Details of the Target

General Information of Target

Target ID LDTP06988
Target Name 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial (COQ5)
Gene Name COQ5
Gene ID 84274
Synonyms
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; EC 2.1.1.201; Ubiquinone biosynthesis methyltransferase COQ5
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAPGSCALWSYCGRGWSRAMRGCQLLGLRSSWPGDLLSARLLSQEKRAAETHFGFETVS
EEEKGGKVYQVFESVAKKYDVMNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDI
AFRFLNYVQSQHQRKQKRQLRAQQNLSWEEIAKEYQNEEDSLGGSRVVVCDINKEMLKVG
KQKALAQGYRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGG
RFLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDM
IEDAGFHKVTYESLTSGIVAIHSGFKL
Target Bioclass
Enzyme
Family
Class I-like SAM-binding methyltransferase superfamily, MenG/UbiE family
Subcellular location
Mitochondrion inner membrane
Function Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2). {|HAMAP-Rule:MF_03191}.
Uniprot ID
Q5HYK3
Ensemble ID
ENST00000288532.11
HGNC ID
HGNC:28722

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
Probe 1
 Probe Info  		Y155(29.57)  LDD3495  [3]
NAIA_5
 Probe Info  		C170(20.00)  LDD2227  [4]
HPAP
 Probe Info  		3.55  LDD0063  [5]
DBIA
 Probe Info  		C170(95.80)  LDD0209  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		18.51  LDD1793  [13]
C362
 Probe Info  		43.71  LDD2023  [13]
C364
 Probe Info  		17.03  LDD2025  [13]
C366
 Probe Info  		5.24  LDD2027  [13]
FFF probe11
 Probe Info  		20.00  LDD0471  [14]
FFF probe13
 Probe Info  		20.00  LDD0475  [14]
FFF probe14
 Probe Info  		20.00  LDD0477  [14]
FFF probe2
 Probe Info  		20.00  LDD0463  [14]
A-DA
 Probe Info  		3.43  LDD0145  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C244(0.57)  LDD1093  [16]
 LDCM0215  AC10 PaTu 8988t C244(0.73)  LDD1094  [16]
 LDCM0216  AC100 HEK-293T C170(1.20); C244(1.20)  LDD0814  [16]
 LDCM0217  AC101 HEK-293T C170(0.72); C244(0.72)  LDD0815  [16]
 LDCM0218  AC102 HEK-293T C170(1.07); C244(1.07)  LDD0816  [16]
 LDCM0219  AC103 HEK-293T C170(0.89); C244(0.89)  LDD0817  [16]
 LDCM0220  AC104 HEK-293T C170(0.98); C244(0.98)  LDD0818  [16]
 LDCM0221  AC105 HEK-293T C170(1.01); C244(1.01)  LDD0819  [16]
 LDCM0222  AC106 HEK-293T C170(0.93); C244(0.93)  LDD0820  [16]
 LDCM0223  AC107 HEK-293T C170(0.82); C244(0.82)  LDD0821  [16]
 LDCM0224  AC108 HEK-293T C170(0.94); C244(0.94)  LDD0822  [16]
 LDCM0225  AC109 HEK-293T C170(1.05); C244(1.05)  LDD0823  [16]
 LDCM0226  AC11 PaTu 8988t C244(0.80)  LDD1105  [16]
 LDCM0227  AC110 HEK-293T C170(1.44); C244(1.44)  LDD0825  [16]
 LDCM0228  AC111 HEK-293T C170(1.45); C244(1.45)  LDD0826  [16]
 LDCM0229  AC112 HEK-293T C170(1.09); C244(1.09)  LDD0827  [16]
 LDCM0230  AC113 PaTu 8988t C244(1.11)  LDD1109  [16]
 LDCM0231  AC114 PaTu 8988t C244(0.89)  LDD1110  [16]
 LDCM0232  AC115 PaTu 8988t C244(0.70)  LDD1111  [16]
 LDCM0233  AC116 PaTu 8988t C244(0.84)  LDD1112  [16]
