Details of the Target

General Information of Target

Target ID LDTP01502
Target Name NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6)
Gene Name NDUFB6
Gene ID 4712
Synonyms
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; Complex I-B17; CI-B17; NADH-ubiquinone oxidoreductase B17 subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPQKMGPMEKFWNKFLENKSPWRKM
VHGVYKKSIFVFTHVLVPVWIIHYYMKYHVSEKPYGIVEKKSRIFPGDTILETGEVIPPM
KEFPDQHH
Target Bioclass
Enzyme
Family
Complex I NDUFB6 subunit family
Subcellular location
Mitochondrion inner membrane
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Uniprot ID
O95139
Ensemble ID
ENST00000350021.2
HGNC ID
HGNC:7701
ChEMBL ID
CHEMBL2363065

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MCC13 Substitution: p.P30S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K24(6.51); K49(7.38); K54(0.37)  LDD0277  [1]
NHS
 Probe Info  		N.A.  LDD0010  [2]
AOyne
 Probe Info  		15.00  LDD0443  [3]
PAL-AfBPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		14.93  LDD1752  [4]
C056
 Probe Info  		47.18  LDD1753  [4]
C106
 Probe Info  		21.41  LDD1793  [4]
C201
 Probe Info  		23.92  LDD1877  [4]
C210
 Probe Info  		38.85  LDD1884  [4]
C218
 Probe Info  		11.79  LDD1892  [4]
C220
 Probe Info  		15.89  LDD1894  [4]
C278
 Probe Info  		61.39  LDD1948  [4]
C287
 Probe Info  		11.00  LDD1957  [4]
C289
 Probe Info  		46.53  LDD1959  [4]
C343
 Probe Info  		13.09  LDD2005  [4]
C362
 Probe Info  		91.14  LDD2023  [4]
C363
 Probe Info  		19.84  LDD2024  [4]
C364
 Probe Info  		18.25  LDD2025  [4]
C366
 Probe Info  		6.63  LDD2027  [4]
C388
 Probe Info  		37.27  LDD2047  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587