Details of the Target
General Information of Target
| Target ID | LDTP12287 | |||||
|---|---|---|---|---|---|---|
| Target Name | Ran guanine nucleotide release factor (RANGRF) | |||||
| Gene Name | RANGRF | |||||
| Gene ID | 29098 | |||||
| Synonyms |
MOG1; RANGNRF; Ran guanine nucleotide release factor; RanGNRF; Ran-binding protein MOG1 |
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| 3D Structure | ||||||
| Sequence |
MAGAGGGLGVWGNLVLLGLCSWTGARAPAPNPGRNLTVETQTTSSISLSWEVPDGLDSQN
SNYWVQCTGDGGTTETRNTTATNVTVDGLGPGSLYTCSVWVEKDGVNSSVGTVTTATAPN PVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDGLEP GCLYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGTDPQNST YCVQCTGDGGRTETRNTTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSVEIVTSATAPNPV RNLTVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAHTNITVDRLEPGC LYVFSVWVGKNGINSSRETRNATTAPNPVRNLHMETQTNSSIALCWEVPDGPYPQDYTYW VEYTGDGGGTETRNTTNTSVTAERLEPGTLYTFSVWAEKNGARGSRQNVSISTVPNAVTS LSKQDWTNSTIALRWTAPQGPGQSSYSYWVSWVREGMTDPRTQSTSGTDITLKELEAGSL YHLTVWAERNEVRGYNSTLTAATAPNEVTDLQNETQTKNSVMLWWKAPGDPHSQLYVYWV QWASKGHPRRGQDPQANWVNQTSRTNETWYKVEALEPGTLYNFTVWAERNDVASSTQSLC ASTYPDTVTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLG LGPARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRN KKKQQKPELRDLVFSSPGDIPAEDFADHVRKNERDSNCGFADEYQQLSLVGHSQSQMVAS ASENNAKNRYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTV GDFWRLVWEQQSHTLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTV RELLLLQVEEQKTLSVRQFHYQAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHC SAGVGRTGTLIALDVLLRQLQSEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFL QQSAQAPAEKEVPYEDVENLIYENVAAIQAHKLEV |
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| Target Bioclass |
Other
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| Family |
MOG1 family
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| Subcellular location |
Nucleus
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| Function |
May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
m-APA Probe Info |
 |
H81(0.00); H125(0.00) | LDD2231 | [1] | |
PAL-AfBPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
C004 Probe Info |
 |
8.69 | LDD1714 | [2] | |
|
C106 Probe Info |
 |
50.56 | LDD1793 | [2] | |
|
C198 Probe Info |
 |
10.70 | LDD1874 | [2] | |
|
C244 Probe Info |
 |
20.53 | LDD1917 | [2] | |
|
C249 Probe Info |
 |
15.03 | LDD1922 | [2] | |
|
C293 Probe Info |
 |
39.67 | LDD1963 | [2] | |
|
C296 Probe Info |
 |
13.55 | LDD1966 | [2] | |
|
C350 Probe Info |
 |
99.73 | LDD2011 | [2] | |
|
C363 Probe Info |
 |
18.00 | LDD2024 | [2] | |
|
C366 Probe Info |
 |
5.62 | LDD2027 | [2] | |
|
C388 Probe Info |
 |
56.89 | LDD2047 | [2] | |
|
C431 Probe Info |
 |
80.45 | LDD2086 | [2] | |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
Other
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Heat shock-related 70 kDa protein 2 (HSPA2) | Heat shock protein 70 family | P54652 | |||
| Gelsolin (GSN) | Villin/gelsolin family | P06396 | |||
References