Details of the Target

General Information of Target

Target ID LDTP01647
Target Name Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (ASMTL)
Gene Name ASMTL
Gene ID 8623
Synonyms
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase; dTTPase/UTPase; EC 3.6.1.9; Nucleoside triphosphate pyrophosphatase; Nucleotide pyrophosphatase; Nucleotide PPase; N-acetylserotonin O-methyltransferase-like protein; ASMTL; EC 2.1.1.-)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLCPVIGKLLHKRVVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASFATPYGYAME
TAKQKALEVANRLYQKDLRAPDVVIGADTIVTVGGLILEKPVDKQDAYRMLSRLSGREHS
VFTGVAIVHCSSKDHQLDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKAGGYGIQA
LGGMLVESVHGDFLNVVGFPLNHFCKQLVKLYYPPRPEDLRRSVKHDSIPAADTFEDLSD
VEGGGSEPTQRDAGSRDEKAEAGEAGQATAEAECHRTRETLPPFPTRLLELIEGFMLSKG
LLTACKLKVFDLLKDEAPQKAADIASKVDASACGMERLLDICAAMGLLEKTEQGYSNTET
ANVYLASDGEYSLHGFIMHNNDLTWNLFTYLEFAIREGTNQHHRALGKKAEDLFQDAYYQ
SPETRLRFMRAMHGMTKLTACQVATAFNLSRFSSACDVGGCTGALARELAREYPRMQVTV
FDLPDIIELAAHFQPPGPQAVQIHFAAGDFFRDPLPSAELYVLCRILHDWPDDKVHKLLS
RVAESCKPGAGLLLVETLLDEEKRVAQRALMQSLNMLVQTEGKERSLGEYQCLLELHGFH
QVQVVHLGGVLDAILATKVAP
Target Bioclass
Enzyme
Family
Maf family, YhdE subfamily; Class I-like SAM-binding methyltransferase superfamily, Cation-independent O-methyltransferase family
Function
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable).
Uniprot ID
O95671
Ensemble ID
ENST00000381317.9
HGNC ID
HGNC:751

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.E157D DBIA    Probe Info 
CAL51 SNV: p.A613V DBIA    Probe Info 
CCK81 Insertion: p.G245WfsTer14 DBIA    Probe Info 
COLO792 Substitution: p.S50F DBIA    Probe Info 
COLO800 SNV: p.P495T DBIA    Probe Info 
HCC1395 SNV: p.P422S DBIA    Probe Info 
HCT116 SNV: p.S540N DBIA    Probe Info 
MDAMB453 SNV: p.L114F DBIA    Probe Info 
NCIH1993 SNV: p.S132G .
P31FUJ SNV: p.R24S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K41(0.87)  LDD0277  [1]
BTD
 Probe Info  		C4(5.63)  LDD1699  [2]
Probe 1
 Probe Info  		Y145(17.24); Y419(42.38)  LDD3495  [3]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [4]
Sulforaphane-probe2
 Probe Info  		3.22  LDD0042  [5]
Johansson_61
 Probe Info  		_(20.00)  LDD1490  [6]
DBIA
 Probe Info  		C274(1.19); C333(1.15)  LDD0078  [7]
W1
 Probe Info  		C333(0.72); C4(1.35)  LDD0239  [8]
ATP probe
 Probe Info  		K65(0.00); K9(0.00); K13(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C274(0.00); C305(0.00); C342(0.00); C546(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C274(0.00); C205(0.00); C130(0.00); C305(0.00)  LDD0036  [10]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C274(0.00); C205(0.00); C130(0.00); C305(0.00)  LDD0037  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
WYneN
 Probe Info  		C333(0.00); C274(0.00); C4(0.00)  LDD0021  [14]
WYneO
 Probe Info  		C333(0.00); C274(0.00)  LDD0022  [14]
Compound 10
 Probe Info  		C274(0.00); C333(0.00)  LDD2216  [15]
Compound 11
 Probe Info  		C274(0.00); C333(0.00)  LDD2213  [15]
ENE
 Probe Info  		C274(0.00); C333(0.00)  LDD0006  [14]
IPM
 Probe Info  		C333(0.00); C274(0.00); C4(0.00)  LDD0005  [14]
VSF
 Probe Info  		C4(0.00); C333(0.00); C274(0.00)  LDD0007  [14]
Phosphinate-6
 Probe Info  		C4(0.00); C333(0.00)  LDD0018  [16]
Acrolein
 Probe Info  		C274(0.00); C333(0.00); C4(0.00)  LDD0217  [17]
Methacrolein
 Probe Info  		C333(0.00); C274(0.00)  LDD0218  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
NAIA_5
 Probe Info  		C333(0.00); C274(0.00); C205(0.00); C130(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C4(1.02)  LDD2130  [2]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C4(0.91); C305(0.82)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C4(0.90); C305(1.39)  LDD2152  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C4(1.35)  LDD2103  [2]
 LDCM0214  AC1 HCT 116 C274(1.43); C305(1.37); C333(1.36); C456(1.21)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C274(0.99); C305(1.09); C333(1.09); C456(0.78)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C274(1.04); C305(1.07); C333(1.07); C456(0.83)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C274(1.01); C305(0.98); C333(1.06); C456(0.68)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C274(1.07); C305(1.01); C333(1.13); C456(0.77)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C274(1.29); C305(1.00); C333(1.20); C456(0.65)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C274(1.05); C305(1.18); C333(1.06); C456(0.83)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C274(1.15); C305(1.00); C333(1.16); C456(0.64)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C274(1.23); C305(1.03); C333(1.25); C456(0.72)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C274(1.09); C305(1.03); C333(1.04); C456(0.76)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C274(1.04); C305(1.10); C333(1.10); C456(0.77)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C274(0.92); C305(1.20); C333(1.08); C456(0.74)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C274(1.26); C305(1.02); C333(1.10); C456(0.71)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C274(1.02); C305(0.98); C333(1.17); C456(0.68)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C274(1.03); C305(0.91); C333(1.11); C456(0.57)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C274(1.09); C305(0.89); C333(1.17); C456(0.52)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C274(1.01); C333(1.06); C456(0.95); C461(1.08)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C274(1