Details of the Target

General Information of Target

Target ID LDTP13971
Target Name Large ribosomal subunit protein uL11m (MRPL11)
Gene Name MRPL11
Gene ID 65003
Synonyms
Large ribosomal subunit protein uL11m; 39S ribosomal protein L11, mitochondrial; L11mt; MRP-L11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMQAAKRANIRLPPEVNRILYIRNLPYKITAEEMYDIFGKYGPIRQIRVGNTPETRGTA
YVVYEDIFDAKNACDHLSGFNVCNRYLVVLYYNANRAFQKMDTKKKEEQLKLLKEKYGIN
TDPPK
Target Bioclass
Other
Family
Universal ribosomal protein uL11 family
Subcellular location
Mitochondrion
Uniprot ID
Q9Y3B7
Ensemble ID
ENST00000310999.11
HGNC ID
HGNC:14042

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HUPT3 SNV: p.D158H DBIA    Probe Info 
KATOIII SNV: p.V24L .
RKN SNV: p.G152D DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.28  LDD0318  [1]
STPyne
 Probe Info  		K69(10.00)  LDD0277  [2]
BTD
 Probe Info  		C50(2.65)  LDD2093  [3]
Acrolein
 Probe Info  		N.A.  LDD0223  [4]
DBIA
 Probe Info  		C50(1.91)  LDD0080  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
IPM
 Probe Info  		N.A.  LDD0147  [8]
NHS
 Probe Info  		N.A.  LDD0010  [10]
PF-06672131
 Probe Info  		N.A.  LDD0017  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
1c-yne
 Probe Info  		N.A.  LDD0228  [13]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [4]
Methacrolein
 Probe Info  		N.A.  LDD0218  [4]
MPP-AC
 Probe Info  		N.A.  LDD0428  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
TER-AC
 Probe Info  		N.A.  LDD0426  [14]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C278
 Probe Info  		64.45  LDD1948  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C50(0.96)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C50(1.15)  LDD2152  [3]
 LDCM0214  AC1 HCT 116 C50(1.24)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C50(1.15)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C50(0.72)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C50(0.66)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C50(0.70)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C50(0.64)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C50(0.78)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C50(0.61)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C50(0.59)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C50(0.82)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C50(0.59)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C50(0.80)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C50(1.01)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C50(0.55)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C50(0.57)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C50(0.62)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C50(1.42)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C50(0.82)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C50(0.76)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C50(0.73)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C50(0.78)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C50(0.77)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C50(0.77)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C50(1.34)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C50(0.83)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C50(0.78)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C50(0.92)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C50(0.88)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C50(0.81)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C50(0.80)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C50(0.66)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C50(0.82)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C50(0.91)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C50(1.14)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C50(0.77)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C50(0.97)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C50(1.16)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C50(0.94)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C50(0.97)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C50(1.13)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C50(0.96)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C50(1.08)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C50(0.98)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C50(1.01)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C50(0.97)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C50(0.75)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C50(0.77)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C50(1.07)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C50(0.86)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C50(0.76)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C50(0.77)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C50(0.74)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C50(0.67)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C50(0.66)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C50(0.74)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C50(1.10)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C50(0.82)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C50(0.83)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C50(0.79)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C50(0.94)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C50(0.73)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C50(0.78)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C50(0.90)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C50(0.97)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C50(0.75)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C50(0.76)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C50(0.69)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C50(1.11)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C50(0.55)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C50(0.55)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C50(0.86)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C50(0.68)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C50(0.91)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C50(0.41)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C50(0.37)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C50(0.48)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C50(0.47)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C50(0.47)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C50(1.39)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C50(0.42)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C50(0.57)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C50(0.42)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C50(0.45)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C50(0.50)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C50(0.91)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C50(0.81)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C50(0.84)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C50(0.93)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C50(0.86)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C50(1.98)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C50(1.04)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C50(0.75)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C50(0.76)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C50(0.67)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C50(0.81)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C50(0.82)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C50(1.19)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C50(1.23)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C50(1.07)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C50(0.91)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C50(1.76)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C50(1.02)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C50(1.08)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C50(1.08)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C50(1.06)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C50(1.43)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C50(1.28)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C50(1.28)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C50(0.88)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C50(0.94)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C50(0.88)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C50(1.01)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C50(0.82)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C50(1.13)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C50(1.01)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C50(0.99)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C50(0.89)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C50(0.96)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C50(0.93)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C50(0.94)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C50(1.06)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C50(1.15)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C50(1.05)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C50(0.92)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C50(1.47)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C50(1.21)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C50(1.02)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C50(1.37)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C50(0.87)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C50(0.94)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C50(0.95)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C50(1.09)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C50(1.05)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C50(0.93)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C50(1.03)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C50(1.21)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C50(1.01)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C50(0.82)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C50(1.05)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C50(0.86)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C50(0.83)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C50(1.08)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C50(0.95)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C50(0.87)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C50(0.80)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C50(0.90)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C50(0.97)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C50(0.93)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C50(1.23)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C50(0.86)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C50(1.15)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C50(0.72)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C50(0.59)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C50(0.70)  LDD0683  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C50(0.53)  LDD2113  [3]
 LDCM0248  AKOS034007472 HCT 116 C50(1.02)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C50(1.26)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C50(1.15)  LDD0592  [5]
