Details of the Target

General Information of Target

Target ID LDTP05035
Target Name Growth factor receptor-bound protein 2 (GRB2)
Gene Name GRB2
Gene ID 2885
Synonyms
ASH; Growth factor receptor-bound protein 2; Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
Target Type
Clinical trial
Target Bioclass
Other
Family
GRB2/sem-5/DRK family
Subcellular location
Nucleus
Function
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.; [Isoform 2]: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
TTD ID
T30926
Uniprot ID
P62993
DrugMap ID
TTEYRJ9
Ensemble ID
ENST00000316615.9
HGNC ID
HGNC:4566
ChEMBL ID
CHEMBL3663

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH1155 SNV: p.P92L DBIA    Probe Info 
SHP77 SNV: p.R207C DBIA    Probe Info 
SNGM Insertion: p.G63WfsTer13 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y52(14.32); Y209(5.56)  LDD0257  [2]
STPyne
 Probe Info  		K20(10.00); K50(0.72); K69(1.52); K76(9.68)  LDD0277  [3]
Probe 1
 Probe Info  		Y209(56.65)  LDD3495  [4]
BTD
 Probe Info  		C198(1.34)  LDD2093  [5]
AHL-Pu-1
 Probe Info  		C32(2.51)  LDD0169  [6]
HHS-482
 Probe Info  		Y209(1.02)  LDD0285  [7]
HHS-475
 Probe Info  		Y209(0.91); Y52(0.96); Y160(1.84)  LDD0264  [8]
HHS-465
 Probe Info  		Y209(9.36); Y52(9.83)  LDD2237  [9]
DBIA
 Probe Info  		C32(0.94)  LDD0078  [10]
5E-2FA
 Probe Info  		H199(0.00); H58(0.00); H184(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		K56(0.00); K109(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C198(0.00); C32(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
Lodoacetamide azide
 Probe Info  		C198(0.00); C32(0.00)  LDD0037  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [15]
WYneO
 Probe Info  		N.A.  LDD0022  [16]
Compound 10
 Probe Info  		N.A.  LDD2216  [17]
Compound 11
 Probe Info  		N.A.  LDD2213  [17]
ENE
 Probe Info  		N.A.  LDD0006  [16]
IPM
 Probe Info  		N.A.  LDD0005  [16]
NHS
 Probe Info  		N.A.  LDD0010  [16]
SF
 Probe Info  		Y209(0.00); Y134(0.00); Y52(0.00)  LDD0028  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [19]
1c-yne
 Probe Info  		N.A.  LDD0228  [20]
Acrolein
 Probe Info  		N.A.  LDD0217  [21]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [21]
Methacrolein
 Probe Info  		C198(0.00); C32(0.00)  LDD0218  [21]
W1
 Probe Info  		N.A.  LDD0236  [22]
AOyne
 Probe Info  		14.80  LDD0443  [23]
NAIA_5
 Probe Info  		C198(0.00); C32(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		7.46  LDD1779  [24]
C322
 Probe Info  		5.62  LDD1988  [24]
C348
 Probe Info  		21.41  LDD2009  [24]
FFF probe11
 Probe Info  		6.44  LDD0471  [25]
FFF probe12
 Probe Info  		9.27  LDD0473  [25]
FFF probe13
 Probe Info  		14.47  LDD0475  [25]
FFF probe2
 Probe Info  		8.18  LDD0463  [25]
FFF probe3
 Probe Info  		14.04  LDD0464  [25]
FFF probe9
 Probe Info  		12.07  LDD0470  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C198(1.10)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C198(1.54)  LDD2152  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C32(2.51)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C198(1.08); C32(1.21)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C198(1.24); C32(1.12)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C198(0.90); C32(1.09)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C198(0.81); C32(0.97)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C198(0.86); C32(1.03)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C198(1.00); C32(1.25)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C198(1.12); C32(1.07)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C198(0.90); C32(1.12)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C198(0.97); C32(1.29)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C198(0.71); C32(1.15)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C198(0.82); C32(0.93)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C198(1.07); C32(0.85)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C198(1.10); C32(1.29)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C198(0.82); C32(1.03)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C198(0.83); C32(1.04)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C198(0.75); C32(1.06)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C198(0.95); C32(0.99)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C198(1.17); C32(1.11)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C198(1.22); C32(1.22)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C198(1.32); C32(1.29)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C198(1.25); C32(1.19)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C198(1.23); C32(1.14)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C198(1.16); C32(1.17)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C198(0.96); C32(1.33)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C198(1.18); C32(1.24)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C198(0.94); C32(1.06)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C198(1.01); C32(1.12)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C198(0.90); C32(0.97)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C198(1.02); C32(1.14)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C198(1.04); C32(1.10)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C198(1.30); C32(1.25)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C198(1.11); C32(1.30)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C32(1.26)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C32(0.90)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C32(1.14)