 LDCM0234  AC117 PaTu 8988t C244(0.84)  LDD1113  [16]
 LDCM0235  AC118 PaTu 8988t C244(0.74)  LDD1114  [16]
 LDCM0236  AC119 PaTu 8988t C244(1.09)  LDD1115  [16]
 LDCM0237  AC12 PaTu 8988t C244(0.74)  LDD1116  [16]
 LDCM0238  AC120 PaTu 8988t C244(1.11)  LDD1117  [16]
 LDCM0239  AC121 PaTu 8988t C244(0.83)  LDD1118  [16]
 LDCM0240  AC122 PaTu 8988t C244(1.10)  LDD1119  [16]
 LDCM0241  AC123 PaTu 8988t C244(1.14)  LDD1120  [16]
 LDCM0242  AC124 PaTu 8988t C244(0.91)  LDD1121  [16]
 LDCM0243  AC125 PaTu 8988t C244(0.71)  LDD1122  [16]
 LDCM0244  AC126 PaTu 8988t C244(0.95)  LDD1123  [16]
 LDCM0245  AC127 PaTu 8988t C244(0.77)  LDD1124  [16]
 LDCM0246  AC128 HEK-293T C170(1.23); C244(1.23)  LDD0844  [16]
 LDCM0247  AC129 HEK-293T C170(1.14); C244(1.14)  LDD0845  [16]
 LDCM0249  AC130 HEK-293T C170(1.25); C244(1.25)  LDD0847  [16]
 LDCM0250  AC131 HEK-293T C170(1.33); C244(1.33)  LDD0848  [16]
 LDCM0251  AC132 HEK-293T C170(0.78); C244(0.78)  LDD0849  [16]
 LDCM0252  AC133 HEK-293T C170(1.30); C244(1.30)  LDD0850  [16]
 LDCM0253  AC134 HEK-293T C170(1.15); C244(1.15)  LDD0851  [16]
 LDCM0254  AC135 HEK-293T C170(1.49); C244(1.49)  LDD0852  [16]
 LDCM0255  AC136 HEK-293T C170(1.01); C244(1.01)  LDD0853  [16]
 LDCM0256  AC137 HEK-293T C170(0.98); C244(0.98)  LDD0854  [16]
 LDCM0257  AC138 HEK-293T C170(1.47); C244(1.47)  LDD0855  [16]
 LDCM0258  AC139 HEK-293T C170(1.57); C244(1.57)  LDD0856  [16]
 LDCM0259  AC14 PaTu 8988t C244(1.02)  LDD1138  [16]
 LDCM0260  AC140 HEK-293T C170(1.37); C244(1.37)  LDD0858  [16]
 LDCM0261  AC141 HEK-293T C170(1.31); C244(1.31)  LDD0859  [16]
 LDCM0262  AC142 HEK-293T C170(1.43); C244(1.43)  LDD0860  [16]
 LDCM0270  AC15 PaTu 8988t C244(0.85)  LDD1149  [16]
 LDCM0276  AC17 HEK-293T C170(0.93); C244(0.93)  LDD0874  [16]
 LDCM0277  AC18 HEK-293T C170(0.72); C244(0.72)  LDD0875  [16]
 LDCM0278  AC19 HEK-293T C170(0.71); C244(0.71)  LDD0876  [16]
 LDCM0279  AC2 PaTu 8988t C244(1.08)  LDD1158  [16]
 LDCM0280  AC20 HEK-293T C170(0.88); C244(0.88)  LDD0878  [16]
 LDCM0281  AC21 HEK-293T C170(1.08); C244(1.08)  LDD0879  [16]
 LDCM0282  AC22 HEK-293T C170(0.85); C244(0.85)  LDD0880  [16]
 LDCM0283  AC23 HEK-293T C170(0.80); C244(0.80)  LDD0881  [16]
 LDCM0284  AC24 HEK-293T C170(0.83); C244(0.83)  LDD0882  [16]
 LDCM0285  AC25 PaTu 8988t C244(0.96)  LDD1164  [16]
 LDCM0286  AC26 PaTu 8988t C244(0.99)  LDD1165  [16]
 LDCM0287  AC27 PaTu 8988t C244(1.09)  LDD1166  [16]
 LDCM0288  AC28 PaTu 8988t C244(1.06)  LDD1167  [16]
 LDCM0289  AC29 PaTu 8988t C244(1.16)  LDD1168  [16]
 LDCM0290  AC3 PaTu 8988t C244(0.89)  LDD1169  [16]
 LDCM0291  AC30 PaTu 8988t C244(1.13)  LDD1170  [16]
 LDCM0292  AC31 PaTu 8988t C244(1.16)  LDD1171  [16]
 LDCM0293  AC32 PaTu 8988t C244(0.94)  LDD1172  [16]
 LDCM0294  AC33 PaTu 8988t C244(1.18)  LDD1173  [16]
 LDCM0295  AC34 PaTu 8988t C244(1.02)  LDD1174  [16]
 LDCM0296  AC35 PaTu 8988t C244(1.17)  LDD1175  [16]
 LDCM0297  AC36 PaTu 8988t C244(0.78)  LDD1176  [16]
