Details of the Target

General Information of Target

Target ID LDTP12381
Target Name Synembryn-A (RIC8A)
Gene Name RIC8A
Gene ID 60626
Synonyms
Synembryn-A; Protein Ric-8A
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MNFIKDNSRALIQRMGMTVIKQITDDLFVWNVLNREEVNIICCEKVEQDAARGIIHMILK
KGSESCNLFLKSLKEWNYPLFQDLNGQSLFHQTSEGDLDDLAQDLKDLYHTPSFLNFYPL
GEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTLNGLLQALQSPCIIEGESGKGKSTLLQ
RIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLR
QRVLFLLDGYNEFKPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDM
TEDSAQALIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGESEFHSHTQT
TLFHTFYDLLIQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQDVSSVNEDV
LLTTGLLCKYTAQRFKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSI
SDITSTYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNT
TEQEILKAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFE
HLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAVSLFFNWKQEFR
TLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVE
ASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNLTKLIMDNIKMNEEDA
IKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKIL
AQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLL
KHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGV
FENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFK
LVTA
Target Type
Literature-reported
Target Bioclass
Other
Family
Synembryn family
Subcellular location
Cytoplasm
Function
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
TTD ID
T14196
Uniprot ID
Q9NPQ8
DrugMap ID
TTDFTJG
Ensemble ID
ENST00000325207.9
HGNC ID
HGNC:29550
ChEMBL ID
CHEMBL4296100

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KMRC1 SNV: p.D531E DBIA    Probe Info 
LNCaP clone FGC Deletion: p.R504GfsTer127
SNV: p.A417D		 .
SNGM SNV: p.Q511R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.18  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
STPyne
 Probe Info  		K143(3.78); K323(10.00); K328(7.69); K353(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y248(135.36)  LDD3495  [4]
DBIA
 Probe Info  		C341(3.59)  LDD3312  [5]
BTD
 Probe Info  		C79(1.22)  LDD2090  [6]
HHS-475
 Probe Info  		Y413(0.87)  LDD0264  [7]
IPM
 Probe Info  		C341(5.75); C79(5.01)  LDD1702  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C341(0.00); C258(0.00); C79(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C341(0.00); C79(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
SF
 Probe Info  		N.A.  LDD0028  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]
AOyne
 Probe Info  		8.80  LDD0443  [18]
NAIA_5
 Probe Info  		C79(0.00); C341(0.00); C400(0.00)  LDD2223  [12]
HHS-465
 Probe Info  		N.A.  LDD2240  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C79(0.69)  LDD2142  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C258(0.54)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C258(0.94)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C258(1.50); C79(1.42)  LDD2117  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C258(0.93); C79(0.59)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C258(0.52)  LDD2131  [6]
 LDCM0214  AC1 HEK-293T C79(0.98); C341(1.06); C286(1.00); C400(1.05)  LDD1507  [20]
 LDCM0215  AC10 HEK-293T C79(1.06); C341(0.97); C286(1.07); C400(0.96)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C79(1.12); C341(1.00); C286(1.07); C400(0.88)  LDD1509  [20]
 LDCM0237  AC12 HEK-293T C79(1.03); C341(1.12); C286(1.01); C400(0.94)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C79(1.00); C341(0.99); C286(0.93); C400(1.07)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C79(1.05); C341(1.00); C286(1.07); C400(1.04)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C79(1.02); C341(0.95); C286(1.05); C400(0.96)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C79(0.98); C341(1.05); C286(1.12); C400(1.08)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C79(1.09); C341(1.02); C286(0.91); C400(0.91)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C79(1.01); C341(0.92); C286(1.07); C400(1.00)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C79(1.02); C341(1.06); C286(1.01); C400(1.02)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C79(1.01); C341(0.92); C286(1.14); C400(1.00)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C79(0.97); C341(1.06); C286(0.97); C400(1.01)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C79(1.03); C341(0.94); C286(1.13); C400(0.99)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C79(0.94); C341(1.04); C286(0.92); C400(0.94)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C79(0.99); C341(1.00); C286(1.03); C400(1.05)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C79(1.04); C341(0.98); C286(1.00); C400(1.00)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C79(1.06); C341(0.99); C286(0.83); C400(0.95)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C79(1.01); C341(0.99); C286(1.24); C400(0.90)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C79(1.00); C341(1.04); C286(0.83); C400(1.00)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C79(1.02); C341(1.04); C286(1.06); C400(0.98)  LDD1529  [20]
