Details of the Target

General Information of Target

Target ID LDTP06300
Target Name DNA polymerase delta subunit 3 (POLD3)
Gene Name POLD3
Gene ID 10714
Synonyms
KIAA0039; DNA polymerase delta subunit 3; DNA polymerase delta subunit C; DNA polymerase delta subunit p66; DNA polymerase delta subunit p68
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MADQLYLENIDEFVTDQNKIVTYKWLSYTLGVHVNQAKQMLYDYVERKRKENSGAQLHVT
YLVSGSLIQNGHSCHKVAVVREDKLEAVKSKLAVTASIHVYSIQKAMLKDSGPLFNTDYD
ILKSNLQNCSKFSAIQCAAAVPRAPAESSSSSKKFEQSHLHMSSETQANNELTTNGHGPP
ASKQVSQQPKGIMGMFASKAAAKTQETNKETKTEAKEVTNASAAGNKAPGKGNMMSNFFG
KAAMNKFKVNLDSEQAVKEEKIVEQPTVSVTEPKLATPAGLKKSSKKAEPVKVLQKEKKR
GKRVALSDDETKETENMRKKRRRIKLPESDSSEDEVFPDSPGAYEAESPSPPPPPSPPLE
PVPKTEPEPPSVKSSSGENKRKRKRVLKSKTYLDGEGCIVTEKVYESESCTDSEEELNMK
TSSVHRPPAMTVKKEPREERKGPKKGTAALGKANRQVSITGFFQRK
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated. Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation. In this context, POLD3, along with PCNA and RFC1-replication factor C complex, is required to recruit POLD1, the catalytic subunit of the polymerase delta complex, to DNA damage sites. Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS, as a component of the tetrametric DNA polymerase zeta complex. Along with POLD2, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7.
Uniprot ID
Q15054
Ensemble ID
ENST00000263681.7
HGNC ID
HGNC:20932
ChEMBL ID
CHEMBL2363042

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.Q265R DBIA    Probe Info 
HS578T SNV: p.Y344H DBIA    Probe Info 
HUH7 SNV: p.K109R DBIA    Probe Info 
IM95 SNV: p.E368K DBIA    Probe Info 
SNGM SNV: p.T15M DBIA    Probe Info 
TE4 SNV: p.G395W DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
C-Sul
 Probe Info  		3.29  LDD0066  [2]
Probe 1
 Probe Info  		Y42(11.42); Y119(17.85)  LDD3495  [3]
BTD
 Probe Info  		C129(0.51)  LDD2091  [4]
AHL-Pu-1
 Probe Info  		C398(2.08)  LDD0169  [5]
DBIA
 Probe Info  		C137(0.98)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C398(0.00); C129(0.00); C137(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C137(0.00); C129(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C137(0.00); C398(0.00); C129(0.00)  LDD0037  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_4
 Probe Info  		C129(0.00); C137(0.00)  LDD2226  [9]
IPM
 Probe Info  		C129(0.00); C137(0.00)  LDD0005  [10]
TFBX
 Probe Info  		C137(0.00); C129(0.00)  LDD0148  [8]
Acrolein
 Probe Info  		C137(0.00); C398(0.00); C129(0.00)  LDD0217  [11]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [11]
Methacrolein
 Probe Info  		C137(0.00); C398(0.00); C129(0.00)  LDD0218  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		C129(0.00); C137(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C129(0.72)  LDD2117  [4]
 LDCM0025  4SU-RNA DM93 C137(3.08)  LDD0170  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C398(2.08)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C129(1.09); C137(0.74)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C129(1.06); C137(0.89)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C129(0.92); C137(0.91)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C129(0.80); C137(1.08)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C129(0.85); C137(0.90)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C129(0.81); C137(1.07)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C129(0.81); C137(0.92)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C129(0.78); C137(0.99)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C129(0.86); C137(1.01)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C129(0.79); C137(1.01)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C129(0.84); C137(0.80)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C129(0.90); C137(0.85)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C129(0.98); C137(0.84)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C129(0.90); C137(0.88)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C129(0.83); C137(0.93)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C129(0.80); C137(0.84)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C129(1.04); C137(1.05)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C129(1.01); C137(1.04)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C129(0.98); C137(1.02)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C129(0.92); C137(1.02)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C129(1.04); C137(0.95)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C129(1.00); C137(1.03)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C129(0.97); C137(1.13)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C129(1.15); C137(0.92)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C129(0.99); C137(1.18)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C129(1.05); C137(0.90)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C129(1.12); C137(1.06)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C129(1.07); C137(1.05)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C129(0.99); C137(1.05)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C129(0.95); C137(1.04)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C129(1.03); C137(1.04)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C129(1.07); C137(0.96)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C129(1.21)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C129(1.18)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C129(1.17)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C129(1.04)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C129(1.17)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C129(1.08)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C129(1.12)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C129(1.15)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C129(1.16)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C129(1.23)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C129(1.43)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C129(1.25)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C129(0.96); C137(0.88)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C129(1.28)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C129(1.21)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C129(1.20)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C129(0.98); C137(1.16)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C137(0.93); C129(0.93)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C137(0.89); C129(0.99)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C137(1.02); C129(1.04)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C137(0.92); C129(0.94)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C137(0.95); C129(1.11)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C137(0.99); C129(1.00)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C129(1.03); C137(1.03)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C137(0.98); C129(0.98)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