Details of the Target

General Information of Target

Target ID LDTP00885
Target Name Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (IDH3B)
Gene Name IDH3B
Gene ID 3420
Synonyms
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; Isocitric dehydrogenase subunit beta; NAD(+)-specific ICDH subunit beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVG
PELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPME
YKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESAR
GVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELY
PKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY
AVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRT
RDMGGYSTTTDFIKSVIGHLQTKGS
Target Bioclass
Enzyme
Family
Isocitrate and isopropylmalate dehydrogenases family
Subcellular location
Mitochondrion
Function
Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
Uniprot ID
O43837
Ensemble ID
ENST00000380843.9
HGNC ID
HGNC:5385

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y171(20.00); Y366(17.66); Y128(7.92)  LDD0257  [2]
TH214
 Probe Info  		Y340(20.00)  LDD0258  [2]
TH216
 Probe Info  		Y340(14.62); Y121(14.62); Y366(8.56)  LDD0259  [2]
STPyne
 Probe Info  		K114(8.71); K135(5.11); K199(0.80); K207(5.75)  LDD0277  [3]
Probe 1
 Probe Info  		Y128(23.90); Y151(22.83); Y171(20.77)  LDD3495  [4]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [5]
BTD
 Probe Info  		C185(1.39)  LDD2099  [6]
AHL-Pu-1
 Probe Info  		C185(3.43); C233(2.07)  LDD0170  [7]
HPAP
 Probe Info  		3.42  LDD0062  [8]
HHS-482
 Probe Info  		Y171(0.28)  LDD0285  [9]
HHS-475
 Probe Info  		Y366(0.72)  LDD0264  [10]
DBIA
 Probe Info  		C185(1.49)  LDD0080  [11]
5E-2FA
 Probe Info  		N.A.  LDD2235  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [14]
IA-alkyne
 Probe Info  		C185(0.00); C233(0.00); C232(0.00)  LDD0036  [14]
Lodoacetamide azide
 Probe Info  		C185(0.00); C233(0.00); C232(0.00)  LDD0037  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [15]
WYneN
 Probe Info  		N.A.  LDD0021  [16]
ENE
 Probe Info  		N.A.  LDD0006  [16]
IPM
 Probe Info  		N.A.  LDD0005  [16]
NHS
 Probe Info  		N.A.  LDD0010  [16]
SF
 Probe Info  		N.A.  LDD0028  [17]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
1c-yne
 Probe Info  		K374(0.00); K68(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		H176(0.00); C185(0.00); H379(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [20]
AOyne
 Probe Info  		15.00  LDD0443  [21]
NAIA_5
 Probe Info  		C233(0.00); C232(0.00)  LDD2223  [22]
HHS-465
 Probe Info  		Y366(0.00); K122(0.00); Y121(0.00)  LDD2240  [23]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		22.78  LDD1838  [24]
FFF probe2
 Probe Info  		5.11  LDD0463  [25]
FFF probe3
 Probe Info  		5.63  LDD0464  [25]
STS-2
 Probe Info  		1.00  LDD0139  [26]
VE-P
 Probe Info  		N.A.  LDD0396  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C185(3.43); C233(2.07)  LDD0170  [7]
 LDCM0026  4SU-RNA+native RNA DM93 C185(3.91)  LDD0171  [7]
 LDCM0214  AC1 HCT 116 C185(1.07); C232(0.52); C233(0.52)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C185(1.10)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C185(1.02)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C185(0.97)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C185(0.83)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C185(0.85)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C185(0.84)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C185(0.84)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C185(0.98)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C185(0.73)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C185(0.64)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C185(0.59)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C185(1.06)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C185(0.63)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C185(0.70)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C185(0.70)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C185(0.92); C232(0.88); C233(0.88)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C185(1.12); C232(0.55); C233(0.55)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C185(1.29); C232(0.50); C233(0.50)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C185(1.12); C232(0.48); C233(0.48)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C185(1.08); C232(0.66); C233(0.66)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C185(1.08); C232(0.68); C233(0.68)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C185(1.06); C232(0.65); C233(0.65)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C185(1.06)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C185(1.12); C232(0.56); C233(0.56)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C185(0.98); C232(0.74); C233(0.74)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C185(1.05); C232(0.68); C233(0.68)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C185(0.94); C232(0.84); C233(0.84)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C185(0.89); C232(0.79); C233(0.79)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C185(1.03); C232(0.71); C233(0.71)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C185(1.13); C232(0.50); C233(0.50)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C185(1.16); C232(0.51); C233(0.51)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C185(0.86); C232(0.80); C233(0.80)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C185(0.94); C232(1.01); C233(1.01)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C185(1.04); C232(0.73); C233(0.73)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C185(1.03); C232(1.04); C233(1.04)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C185(1.10); C232(1.20); C233(1.20)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C185(1.28); C232(0.93); C233(0.93)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C185(1.36); C232(0.88); C233(0.88)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C185(1.06); C232(0.80); C233(0.80)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C185(1.23); C232(0.82); C233(0.82)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C185(1.27); C232(0.87); C233(0.87)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C185(1.57); C232(0.80); C233(0.80)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C185(1.80); C232(0.89); C233(0.89)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C185(0.85)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C185(1.88); C232(0.83); C233(0.83)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C185(1.86); C232(0.86); C233(0.86)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C185(1.33); C232(1.02); C233(1.02)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C185(1.02); C232(0.75); C233(0.75)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C232(0.87); C233(0.87); C185(0.95)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C232(0.87); C233(0.87); C185(0.95)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C232(0.77); C233(0.77); C185(0.82)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C232(0.59); C233(0.59); C185(0.89)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C232(0.70); C233(0.70); C185(0.84)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C185(0.80); C232(0.91); C233(0.91)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C185(0.92)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C232(0.79); C233(0.79); C185(0.89)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C185(0.97); C232(0.98); C233(0.98)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C232(0.57); C233(0.57); C185(0.82)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C232(0.68); C233(0.68); C185(0.89)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C185(0.90); C232(0.65); C233(0.65)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C185(0.88); C232(1.08); C233(1.08)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C185(0.84); C232(1.76); C233(1.76)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C185(0.81); C232(1.82); C233(1.82)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C185(1.00)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C185(0.88)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C185(0.84)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C232(0.60); C233(0.60); C185(0.93)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C185(0.88)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C185(0.77)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C185(1.00)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C185(0.94)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C185(1.05)  LDD0601  [11]
 LDCM0285  AC25 PaTu 8988t C232(1.00); C233(1.00)  LDD1164  [11]
 LDCM0286  AC26 PaTu 8988t C232(0.84); C233(0.84)  LDD1165  [11]
 LDCM0287  AC27 PaTu 8988t C232(0.75); C233(0.75)  LDD1166  [11]
 LDCM0288  AC28 PaTu 8988t C232(0.72); C233(0.72)  LDD1167  [11]
 LDCM0289  AC29 PaTu 8988t C232(0.79); C233(0.79)  LDD1168  [11]
 LDCM0290  AC3 HCT 116 C232(0.65); C233(0.65); C185(0.95)  LDD0607  [11]
 LDCM0291  AC30 PaTu 8988t C232(0.92); C233(0.92)  LDD1170  [11]
 LDCM0292  AC31 PaTu 8988t C232(1.04); C233(1.04)  LDD1171  [11]
 LDCM0293  AC32 PaTu 8988t C232(0.82); C233(0.82)  LDD1172  [11]
 LDCM0294  AC33 PaTu 8988t C232(0.76); C233(0.76)  LDD1173  [11]
 LDCM0295  AC34 PaTu 8988t C232(0.91); C233(0.91)  LDD1174  [11]
 LDCM0296  AC35 HCT 116 C185(1.15); C232(1.16); C233(1.16)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C185(1.17); C232(1.18); C233(1.18)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C185(1.07); C232(1.17); C233(1.17)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C185(1.05); C232(1.18); C233(1.18)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C232(1.06); C233(1.06); C185(1.14)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C232(0.48); C233(0.48); C185(0.94)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C232(0.99); C233(0.99); C185(1.12)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C232(1.05); C233(1.05); C185(1.26)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C185(1.08); C232(1.09); C233(1.09)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C232(0.97); C233(0.97); C185(1.09)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C232(0.99); C233(0.99); C185(1.18)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C232(0.97); C233(0.97); C185(1.26)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C185(1.28)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C185(1.18)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C185(1.20)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C185(1.30)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C232(0.50); C233(0.50); C185(0.86)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C185(1.26)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C185(1.24)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C185(1.27)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C185(1.05)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C185(1.25)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C185(1.19)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C185(1.27)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C232(0.41); C233(0.41); C185(1.09)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C232(0.43); C233(0.43); C185(0.99)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C232(0.46); C233(0.46); C185(1.01)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