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C32(0.95)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C32(1.01)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C32(1.16)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C32(1.26)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C32(1.10)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C32(1.13)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C32(1.06)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C32(1.22)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C32(1.29)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C198(1.08); C32(1.10)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C32(1.31)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C32(1.28)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C32(1.03)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C198(1.10); C32(1.28)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C198(1.20); C32(1.32)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C198(1.14); C32(1.20)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C198(1.19); C32(1.45)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C198(1.22); C32(1.31)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C198(1.33); C32(1.73)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C198(1.35); C32(1.72)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C198(1.15); C32(1.57)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C198(1.14); C32(1.24)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C32(1.13); C198(1.14)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C198(1.31); C32(1.40)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C198(1.24); C32(2.06)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C198(1.17); C32(1.35)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C198(1.14); C32(1.43)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C198(0.94); C32(1.14)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C198(0.96); C32(1.08)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C32(1.11); C198(1.12)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C32(1.42); C198(1.51)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C32(1.18); C198(1.21)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C198(1.04); C32(1.16)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C198(1.09); C32(1.13)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C32(1.09); C198(1.11)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C198(1.03); C32(1.17)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C198(0.92); C32(1.29)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C32(1.01); C198(1.16)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C32(1.03); C198(1.10)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C32(1.20); C198(1.29)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C32(1.15); C198(1.35)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C32(1.14); C198(1.36)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C32(1.18); C198(1.28)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C198(0.97); C32(1.11)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C32(1.30); C198(1.42)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C32(1.13); C198(1.35)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C32(1.34); C198(1.51)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C32(1.16); C198(1.40)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C198(1.33); C32(1.33)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C32(0.89); C198(0.96)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C32(0.87); C198(0.93)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C32(0.96); C198(1.03)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C32(0.83); C198(1.04)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C32(1.06); C198(1.10)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C198(0.91); C32(1.17)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C32(0.93); C198(1.03)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C198(1.03); C32(1.03)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C32(1.03); C198(1.07)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C198(1.05); C32(1.11)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C32(0.99); C198(1.06)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C32(1.07); C198(1.15)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C198(0.91); C32(1.12)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C198(0.97); C32(1.14)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C198(1.10); C32(1.24)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C198(1.20); C32(1.46)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C198(1.01); C32(1.35)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C198(1.05); C32(1.44)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C198(0.90); C32(1.02)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C198(1.11); C32(1.24)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C198(1.07); C32(1.16)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C198(1.11); C32(1.19)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C198(1.14); C32(1.42)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C198(1.02); C32(1.82)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C32(1.04); C198(1.18)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C32(0.93); C198(1.16)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C32(1.13); C198(1.25)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C198(1.14); C32(1.18)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