Details of the Target

General Information of Target

Target ID LDTP05530
Target Name Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Gene Name MCL1
Gene ID 4170
Synonyms
BCL2L3; Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
Target Type
Successful
Target Bioclass
Other
Family
Bcl-2 family
Subcellular location
Membrane
Function
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
TTD ID
T33765
Uniprot ID
Q07820
DrugMap ID
TTN6ORK
Ensemble ID
ENST00000307940.3
HGNC ID
HGNC:6943
ChEMBL ID
CHEMBL4361

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH1155 SNV: p.R215G .
SW1783 SNV: p.G344V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C286(1.52)  LDD0304  [1]
DBIA
 Probe Info  		C16(1.48)  LDD0078  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [4]
AOyne
 Probe Info  		14.10  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		8.88  LDD1740  [6]
C055
 Probe Info  		14.83  LDD1752  [6]
C056
 Probe Info  		26.35  LDD1753  [6]
C070
 Probe Info  		8.51  LDD1766  [6]
C091
 Probe Info  		12.21  LDD1782  [6]
C092
 Probe Info  		21.86  LDD1783  [6]
C094
 Probe Info  		29.24  LDD1785  [6]
C106
 Probe Info  		24.76  LDD1793  [6]
C112
 Probe Info  		24.76  LDD1799  [6]
C134
 Probe Info  		27.86  LDD1816  [6]
C135
 Probe Info  		9.65  LDD1817  [6]
C169
 Probe Info  		29.45  LDD1849  [6]
C201
 Probe Info  		29.86  LDD1877  [6]
C210
 Probe Info  		56.89  LDD1884  [6]
C218
 Probe Info  		11.79  LDD1892  [6]
C228
 Probe Info  		18.51  LDD1901  [6]
C231
 Probe Info  		18.25  LDD1904  [6]
C232
 Probe Info  		35.02  LDD1905  [6]
C235
 Probe Info  		20.68  LDD1908  [6]
C285
 Probe Info  		21.26  LDD1955  [6]
C289
 Probe Info  		41.64  LDD1959  [6]
C299
 Probe Info  		5.98  LDD1968  [6]
C355
 Probe Info  		26.17  LDD2016  [6]
C362
 Probe Info  		45.57  LDD2023  [6]
C366
 Probe Info  		5.74  LDD2027  [6]
C388
 Probe Info  		51.27  LDD2047  [6]
C390
 Probe Info  		30.70  LDD2049  [6]
C403
 Probe Info  		14.62  LDD2061  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C16(1.12); C286(0.92)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C16(1.07); C286(1.00)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C16(0.97); C286(0.99)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C16(0.95); C286(0.99)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C16(1.14); C286(0.99)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C286(0.92)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C16(0.98); C286(1.07)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C16(1.08); C286(1.03)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C16(0.76); C286(0.93)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C16(1.17); C286(1.10)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C16(1.04); C286(0.90)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C16(1.03); C286(1.19)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C16(1.06); C286(0.98)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C286(0.99)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C16(1.04); C286(1.09)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C16(1.08); C286(1.00)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C16(1.01); C286(1.00)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C16(1.00); C286(0.97)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C16(1.13); C286(0.99)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C16(1.03); C286(1.10)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C16(0.83); C286(0.96)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C16(1.19); C286(1.05)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C286(1.03)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C16(0.98); C286(1.06)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C16(1.14); C286(0.97)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C16(1.01); C286(1.14)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C16(0.99); C286(0.88)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C16(1.08); C286(0.93)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C16(1.15); C286(1.06)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C16(1.05); C286(0.93)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C286(1.05)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C16(0.92); C286(0.96)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C16(1.02); C286(1.07)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C16(1.30); C286(0.89)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C16(0.96); C286(1.13)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C16(1.13); C286(0.96)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C16(1.16); C286(1.03)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C16(1.08); C286(1.02)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C16(1.25); C286(0.87)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C286(1.10)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C16(1.04); C286(1.01)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C16(1.04); C286(0.91)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C16(0.95); C286(0.97)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C16(1.04); C286(1.16)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C16(0.80); C286(1.11)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C16(1.10); C286(0.90)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C16(1.08); C286(0.99)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C16(1.00); C286(1.02)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C286(0.95)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C16(1.13); C286(1.12)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C16(0.96); C286(0.96)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C16(1.01); C286(1.05)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C16(0.89); C286(0.96)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C16(1.07); C286(1.02)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C16(1.01); C286(0.95)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C16(0.97); C286(1.13)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C16(1.11); C286(0.98)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C286(0.85)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C16(1.14); C286(1.01)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C286(0.88)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C16(1.07); C286(0.92)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C16(1.04); C286(1.18)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C16(1.31); C286(0.90)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C16(1.21); C286(1.01)  LDD1514  [7]
 LDCM0020  ARS-1620 HCC44 C16(1.48)  LDD0078  [2]
 LDCM0367  CL1 HEK-293T C16(0.93); C286(1.08)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C16(1.21); C286(0.55)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C16(0.67); C286(1.12)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C16(0.99); C286(0.94)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C16(1.09); C286(0.96)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C286(0.97)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C16(0.74); C286(1.00)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C16(0.96); C286(0.99)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C16(1.35); C286(0.72)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C286(0.87)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C16(0.85); C286(1.14)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C16(1.02); C286(0.93)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C286(1.12)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C16(1.28); C286(0.87)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C286(0.86)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C16(0.55); C286(1.10)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C16(0.99); C286(1.04)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C16(1.64); C286(0.93)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C286(0.93)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C16(0.69); C286(1.10)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C16(0.94); C286(0.95)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C16(1.09); C286(1.06)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C286(1.06)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C16(1.31); C286(1.06)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C16(0.85); C286(1.12)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C16(1.22); C286(0.94)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C16(1.12); C286(0.96)