 LDCM0367  CL1 HCT 116 C50(1.09)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C50(1.00)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C50(1.14)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C50(0.88)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C50(1.16)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C50(1.11)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C50(1.17)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C50(0.52)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C50(0.63)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C50(0.59)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C50(0.60)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C50(0.63)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C50(1.06)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C50(0.66)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C50(0.79)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C50(0.46)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C50(0.54)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C50(0.48)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C50(0.59)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C50(0.56)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C50(0.85)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C50(0.79)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C50(0.76)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C50(1.02)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C50(0.72)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C50(1.10)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C50(1.47)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C50(1.12)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C50(1.17)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C50(1.02)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C50(0.95)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C50(0.92)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C50(0.95)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C50(1.26)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C50(1.01)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C50(1.07)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C50(0.82)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C50(0.78)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C50(0.69)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C50(0.90)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C50(1.09)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C50(0.78)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C50(1.05)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C50(1.31)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C50(0.83)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C50(0.84)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C50(0.99)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C50(0.96)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C50(1.04)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C50(0.73)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C50(0.68)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C50(1.09)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C50(0.85)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C50(1.07)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C50(1.20)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C50(0.98)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C50(1.26)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C50(1.17)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C50(1.13)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C50(1.31)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C50(0.91)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C50(0.95)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C50(0.91)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C50(0.95)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C50(1.82)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C50(1.23)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C50(1.78)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C50(1.20)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C50(1.23)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C50(1.38)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C50(1.33)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C50(1.00)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C50(1.11)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C50(1.64)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C50(0.90)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C50(1.28)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C50(1.18)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C50(1.02)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C50(0.94)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C50(1.00)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C50(1.55)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C50(0.90)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C50(1.34)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C50(1.01)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C50(1.29)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C50(0.90)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C50(0.84)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C50(0.83)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C50(0.93)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C50(1.08)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C50(0.99)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C50(0.99)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C50(1.05)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C50(0.93)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C50(1.08)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C50(0.99)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C50(0.90)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C50(1.11)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C50(0.84)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C50(0.85)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C50(1.11)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C50(1.14)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C50(0.93)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C50(0.99)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C50(1.00)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C50(1.35)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C50(1.14)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C50(1.26)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C50(0.93)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C50(0.99)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C50(1.06)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C50(1.09)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C50(0.97)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C50(0.96)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C50(1.32)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C50(1.02)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C50(1.11)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C50(0.92)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C50(0.84)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C50(1.02)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C50(0.91)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C50(1.38)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C50(1.16)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C50(1.15)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C50(1.14)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C50(1.07)  LDD0811  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C50(3.72)  LDD1702  [3]
 LDCM0625  F8 Ramos C50(1.18)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C50(1.09)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C50(0.02)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C50(0.87)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C50(0.79)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C50(0.40)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C50(0.79)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C50(0.86)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C50(0.97)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C50(0.75)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C50(0.76)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C50(1.08)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C50(0.76)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C50(0.73)  LDD2201  [17]
 LDCM0468  Fragment33 HCT 116 C50(0.91)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C50(0.72)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C50(0.97)  LDD2184  [17]
 LDCM0427  Fragment51 HCT 116 C50(1.34)  LDD0744  [5]
 LDCM0610  Fragment52 Ramos C50(0.87)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C50(1.07)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C50(1.04)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C50(1.30)  LDD2188  [17]
 LDCM0015  HNE MDA-MB-231 C50(0.88)  LDD0346  [17]
 LDCM0022  KB02 HCT 116 C50(1.91)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C50(1.06)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C50(2.21)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C50(2.65)  LDD2093  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C50(1.15)  LDD2096  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C50(0.57)  LDD2097  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C50(1.08)  LDD2099  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C50(0.71)  LDD2101  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C50(1.00)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C50(0.85)  LDD2109  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C50(0.43)  LDD2115  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C50(1.23)  LDD2118  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C50(1.31)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C50(0.94)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C50(0.66)  LDD2124  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C50(0.88)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C50(1.05)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C50(0.91)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C50(1.25)  LDD2129  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C50(0.50)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C50(0.38)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C50(1.52)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C50(1.67)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C50(1.18)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C50(1.36)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C50(0.28)  LDD2141  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C50(2.64)  LDD2144  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C50(1.79)  LDD2149  [3]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C50(1.02)  LDD2151  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C50(0.93)  LDD2206  [18]
 LDCM0628  OTUB2-COV-1 HEK-293T C50(0.35)  LDD2207  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B) CAMK Ser/Thr protein kinase family Q13554
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) CAMK Ser/Thr protein kinase family Q13557
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Monocarboxylate transporter 9 (SLC16A9) Monocarboxylate porter (TC 2.A.1.13) family Q7RTY1
Transcription factor
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-globin transcription factor CP2 (TFCP2) Grh/CP2 family Q12800
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Zinc finger protein 438 (ZNF438) Krueppel C2H2-type zinc-finger protein family Q7Z4V0
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
THAP domain-containing protein 1 (THAP1) THAP1 family Q9NVV9
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Zinc finger and BTB domain-containing protein 2 (ZBTB2) . Q8N680
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 172 (CCDC172) CCDC172 family P0C7W6
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Janus kinase and microtubule-interacting protein 1 (JAKMIP1) JAKMIP family Q96N16
Janus kinase and microtubule-interacting protein 2 (JAKMIP2) JAKMIP family Q96AA8
Large ribosomal subunit protein mL54 (MRPL54) Mitochondrion-specific ribosomal protein mL54 family Q6P161
Phosducin-like protein (PDCL) Phosducin family Q13371
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Tax1-binding protein 1 (TAX1BP1) . Q86VP1

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.