.18); C333(1.29); C456(0.89); C461(0.98)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C274(1.44); C333(1.39); C456(0.89); C461(0.98)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C274(1.44); C333(1.20); C456(0.83); C461(1.08)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C274(1.06); C333(1.13); C456(0.88); C461(1.17)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C274(1.12); C333(1.22); C456(1.17); C461(1.14)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C274(1.32); C333(1.19); C456(0.88); C461(1.11)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C274(1.08); C305(1.25); C333(1.18); C456(0.80)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C274(1.28); C333(1.29); C456(0.88); C461(1.00)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C274(1.02); C333(1.21); C456(1.63); C461(1.42)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C274(1.21); C333(1.23); C456(1.20); C461(1.07)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C274(1.08); C333(1.35); C456(1.44); C461(1.28)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C274(1.06); C333(1.01); C456(1.43); C461(1.31)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C274(1.11); C333(1.11); C456(1.30); C461(1.10)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C274(1.36); C333(1.51); C456(1.26); C461(1.08)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C274(1.21); C333(1.43); C456(1.58); C461(1.22)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C274(1.19); C305(1.00); C333(1.29); C461(0.95)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C274(0.83); C305(1.06); C333(0.90); C461(0.99)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C274(0.89); C305(0.95); C333(1.18); C461(1.09)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C274(0.79); C305(1.04); C333(0.91); C461(1.07)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C274(0.93); C305(1.00); C333(1.08); C461(1.08)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C274(1.03); C305(1.05); C333(1.15); C461(1.03)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C274(1.09); C305(0.84); C333(1.32); C461(1.16)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C274(1.09); C305(0.88); C333(1.05); C461(1.10)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C274(1.20); C305(0.81); C333(1.15); C461(1.02)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C274(0.99); C305(0.79); C333(1.13); C461(0.91)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C274(1.08); C305(0.69); C333(1.32); C461(0.90)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C274(0.89); C305(0.76); C333(1.22); C461(1.10)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C274(1.08); C305(1.02); C333(1.17); C456(0.82)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C274(1.07); C305(0.75); C333(1.34); C461(1.11)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C274(1.00); C305(0.72); C333(1.28); C461(1.01)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C274(1.03); C305(0.90); C333(1.12); C461(1.12)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C274(1.25); C305(0.81); C333(1.25)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C305(0.81); C274(1.36); C333(1.61)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C305(0.90); C333(1.26); C274(1.29)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C305(0.70); C274(1.36); C333(1.47)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C305(1.13); C274(1.43); C333(1.51)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C305(0.65); C274(1.94); C333(2.08)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C305(0.68); C274(1.57); C333(1.79)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C456(0.74); C461(1.10); C305(1.12); C333(1.18)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C274(1.09); C305(1.15); C333(1.27)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C305(0.76); C333(1.11); C274(1.24)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C305(0.80); C274(1.69); C333(1.72)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C305(0.57); C274(2.04); C333(2.19)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C274(1.34); C305(0.80); C333(1.40)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C274(1.40); C305(0.73); C333(1.48)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C274(1.03); C305(0.87); C333(1.13)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C274(1.15); C305(0.71); C333(1.07)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C274(1.05); C333(1.13); C461(1.18); C456(1.29)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C456(0.78); C461(0.79); C333(1.37); C274(1.41)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C461(0.88); C456(0.88); C274(1.02); C333(1.03)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C333(1.15); C274(1.35); C305(1.36); C461(1.36)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C333(0.95); C274(1.10); C461(1.15); C456(1.18)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C274(1.13); C333(1.18); C461(1.79); C456(1.87)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C333(1.00); C274(1.15); C461(1.63); C456(1.66)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C333(1.07); C274(1.09); C461(1.39); C456(1.45)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C274(1.01); C333(1.05); C461(1.46); C456(1.61)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C274(0.90); C461(0.97); C456(1.00); C333(1.15)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C461(0.94); C456(1.04); C274(1.08); C333(1.24)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