C32(1.22); C198(1.37)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C32(1.18); C198(1.21)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C32(0.94); C198(1.18)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C32(1.03); C198(1.26)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C32(0.99); C198(1.42)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C32(1.18); C198(1.47)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C32(1.12); C198(1.43)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C32(1.15); C198(1.28)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C32(1.03); C198(1.20)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C32(1.03); C198(1.11)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C198(0.96); C32(1.15)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C198(1.04); C32(1.15)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C32(0.90); C198(1.10)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C198(1.01); C32(1.01)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C198(1.06); C32(1.28)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C198(1.11); C32(1.18)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C198(0.80); C32(1.53)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C32(1.07); C198(1.08)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C32(1.14); C198(1.17)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C198(1.02); C32(1.03)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C198(0.92); C32(0.96)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C198(1.15); C32(1.42)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C32(1.04); C198(1.07)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C32(0.96); C198(1.04)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C198(0.71); C32(1.70)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C198(1.30); C32(1.41)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C198(1.24); C32(1.34)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C198(1.20); C32(1.28)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C32(1.06); C198(1.26)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C198(1.02); C32(1.11)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C32(1.18); C198(1.24)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C32(1.21); C198(1.36)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C32(0.97); C198(1.09)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C198(1.34); C32(1.49)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C198(1.28); C32(1.39)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C198(1.15); C32(1.17)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C198(1.13); C32(1.16)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C32(1.11); C198(1.16)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C32(1.12); C198(1.25)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C32(1.35); C198(1.37)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C198(0.55); C32(1.58)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C198(0.76); C32(1.10)  LDD0683  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C198(0.63)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C198(0.96); C32(1.19)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C32(1.09); C198(1.13)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C198(1.45); C32(1.92)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 12.82  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C32(0.94)  LDD0078  [10]
 LDCM0108  Chloroacetamide HeLa C198(0.00); C32(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C32(2.41); C32(1.94); C32(0.97)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C32(0.85); C198(0.91)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C198(0.91); C32(1.05)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C198(0.97); C32(1.30)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C198(1.21); C32(1.27)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C198(1.00); C32(1.04)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C198(0.92); C32(1.19)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C198(0.91); C32(1.15)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C198(1.15); C32(1.23)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C198(1.35); C32(1.49)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C198(1.22); C32(1.51)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C32(1.32); C198(1.47)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C198(1.11); C32(1.17)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C198(1.03); C32(1.18)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C32(1.13); C198(1.14)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C198(1.03); C32(1.26)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C32(1.04); C198(1.10)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C198(1.31); C32(1.37)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C198(1.18); C32(1.25)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C32(1.15); C198(1.22)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C32(1.15); C198(1.27)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C198(1.13); C32(1.31)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C32(1.00); C198(1.13)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C198(1.05); C32(1.06)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C198(1.14); C32(1.28)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C32(1.00); C198(1.04)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C32(1.25); C198(1.56)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