Details of the Target
General Information of Target
| Target ID | LDTP00831 | |||||
|---|---|---|---|---|---|---|
| Target Name | NADH dehydrogenase 1 beta subcomplex subunit 5, mitochondrial (NDUFB5) | |||||
| Gene Name | NDUFB5 | |||||
| Gene ID | 4711 | |||||
| Synonyms |
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial; Complex I-SGDH; CI-SGDH; NADH-ubiquinone oxidoreductase SGDH subunit |
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| 3D Structure | ||||||
| Sequence |
MAAMSLLRRVSVTAVAALSGRPLGTRLGFGGFLTRGFPKAAAPVRHSGDHGKRLFVIRPS
RFYDRRFLKLLRFYIALTGIPVAIFITLVNVFIGQAELAEIPEGYVPEHWEYYKHPISRW IARNFYDSPEKIYERTMAVLQIEAEKAELRVKELEVRKLMHVRGDGPWYYYETIDKELID HSPKATPDN |
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| Target Bioclass |
Enzyme
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| Family |
Complex I NDUFB5 subunit family
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| Subcellular location |
Mitochondrion inner membrane
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| Function |
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
PAL-AfBPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
C055 Probe Info |
 |
13.55 | LDD1752 | [1] | |
|
C218 Probe Info |
 |
11.24 | LDD1892 | [1] | |
|
C232 Probe Info |
 |
34.30 | LDD1905 | [1] | |
|
C289 Probe Info |
 |
25.99 | LDD1959 | [1] | |
|
C355 Probe Info |
 |
22.16 | LDD2016 | [1] | |
|
C362 Probe Info |
 |
39.67 | LDD2023 | [1] | |
|
C363 Probe Info |
 |
18.64 | LDD2024 | [1] | |
|
C364 Probe Info |
 |
17.63 | LDD2025 | [1] | |
|
C366 Probe Info |
 |
6.96 | LDD2027 | [1] | |
|
C367 Probe Info |
 |
19.29 | LDD2028 | [1] | |