General Information of Target

Target ID LDTP12379
Target Name Complex I assembly factor TIMMDC1, mitochondrial (TIMMDC1)
Gene Name TIMMDC1
Gene ID 51300
Synonyms
C3orf1; Complex I assembly factor TIMMDC1, mitochondrial; Protein M5-14; Translocase of inner mitochondrial membrane domain-containing protein 1; TIMM domain containing-protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MATSLDFKTYVDQACRAAEEFVNIYYETMDKRRRALTRLYLDKATLIWNGNAVSGLDALN
NFFDTLPSSEFQVNMLDCQPVHEQATQSQTTVLVVTSGTVKFDGNKQHFFNQNFLLTAQS
TPNNTVWKIASDCFRFQDWSSS
Target Bioclass
Other
Family
Tim17/Tim22/Tim23 family
Subcellular location
Mitochondrion membrane
Function Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I.
Uniprot ID
Q9NPL8
Ensemble ID
ENST00000494664.6
HGNC ID
HGNC:1321

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info 
Y212(15.90)  LDD3495  [1]
BTD
 Probe Info 
C78(0.43)  LDD2109  [2]
Acrolein
 Probe Info 
N.A.  LDD0227  [3]
DBIA
 Probe Info 
C78(0.86)  LDD0531  [4]
IA-alkyne
 Probe Info 
N.A.  LDD0165  [5]
IPM
 Probe Info 
N.A.  LDD2156  [6]
PF-06672131
 Probe Info 
N.A.  LDD0152  [7]
Ox-W18
 Probe Info 
N.A.  LDD2175  [8]
AOyne
 Probe Info 
15.00  LDD0443  [9]
NAIA_5
 Probe Info 
N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info 
11.00  LDD1740  [11]
C056
 Probe Info 
17.15  LDD1753  [11]
C094
 Probe Info 
28.05  LDD1785  [11]
C106
 Probe Info 
20.11  LDD1793  [11]
C112
 Probe Info 
23.10  LDD1799  [11]
C159
 Probe Info 
7.21  LDD1839  [11]
C161
 Probe Info 
11.71  LDD1841  [11]
C169
 Probe Info 
23.59  LDD1849  [11]
C210
 Probe Info 
88.65  LDD1884  [11]
C228
 Probe Info 
23.10  LDD1901  [11]
C231
 Probe Info 
12.91  LDD1904  [11]
C235
 Probe Info 
16.80  LDD1908  [11]
C246
 Probe Info 
12.38  LDD1919  [11]
C278
 Probe Info 
71.51  LDD1948  [11]
C285
 Probe Info 
21.86  LDD1955  [11]
C287
 Probe Info 
9.19  LDD1957  [11]
C288
 Probe Info 
6.19  LDD1958  [11]
C289
 Probe Info 
46.21  LDD1959  [11]
C339
 Probe Info 
5.46  LDD2002  [11]
C343
 Probe Info 
17.27  LDD2005  [11]
C348
 Probe Info 
10.13  LDD2009  [11]
C349
 Probe Info 
12.38  LDD2010  [11]
C350
 Probe Info 
34.30  LDD2011  [11]
C362
 Probe Info 
68.59  LDD2023  [11]
C363
 Probe Info 
20.25  LDD2024  [11]
C364
 Probe Info 
16.68  LDD2025  [11]
C366
 Probe Info 
6.45  LDD2027  [11]
C367
 Probe Info 
5.28  LDD2028  [11]
C388
 Probe Info 
52.35  LDD2047  [11]
C390
 Probe Info 
29.04  LDD2049  [11]
C403
 Probe Info 
17.51  LDD2061  [11]
C431
 Probe Info 
15.78  LDD2086  [11]
FFF probe11
 Probe Info 
20.00  LDD0471  [12]
FFF probe13
 Probe Info 
18.48  LDD0475  [12]
FFF probe14
 Probe Info 
20.00  LDD0477  [12]
FFF probe2
 Probe Info 
20.00  LDD0463  [12]
OEA-DA
 Probe Info 
8.56  LDD0046  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C78(0.86)  LDD0531  [4]
 LDCM0215  AC10 HEK-293T C78(0.97)  LDD1508  [14]
 LDCM0216  AC100 HCT 116 C78(1.24)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C78(1.17)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C78(0.93)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C78(0.92)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C78(0.98)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C78(1.09)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C78(0.99)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C78(0.84)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C78(0.88)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C78(1.09)  LDD0542  [4]
 LDCM0226  AC11 HEK-293T C78(0.96)  LDD1509  [14]
 LDCM0227  AC110 HCT 116 C78(0.95)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C78(0.99)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C78(0.98)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C78(1.03)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C78(0.93)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C78(0.98)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C78(1.07)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C78(1.40)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C78(1.06)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C78(1.08)  LDD0553  [4]
 LDCM0237  AC12 HEK-293T C78(1.02)  LDD1510  [14]
 LDCM0238  AC120 HCT 116 C78(0.90)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C78(1.47)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C78(1.00)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C78(1.54)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C78(1.30)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C78(0.94)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C78(0.87)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C78(1.11)  LDD0562  [4]
 LDCM0259  AC14 HEK-293T C78(1.02)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C78(0.96)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C78(0.96)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C78(0.96)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C78(0.87)  LDD1517  [14]
 LDCM0279  AC2 HCT 116 C78(1.03)  LDD0596  [4]
 LDCM0280  AC20 HEK-293T C78(1.00)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C78(1.07)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C78(1.02)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C78(0.97)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C78(0.98)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C78(0.97)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C78(1.03)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C78(0.97)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C78(1.03)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C78(1.06)  LDD1528  [14]
 LDCM0290  AC3 HCT 116 C78(1.18)  LDD0607  [4]