C129(0.92); C137(0.99)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C137(0.82); C129(0.98)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C137(1.05); C129(1.12)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C129(0.87); C137(0.95)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C129(0.88); C137(1.05)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C129(0.96); C137(1.03)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C129(0.81); C137(0.91)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C137(1.02); C129(1.08)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C137(0.91); C129(1.10)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C137(0.96); C129(0.97)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C137(0.90); C129(1.06)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C129(0.71); C137(0.98)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C129(0.82); C137(0.94)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C129(0.93); C137(1.03)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C137(0.88); C129(0.98)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C129(0.89); C137(1.05)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C129(1.16)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C129(1.10)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C129(1.40)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C129(1.66)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C129(1.12)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C129(1.10); C137(1.22)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C129(1.02)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C129(1.00)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C129(1.69)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C129(1.45)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C129(1.20)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C137(0.88); C129(1.04)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C129(0.97); C137(1.00)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C129(1.03); C137(1.07)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C129(0.91); C137(1.07)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C137(0.98); C129(1.01)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C137(0.95); C129(1.05)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C129(0.92); C137(1.15)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C129(1.04); C137(1.27)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C129(1.15); C137(1.19)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C129(1.04); C137(1.23)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C129(0.90); C137(1.19)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C129(1.18); C137(1.27)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C129(0.96); C137(1.22)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C129(0.89); C137(1.12)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C129(0.95); C137(1.16)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C129(1.09); C137(1.23)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C137(0.61); C129(1.17)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C129(0.99); C137(1.16)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C129(0.84); C137(1.10)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C129(0.96); C137(1.04)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C129(0.94); C137(1.04)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C129(0.97); C137(1.07)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C129(0.90); C137(1.18)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C137(1.11); C129(1.22)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C129(1.19)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C129(1.18)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C129(1.36)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C129(0.82); C137(1.04)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C129(1.16)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C129(1.10)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C129(1.56)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C129(1.32)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C129(1.27)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C129(1.35)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C129(1.26)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C129(1.20)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C137(1.03); C129(1.09)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C137(0.91); C129(1.05)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C137(0.88); C129(0.96)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C129(0.99); C137(1.01)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C137(0.97); C129(1.15)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C137(1.01); C129(1.06)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C137(1.15); C129(1.20)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C137(0.99); C129(1.17)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C137(1.06); C129(1.25)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C137(0.98); C129(1.02)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C129(1.04); C137(1.08)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C129(1.10); C137(1.13)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C137(1.07); C129(1.15)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C129(0.82); C137(1.07)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C129(1.05); C137(1.18)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C129(1.16); C137(1.25)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C137(0.93); C129(1.28)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C137(0.90); C129(0.95)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C129(1.00); C137(1.04)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C137(1.03); C129(1.04)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C137(0.98); C129(1.00)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C137(0.94); C129(0.97)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C129(0.99); C137(1.00)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C137(0.95); C129(0.98)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C137(0.82); C129(1.05)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C137(0.92); C129(1.12)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C137(0.84); C129(1.16)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C137(0.94); C129(1.08)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C129(1.10); C137(1.60)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C129(0.98); C137(1.05)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C129(1.06); C137(1.77)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C129(1.07); C137(1.35)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C129(0.88); C137(1.09)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C137(0.77); C129(0.86)  LDD0683  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C129(1.04)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C129(0.92); C137(0.99)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C129(0.86); C137(0.97)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C137(1.12); C129(1.25)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 11.83  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C137(0.98)  LDD0078  [6]