C198(1.11); C32(1.22)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C198(0.88); C32(1.19)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C198(1.13); C32(1.33)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C32(1.07); C198(1.08)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C32(0.91); C198(1.23)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C32(0.94); C198(1.12)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C32(0.82); C198(1.24)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C198(1.16); C32(1.18)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C198(0.86); C32(0.99)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C198(0.69); C32(1.11)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C198(1.04); C32(1.16)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C198(0.99); C32(1.23)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C198(1.14); C32(1.38)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C198(1.15); C32(1.18)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C32(0.96); C198(0.99)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C198(1.27); C32(1.29)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C198(1.14); C32(1.49)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C198(1.17); C32(2.06)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C198(1.06); C32(1.21)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C198(1.07); C32(1.56)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C198(1.18); C32(1.34)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C198(1.00); C32(1.41)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C198(1.13); C32(1.17)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C198(1.18); C32(1.31)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C198(1.27); C32(1.37)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C198(0.88); C32(0.95)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C198(0.92); C32(1.17)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C198(1.03); C32(1.15)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C198(1.10); C32(1.07)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C198(0.96); C32(1.17)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C198(1.08); C32(1.20)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C198(1.18); C32(1.38)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C198(1.07); C32(1.09)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C198(1.23); C32(1.37)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C198(1.06); C32(1.40)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C198(1.00); C32(0.93)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C198(1.06); C32(1.26)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C198(1.07); C32(1.10)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C198(1.07); C32(1.62)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C198(1.07); C32(1.29)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C198(1.13); C32(1.17)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C198(1.25); C32(1.48)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C198(1.34); C32(0.89)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C198(1.26); C32(0.99)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C198(1.36); C32(0.97)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C198(1.36); C32(0.86)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C198(0.98); C32(0.85)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C198(1.19); C32(0.86)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C198(1.28); C32(0.89)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C198(1.48); C32(0.93)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C198(1.11); C32(0.87)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C198(1.25); C32(0.88)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C198(1.25); C32(0.91)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C198(1.27); C32(1.08)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C198(1.09); C32(0.89)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C198(1.29); C32(0.88)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C198(1.27); C32(0.89)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C198(1.01); C32(1.05)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C198(1.47); C32(0.93)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C198(1.15); C32(1.01)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C198(1.01); C32(1.01)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C198(1.19); C32(1.16)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C198(1.21); C32(1.24)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C198(1.06); C32(1.07)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C198(1.46); C32(1.45)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C198(1.38); C32(1.32)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C198(1.25); C32(1.10)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C198(1.02); C32(1.05)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C198(1.09); C32(1.01)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C198(1.07); C32(1.17)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C198(1.18); C32(1.16)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C198(1.09); C32(1.10)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C198(1.14); C32(1.10)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C198(1.21); C32(1.14)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C198(0.96); C32(1.09)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C198(0.80); C32