 LDCM0298  AC37 PaTu 8988t C244(0.79)  LDD1177  [16]
 LDCM0299  AC38 PaTu 8988t C244(0.90)  LDD1178  [16]
 LDCM0300  AC39 PaTu 8988t C244(1.00)  LDD1179  [16]
 LDCM0301  AC4 PaTu 8988t C244(1.07)  LDD1180  [16]
 LDCM0302  AC40 PaTu 8988t C244(0.93)  LDD1181  [16]
 LDCM0303  AC41 PaTu 8988t C244(0.74)  LDD1182  [16]
 LDCM0304  AC42 PaTu 8988t C244(0.70)  LDD1183  [16]
 LDCM0305  AC43 PaTu 8988t C244(1.10)  LDD1184  [16]
 LDCM0306  AC44 PaTu 8988t C244(0.74)  LDD1185  [16]
 LDCM0307  AC45 PaTu 8988t C244(0.71)  LDD1186  [16]
 LDCM0308  AC46 PaTu 8988t C170(1.16)  LDD1187  [16]
 LDCM0309  AC47 PaTu 8988t C170(1.31)  LDD1188  [16]
 LDCM0310  AC48 PaTu 8988t C170(1.20)  LDD1189  [16]
 LDCM0311  AC49 PaTu 8988t C170(1.29)  LDD1190  [16]
 LDCM0312  AC5 PaTu 8988t C244(0.82)  LDD1191  [16]
 LDCM0313  AC50 PaTu 8988t C170(1.24)  LDD1192  [16]
 LDCM0314  AC51 PaTu 8988t C170(0.29)  LDD1193  [16]
 LDCM0315  AC52 PaTu 8988t C170(1.18)  LDD1194  [16]
 LDCM0316  AC53 PaTu 8988t C170(1.30)  LDD1195  [16]
 LDCM0317  AC54 PaTu 8988t C170(1.16)  LDD1196  [16]
 LDCM0318  AC55 PaTu 8988t C170(1.05)  LDD1197  [16]
 LDCM0319  AC56 PaTu 8988t C170(1.18)  LDD1198  [16]
 LDCM0320  AC57 HEK-293T C170(0.97)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C170(0.92); C244(1.16)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C170(0.95)  LDD1561  [17]
 LDCM0323  AC6 PaTu 8988t C244(0.94)  LDD1202  [16]
 LDCM0324  AC60 HEK-293T C244(1.01)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C170(0.97); C244(0.79)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C170(0.97); C244(0.91)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C170(0.97)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C170(0.89); C244(1.53)  LDD1567  [17]
 LDCM0334  AC7 PaTu 8988t C244(0.88)  LDD1213  [16]
 LDCM0345  AC8 PaTu 8988t C244(0.92)  LDD1224  [16]
 LDCM0365  AC98 HEK-293T C170(0.89); C244(0.89)  LDD0963  [16]
 LDCM0366  AC99 HEK-293T C170(1.13); C244(1.13)  LDD0964  [16]
 LDCM0248  AKOS034007472 PaTu 8988t C244(0.80)  LDD1127  [16]
 LDCM0356  AKOS034007680 PaTu 8988t C244(0.89)  LDD1235  [16]
 LDCM0275  AKOS034007705 PaTu 8988t C244(0.83)  LDD1154  [16]
 LDCM0156  Aniline NCI-H1299 11.54  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C170(20.00)  LDD2227  [4]
 LDCM0367  CL1 HEK-293T C170(0.93); C244(1.26)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C170(1.46); C244(1.41)  LDD1572  [17]
 LDCM0369  CL100 PaTu 8988t C244(0.76)  LDD1248  [16]
 LDCM0370  CL101 PaTu 8988t C244(0.84)  LDD1249  [16]
 LDCM0371  CL102 PaTu 8988t C244(0.89)  LDD1250  [16]
 LDCM0372  CL103 PaTu 8988t C244(0.79)  LDD1251  [16]
 LDCM0373  CL104 PaTu 8988t C244(0.80)  LDD1252  [16]
 LDCM0374  CL105 HEK-293T C170(1.02); C244(1.02)  LDD0972  [16]
 LDCM0375  CL106 HEK-293T C170(0.84); C244(0.84)  LDD0973  [16]
 LDCM0376  CL107 HEK-293T C170(0.93); C244(0.93)  LDD0974  [16]
 LDCM0377  CL108 HEK-293T C170(1.07); C244(1.07)  LDD0975  [16]