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C286(0.86)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C16(0.76); C286(1.12)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C16(1.10); C286(1.06)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C16(0.93); C286(0.96)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C286(0.88)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C16(0.69); C286(1.17)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C16(0.95); C286(0.99)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C16(1.18); C286(1.04)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C286(0.99)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C16(1.21); C286(1.09)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C16(1.20); C286(0.95)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C16(1.08); C286(1.23)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C16(0.88); C286(1.11)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C16(0.98); C286(0.98)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C16(1.20); C286(1.00)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C16(1.16); C286(0.99)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C16(1.27); C286(0.98)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C286(1.02)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C16(1.36); C286(1.12)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C16(1.08); C286(0.85)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C16(0.92); C286(1.08)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C286(0.98)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C16(0.69); C286(1.18)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C16(1.13); C286(0.93)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C286(1.01)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C16(1.00); C286(1.08)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C16(0.99); C286(0.98)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C16(1.14); C286(0.95)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C16(1.25); C286(1.04)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C16(1.23); C286(0.90)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C286(0.83)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C16(1.23); C286(0.73)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C16(0.80); C286(1.07)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C286(0.92)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C16(1.10); C286(1.19)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C16(0.80); C286(1.28)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C16(1.08); C286(0.96)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C16(0.99); C286(1.10)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C16(1.17); C286(0.93)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C16(1.04); C286(1.06)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C16(1.06); C286(0.97)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C16(1.10); C286(1.00)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C286(0.92)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C16(1.12); C286(1.14)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C16(0.96); C286(1.06)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C16(0.98); C286(1.01)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C16(1.25); C286(0.99)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C16(0.72); C286(1.26)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C16(1.19); C286(0.95)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C16(1.02); C286(1.07)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C16(1.60); C286(1.03)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C16(1.03); C286(1.04)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C16(1.08); C286(1.02)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C16(1.42); C286(0.97)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C286(1.08)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C16(1.07); C286(1.11)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C16(1.25); C286(1.01)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C16(0.98); C286(0.98)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C16(1.36); C286(0.98)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C286(0.80)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C16(0.72); C286(1.03)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C16(1.08); C286(0.98)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C16(0.87); C286(1.13)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C16(0.78); C286(1.05)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C16(1.08); C286(0.97)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C16(1.19); C286(1.05)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C16(1.07); C286(1.07)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C16(1.32); C286(0.93)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C286(0.91)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C16(1.19); C286(1.10)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C16(0.88); C286(1.03)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C16(1.21); C286(1.07)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C16(0.69); C286(1.20)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C16(1.32); C286(1.02)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C16(0.99); C286(1.18)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C16(0.98); C286(1.05)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C16(1.24); C286(0.85)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C16(1.11); C286(1.10)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C16(1.12); C286(1.14)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C16(1.09); C286(0.94)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C286(1.01)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C16(1.05); C286(1.07)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C16(0.93); C286(1.14)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C16(1.00); C286(0.96)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C286(0.82)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C16(0.68); C286(1.04)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C16(0.90); C286(0.97)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C16(1.11); C286(1.09)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C16(1.31); C286(0.98)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C16(1.16); C286(1.06)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C16(1.02); C286(0.93)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C16(1.06); C286(0.98)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C16(1.19); C286(1.02)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C286(0.71)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C16(0.98); C286(0.90)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C16(0.96); C286(0.92)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C16(1.00); C286(0.92)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C286(0.98)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C286(0.89)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C286(0.94)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C16(0.95); C286(1.06)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C16(1.07); C286(0.98)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C16(1.05); C286(1.08)  LDD1497  [7]
 LDCM0024  KB05 HMCB C286(2.64)  LDD3312  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C16(0.09)  LDD2206  [9]
 LDCM0628  OTUB2-COV-1 HEK-293T C16(1.21)  LDD2207  [9]
 LDCM0131  RA190 MM1.R C286(1.52)  LDD0304  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable ubiquitin carboxyl-terminal hydrolase FAF-X (USP9X) Peptidase C19 family Q93008
E3 ubiquitin-protein ligase HUWE1 (HUWE1) UPL family Q7Z6Z7
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apoptosis regulator BAX (BAX) Bcl-2 family Q07812
Bcl-2 homologous antagonist/killer (BAK1) Bcl-2 family Q16611
Bcl-2-like protein 11 (BCL2L11) Bcl-2 family O43521
Beclin-1 (BECN1) Beclin family Q14457
Caveolin-1 (CAV1) Caveolin family Q03135
Potassium voltage-gated channel subfamily F member 1 (KCNF1) Potassium channel family Q9H3M0
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-binding component 3, isoforms 1/2 (BBC3) Bcl-2 family Q9BXH1
Bcl-2-modifying factor (BMF) Bcl-2 family Q96LC9
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) PMAIP1 family Q13794
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
BH3-interacting domain death agonist (BID) . P55957
Protein Bop (RTL10) . Q7L3V2