C461(1.01); C456(1.05); C274(1.07); C333(1.23)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C456(1.15); C461(1.18); C274(1.22); C333(1.32)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C274(1.18); C333(1.30); C461(1.98); C456(2.05)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C333(1.27); C274(1.28); C305(1.29); C461(1.38)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C461(1.12); C456(1.22); C274(1.32); C333(1.38)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C456(1.16); C274(1.24); C461(1.27); C333(1.31)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C461(0.91); C456(1.08); C274(1.41); C333(1.59)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C461(0.89); C456(0.98); C274(1.19); C333(1.36)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C456(0.93); C461(1.25); C274(1.31); C333(1.59)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C274(0.90); C333(0.97); C305(0.97); C456(1.22)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C274(0.87); C305(0.95); C333(0.98); C456(1.42)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C274(0.92); C333(1.00); C305(1.05); C456(1.97)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C274(0.88); C305(0.95); C333(0.97); C456(1.13)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C305(0.93); C461(0.97); C456(0.97); C274(1.05)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C305(0.87); C461(1.41); C333(1.42); C274(1.42)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C456(0.76); C461(0.82); C305(1.03); C274(1.18)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C456(1.00); C274(1.03); C305(1.11); C461(1.16)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C456(0.77); C461(0.89); C305(0.91); C274(1.06)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C456(0.88); C305(1.02); C461(1.06); C274(1.09)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C456(0.77); C461(0.99); C305(1.05); C274(1.06)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C456(0.71); C461(0.88); C305(1.10); C274(1.27)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C456(0.92); C274(0.94); C333(1.06); C461(1.38)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C456(0.87); C274(0.88); C461(0.89); C333(1.45)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C456(0.82); C274(0.97); C333(1.31); C461(1.43)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C461(0.80); C456(0.90); C274(1.33); C333(1.74)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C305(1.06); C461(1.27); C333(1.38); C274(1.46)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C461(0.81); C456(0.98); C274(1.32); C333(1.67)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C274(0.79); C456(0.89); C333(1.06); C461(1.60)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C456(0.85); C274(0.90); C461(0.93); C333(1.13)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C461(0.71); C456(0.78); C274(1.05); C333(1.29)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C461(0.87); C456(0.98); C274(1.13); C333(1.44)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C456(0.63); C461(0.71); C274(1.30); C333(1.59)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C461(0.55); C456(0.64); C274(1.34); C333(2.18)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C305(0.41); C461(0.81); C333(1.35); C274(1.37)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C305(0.45); C461(0.73); C274(1.29); C333(1.57)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C305(0.34); C461(0.69); C456(1.05); C274(1.42)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C456(0.75); C461(0.85); C305(0.91); C274(1.09)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C305(0.57); C461(0.84); C456(0.92); C274(1.29)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C305(0.92); C461(1.07); C274(1.22); C333(1.48)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C305(0.34); C461(0.56); C456(0.96); C274(1.50)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C305(0.43); C461(0.68); C456(1.07); C274(1.20)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C305(0.38); C461(0.71); C456(1.00); C274(1.32)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C305(0.68); C461(0.96); C456(1.21); C274(1.49)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C305(0.82); C461(1.16); C274(1.45); C456(1.81)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C305(0.44); C461(0.70); C456(1.12); C274(1.64)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C461(0.85); C456(0.88); C274(1.04); C333(1.26)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C461(0.81); C456(0.87); C274(1.09); C333(1.26)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C456(0.86); C461(0.97); C305(0.99); C333(1.06)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C461(0.80); C456(0.99); C274(1.16); C333(1.18)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C274(1.00); C333(1.04); C461(1.08); C456(1.27)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C461(0.91); C456(1.07); C274(1.09); C333(1.22)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C461(0.62); C456(0.76); C274(1.54); C333(1.59)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C461(0.66); C456(0.79); C274(1.31); C333(1.64)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C461(0.70); C456(0.94); C274(1.53); C333(2.05)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C461(0.85); C456(1.15); C274(1.17); C333(1.28)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C461(0.77); C456(0.82); C274(1.23); C333(1.26)