 LDCM0378  CL109 HEK-293T C170(1.06); C244(1.06)  LDD0976  [16]
 LDCM0379  CL11 HEK-293T C170(1.13)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C170(0.89); C244(0.89)  LDD0978  [16]
 LDCM0381  CL111 HEK-293T C170(1.16); C244(1.16)  LDD0979  [16]
 LDCM0382  CL112 PaTu 8988t C244(1.10)  LDD1261  [16]
 LDCM0383  CL113 PaTu 8988t C244(1.09)  LDD1262  [16]
 LDCM0384  CL114 PaTu 8988t C244(1.10)  LDD1263  [16]
 LDCM0385  CL115 PaTu 8988t C244(0.84)  LDD1264  [16]
 LDCM0386  CL116 PaTu 8988t C244(0.93)  LDD1265  [16]
 LDCM0387  CL117 PaTu 8988t C244(0.74)  LDD1266  [16]
 LDCM0388  CL118 PaTu 8988t C244(0.98)  LDD1267  [16]
 LDCM0389  CL119 PaTu 8988t C244(1.00)  LDD1268  [16]
 LDCM0390  CL12 HEK-293T C170(1.00); C244(0.81)  LDD1594  [17]
 LDCM0391  CL120 PaTu 8988t C244(0.89)  LDD1270  [16]
 LDCM0392  CL121 PaTu 8988t C170(1.29)  LDD1271  [16]
 LDCM0393  CL122 PaTu 8988t C170(1.26)  LDD1272  [16]
 LDCM0394  CL123 PaTu 8988t C170(1.42)  LDD1273  [16]
 LDCM0395  CL124 PaTu 8988t C170(1.27)  LDD1274  [16]
 LDCM0396  CL125 HEK-293T C170(0.93); C244(1.37)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C170(0.95)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C170(0.92); C244(1.04)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C170(0.92); C244(1.04)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C170(0.90); C244(0.95)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C170(1.00)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C170(1.16); C244(1.27)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C170(1.00); C244(1.04)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C170(1.14)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C170(1.04); C244(1.26)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C170(1.13)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C170(1.06)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C244(1.14)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C170(1.20); C244(1.82)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C170(1.08); C244(1.11)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C170(1.05)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C170(0.94); C244(1.41)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C170(1.03); C244(1.30)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C170(0.97)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C170(0.96); C244(1.01)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C170(0.98); C244(0.86)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C170(1.01)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C170(1.00); C244(0.96)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C170(0.99); C244(1.16)  LDD1623  [17]
 LDCM0420  CL31 PaTu 8988t C170(0.91); C244(0.58)  LDD1299  [16]
 LDCM0421  CL32 PaTu 8988t C170(0.95); C244(0.61)  LDD1300  [16]
 LDCM0422  CL33 PaTu 8988t C170(0.94); C244(0.67)  LDD1301  [16]