 LDCM0291  AC30 HEK-293T C79(0.99); C341(1.00); C286(1.06); C400(0.92)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C79(1.00); C341(0.96); C286(0.99); C400(0.92)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C79(0.97); C341(0.99); C286(0.97); C400(1.03)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C79(1.01); C341(1.13); C286(0.98); C400(1.00)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C79(1.03); C341(1.09); C286(1.13); C400(1.08)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C79(1.11); C341(1.04); C286(1.21); C400(1.15)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C79(1.06); C341(0.99); C286(1.05); C400(0.94)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C79(1.02); C341(0.91); C286(0.82); C400(0.93)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C79(1.01); C341(0.91); C286(1.09); C400(0.96)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C79(0.99); C341(1.00); C286(1.09); C400(0.94)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C79(1.08); C341(1.08); C286(1.06); C400(0.96)  LDD1540  [20]
 LDCM0302  AC40 HEK-293T C79(1.00); C341(1.11); C286(0.90); C400(1.04)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C79(0.99); C341(1.06); C286(0.97); C400(0.95)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C79(1.07); C341(0.99); C286(1.11); C400(1.12)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C79(1.11); C341(1.03); C286(0.97); C400(1.08)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C79(1.12); C341(1.05); C286(1.00); C400(0.98)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C79(1.02); C341(0.97); C286(1.13); C400(0.93)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C79(1.04); C341(0.90); C286(0.87); C400(1.06)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C79(0.97); C341(1.00); C286(1.17); C400(1.08)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C79(1.05); C341(1.04); C286(0.89); C400(0.95)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C79(1.02); C341(0.97); C286(1.02); C400(1.03)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C79(1.03); C341(0.86); C286(0.93); C400(0.94)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C79(1.03); C341(1.00); C286(0.98); C400(1.11)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C79(1.11); C341(0.97); C286(1.06); C400(0.96)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C79(1.07); C341(1.05); C286(0.93); C400(0.93)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C79(1.02); C341(0.93); C286(1.24); C400(0.99)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C79(1.02); C341(1.00); C286(0.94); C400(0.96)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C79(1.06); C341(0.97); C286(1.01); C400(1.08)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C79(0.99); C341(1.03); C286(0.98); C400(0.89)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C79(1.01); C341(1.18); C286(1.08); C400(1.05)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C79(1.05); C341(0.99); C286(1.09); C400(1.01)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C79(1.13); C341(0.99); C286(1.09); C400(1.12)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C79(1.03); C341(1.00); C286(0.99); C400(1.12)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C79(1.06); C341(1.05); C286(0.99); C400(1.02)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C79(1.06); C341(0.96); C286(0.92); C400(1.01)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C79(1.05); C341(0.97); C286(0.91); C400(0.98)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C79(1.04); C341(1.02); C286(0.88); C400(0.99)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C79(0.99); C341(0.99); C286(0.79); C400(1.02)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C79(1.04); C341(0.96); C286(0.99); C400(1.03)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C79(0.90); C341(0.97); C286(1.12); C400(0.96)  LDD1569  [20]
 LDCM0545  Acetamide MDA-MB-231 C258(1.05)  LDD2138  [6]
 LDCM0248  AKOS034007472 HEK-293T C79(1.02); C341(0.93); C286(0.96); C400(0.92)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C79(1.03); C341(1.00); C286(0.98); C400(1.07)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C79(1.06); C341(1.08); C286(0.83); C400(1.07)  LDD1514  [20]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C258(1.09)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C341(1.72); C341(0.84); C79(0.67)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C79(1.05); C341(1.07); C286(1.00); C400(1.05)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C79(1.00); C341(1.03); C286(1.18); C400(1.07)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C79(1.02); C341(0.89); C286(1.07); C400(1.06)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C79(1.02); C341(0.99); C286(0.95); C400(1.01)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C79(1.05); C341(1.05); C286(1.00); C400(0.81)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C79(1.09); C341(0.92); C286(1.15); C400(1.03)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C79(0.97); C341(0.94); C286(0.91); C400(1.13)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C79(1.01); C341(1.05); C286(1.03); C400(1.02)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C79(1.01); C341(1.02); C286(0.98); C400(0.89)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C79(1.08); C341(1.13); C286(0.86); C400(1.10)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C79(0.98); C341(0.96); C286(0.93); C400(1.04)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C79(1.02); C341(0.97); C286(0.93); C400(1.05)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C79(0.98); C341(1.06); C286(0.92); C400(1.15)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C79(1.05); C341(1.11); C286(0.93); C400(0.90)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C79(1.07); C341(0.95); C286(0.90); C400(1.00)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C79(0.91); C341(1.00); C286(0.95); C400(1.00)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C79(1.05); C341(0.97); C286(0.99); C400(1.16)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C79(1.08); C341(1.12); C286(1.03); C400(0.85)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C79(1.02); C341(1.05); C286(1.18); C400(1.05)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C79(1.03); C341(0.94); C286(0.99); C400(1.20)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C79(1.07); C341(1.04); C286(0.97); C400(1.09)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C79(1.07); C341(1.05); C286(1.11); C400(0.93)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C79(1.05); C341(0.99); C286(1.04); C400(1.14)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C79(1.08); C341(1.01); C286(0.91); C400(0.96)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C79(0.96); C341(0.97); C286(1.00); C400(1.15)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C79(1.08); C341(1.00); C286(0.95); C400(0.99)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C79(1.07); C341(0.99); C286(1.06); C400(1.07)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C79(1.06); C341(1.03); C286(1.11); C400(0.91)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C79(1.15); C341(0.98); C286(0.99); C400(1.03)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C79(0.96); C341(0.97); C286(1.01); C400(1.17)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C79(1.01); C341(1.08); C286(1.03); C400(1.12)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C79(1.09); C341(1.02); C286(0.96); C400(1.06)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C79(0.91); C341(0.95); C286(0.98); C400(1.10)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C79(1.01); C341(0.92); C286(0.86); C400(1.06)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C79(1.13); C341(1.06); C286(1.02); C400(0.93)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C79(1.10); C341(1.07); C286(0.88); C400(1.20)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C79(1.05); C341(0.96); C286(1.00); C400(1.05)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C79(1.06); C341(1.17); C286(0.97); C400(1.11)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C79(1.00); C341(1.06); C286(1.15); C400(1.01)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C79(1.13); C341(0.96); C286(1.18); C400(0.91)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C79(1.12); C341(1.24); C286(1.23); C400(1.04)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C79(0.94); C341(1.03); C286(0.97); C400(0.99)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C79(0.64); C341(0.93); C286(1.25); C400(1.02)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C79(0.88); C341(0.93); C286(1.21); C400(1.02)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C79(0.90); C341(0.98); C286(1.03); C400(1.05)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C79(1.12); C341(0.94); C286(0.89); C400(0.95)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C79(0.97); C341(1.21); C286(0.89); C400(0.99)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C79(1.01); C341(1.02); C286(0.97); C400(0.92)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C79(0.99); C341(1.00); C286(1.13); C400(1.17)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C79(1.03); C341(0.94); C286(1.06); C400(1.03)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C79(1.00); C341(0.94); C286(1.07); C400(1.02)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C79(1.07); C341(1.00); C286(1.00); C400(1.14)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C79(0.87); C341(1.02); C286(1.19); C400(0.99)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C79(1.07); C341(1.02); C286(0.96); C400(1.01)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C79(0.88); C341(1.05); C286(1.04); C400(0.99)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C79(0.97); C341(0.92); C286(1.00); C400(0.98)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C79(0.83); C341(0.94); C286(0.79); C400(0.97)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C79(0.84); C341(0.94); C286(0.91); C400(1.14)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C79(0.96); C341(1.03); C286(0.75); C400(1.02)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C79(0.99); C341(0.94); C286(0.84); C400(1.09)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C79(1.03); C341(1.02); C286(1.11); C400(1.13)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C79(0.92); C341(1.09); C286(1.03); C400(1.04)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C79(0.97); C341(0.96); C286(1.00); C400(1.07)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C79(1.00); C341(0.98); C286(1.06); C400(1.12)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C79(0.97); C341(0.94); C286(1.02); C400(1.05)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C79(1.12); C341(0.93); C286(1.06); C400(0.94)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C79(0.98); C341(0.99); C286(1.06); C400(0.98)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C79(0.96); C341(0.85); C286(1.04); C400(0.95)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C79(0.84); C341(0.92); C286(1.20); C400(0.99)