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C461(0.91); C456(1.02); C274(1.10); C333(1.20)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C274(1.06); C461(1.20); C333(1.36); C456(1.39)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C456(0.72); C461(0.91); C305(1.01); C274(1.17)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C461(0.85); C456(0.94); C274(1.12); C333(1.22)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C461(1.08); C274(1.09); C456(1.26); C333(1.27)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C461(0.70); C456(0.85); C274(1.47); C333(1.79)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C461(1.07); C333(1.60); C274(1.67)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C461(1.25); C333(1.43); C274(1.44)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C461(1.11); C274(1.25); C333(1.48)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C461(1.14); C274(1.23); C333(1.23)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C274(1.01); C333(1.04); C461(1.18)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C461(1.05); C274(1.13); C333(1.13)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C461(1.06); C274(1.18); C333(1.25)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C274(0.95); C333(1.07); C461(1.15)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C461(1.10); C333(1.52); C274(1.66)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C461(1.09); C274(1.42); C333(1.48)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C461(1.14); C274(1.23); C333(1.29)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C461(1.10); C274(1.17); C333(1.21)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C461(1.07); C274(1.11); C333(1.12)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C461(1.23); C274(1.27); C333(1.29)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C461(1.03); C274(1.27); C333(1.38)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C456(0.55); C461(0.72); C305(0.97); C274(1.45)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C456(0.53); C461(0.71); C274(0.96); C305(1.02)  LDD0683  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C4(0.84)  LDD2113  [2]
 LDCM0248  AKOS034007472 HCT 116 C274(1.06); C305(1.13); C333(1.06); C456(1.06)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C456(0.75); C461(0.85); C305(1.05); C333(1.10)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C456(0.41); C461(0.89); C305(1.16); C333(1.63)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C274(1.19); C333(1.15)  LDD0078  [7]
 LDCM0498  BS-3668 MDA-MB-231 C4(0.54)  LDD2091  [2]
 LDCM0108  Chloroacetamide HeLa C274(0.00); C546(0.00); C333(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C333(1.69); C274(1.59); C333(1.36); C274(1.27)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C456(0.70); C461(0.82); C305(0.92); C274(0.97)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C461(0.63); C456(0.77); C305(1.14); C333(1.32)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C456(0.87); C461(1.06); C305(1.19); C333(1.42)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C456(0.65); C305(0.90); C274(1.16); C461(1.17)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C305(0.78); C456(0.95); C274(1.07); C333(1.09)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C456(0.88); C305(0.99); C274(0.99); C333(1.02)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C305(1.00); C333(1.05); C274(1.05); C456(1.12)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C456(0.84); C461(0.91); C274(1.16); C333(1.22)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C456(0.59); C461(0.66); C333(1.44); C274(1.45)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C456(0.72); C461(0.78); C333(1.31); C274(1.47)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C461(0.81); C456(0.85); C333(1.35); C274(1.40)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C456(0.79); C461(0.82); C274(1.20); C333(1.23)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C461(0.60); C456(0.81); C305(0.89); C333(1.52)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C461(0.81); C456(0.89); C274(1.13); C333(1.32)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C456(0.74); C461(0.80); C333(1.19); C274(1.37)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C274(0.95); C456(1.18); C333(1.18); C461(1.19)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C461(0.94); C456(1.11); C274(1.41); C333(1.48)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C461(0.98); C274(1.02); C456(1.12); C333(1.45)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C274(1.10); C333(1.37); C461(1.42); C456(1.58)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C274(1.15); C461(1.19); C456(1.27); C333(1.38)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C456(0.53); C461(0.59); C305(0.92); C274(1.38)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C305(0.96); C274(1.01); C456(1.06); C333(1.23)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C456(0.90); C305(1.02); C461(1.03); C274(1.06)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C461(0.69); C456(1.03); C305(1.08); C333(1.51)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C456(0.98); C305(1.00); C274(1.05); C461(1.10)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C461(0.59); C456(0.69); C333(0.88); C274(1.03)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C456(0.76); C274(1.10); C333(1.20); C461(1.35)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C456(0.47); C461(0.50); C274(1.28); C333(1.80)