C185(1.06)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C232(0.47); C233(0.47); C185(1.08)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C232(0.49); C233(0.49); C185(0.98)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C232(0.42); C233(0.42); C185(1.16)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C232(0.47); C233(0.47); C185(1.18)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C232(0.47); C233(0.47); C185(1.17)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C232(0.53); C233(0.53); C185(1.05)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C232(0.58); C233(0.58); C185(0.94)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C232(0.49); C233(0.49); C185(1.13)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C185(0.86); C232(0.95); C233(0.95)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C232(0.77); C233(0.77); C185(1.04)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C185(1.01)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C232(0.68); C233(0.68); C185(1.07)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C185(0.95); C232(1.02); C233(1.02)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C232(0.69); C233(0.69); C185(1.02)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C232(0.72); C233(0.72); C185(1.08)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C232(0.88); C233(0.88); C185(1.01)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C232(0.84); C233(0.84); C185(1.01)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C232(0.76); C233(0.76); C185(1.17)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C232(0.80); C233(0.80); C185(0.92)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C232(0.70); C233(0.70); C185(1.03)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C232(0.81); C233(0.81); C185(0.92)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C185(1.01)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C232(0.75); C233(0.75); C185(1.04)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C232(0.82); C233(0.82); C185(1.04)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C232(0.60); C233(0.60); C185(1.10)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C185(1.00)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C185(1.16)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C185(1.04)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C185(0.99)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C185(0.99)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C185(0.92)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C185(0.86)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C185(0.92)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C185(0.82)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C185(0.94)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C185(0.91)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C185(0.89)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C185(0.96)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C185(0.84)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C185(1.01)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C185(0.93)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C185(0.87)  LDD0683  [11]
 LDCM0248  AKOS034007472 HCT 116 C185(0.95)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C185(0.95)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C185(1.12)  LDD0592  [11]
 LDCM0156  Aniline NCI-H1299 12.06  LDD0403  [1]
 LDCM0102  BDHI 8 Jurkat C185(4.10)  LDD0204  [28]
 LDCM0108  Chloroacetamide HeLa C185(0.00); H176(0.00); H379(0.00); H155(0.00)  LDD0222  [20]
 LDCM0367  CL1 HCT 116 C185(0.97); C232(1.35); C233(1.35)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C232(0.70); C233(0.70); C185(1.05)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C232(0.48); C233(0.48); C185(1.18)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C185(0.83)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C185(0.82)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C185(0.82)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C185(0.87)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C185(0.95)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C185(0.99)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C185(0.93)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C185(0.86)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C185(0.92)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C232(0.84); C233(0.84); C185(1.06)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C185(0.93)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C185(1.05)  LDD0698  [11]
 LDCM0382  CL112 PaTu 8988t C232(0.95); C233(0.95)  LDD1261  [11]
 LDCM0383  CL113 PaTu 8988t C232(0.99); C233(0.99)  LDD1262  [11]
 LDCM0384  CL114 PaTu 8988t C232(0.89); C233(0.89)  LDD1263  [11]
 LDCM0385  CL115 PaTu 8988t C232(0.98); C233(0.98)  LDD1264  [11]
 LDCM0386  CL116 PaTu 8988t C232(0.80); C233(0.80)  LDD1265  [11]
