Details of the Target

General Information of Target

Target ID LDTP02643
Target Name Uracil-DNA glycosylase (UNG)
Gene Name UNG
Gene ID 7374
Synonyms
DGU; UNG1; UNG15; Uracil-DNA glycosylase; UDG; EC 3.2.2.27
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIGQKTLYSFFSPSPARKRHAPSPEPAVQGTGVAGVPEESGDAAAIPAKKAPAGQEEPGT
PPSSPLSAEQLDRIQRNKAAALLRLAARNVPVGFGESWKKHLSGEFGKPYFIKLMGFVAE
ERKHYTVYPPPHQVFTWTQMCDIKDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLE
NIYKELSTDIEDFVHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVS
WLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGCRHFSKTNELL
QKSGKKPIDWKEL
Target Bioclass
Enzyme
Family
Uracil-DNA glycosylase (UDG) superfamily, UNG family
Subcellular location
Nucleus; Mitochondrion
Function Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Uniprot ID
P13051
Ensemble ID
ENST00000242576.7
HGNC ID
HGNC:12572
ChEMBL ID
CHEMBL3277

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KMS27 SNV: p.G116R .
MFE319 SNV: p.G3D; p.F10L .
MOLT4 SNV: p.R19L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K78(10.00); K99(6.25)  LDD0277  [1]
HHS-465
 Probe Info  		Y8(4.34)  LDD2237  [2]
Acrolein
 Probe Info  		N.A.  LDD0222  [3]
IA-alkyne
 Probe Info  		C290(0.00); C166(0.00)  LDD0165  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
DBIA
 Probe Info  		C290(0.05)  LDD2236  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
AOyne
 Probe Info  		13.70  LDD0443  [8]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		22.32  LDD1850  [9]
C171
 Probe Info  		5.21  LDD1851  [9]
C173
 Probe Info  		5.54  LDD1853  [9]
C366
 Probe Info  		5.39  LDD2027  [9]
VE-P
 Probe Info  		N.A.  LDD0396  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-8 (CASP8) Peptidase C14A family Q14790
Phospholipase D2 (PLD2) Phospholipase D family O14939
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
Ribosomal protein S6 kinase beta-1 (RPS6KB1) AGC Ser/Thr protein kinase family P23443
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Mitogen-activated protein kinase 3 (MAPK3) CMGC Ser/Thr protein kinase family P27361
Tyrosine-protein kinase Fyn (FYN) Tyr protein kinase family P06241
Ataxin-3 (ATXN3) . P54252
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Platelet glycoprotein 4 (CD36) CD36 family P16671
Protein S100-B (S100B) S-100 family P04271
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transforming growth factor beta-2 proprotein (TGFB2) TGF-beta family P61812
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Actin-related protein 3 (ACTR3) Actin family P61158
Reticulocalbin-2 (RCN2) CREC family Q14257
Nascent polypeptide-associated complex subunit alpha (NACA) NAC-alpha family Q13765
Replication protein A 32 kDa subunit (RPA2) Replication factor A protein 2 family P15927
Transcription initiation factor TFIID subunit 7 (TAF7) TAF7 family Q15545
DnaJ homolog subfamily B member 1 (DNAJB1) . P25685

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-(2-deoxy-5-o-phosphono-beta-d-erythro-pentofuranosyl)-4-methyl-1h-indole . DB07116
3-[(1e7e)-8-(26-dioxo-1236-tetrahydropyrimidin-4-yl)-36-dioxa-27-diazaocta-17-dien-1-yl]Benzoic Acid . DB07760
4-[(1e7e)-8-(26-dioxo-1236-tetrahydropyrimidin-4-yl)-36-dioxa-27-diazaocta-17-dien-1-yl]Benzoic Acid . DB06990

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Global profiling of phosphorylation-dependent changes in cysteine reactivity. Nat Methods. 2022 Mar;19(3):341-352. doi: 10.1038/s41592-022-01398-2. Epub 2022 Feb 28.
Mass spectrometry data entry: PXD026730
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.