(0.90)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C198(0.91); C32(0.91)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C198(0.94); C32(1.02)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C198(1.04); C32(1.17)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C198(0.89); C32(0.87)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C198(1.02); C32(1.01)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C198(0.92); C32(1.49)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C198(0.81); C32(1.47)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C198(0.97); C32(1.63)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C198(0.97); C32(1.28)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C198(0.87); C32(1.16)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C198(0.77); C32(1.12)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C198(0.83); C32(1.31)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C198(0.88); C32(1.58)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C198(0.99); C32(1.11)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C198(0.71); C32(0.90)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C198(0.91); C32(1.07)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C198(0.96); C32(1.10)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C198(0.95); C32(1.11)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C198(0.98); C32(1.06)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C198(1.00); C32(1.15)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C198(0.95); C32(1.11)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C198(0.97); C32(1.07)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C198(1.29); C32(1.19)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C198(1.15); C32(1.24)  LDD0811  [10]
 LDCM0634  CY-0357 Hep-G2 C32(0.97)  LDD2228  [15]
 LDCM0495  E2913 HEK-293T C32(0.99); C198(1.07)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C32(0.86)  LDD1702  [5]
 LDCM0625  F8 Ramos C32(2.90); C198(1.11)  LDD2187  [27]
 LDCM0572  Fragment10 Ramos C32(0.93); C198(0.49)  LDD2189  [27]
 LDCM0573  Fragment11 Ramos C32(0.03); C198(5.35)  LDD2190  [27]
 LDCM0574  Fragment12 Ramos C32(0.54); C198(0.59)  LDD2191  [27]
 LDCM0575  Fragment13 Ramos C32(0.72); C198(0.75)  LDD2192  [27]
 LDCM0576  Fragment14 Ramos C32(0.69); C198(0.85)  LDD2193  [27]
 LDCM0579  Fragment20 Ramos C32(0.92); C198(0.39)  LDD2194  [27]
 LDCM0580  Fragment21 Ramos C32(0.75); C198(0.70)  LDD2195  [27]
 LDCM0582  Fragment23 Ramos C32(1.03); C198(0.76)  LDD2196  [27]
 LDCM0578  Fragment27 Ramos C32(0.72); C198(0.67)  LDD2197  [27]
 LDCM0586  Fragment28 Ramos C32(0.70); C198(0.28)  LDD2198  [27]
 LDCM0588  Fragment30 Ramos C32(0.86); C198(0.94)  LDD2199  [27]
 LDCM0589  Fragment31 Ramos C32(0.66); C198(0.82)  LDD2200  [27]
 LDCM0590  Fragment32 Ramos C32(1.03); C198(0.44)  LDD2201  [27]
 LDCM0468  Fragment33 HCT 116 C198(1.28); C32(1.12)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C32(0.52); C198(0.85)  LDD2203  [27]
 LDCM0566  Fragment4 Ramos C32(0.88); C198(0.68)  LDD2184  [27]
 LDCM0427  Fragment51 HCT 116 C198(1.14); C32(1.46)  LDD0744  [10]
 LDCM0610  Fragment52 Ramos C32(0.73); C198(0.80)  LDD2204  [27]
 LDCM0614  Fragment56 Ramos C32(0.98); C198(0.88)  LDD2205  [27]
 LDCM0569  Fragment7 Ramos C32(0.94); C198(0.60)  LDD2186  [27]
 LDCM0571  Fragment9 Ramos C32(0.83); C198(0.35)  LDD2188  [27]
 LDCM0116  HHS-0101 DM93 Y209(0.91); Y52(0.96); Y160(1.84)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y209(0.87); Y52(1.53); Y160(11.18)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y209(0.91); Y52(1.30); Y160(2.72)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y209(0.77); Y52(1.58); Y160(3.07)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y209(0.81); Y52(1.39); Y160(2.52)  LDD0268  [8]
 LDCM0015  HNE MDA-MB-231 C32(1.09)  LDD0346  [27]
 LDCM0107  IAA HeLa N.A.  LDD0221  [21]
 LDCM0123  JWB131 DM93 Y209(1.02)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y209(0.90)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y209(0.98)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y209(5.33)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y209(2.43)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y209(0.19)  LDD0290  [7]
 LDCM0129  JWB202 DM93 Y209(1.04)  LDD0291  [7]
 LDCM0130  JWB211 DM93 Y209(2.09)  LDD0292  [7]
 LDCM0022  KB02 HCT 116 C32(1.45); C198(1.00)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C32(1.44); C198(1.01)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C32(1.43); C198(1.03)  LDD0082  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C198(1.34)  LDD2093  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C198(0.79)  LDD2097  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C198(0.90)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C198(1.30)  LDD2099  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C198(1.12)  LDD2101  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C198(0.83)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C198(1.06)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C198(1.06)  LDD2111  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C198(1.76)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C198(1.10)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C198(0.94); C32(1.53)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C198(1.16)  LDD2127  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C198(0.87)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C198(0.49)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C198(1.23)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C198(1.11)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C198(0.97)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C198(0.90)  LDD2140  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C198(1.12)  LDD2146  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C198(0.24)  LDD2150  [5]