 LDCM0387  CL117 HCT 116 C232(1.12); C233(1.12); C185(1.18)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C185(1.03); C232(1.06); C233(1.06)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C232(0.96); C233(0.96); C185(1.05)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C232(0.78); C233(0.78); C185(0.97)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C232(1.03); C233(1.03); C185(1.19)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C185(1.08)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C185(1.20)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C185(1.10)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C185(1.27)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C232(0.96); C233(0.96); C185(1.11)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C232(0.66); C233(0.66); C185(1.02)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C232(0.74); C233(0.74); C185(1.07)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C232(0.44); C233(0.44); C185(1.06)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C232(0.84); C233(0.84); C185(0.95)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C232(0.93); C233(0.93); C185(0.98)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C232(0.79); C233(0.79); C185(0.96)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C232(0.62); C233(0.62); C185(1.19)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C232(0.66); C233(0.66); C185(1.13)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C232(0.70); C233(0.70); C185(1.04)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C232(0.63); C233(0.63); C185(0.91)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C185(0.99); C232(1.18); C233(1.18)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C232(0.57); C233(0.57); C185(1.00)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C232(0.58); C233(0.58); C185(0.94)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C232(0.69); C233(0.69); C185(0.93)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C232(0.58); C233(0.58); C185(1.11)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C232(0.57); C233(0.57); C185(1.05)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C185(1.12); C232(0.60); C233(0.60)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C185(1.25); C232(0.63); C233(0.63)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C185(1.01); C232(0.64); C233(0.64)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C185(1.06); C232(0.64); C233(0.64)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C185(0.93); C232(0.60); C233(0.60)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C185(0.94); C232(1.07); C233(1.07)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C185(1.06); C232(0.55); C233(0.55)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C185(0.99)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C185(1.07)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C185(1.15)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C185(1.05)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C185(1.04)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C185(1.09)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C185(1.07)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C185(1.09)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C185(0.87); C232(0.92); C233(0.92)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C185(1.12)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C185(0.99)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C185(1.11)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C185(1.05)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C185(1.09)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C185(1.11)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C185(1.02); C232(1.78); C233(1.78)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C185(0.98); C232(1.61); C233(1.61)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C185(1.07); C232(1.68); C233(1.68)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C185(0.96); C232(1.17); C233(1.17)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C185(0.89); C232(0.91); C233(0.91)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C185(0.96); C232(1.38); C233(1.38)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C185(0.96); C232(1.51); C233(1.51)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C185(1.00); C232(1.49); C233(1.49)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C185(1.05); C232(1.41); C233(1.41)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C185(0.98); C232(1.72); C233(1.72)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C185(1.00); C232(1.53); C233(1.53)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C185(1.08); C232(1.18); C233(1.18)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C185(0.98); C232(1.47); C233(1.47)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C185(0.95); C232(1.77); C233(1.77)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C185(0.96); C232(1.16); C233(1.16)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C185(0.91); C232(0.89); C233(0.89)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C185(0.95); C232(1.21); C233(1.21)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C185(1.05); C232(0.77); C233(0.77)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C185(1.11); C232(0.58); C233(0.58)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C185(1.39); C232(0.55); C233(0.55)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C185(1.09); C232(0.55); C233(0.55)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C185(1.19); C232(0.72); C233(0.72)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C185(1.13); C232(0.52); C233(0.52)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C185(1.26); C232(0.53); C233(0.53)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C185(1.04); C232(0.56); C233(0.56)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C185(1.07); C232(0.94); C233(0.94)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C185(0.97); C232(0.82); C233(0.82)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C185(1.33); C232(0.60); C233(0.60)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C185(1.41); C232(0.53); C233(0.53)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C185(1.10); C232(0.75); C233(0.75)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C185(1.17); C232(0.62); C233(0.62)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C185(1.19); C232(0.59); C233(0.59)