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C79(0.91); C341(0.96); C286(0.93); C400(1.10)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C79(1.13); C341(0.98); C286(0.87); C400(0.90)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C79(0.99); C341(1.02); C286(0.93); C400(1.09)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C79(1.07); C341(0.98); C286(0.90); C400(1.05)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C79(0.99); C341(0.99); C286(1.09); C400(1.13)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C79(0.95); C341(1.02); C286(1.01); C400(1.00)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C79(0.97); C341(1.08); C286(0.98); C400(1.12)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C79(0.94); C341(1.13); C286(0.98); C400(0.97)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C79(1.14); C341(1.01); C286(1.09); C400(1.05)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C79(0.95); C341(1.08); C286(0.93); C400(0.92)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C79(0.99); C341(0.90); C286(1.22); C400(1.13)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C79(0.85); C341(0.93); C286(0.93); C400(1.01)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C79(0.90); C341(0.96); C286(1.02); C400(1.12)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C79(1.00); C341(1.09); C286(1.01); C400(0.92)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C79(1.01); C341(1.26); C286(0.91); C400(1.09)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C79(0.96); C341(1.02); C286(0.98); C400(1.16)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C79(1.04); C341(1.05); C286(1.14); C400(0.94)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C79(1.05); C341(0.99); C286(0.97); C400(0.97)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C79(1.03); C341(1.09); C286(0.90); C400(1.13)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C79(1.01); C341(1.10); C286(0.99); C400(1.03)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C79(0.96); C341(1.14); C286(1.10); C400(1.08)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C79(1.08); C341(0.97); C286(1.04); C400(0.97)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C79(0.98); C341(1.10); C286(0.97); C400(1.00)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C79(0.99); C341(0.95); C286(1.07); C400(1.08)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C79(1.14); C341(0.99); C286(0.99); C400(1.03)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C79(0.90); C341(0.90); C286(1.05); C400(1.01)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C79(0.92); C341(1.01); C286(0.93); C400(1.19)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C79(1.04); C341(1.14); C286(1.14); C400(0.99)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C79(1.00); C341(1.05); C286(0.89); C400(1.21)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C79(1.01); C341(1.01); C286(1.06); C400(0.97)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C79(1.00); C341(0.98); C286(1.00); C400(1.02)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C79(1.03); C341(1.05); C286(1.02); C400(1.01)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C79(0.95); C341(1.03); C286(1.14); C400(1.07)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C79(1.11); C341(1.03); C286(0.98); C400(1.00)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C79(1.09); C341(1.00); C286(1.10); C400(1.28)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C79(0.94); C341(0.97); C286(1.01); C400(1.01)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C79(0.94); C341(0.93); C286(0.96); C400(0.98)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C79(0.88); C341(0.98); C286(1.05); C400(1.14)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C79(0.87); C341(1.08); C286(0.80); C400(1.11)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C79(0.95); C341(0.99); C286(0.85); C400(0.93)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C79(0.93); C341(1.06); C286(0.87); C400(1.25)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C79(0.99); C341(0.93); C286(0.97); C400(1.05)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C79(1.03); C341(0.95); C286(0.97); C400(1.19)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C79(0.96); C341(0.97); C286(1.04); C400(1.11)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C79(1.16); C341(0.95); C286(0.96); C400(1.09)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C79(1.03); C341(0.91); C286(1.02); C400(0.87)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C79(1.13); C341(1.08); C286(0.91); C400(1.04)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C79(1.11); C341(1.02); C286(1.13); C400(1.03)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C79(1.08); C341(1.04); C286(1.12); C400(1.12)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C79(1.01); C341(0.85); C286(0.89); C400(1.08)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C79(0.95); C341(0.93); C286(1.02); C400(1.00)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C79(1.02); C341(1.05); C286(1.18); C400(1.22)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C79(1.00); C341(0.99); C286(0.84); C400(0.98)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C79(1.04); C341(1.08); C286(0.91); C400(1.09)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C79(0.99); C341(1.07); C286(1.09); C400(1.10)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C79(1.05); C341(0.98); C286(1.01); C400(1.25)  LDD1697  [20]