 LDCM0498  BS-3668 MDA-MB-231 C129(0.51)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa C137(0.00); C398(0.00)  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C398(1.16); C137(1.09)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C137(0.85); C129(1.03)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C137(0.80); C129(1.00)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C137(0.61); C129(1.09)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C129(0.84); C137(0.97)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C137(0.72); C129(0.88)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C129(0.72); C137(0.94)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C137(0.88); C129(1.19)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C137(0.95); C129(0.97)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C129(0.83); C137(0.92)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C137(0.95); C129(1.09)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C137(0.95); C129(1.14)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C129(0.85); C137(1.00)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C137(0.63); C129(1.02)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C137(0.91); C129(1.04)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C137(0.90); C129(0.90)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C129(1.02)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C129(1.69)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C129(1.45)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C129(1.14)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C129(1.26)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C137(1.09); C129(1.50)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C137(1.12); C129(1.20)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C137(1.03); C129(1.25)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C137(0.94); C129(0.98)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C129(1.11); C137(1.14)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C129(0.87); C137(1.14)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C129(1.02); C137(1.16)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C137(0.93); C129(0.97)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C129(1.10); C137(1.22)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C129(1.06)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C129(0.99)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C129(0.97)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C129(1.21)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C137(0.81); C129(1.00)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C137(0.79); C129(0.93)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C137(0.77); C129(0.86)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C137(1.17); C129(1.24)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C137(1.01); C129(1.04)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C137(1.14); C129(1.15)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C129(0.95); C137(1.26)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C137(0.88); C129(1.08)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C129(1.12); C137(1.27)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C129(1.00); C137(1.28)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C129(0.91); C137(1.53)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C129(1.05); C137(1.24)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C129(1.01); C137(1.31)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C129(0.99); C137(1.20)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C129(1.06); C137(1.07)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C129(1.02); C137(1.16)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C129(1.04); C137(1.22)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C129(0.94); C137(1.24)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C129(1.08); C137(0.89)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C129(0.96); C137(1.12)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C129(0.92); C137(0.91)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C129(1.32); C137(1.16)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C129(1.07); C137(1.09)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C129(1.02); C137(1.19)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C129(1.11); C137(0.83)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C129(0.88); C137(1.12)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C129(1.01); C137(1.33)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C129(1.19); C137(1.11)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C129(0.86); C137(0.98)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C129(0.96); C137(0.96)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C129(1.18); C137(1.33)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C129(1.00); C137(1.08)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C129(1.20); C137(0.92)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C129(1.18); C137(1.01)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C129(0.87); C137(1.08)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C129(0.88); C137(1.09)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C129(0.91); C137(1.00)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C129(0.98); C137(1.14)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C129(0.93); C137(1.26)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C129(1.04); C137(0.91)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C129(0.85); C137(1.16)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C129(0.89); C137(1.03)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C129(0.88); C137(1.07)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C129(0.89); C137(1.06)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C129(0.91); C137(1.02)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C129(0.94); C137(1.08)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C129(0.95); C137(1.01)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C129(0.83); C137(1.02)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C129(0.91); C137(1.00)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C129(0.90); C137(1.05)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C129(0.94); C137(0.90)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C129(0.88); C137(1.05)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C129(1.10); C137(0.94)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C129(1.08); C137(