 LDCM0291  AC30 HEK-293T C78(1.06)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C78(0.99)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C78(1.01)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C78(0.89)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C78(1.00)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C78(0.93)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C78(1.03)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C78(1.08)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C78(1.05)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C78(0.92)  LDD1539  [14]
 LDCM0301  AC4 HCT 116 C78(0.99)  LDD0618  [4]
 LDCM0302  AC40 HEK-293T C78(1.06)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C78(0.91)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C78(0.94)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C78(0.92)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C78(1.06)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C78(1.03)  LDD1546  [14]
 LDCM0308  AC46 HCT 116 C78(0.99)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C78(1.05)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C78(0.87)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C78(0.82)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C78(1.01)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C78(0.97)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C78(0.70)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C78(0.68)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C78(0.87)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C78(0.79)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C78(0.90)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C78(0.74)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C78(1.18)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C78(1.35)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C78(0.94)  LDD0639  [4]
 LDCM0323  AC6 HEK-293T C78(1.02)  LDD1562  [14]
 LDCM0324  AC60 HCT 116 C78(0.70)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C78(1.38)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C78(1.09)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C78(0.90)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C78(0.98)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C78(1.22)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C78(1.31)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C78(0.97)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C78(1.05)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C78(0.90)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C78(0.91)  LDD1568  [14]
 LDCM0335  AC70 HCT 116 C78(0.97)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C78(0.99)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C78(1.08)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C78(0.93)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C78(0.93)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C78(0.95)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C78(0.97)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C78(0.95)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C78(1.00)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C78(1.11)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C78(1.00)  LDD1569  [14]
 LDCM0346  AC80 HCT 116 C78(0.96)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C78(1.11)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C78(1.10)  LDD0665  [4]
 LDCM0365  AC98 HCT 116 C78(0.92)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C78(1.00)  LDD0683  [4]
 LDCM0248  AKOS034007472 HEK-293T C78(1.06)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C78(0.90)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C78(1.04)  LDD1514  [14]
 LDCM0367  CL1 HEK-293T C78(0.96)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C78(1.10)  LDD1572  [14]
 LDCM0369  CL100 HCT 116 C78(0.91)  LDD0686  [4]
 LDCM0370  CL101 HEK-293T C78(0.96)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C78(1.03)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C78(1.06)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C78(0.91)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C78(1.02)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C78(0.96)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C78(1.01)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C78(0.95)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C78(0.95)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C78(0.92)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C78(0.98)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C78(1.01)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C78(0.89)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C78(0.98)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C78(0.96)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C78(1.09)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C78(0.93)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C78(1.00)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C78(0.95)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C78(1.15)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C78(1.04)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C78(0.97)  LDD1595  [14]