 LDCM0423  CL34 PaTu 8988t C170(0.99); C244(0.69)  LDD1302  [16]
 LDCM0424  CL35 PaTu 8988t C244(0.67); C170(0.93)  LDD1303  [16]
 LDCM0425  CL36 PaTu 8988t C170(0.39); C244(0.43)  LDD1304  [16]
 LDCM0426  CL37 PaTu 8988t C170(0.95); C244(0.54)  LDD1305  [16]
 LDCM0428  CL39 PaTu 8988t C170(0.93); C244(0.63)  LDD1307  [16]
 LDCM0429  CL4 HEK-293T C170(0.97); C244(0.97)  LDD1633  [17]
 LDCM0430  CL40 PaTu 8988t C170(0.85); C244(0.59)  LDD1309  [16]
 LDCM0431  CL41 PaTu 8988t C170(0.93); C244(0.71)  LDD1310  [16]
 LDCM0432  CL42 PaTu 8988t C170(0.91); C244(0.62)  LDD1311  [16]
 LDCM0433  CL43 PaTu 8988t C170(0.91); C244(0.51)  LDD1312  [16]
 LDCM0434  CL44 PaTu 8988t C170(0.93); C244(0.62)  LDD1313  [16]
 LDCM0435  CL45 PaTu 8988t C170(0.92); C244(0.63)  LDD1314  [16]
 LDCM0436  CL46 PaTu 8988t C244(1.01)  LDD1315  [16]
 LDCM0437  CL47 PaTu 8988t C244(0.61)  LDD1316  [16]
 LDCM0438  CL48 PaTu 8988t C244(0.64)  LDD1317  [16]
 LDCM0439  CL49 PaTu 8988t C244(0.83)  LDD1318  [16]
 LDCM0440  CL5 HEK-293T C170(1.08)  LDD1644  [17]
 LDCM0441  CL50 PaTu 8988t C244(0.77)  LDD1320  [16]
 LDCM0442  CL51 PaTu 8988t C244(0.79)  LDD1321  [16]
 LDCM0443  CL52 PaTu 8988t C244(0.60)  LDD1322  [16]
 LDCM0444  CL53 PaTu 8988t C244(0.60)  LDD1323  [16]
 LDCM0445  CL54 PaTu 8988t C244(0.83)  LDD1324  [16]
 LDCM0446  CL55 PaTu 8988t C244(0.70)  LDD1325  [16]
 LDCM0447  CL56 PaTu 8988t C244(0.27)  LDD1326  [16]
 LDCM0448  CL57 PaTu 8988t C244(0.62)  LDD1327  [16]
 LDCM0449  CL58 PaTu 8988t C244(0.71)  LDD1328  [16]
 LDCM0450  CL59 PaTu 8988t C244(0.63)  LDD1329  [16]
 LDCM0451  CL6 HEK-293T C170(1.11); C244(0.84)  LDD1654  [17]
 LDCM0452  CL60 PaTu 8988t C244(0.73)  LDD1331  [16]
 LDCM0453  CL61 PaTu 8988t C170(0.97); C244(0.90)  LDD1332  [16]
 LDCM0454  CL62 PaTu 8988t C170(0.95); C244(0.69)  LDD1333  [16]
 LDCM0455  CL63 PaTu 8988t C170(0.98); C244(1.06)  LDD1334  [16]
 LDCM0456  CL64 PaTu 8988t C170(1.11); C244(0.88)  LDD1335  [16]
 LDCM0457  CL65 PaTu 8988t C170(1.06); C244(1.21)  LDD1336  [16]
 LDCM0458  CL66 PaTu 8988t C170(1.13); C244(0.78)  LDD1337  [16]
 LDCM0459  CL67 PaTu 8988t C170(1.04); C244(0.90)  LDD1338  [16]
 LDCM0460  CL68 PaTu 8988t C170(1.04); C244(0.93)  LDD1339  [16]
 LDCM0461  CL69 PaTu 8988t C170(1.05); C244(0.79)  LDD1340  [16]
 LDCM0462  CL7 HEK-293T C170(1.12)  LDD1665  [17]
 LDCM0463  CL70 PaTu 8988t C170(0.96); C244(0.90)  LDD1342  [16]
 LDCM0464  CL71 PaTu 8988t C170(0.93); C244(0.78)  LDD1343  [16]
 LDCM0465  CL72 PaTu 8988t C170(1.08); C244(0.71)  LDD1344  [16]
 LDCM0466  CL73 PaTu 8988t C170(1.04); C244(0.62)  LDD1345  [16]
 LDCM0467  CL74 PaTu 8988t C170(1.02); C244(0.84)  LDD1346  [16]
 LDCM0469  CL76 HEK-293T C170(1.15); C244(1.15)  LDD1067  [16]
 LDCM0470  CL77 HEK-293T C170(0.84); C244(0.84)  LDD1068  [16]
 LDCM0471  CL78 HEK-293T C170(1.52); C244(1.52)  LDD1069  [16]
 LDCM0472  CL79 HEK-293T C170(1.28); C244(1.28)  LDD1070  [16]