0.98)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C129(0.99); C137(1.00)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C129(1.14); C137(1.10)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C129(0.94); C137(1.05)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C129(0.95); C137(1.14)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C129(1.04); C137(1.12)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C129(0.95); C137(0.95)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C129(1.01); C137(1.04)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C129(0.97); C137(0.81)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C129(0.97); C137(1.03)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C129(1.11); C137(0.93)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C129(0.98); C137(1.10)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C129(0.91); C137(0.93)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C129(0.88); C137(1.00)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C129(1.00); C137(0.93)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C129(1.01); C137(0.91)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C129(0.95); C137(0.85)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C129(0.93); C137(0.95)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C129(0.95); C137(0.71)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C129(0.95); C137(0.96)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C129(0.96); C137(0.90)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C129(0.94); C137(0.94)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C129(0.97); C137(0.94)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C129(1.03); C137(1.03)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C129(0.97); C137(1.07)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C129(1.13); C137(0.97)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C129(0.95); C137(1.03)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C129(0.97); C137(0.96)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C129(0.93); C137(0.94)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C129(1.08); C137(0.84)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C129(0.82); C137(0.82)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C129(1.06); C137(0.80)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C129(0.92); C137(0.86)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C129(1.09); C137(1.15)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C129(0.93); C137(0.80)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C129(0.90); C137(0.81)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C129(0.97); C137(0.76)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C129(0.98); C137(0.83)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C129(1.06); C137(0.89)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C129(1.09); C137(0.96)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C129(0.74); C137(0.91); C398(0.98)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C137(3.15)  LDD1702  [4]
 LDCM0625  F8 Ramos C129(1.43); C137(0.89); C398(1.14)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C129(1.13); C137(0.86); C398(0.70)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C129(0.51); C137(0.64); C398(2.27)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C129(1.11); C137(1.14); C398(0.88)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C129(0.84); C137(0.82); C398(1.28)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C129(1.26); C137(0.81); C398(1.02)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C129(1.38); C137(1.18); C398(0.85)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C129(0.89); C137(0.90); C398(1.08)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C129(0.80); C137(0.84); C398(1.68)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C129(0.82); C137(0.90); C398(0.92)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C129(0.63); C137(1.95); C398(0.67)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C129(1.09); C137(0.83); C398(1.16)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C129(0.98); C137(1.23)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C129(1.23); C137(0.82); C398(0.65)  LDD2201  [15]
 LDCM0468  Fragment33 HCT 116 C129(0.98); C137(0.89)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C129(0.91); C137(1.07); C398(0.67)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C129(1.26); C137(1.37); C398(0.71)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C129(1.07); C137(1.39)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C129(1.20); C137(4.04); C398(1.50)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C129(1.49); C137(1.03); C398(1.16)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C129(1.30); C137(1.21); C398(0.78)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C129(1.70); C137(1.09); C398(0.86)  LDD2188  [15]
 LDCM0015  HNE MDA-MB-231 C137(1.03)  LDD0346  [15]
 LDCM0022  KB02 HCT 116 C137(1.40); C398(1.01)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C137(1.44); C398(1.03)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C137(1.51); C398(1.04)  LDD0082  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C129(1.85)  LDD2121  [4]
 LDCM0109  NEM HeLa N.A.  LDD0233  [11]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C129(0.83)  LDD2093  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C129(0.99)  LDD2096  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C129(0.77)  LDD2099  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C129(0.71)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C129(0.83)  LDD2111  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C129(1.19)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C129(2.64)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C129(1.22)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C129(1.11)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C129(0.62)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C129(1.02)  LDD2124  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C129(0.78)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C129(1.11)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C129(0.80)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C129(0.76)  LDD2136  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C129(2.08)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C137(2.02)  LDD2144  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C129(0.94)  LDD2148  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C129(1.01); C137(0.93)  LDD2206  [16]
 LDCM0628  OTUB2-COV-1 HEK-293T C129(0.75); C137(0.17)  LDD2207  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA polymerase delta subunit 2 (POLD2) DNA polymerase delta/II small subunit family P49005
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proliferating cell nuclear antigen (PCNA) PCNA family P12004

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.