Details of the Target

General Information of Target

Target ID LDTP13986
Target Name Vesicle transport protein GOT1B (GOLT1B)
Gene Name GOLT1B
Gene ID 51026
Synonyms
GCT2; GOT1A; Vesicle transport protein GOT1B; Germ cell tumor 2; Golgi transport 1 homolog B; Putative NF-kappa-B-activating protein 470; hGOT1a
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGSRLETVGSIFSRTRDLVRAGVLKEKPLWFDVYDAFPPLREPVFQRPRVRYGKAKAPI
QDIWYHEDRIRAKFYSVYGSGQRAFDLFNPNFKSTCQRFVEKYTELQKLGETDEEKLFVE
TGKALLAEGVILRRVGEARTQHGGSHVSRKSEHLSVRPQTALEENETQKEVPQDQHLEAP
ADQSKGLLPP
Target Bioclass
Enzyme
Family
GOT1 family
Subcellular location
Golgi apparatus membrane
Function May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
Uniprot ID
Q9Y3E0
Ensemble ID
ENST00000229314.10
HGNC ID
HGNC:20175

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
PAL-AfBPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		8.40  LDD1728  [2]
C040
 Probe Info  		8.63  LDD1740  [2]
C056
 Probe Info  		16.22  LDD1753  [2]
C091
 Probe Info  		17.15  LDD1782  [2]
C092
 Probe Info  		33.82  LDD1783  [2]
C094
 Probe Info  		37.79  LDD1785  [2]
C112
 Probe Info  		18.90  LDD1799  [2]
C134
 Probe Info  		21.26  LDD1816  [2]
C159
 Probe Info  		10.20  LDD1839  [2]
C160
 Probe Info  		8.69  LDD1840  [2]
C161
 Probe Info  		16.34  LDD1841  [2]
C163
 Probe Info  		6.11  LDD1843  [2]
C194
 Probe Info  		9.00  LDD1870  [2]
C201
 Probe Info  		34.30  LDD1877  [2]
C210
 Probe Info  		42.81  LDD1884  [2]
C228
 Probe Info  		17.63  LDD1901  [2]
C231
 Probe Info  		16.34  LDD1904  [2]
C234
 Probe Info  		5.39  LDD1907  [2]
C235
 Probe Info  		21.41  LDD1908  [2]
C246
 Probe Info  		13.18  LDD1919  [2]
C264
 Probe Info  		17.88  LDD1935  [2]
C285
 Probe Info  		19.16  LDD1955  [2]
C287
 Probe Info  		10.56  LDD1957  [2]
C289
 Probe Info  		31.34  LDD1959  [2]
C362
 Probe Info  		49.18  LDD2023  [2]
C363
 Probe Info  		15.45  LDD2024  [2]
C364
 Probe Info  		15.24  LDD2025  [2]
C366
 Probe Info  		5.74  LDD2027  [2]
STS-2
 Probe Info  		N.A.  LDD0138  [3]
OEA-DA
 Probe Info  		9.73  LDD0046  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Inositol polyphosphate 5-phosphatase K (INPP5K) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q9BT40
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein shisa-like-2A (SHISAL2A) Shisa family Q6UWV7

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
3 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
4 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570