Details of the Target

General Information of Target

Target ID LDTP13352
Target Name GTP:AMP phosphotransferase AK3, mitochondrial (AK3)
Gene Name AK3
Gene ID 50808
Synonyms
AK3L1; AK6; AKL3L; GTP:AMP phosphotransferase AK3, mitochondrial; EC 2.7.4.10; Adenylate kinase 3; AK 3; Adenylate kinase 3 alpha-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPSGPGSSARRRCRRVLYWIPVVFITLLLGWSYYAYAIQLCIVSMENTGEQVVCLMAYH
LLFAMFVWSYWKTIFTLPMNPSKEFHLSYAEKDLLEREPRGEAHQEVLRRAAKDLPIYTR
TMSGAIRYCDRCQLIKPDRCHHCSVCDKCILKMDHHCPWVNNCVGFSNYKFFLLFLAYSL
LYCLFIAATDLQYFIKFWTNGLPDTQAKFHIMFLFFAAAMFSVSLSSLFGYHCWLVSKNK
STLEAFRSPVFRHGTDKNGFSLGFSKNMRQVFGDEKKYWLLPIFSSLGDGCSFPTCLVNQ
DPEQASTPAGLNSTAKNLENHQFPAKPLRESQSHLLTDSQSWTESSINPGKCKAGMSNPA
LTMENET
Target Bioclass
Enzyme
Family
Adenylate kinase family, AK3 subfamily
Subcellular location
Mitochondrion matrix
Function
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. {|HAMAP-Rule:MF_03169}.
Uniprot ID
Q9UIJ7
Ensemble ID
ENST00000359883.6
HGNC ID
HGNC:17376

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y85(20.00)  LDD0260  [1]
C-Sul
 Probe Info  		21.24  LDD0066  [2]
STPyne
 Probe Info  		K64(1.41)  LDD0277  [3]
DBIA
 Probe Info  		C81(1.92)  LDD3312  [4]
Acrolein
 Probe Info  		H35(0.00); H30(0.00)  LDD0221  [5]
1c-yne
 Probe Info  		N.A.  LDD0228  [6]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [5]
HHS-465
 Probe Info  		N.A.  LDD2240  [7]
PAL-AfBPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		23.59  LDD1753  [8]
C071
 Probe Info  		8.34  LDD1767  [8]
C094
 Probe Info  		46.85  LDD1785  [8]
C158
 Probe Info  		14.72  LDD1838  [8]
C161
 Probe Info  		10.78  LDD1841  [8]
C201
 Probe Info  		42.52  LDD1877  [8]
C206
 Probe Info  		23.43  LDD1881  [8]
C210
 Probe Info  		68.12  LDD1884  [8]
C232
 Probe Info  		50.56  LDD1905  [8]
C244
 Probe Info  		25.63  LDD1917  [8]
C246
 Probe Info  		17.51  LDD1919  [8]
C278
 Probe Info  		99.73  LDD1948  [8]
C280
 Probe Info  		12.91  LDD1950  [8]
C293
 Probe Info  		63.12  LDD1963  [8]
C349
 Probe Info  		9.92  LDD2010  [8]
C362
 Probe Info  		99.73  LDD2023  [8]
C364
 Probe Info  		22.01  LDD2025  [8]
C366
 Probe Info  		7.36  LDD2027  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H30(0.00); H35(0.00)  LDD0222  [5]
 LDCM0107  IAA HeLa H35(0.00); H30(0.00)  LDD0221  [5]
 LDCM0022  KB02 42-MG-BA C81(2.01)  LDD2244  [4]
 LDCM0023  KB03 22RV1 C81(2.11)  LDD2660  [4]
 LDCM0024  KB05 HMCB C81(1.92)  LDD3312  [4]
 LDCM0109  NEM HeLa H35(0.00); H30(0.00)  LDD0223  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Glyceraldehyde-3-phosphate dehydrogenase family P04406
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein E (APOE) Apolipoprotein A1/A4/E family P02649
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Amyloid protein-binding protein 2 (APPBP2) . Q92624

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587