 LDCM0392  CL121 HCT 116 C78(0.99)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C78(0.92)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C78(0.98)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C78(0.91)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C78(1.14)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C78(1.12)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C78(0.88)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C78(1.10)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C78(0.92)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C78(0.99)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C78(1.11)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C78(0.91)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C78(0.90)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C78(1.01)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C78(0.93)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C78(0.99)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C78(1.06)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C78(1.13)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C78(1.12)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C78(0.91)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C78(1.07)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C78(0.98)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C78(0.96)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C78(1.10)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C78(0.93)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C78(1.02)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C78(1.13)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C78(1.06)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C78(0.98)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C78(1.03)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C78(1.24)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C78(1.10)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C78(1.04)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C78(1.10)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C78(0.99)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C78(1.00)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C78(1.06)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C78(0.97)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C78(0.88)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C78(1.01)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C78(1.07)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C78(1.01)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C78(1.03)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C78(1.07)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C78(1.00)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C78(1.06)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C78(0.95)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C78(0.87)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C78(1.08)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C78(0.95)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C78(0.86)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C78(1.14)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C78(1.00)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C78(1.14)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C78(1.06)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C78(1.12)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C78(0.95)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C78(0.99)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C78(1.11)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C78(0.94)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C78(1.06)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C78(1.12)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C78(0.92)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C78(0.87)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C78(0.98)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C78(0.97)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C78(1.15)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C78(1.12)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C78(0.94)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C78(1.07)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C78(0.98)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C78(1.09)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C78(0.89)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C78(0.94)  LDD1670  [14]
 LDCM0469  CL76 HCT 116 C78(0.56)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C78(0.54)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C78(0.55)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C78(0.59)  LDD0789  [4]
 LDCM0473  CL8 HEK-293T C78(1.45)  LDD1676  [14]
 LDCM0474  CL80 HCT 116 C78(0.53)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C78(0.49)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C78(0.49)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C78(0.62)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C78(0.65)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C78(0.58)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C78(0.57)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C78(0.60)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C78(0.64)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C78(0.97)  LDD0800  [4]
 LDCM0484  CL9 HEK-293T C78(1.13)  LDD1687  [14]
 LDCM0485  CL90 HCT 116 C78(0.53)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C78(1.05)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C78(1.08)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C78(0.72)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C78(0.94)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C78(0.95)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C78(0.98)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C78(0.96)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C78(0.99)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C78(0.99)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C78(1.24)  LDD1698  [14]