 LDCM0473  CL8 HEK-293T C244(1.64)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C170(1.35); C244(1.35)  LDD1072  [16]
 LDCM0475  CL81 HEK-293T C170(1.20); C244(1.20)  LDD1073  [16]
 LDCM0476  CL82 HEK-293T C170(0.95); C244(0.95)  LDD1074  [16]
 LDCM0477  CL83 HEK-293T C170(1.00); C244(1.00)  LDD1075  [16]
 LDCM0478  CL84 HEK-293T C170(1.85); C244(1.85)  LDD1076  [16]
 LDCM0479  CL85 HEK-293T C170(1.31); C244(1.31)  LDD1077  [16]
 LDCM0480  CL86 HEK-293T C170(1.46); C244(1.46)  LDD1078  [16]
 LDCM0481  CL87 HEK-293T C170(1.09); C244(1.09)  LDD1079  [16]
 LDCM0482  CL88 HEK-293T C170(1.24); C244(1.24)  LDD1080  [16]
 LDCM0483  CL89 HEK-293T C170(1.28); C244(1.28)  LDD1081  [16]
 LDCM0484  CL9 HEK-293T C170(1.12); C244(1.07)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C170(0.87); C244(0.87)  LDD1083  [16]
 LDCM0486  CL91 PaTu 8988t C244(0.82)  LDD1365  [16]
 LDCM0487  CL92 PaTu 8988t C244(0.84)  LDD1366  [16]
 LDCM0488  CL93 PaTu 8988t C244(0.73)  LDD1367  [16]
 LDCM0489  CL94 PaTu 8988t C244(0.86)  LDD1368  [16]
 LDCM0490  CL95 PaTu 8988t C244(0.80)  LDD1369  [16]
 LDCM0491  CL96 PaTu 8988t C244(0.62)  LDD1370  [16]
 LDCM0492  CL97 PaTu 8988t C244(0.75)  LDD1371  [16]
 LDCM0493  CL98 PaTu 8988t C244(0.74)  LDD1372  [16]
 LDCM0494  CL99 PaTu 8988t C244(0.99)  LDD1373  [16]
 LDCM0495  E2913 HEK-293T C170(1.01); C244(1.12)  LDD1698  [17]
 LDCM0625  F8 Ramos C170(1.43)  LDD2187  [18]
 LDCM0576  Fragment14 Ramos C170(0.54)  LDD2193  [18]
 LDCM0580  Fragment21 Ramos C170(0.78)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C170(0.25)  LDD2196  [18]
 LDCM0586  Fragment28 Ramos C170(1.22)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C170(0.59)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C170(0.73)  LDD2200  [18]
 LDCM0468  Fragment33 PaTu 8988t C170(0.89); C244(0.72)  LDD1347  [16]
 LDCM0596  Fragment38 Ramos C170(0.88)  LDD2203  [18]
 LDCM0427  Fragment51 PaTu 8988t C170(0.99); C244(0.57)  LDD1306  [16]
 LDCM0614  Fragment56 Ramos C170(0.90)  LDD2205  [18]
 LDCM0022  KB02 HEK-293T C244(0.99); C170(0.91)  LDD1492  [17]
 LDCM0023  KB03 Jurkat C170(95.80)  LDD0209  [6]
 LDCM0024  KB05 COLO792 C244(1.58); C170(2.79)  LDD3310  [19]
 LDCM0109  NEM HeLa N.A.  LDD0224  [11]
 LDCM0627  NUDT7-COV-1 HEK-293T C244(1.55); C170(0.91)  LDD2206  [20]
 LDCM0628  OTUB2-COV-1 HEK-293T C170(0.84); C244(0.55)  LDD2207  [20]
 LDCM0014  Panhematin K562 3.55  LDD0063  [5]
 LDCM0084  Ro 48-8071 A-549 3.43  LDD0145  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquinone biosynthesis O-methyltransferase, mitochondrial (COQ3) UbiG/COQ3 family Q9NZJ6
5-demethoxyubiquinone hydroxylase, mitochondrial (COQ7) COQ7 family Q99807
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (COQ6) UbiH/COQ6 family Q9Y2Z9
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial (COQ4) COQ4 family Q9Y3A0
Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) COQ9 family O75208

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.