 LDCM0131  RA190 MM1.R C32(1.05)  LDD0304  [28]
 LDCM0021  THZ1 HCT 116 C32(0.95)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 56 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-1 (PRKAB1) 5'-AMP-activated protein kinase beta subunit family Q9Y478
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Protein arginine N-methyltransferase 5 (PRMT5) Protein arginine N-methyltransferase family O14744
Aspartate--tRNA ligase, cytoplasmic (DARS1) Class-II aminoacyl-tRNA synthetase family P14868
Probable ATP-dependent RNA helicase DDX17 (DDX17) DEAD box helicase family Q92841
Probable E3 ubiquitin-protein ligase DTX3 (DTX3) Deltex family Q8N9I9
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Endoplasmic reticulum chaperone BiP (HSPA5) Heat shock protein 70 family P11021
Phosphatidate phosphatase LPIN1 (LPIN1) Lipin family Q14693
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
STAM-binding protein (STAMBP) Peptidase M67C family O95630
Phospholipase D2 (PLD2) Phospholipase D family O14939
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) PI3/PI4-kinase family P42336
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B) PI3/PI4-kinase family O00750
Protein phosphatase 3 catalytic subunit alpha (PPP3CA) PPP phosphatase family Q08209
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5) STE Ser/Thr protein kinase family Q13163
Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1) STE Ser/Thr protein kinase family Q92918
Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) STE Ser/Thr protein kinase family Q8IVH8
Mitogen-activated protein kinase kinase kinase kinase 5 (MAP4K5) STE Ser/Thr protein kinase family Q9Y4K4
Serine/threonine-protein kinase PAK 2 (PAK2) STE Ser/Thr protein kinase family Q13177
Tyrosine-protein kinase ABL2 (ABL2) Tyr protein kinase family P42684
Tyrosine-protein kinase receptor TYRO3 (TYRO3) Tyr protein kinase family Q06418
Tyrosine-protein kinase receptor UFO (AXL) Tyr protein kinase family P30530
Mast/stem cell growth factor receptor Kit (KIT) Tyr protein kinase family P10721
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Receptor tyrosine-protein kinase erbB-3 (ERBB3) Tyr protein kinase family P21860
Ephrin type-B receptor 1 (EPHB1) Tyr protein kinase family P54762
Focal adhesion kinase 1 (PTK2) Tyr protein kinase family Q05397
Fibroblast growth factor receptor 2 (FGFR2) Tyr protein kinase family P21802
Tyrosine-protein kinase TXK (TXK) Tyr protein kinase family P42681
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) Protein-tyrosine phosphatase family P18031
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) Protein-tyrosine phosphatase family Q06124
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) Protein-tyrosine phosphatase family P29350
Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) Protein-tyrosine phosphatase family Q9Y2R2
Tyrosine-protein phosphatase non-receptor type 23 (PTPN23) Protein-tyrosine phosphatase family Q9H3S7
Receptor-type tyrosine-protein phosphatase T (PTPRT) Protein-tyrosine phosphatase family O14522
Receptor-type tyrosine-protein phosphatase alpha (PTPRA) Protein-tyrosine phosphatase family P18433
Zinc-regulated GTPase metalloprotein activator 1A (ZNG1A) SIMIBI class G3E GTPase family Q9BRT8
Ras-related protein Rab-11B (RAB11B) Rab family Q15907
Synaptojanin-2 (SYNJ2) Synaptojanin family; Inositol 1,4,5-trisphosphate 5-phosphatase family O15056
Dynamin-1 (DNM1) Dynamin/Fzo/YdjA family Q05193
Dynamin-2 (DNM2) Dynamin/Fzo/YdjA family P50570
Myosin-9 (MYH9) Myosin family P35579
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
UTP--glucose-1-phosphate uridylyltransferase (UGP2) UDPGP type 1 family Q16851
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) . P19174
Breakpoint cluster region protein (BCR) . P11274
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) . O14672
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM15) . Q13444
E3 ubiquitin-protein ligase CBL (CBL) . P22681
E3 ubiquitin-protein ligase CBL-B (CBLB) . Q13191
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
RING finger protein 208 (RNF208) . Q9H0X6
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beclin-1 (BECN1) Beclin family Q14457
Filamin-A (FLNA) Filamin family P21333
Filamin-B (FLNB) Filamin family O75369
Filamin-C (FLNC) Filamin family Q14315
Transportin-1 (TNPO1) Importin beta family Q92973
Peroxisome proliferator-activated receptor alpha (PPARA) Nuclear hormone receptor family Q07869
Ankyrin-2 (ANK2) . Q01484
CD2-associated protein (CD2AP) . Q9Y5K6
SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) . Q9BYB0
Transcription factor
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear factor erythroid 2-related factor 2 (NFE2L2) BZIP family Q16236
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein 232 (ZNF232) Krueppel C2H2-type zinc-finger protein family Q9UNY5
Zinc finger protein 341 (ZNF341) Krueppel C2H2-type zinc-finger protein family Q9BYN7
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Krueppel-like factor 15 (KLF15) Sp1 C2H2-type zinc-finger protein family Q9UIH9
Achaete-scute homolog 4 (ASCL4) . Q6XD76
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
LIM homeobox transcription factor 1-alpha (LMX1A) . Q8TE12