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C185(0.98); C232(0.68); C233(0.68)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C185(1.03); C232(0.71); C233(0.71)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C185(1.08); C232(0.64); C233(0.64)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C185(0.97); C232(0.55); C233(0.55)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C185(0.98); C232(0.65); C233(0.65)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C185(1.02); C232(0.68); C233(0.68)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C185(1.06); C232(0.64); C233(0.64)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C185(1.04); C232(0.55); C233(0.55)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C185(0.98); C232(0.52); C233(0.52)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C185(1.10); C232(0.63); C233(0.63)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C185(1.11); C232(0.63); C233(0.63)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C185(1.14); C232(0.91); C233(0.91)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C185(1.02); C232(0.69); C233(0.69)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C185(1.04); C232(0.64); C233(0.64)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C185(1.01); C232(0.71); C233(0.71)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C185(1.00); C232(0.83); C233(0.83)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C185(1.02); C232(1.19); C233(1.19)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C185(0.98); C232(0.66); C233(0.66)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C185(0.92); C232(0.63); C233(0.63)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C185(1.01); C232(0.67); C233(0.67)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C185(0.81); C232(0.48); C233(0.48)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C185(0.79); C232(0.46); C233(0.46)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C185(0.83); C232(0.58); C233(0.58)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C185(0.79); C232(0.57); C233(0.57)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C185(1.03); C232(0.54); C233(0.54)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C185(1.00); C232(0.53); C233(0.53)  LDD0811  [11]
 LDCM0625  F8 Ramos C185(1.23); 0.49  LDD2187  [29]
 LDCM0572  Fragment10 Ramos C185(1.71)  LDD2189  [29]
 LDCM0573  Fragment11 Ramos C185(0.06); 2.70  LDD2190  [29]
 LDCM0574  Fragment12 Ramos C185(1.51)  LDD2191  [29]
 LDCM0575  Fragment13 Ramos C185(0.97)  LDD2192  [29]
 LDCM0576  Fragment14 Ramos C185(1.27); 2.61  LDD2193  [29]
 LDCM0579  Fragment20 Ramos C185(1.76)  LDD2194  [29]
 LDCM0580  Fragment21 Ramos C185(0.92)  LDD2195  [29]
 LDCM0582  Fragment23 Ramos C185(1.48)  LDD2196  [29]
 LDCM0578  Fragment27 Ramos C185(0.91)  LDD2197  [29]
 LDCM0586  Fragment28 Ramos C185(0.71); 2.02  LDD2198  [29]
 LDCM0588  Fragment30 Ramos C185(1.41)  LDD2199  [29]
 LDCM0589  Fragment31 Ramos C185(1.04)  LDD2200  [29]
 LDCM0590  Fragment32 Ramos C185(1.80)  LDD2201  [29]
 LDCM0468  Fragment33 HCT 116 C185(1.34); C232(0.54); C233(0.54)  LDD0785  [11]
 LDCM0596  Fragment38 Ramos C185(1.05)  LDD2203  [29]
 LDCM0566  Fragment4 Ramos C185(1.25); 0.37  LDD2184  [29]
 LDCM0427  Fragment51 HCT 116 C185(0.96)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C185(0.80)  LDD2204  [29]
 LDCM0614  Fragment56 Ramos C185(1.25)  LDD2205  [29]
 LDCM0569  Fragment7 Ramos C185(1.95)  LDD2186  [29]
 LDCM0571  Fragment9 Ramos C185(2.09)  LDD2188  [29]
 LDCM0116  HHS-0101 DM93 Y366(0.72)  LDD0264  [10]
 LDCM0117  HHS-0201 DM93 Y366(1.26)  LDD0265  [10]
 LDCM0118  HHS-0301 DM93 Y366(0.74)  LDD0266  [10]
 LDCM0119  HHS-0401 DM93 Y366(1.07)  LDD0267  [10]
 LDCM0120  HHS-0701 DM93 Y366(0.50)  LDD0268  [10]
 LDCM0015  HNE MDA-MB-231 C185(1.06)  LDD0346  [29]
 LDCM0107  IAA HeLa H176(0.00); H155(0.00); H309(0.00)  LDD0221  [20]
 LDCM0123  JWB131 DM93 Y171(0.28)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y171(0.37)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y171(1.41)  LDD0287  [9]
 LDCM0129  JWB202 DM93 Y171(0.36)  LDD0291  [9]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [5]
 LDCM0022  KB02 HCT 116 C185(1.49)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C185(1.52)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C185(1.60)  LDD0082  [11]
 LDCM0109  NEM HeLa H176(0.00); H155(0.00); H379(0.00)  LDD0223  [20]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C185(1.39)  LDD2099  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C185(1.14)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C185(0.78)  LDD2108  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C185(0.92)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C185(1.03)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C185(0.99)  LDD2127  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C185(1.31)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C185(1.52)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C185(0.92)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C185(0.96)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C185(0.72)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C185(1.01)  LDD2143  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C185(0.86)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C185(0.54)  LDD2148  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C185(0.99); C233(0.43)  LDD2206  [30]
 LDCM0628  OTUB2-COV-1 HEK-293T C185(0.73); C232(0.24)  LDD2207  [30]
 LDCM0014  Panhematin HEK-293T 3.42  LDD0062  [8]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD038010
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD027578
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