 LDCM0495  E2913 HEK-293T C79(1.08); C341(0.99); C286(0.97); C400(1.26)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C341(5.75); C79(5.01)  LDD1702  [6]
 LDCM0625  F8 Ramos C341(0.78); C79(1.28)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C341(0.69); C79(0.50)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C341(0.25); C79(5.88)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C341(0.77); C79(0.56)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C341(0.96); C79(0.68)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C341(0.85); C79(1.09)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C341(1.07)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C341(0.68); C79(0.51)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C341(0.91); C79(0.42)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C341(0.64); C79(0.59)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C341(0.58); C79(0.74)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C341(0.77); C79(0.65)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C341(0.80); C79(0.48)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C341(0.60); C79(0.75)  LDD2201  [21]
 LDCM0468  Fragment33 HEK-293T C79(1.09); C341(0.99); C286(0.86); C400(1.08)  LDD1671  [20]
 LDCM0596  Fragment38 Ramos C341(1.61); C79(0.45)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C341(1.09); C79(0.72)  LDD2184  [21]
 LDCM0427  Fragment51 HEK-293T C79(0.99); C341(0.97); C286(0.96); C400(1.14)  LDD1631  [20]
 LDCM0610  Fragment52 Ramos C341(1.01); C79(0.98)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C341(0.66); C79(0.56)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C341(0.87); C79(1.77)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C341(1.04); C79(0.75)  LDD2188  [21]
 LDCM0116  HHS-0101 DM93 Y413(0.87)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y413(0.78)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y413(0.59)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y413(0.71)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y413(0.82)  LDD0268  [7]
 LDCM0015  HNE MDA-MB-231 C341(0.91)  LDD0346  [21]
 LDCM0022  KB02 HEK-293T C286(0.99); C79(1.00); C341(1.05); C120(0.82)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C286(1.02); C79(1.09); C341(0.97); C120(1.28)  LDD1497  [20]
 LDCM0024  KB05 HMCB C341(3.59)  LDD3312  [5]
 LDCM0109  NEM HeLa N.A.  LDD0225  [16]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C79(1.22)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C79(0.65)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C79(1.14)  LDD2093  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C79(0.75)  LDD2096  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C79(0.95)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C79(0.97)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C79(0.78)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C258(0.91); C79(0.96)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C79(0.87)  LDD2104  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C79(1.08)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C79(0.89)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C258(0.83); C79(0.83)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C79(1.00)  LDD2111  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C258(0.63)  LDD2115  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C79(1.01)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C258(1.18)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C258(0.43)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C258(0.51); C79(1.08)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C258(0.97); C79(0.89)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C258(0.49)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C258(1.00); C79(0.75)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C258(1.26)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C79(0.96)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C258(1.54)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C258(0.70)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C79(0.43)  LDD2134  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C258(1.05)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C258(1.13); C79(0.81)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C79(1.04)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C258(0.56); C79(0.88)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C258(1.24)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C258(1.02); C79(1.01)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C79(1.75)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C79(0.43)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C258(1.05); C79(0.71)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C79(0.97)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C79(1.96)  LDD2153  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Proton myo-inositol cotransporter (SLC2A13) Sugar transporter (TC 2.A.1.1) family Q96QE2
Prenylated Rab acceptor protein 1 (RABAC1) PRA1 family Q9UI14
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) Fibulin family Q12805
NUT family member 1 (NUTM1) NUT family Q86Y26
Protein kinase C and casein kinase substrate in neurons protein 2 (PACSIN2) PACSIN family Q9UNF0
Ubiquilin-1 (UBQLN1) . Q9UMX0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578