Proto-oncogene c-Rel (REL) . Q04864
Zinc finger and BTB domain-containing protein 12 (ZBTB12) . Q9Y330
Zinc finger and BTB domain-containing protein 7B (ZBTB7B) . O15156
Zinc finger protein 474 (ZNF474) . Q6S9Z5
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Advanced glycosylation end product-specific receptor (AGER) . Q15109
Lymphocyte antigen 6 complex locus protein G6f (LY6G6F) . Q5SQ64
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leptin receptor (LEPR) Type I cytokine receptor family P48357
Other
Click To Hide/Show 81 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ABI gene family member 3 (ABI3) ABI family Q9P2A4
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1) BACURD family Q13829
Protein BTG1 (BTG1) BTG family P62324
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Dedicator of cytokinesis protein 1 (DOCK1) DOCK family Q14185
Dedicator of cytokinesis protein 4 (DOCK4) DOCK family Q8N1I0
Translation initiation factor eIF2B subunit delta (EIF2B4) EIF-2B alpha/beta/delta subunits family Q9UI10
Epidermal growth factor receptor kinase substrate 8 (EPS8) EPS8 family Q12929
GRB2-associated-binding protein 1 (GAB1) GAB family Q13480
GRB2-associated-binding protein 2 (GAB2) GAB family Q9UQC2
GRB2-associated and regulator of MAPK protein 1 (GAREM1) GAREM family Q9H706
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type II cytoskeletal 8 (KRT8) Intermediate filament family P05787
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) KHDRBS family Q07666
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Mediator of RNA polymerase II transcription subunit 28 (MED28) Mediator complex subunit 28 family Q9H204
Meiosis-specific protein MEI4 (MEI4) MEI4L family A8MW99
ERBB receptor feedback inhibitor 1 (ERRFI1) MIG6 family Q9UJM3
Negative elongation factor B (NELFB) NELF-B family Q8WX92
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) PI3K p85 subunit family P27986
Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) PI3K p85 subunit family O00459
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
Retinoblastoma-associated protein (RB1) Retinoblastoma protein (RB) family P06400
Rho GDP-dissociation inhibitor 2 (ARHGDIB) Rho GDI family P52566
Disks large-associated protein 1 (DLGAP1) SAPAP family O14490
Disks large-associated protein 2 (DLGAP2) SAPAP family Q9P1A6
Disks large-associated protein 4 (DLGAP4) SAPAP family Q9Y2H0
Actin-binding protein WASF1 (WASF1) SCAR/WAVE family Q92558
Splicing factor 3A subunit 2 (SF3A2) SF3A2 family Q15428
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
SH3 and multiple ankyrin repeat domains protein 2 (SHANK2) SHANK family Q9UPX8
Spermatogenesis-associated protein 2-like protein (SPATA2L) SPATA2 family Q8IUW3
Protein sprouty homolog 2 (SPRY2) Sprouty family O43597
Tetraspanin-2 (TSPAN2) Tetraspanin (TM4SF) family O60636
Protein THEMIS (THEMIS) Themis family Q8N1K5
Transmembrane protein 185A (TMEM185A) TMEM185 family Q8NFB2
TOM1-like protein 1 (TOM1L1) TOM1 family O75674
Targeting protein for Xklp2 (TPX2) TPX2 family Q9ULW0
WAS/WASL-interacting protein family member 1 (WIPF1) Verprolin family O43516
WAS/WASL-interacting protein family member 2 (WIPF2) Verprolin family Q8TF74
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Actin nucleation-promoting factor WASL (WASL) . O00401
Ankyrin repeat domain-containing protein 23 (ANKRD23) . Q86SG2
ARF GTPase-activating protein GIT1 (GIT1) . Q9Y2X7
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1) . Q15027
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1) . Q9ULH1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (ASAP2) . O43150
B-cell linker protein (BLNK) . Q8WV28
Bromodomain-containing protein 4 (BRD4) . O60885
Centromere protein R (ITGB3BP) . Q13352
Developmental pluripotency-associated protein 4 (DPPA4) . Q7L190
Disabled homolog 2 (DAB2) . P98082
Drebrin (DBN1) . Q16643
EF-hand domain-containing family member C2 (EFHC2) . Q5JST6
Fanconi anemia group A protein (FANCA) . O15360
Gametogenetin (GGN) . Q86UU5
Guanine nucleotide exchange factor VAV3 (VAV3) . Q9UKW4
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
Linker for activation of T-cells family member 1 (LAT) . O43561
Lymphocyte cytosolic protein 2 (LCP2) . Q13094
Phosphoinositide 3-kinase adapter protein 1 (PIK3AP1) . Q6ZUJ8
Proto-oncogene vav (VAV1) . P15498
RalBP1-associated Eps domain-containing protein 2 (REPS2) . Q8NFH8
Rho GTPase-activating protein 9 (ARHGAP9) . Q9BRR9
Rho guanine nucleotide exchange factor 5 (ARHGEF5) . Q12774
Rhombotin-2 (LMO2) . P25791
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
SHC-transforming protein 1 (SHC1) . P29353
SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3) . O43295
Son of sevenless homolog 1 (SOS1) . Q07889
Son of sevenless homolog 2 (SOS2) . Q07890
Suppressor of cytokine signaling 4 (SOCS4) . Q8WXH5
Suppressor of cytokine signaling 7 (SOCS7) . O14512
TBC1 domain family member 3G (TBC1D3G) . Q6DHY5
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5
Uncharacterized protein KIAA0408 (KIAA0408) . Q6ZU52
WW domain-binding protein 11 (WBP11) . Q9Y2W2

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pegademase BiotechDrug DB00061
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bp-100-1-01 . D0L3KA
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
4-[(10s14s18s)-18-(2-amino-2-oxoethyl)-14-(1-naphthylmethyl)-81720-trioxo-71619-triazaspiro[5.14]Icos-11-en-10-yl]Benzylphosphonic Acid . DB03276

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
28 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.