 LDCM0625  F8 Ramos C78(0.76)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C78(2.01)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C78(0.20)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C78(4.63)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C78(0.87)  LDD2192  [15]
 LDCM0580  Fragment21 Ramos C78(0.98)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C78(1.33)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C78(0.83)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C78(0.81)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C78(1.11)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C78(1.22)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C78(2.86)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C78(1.14)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C78(1.41)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C78(2.03)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C78(0.96)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C78(1.27)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C78(1.05)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C78(0.65)  LDD2186  [15]
 LDCM0022  KB02 HEK-293T C78(0.91)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C78(0.98)  LDD1497  [14]
 LDCM0024  KB05 COLO792 C78(3.01)  LDD3310  [16]
 LDCM0109  NEM HeLa N.A.  LDD0227  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C78(0.43)  LDD2109  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C78(0.93)  LDD2125  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C78(1.02)  LDD2136  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C78(0.94)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C78(0.77)  LDD2146  [2]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C78(1.15)  LDD2149  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C78(0.89)  LDD2206  [17]
 LDCM0628  OTUB2-COV-1 HEK-293T C78(1.59)  LDD2207  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 3 (AGR3) AGR family Q8TD06
Phosphatidate cytidylyltransferase 2 (CDS2) CDS family O95674
NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial (NDUFB11) Complex I NDUFB11 subunit family Q9NX14
Cytochrome P450 4F12 (CYP4F12) Cytochrome P450 family Q9HCS2
Glycosaminoglycan xylosylkinase (FAM20B) FAM20 family O75063
Stearoyl-CoA desaturase (SCD) Fatty acid desaturase type 1 family O00767
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Phosphatidylinositol-glycan biosynthesis class F protein (PIGF) PIGF family Q07326
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) Protein-tyrosine phosphatase family P18031
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Lysoplasmalogenase TMEM86A (TMEM86A) TMEM86 family Q8N2M4
E3 ubiquitin-protein ligase MARCHF5 (MARCHF5) . Q9NX47
Transporter and channel
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell receptor-associated protein 31 (BCAP31) BCAP29/BCAP31 family P51572
Gap junction beta-2 protein (GJB2) Connexin family P29033
DNA damage-regulated autophagy modulator protein 1 (DRAM1) DRAM/TMEM150 family Q8N682
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Molybdate-anion transporter (MFSD5) Major facilitator superfamily Q6N075
Ninjurin-1 (NINJ1) Ninjurin family Q92982
Secretory carrier-associated membrane protein 5 (SCAMP5) SCAMP family Q8TAC9
Solute carrier family 35 member F6 (SLC35F6) SLC35F solute transporter family Q8N357
Syntaxin-6 (STX6) Syntaxin family O43752
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 144 (TMEM144) TMEM144 family Q7Z5S9
Transmembrane protein 176A (TMEM176A) TMEM176 family Q96HP8
Solute carrier family 35 member E4 (SLC35E4) TPT transporter family Q6ICL7
Protein YIPF1 (YIPF1) YIP1 family Q9Y548
Renin receptor (ATP6AP2) . O75787
Transmembrane protein 199 (TMEM199) . Q8N511
Transmembrane protein 203 (TMEM203) . Q969S6
Transmembrane protein 65 (TMEM65) . Q6PI78
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 151 (GPR151) G-protein coupled receptor 1 family Q8TDV0
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) Immunoglobulin superfamily Q99706
Cytokine and receptor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon alpha-2 (IFNA2) Alpha/beta interferon family P01563
CKLF-like MARVEL transmembrane domain-containing protein 2 (CMTM2) Chemokine-like factor family Q8TAZ6
C-C motif chemokine 4 (CCL4) Intercrine beta (chemokine CC) family P13236
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein C-IV (APOC4) Apolipoprotein C4 family P55056
ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL6IP6) ARL6IP6 family Q8N6S5
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
Stress-associated endoplasmic reticulum protein 2 (SERP2) RAMP4 family Q8N6R1
Small EDRK-rich factor 1 (SERF1A; SERF1B) SERF family O75920
Syntaxin-12 (STX12) Syntaxin family Q86Y82
Transmembrane protein 54 (TMEM54) TMEM54 family Q969K7
Golgi apparatus membrane protein TVP23 homolog B (TVP23B) TVP23 family Q9NYZ1
Protein YIF1A (YIF1A) YIF1 family O95070
Diablo IAP-binding mitochondrial protein (DIABLO) . Q9NR28
Fetal and adult testis-expressed transcript protein (FATE1) . Q969F0
Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC) . Q8N912
TPA-induced transmembrane protein (TTMP) . Q5BVD1
Uncharacterized protein C5orf46 (C5orf46) . Q6UWT4

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
8 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.