Details of the Target

General Information of Target

Target ID LDTP07439
Target Name Mitochondrial adenyl nucleotide antiporter SLC25A25 (SLC25A25)
Gene Name SLC25A25
Gene ID 114789
Synonyms
APC3; KIAA1896; MCSC3; SCAMC2; Mitochondrial adenyl nucleotide antiporter SLC25A25; Mitochondrial ATP-Mg/Pi carrier protein 3; Mitochondrial Ca(2+)-dependent solute carrier protein 3; Short calcium-binding mitochondrial carrier protein 2; SCaMC-2; Solute carrier family 25 member 25
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLCLCLYVPVIGEAQTEFQYFESKGLPAELKSIFKLSVFIPSQEFSTYRQWKQKIVQAGD
KDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAE
KILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEE
RQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMGIVGGFTQMIREGGAR
SLWRGNGINVLKIAPESAIKFMAYEQIKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYP
MEVLKTRMALRKTGQYSGMLDCARRILAREGVAAFYKGYVPNMLGIIPYAGIDLAVYETL
KNAWLQHYAVNSADPGVFVLLACGTMSSTCGQLASYPLALVRTRMQAQASIEGAPEVTMS
SLFKHILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR
Target Bioclass
Transporter and channel
Family
Mitochondrial carrier (TC 2.A.29) family
Subcellular location
Mitochondrion inner membrane
Function
Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it could have a broader specificity for adenyl nucleotides. By regulating the mitochondrial matrix adenyl nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways.
Uniprot ID
Q6KCM7
Ensemble ID
ENST00000373064.9
HGNC ID
HGNC:20663

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C249(3.63)  LDD3311  [1]
Curcusone 37
 Probe Info  		2.02  LDD0188  [2]
IA-alkyne
 Probe Info  		C203(5.08)  LDD1706  [3]
TFBX
 Probe Info  		N.A.  LDD0027  [4]
IPM
 Probe Info  		C203(0.00); C322(0.00)  LDD2156  [5]
PAL-AfBPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		9.32  LDD1740  [6]
C055
 Probe Info  		12.21  LDD1752  [6]
C056
 Probe Info  		30.27  LDD1753  [6]
C063
 Probe Info  		14.32  LDD1760  [6]
C070
 Probe Info  		10.48  LDD1766  [6]
C072
 Probe Info  		7.36  LDD1768  [6]
C087
 Probe Info  		8.11  LDD1779  [6]
C112
 Probe Info  		24.93  LDD1799  [6]
C134
 Probe Info  		26.72  LDD1816  [6]
C201
 Probe Info  		36.25  LDD1877  [6]
C206
 Probe Info  		17.88  LDD1881  [6]
C210
 Probe Info  		62.68  LDD1884  [6]
C225
 Probe Info  		5.62  LDD1898  [6]
C226
 Probe Info  		6.15  LDD1899  [6]
C228
 Probe Info  		34.30  LDD1901  [6]
C278
 Probe Info  		61.39  LDD1948  [6]
C362
 Probe Info  		51.98  LDD2023  [6]
C363
 Probe Info  		16.34  LDD2024  [6]
C364
 Probe Info  		17.88  LDD2025  [6]
C366
 Probe Info  		5.74  LDD2027  [6]
C399
 Probe Info  		6.77  LDD2058  [6]
C403
 Probe Info  		30.48  LDD2061  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0033  Curcusone1d MCF-7 2.02  LDD0188  [2]
 LDCM0625  F8 Ramos C322(1.64)  LDD2187  [7]
 LDCM0573  Fragment11 Ramos C322(6.80)  LDD2190  [7]
 LDCM0576  Fragment14 Ramos C322(0.74)  LDD2193  [7]
 LDCM0566  Fragment4 Ramos C322(1.89)  LDD2184  [7]
 LDCM0614  Fragment56 Ramos C322(0.90)  LDD2205  [7]
 LDCM0022  KB02 A101D C249(2.23)  LDD2250  [1]
 LDCM0023  KB03 Ramos C322(1.31)  LDD2183  [7]
 LDCM0024  KB05 G361 C249(3.63)  LDD3311  [1]
 LDCM0627  NUDT7-COV-1 HEK-293T C322(15.00)  LDD2206  [8]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
8 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.