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Obatoclax Small molecular drug D02OZK
Phase 1
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Abbv-467 Small molecular drug D63QIY
Amg 397 Small molecular drug DBI81F
Mik665 Small molecular drug D7LC8N
Prt1419 Small molecular drug D50CXM
Amg 176 . D0I5DP
Azd5991 . D06XCP
Investigative
Click To Hide/Show 13 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Altenusin Small molecular drug D0G3SZ
Amentoflavone Small molecular drug D06HRX
Gnf-pf-1591 Small molecular drug D0G5LZ
Gnf-pf-3955 Small molecular drug D0H7BH
Gnf-pf-5134 Small molecular drug D0IK4V
Morin Small molecular drug D0NJ4H
Nsc-180246 Small molecular drug D0WN7V
Nsc-66209 Small molecular drug D0XU4Y
Rosmarinic Acid Small molecular drug D05PTT
Sulfuretin Small molecular drug D0GN5Z
Tw-37 Small molecular drug D00LHS
Eu-517 . D0U4QZ
Qediirniarhlaqvgdsmdr . D0S6IW
Patented
Click To Hide/Show 22 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Biphenyl Carboxylic Acid Derivative 1 Small molecular drug D03FZI
Biphenyl Carboxylic Acid Derivative 2 Small molecular drug D09SGU
Indole-based Analog 1 Small molecular drug D0F8LE
Indole-based Analog 2 Small molecular drug D0C2DV
Indole-based Analog 3 Small molecular drug D0MZ7I
Pmid27744724-compound-10 Small molecular drug D0IS8R
Pmid27744724-compound-13 Small molecular drug D0I9PC
Pmid27744724-compound-18 Small molecular drug D0TU3N
Pmid27744724-compound-19 Small molecular drug D00BEJ
Pmid27744724-compound-20 Small molecular drug D0NT2S
Pmid27744724-compound-21 Small molecular drug D0J9FN
Pmid27744724-compound-22 Small molecular drug D0QE9E
Pmid27744724-compound-23 Small molecular drug D0LO7X
Pmid27744724-compound-26 Small molecular drug D09XWR
Pmid27744724-compound-27 Small molecular drug D0F9QC
Pmid27744724-compound-28 Small molecular drug D0M6MP
Pmid27744724-compound-29 Small molecular drug D0JZ4W
Pmid27744724-compound-3 Small molecular drug D0JA5B
Pmid27744724-compound-4 Small molecular drug D0H3NO
Pmid27744724-compound-5 Small molecular drug D0IV8T
Pmid27744724-compound-6 Small molecular drug D0RJ1U
Pmid27744724-compound-fomula2 Small molecular drug D0DG0F
Withdrawn from market
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bithionol Small molecular drug D0QQ1J
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sch-45752 Small molecular drug D00MEV

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.