDTEFPGVVVRPIGEFRSSIDY
QYQLLRCNVDLLKIIQLGLTFTNEKGEYPSGINTWQFNFKFNLTEDMYSQDSIDLLANSG
LQFQKHEEEGIDTLHFAELLMTSGVVLCDNVKWLSFHSGYDFGYMVKLLTDSRLPEEEHE
FFHILNLFFPSIYDVKYLMKSCKNLKGGLQEVADQLDLQRIGRQHQAGSDSLLTGMAFFR
MKELFFEDSIDDAKYCGRLYGLGTGVAQKQNEDVDSAQEKMSILAIINNMQQ
Target Bioclass
Other
Family
UPF0449 family
Uniprot ID
Q9UFG5
Ensemble ID
ENST00000436106.3
HGNC ID
HGNC:26711

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JURKAT SNV: p.R92Ter .
MOLT4 Substitution: p.R50I .
TOV21G SNV: p.S117Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C87(0.88)  LDD2092  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0177  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		N.A.  LDD0147  [4]
NPM
 Probe Info  		N.A.  LDD0016  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C210
 Probe Info  		43.41  LDD1884  [8]
C212
 Probe Info  		5.17  LDD1886  [8]
C285
 Probe Info  		46.53  LDD1955  [8]
C287
 Probe Info  		18.38  LDD1957  [8]
C288
 Probe Info  		12.91  LDD1958  [8]
C289
 Probe Info  		56.49  LDD1959  [8]
C290
 Probe Info  		8.57  LDD1960  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C87(0.57)  LDD2142  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C87(1.05)  LDD2103  [2]
 LDCM0520  AKOS000195272 MDA-MB-231 C87(0.57)  LDD2113  [2]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C87(0.94)  LDD1702  [2]
 LDCM0023  KB03 MDA-MB-231 C87(2.74)  LDD1701  [2]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C87(0.81)  LDD2102  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C87(0.88)  LDD2092  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C87(1.10)  LDD2094  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C87(0.82)  LDD2100  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C87(0.68)  LDD2104  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C87(1.40)  LDD2105  [2]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C87(1.17)  LDD2114  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C87(0.89)  LDD2120  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C87(0.64)  LDD2141  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C87(0.73)  LDD2143  [2]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C87(0.97)  LDD2151  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diamine acetyltransferase 1 (SAT1) Acetyltransferase family P21673
Cytochrome b-c1 complex subunit 1, mitochondrial (UQCRC1) Peptidase M16 family P31930
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein c-Fos (FOS) BZIP family P01100
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BLOC-1-related complex subunit 6 (BORCS6) BORCS6 family Q96GS4
Coiled-coil domain-containing protein 85B (CCDC85B) CCDC85 family Q15834
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Epidermal growth factor receptor kinase substrate 8 (EPS8) EPS8 family Q12929
Inhibitory synaptic factor 1 (INSYN1) INSYN1 family Q2T9L4
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Meiosis-specific protein MEI4 (MEI4) MEI4L family A8MW99
Paraneoplastic antigen Ma3 (PNMA3) PNMA family Q9UL41
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
Arfaptin-2 (ARFIP2) . P53365
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) . Q9UQB8
TCF3 fusion partner (TFPT) . P0C1Z6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587