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C461(0.68); C456(0.72); C274(1.25); C333(1.45)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C305(0.81); C274(0.91); C461(1.05); C333(1.23)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C305(0.50); C461(0.92); C456(1.06); C274(1.07)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C305(0.81); C274(1.04); C461(1.06); C456(1.26)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C305(0.36); C461(0.68); C333(1.36); C274(1.40)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C461(0.74); C456(0.99); C305(1.08); C333(1.26)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C461(0.70); C456(0.80); C305(1.09); C274(1.13)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C456(0.80); C461(0.92); C305(0.97); C333(1.32)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C456(0.66); C461(0.78); C305(1.01); C274(1.12)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C456(0.60); C461(0.69); C305(0.76); C274(1.02)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C456(0.59); C274(1.07); C305(1.08); C461(1.16)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C456(0.67); C305(1.00); C461(1.06); C333(1.10)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C461(0.86); C456(0.93); C274(0.96); C305(0.99)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C456(0.57); C461(0.58); C305(1.09); C333(1.19)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C461(0.42); C456(0.42); C305(0.81); C333(1.44)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C456(0.44); C461(0.61); C305(1.00); C333(1.77)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C456(0.50); C461(0.54); C305(0.91); C274(1.24)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C456(0.51); C461(0.54); C333(1.38); C305(1.48)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C274(1.45); C305(1.09); C333(1.43); C456(0.52)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C274(1.20); C305(0.98); C333(1.23); C456(0.56)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C274(1.17); C305(1.40); C333(1.26); C456(0.65)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C274(1.32); C305(1.18); C333(1.25); C456(0.49)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C274(1.25); C305(1.62); C333(1.37); C456(0.63)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C274(1.02); C305(1.01); C333(1.09); C456(1.09)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C274(1.04); C305(1.41); C333(1.14); C456(0.76)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C274(1.15); C305(0.68); C333(1.14); C456(0.86)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C274(1.12); C305(1.02); C333(1.26); C456(0.59)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C274(1.23); C305(0.67); C333(1.18); C456(0.50)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C274(1.37); C305(0.65); C333(1.35); C456(0.60)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C274(1.42); C305(0.72); C333(1.36); C456(0.71)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C274(1.12); C305(0.63); C333(1.29); C456(0.82)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C274(1.54); C305(0.71); C333(1.42); C456(0.76)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C274(1.67); C305(0.73); C333(1.43); C456(0.63)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C274(1.10); C305(0.54); C333(1.19); C456(1.21)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C274(1.29); C305(0.56); C333(1.34); C456(0.71)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C274(1.33); C305(0.65); C333(1.26); C456(0.78)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C274(1.72); C305(0.71); C333(1.97); C456(0.84)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C274(1.46); C305(0.75); C333(1.51); C456(0.66)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C274(1.30); C305(0.84); C333(1.37); C456(0.78)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C274(1.56); C305(0.73); C333(1.69); C456(0.77)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C274(0.93); C333(1.06); C456(2.10); C461(1.39)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C274(0.96); C333(0.88); C456(1.61); C461(1.32)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C274(0.88); C333(0.86); C456(2.32); C461(1.80)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C274(0.95); C333(1.00); C456(1.42); C461(1.23)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C274(1.21); C305(0.97); C333(1.17); C456(1.16)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C274(0.95); C333(1.10); C456(1.91); C461(1.44)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C274(0.91); C333(0.98); C456(2.49); C461(1.35)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C274(1.01); C333(1.35); C456(1.84); C461(1.19)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C274(1.00); C333(1.16); C456(2.02); C461(1.50)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C274(0.92); C333(0.86); C456(1.84); C461(1.03)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C274(0.93); C333(0.99); C456(1.95); C461(1.25)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C274(1.05); C333(1.24); C456(1.30); C461(1.03)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C274(0.89); C333(0.88); C456(1.69); C461(1.33)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C274(0.87); C333(0.94); C456(2.05); C461(1.48)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C274(0.94); C333(0.96); C456(1.68); C461(1.17)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C274(1.19); C305(1.02); C333(1.19); C456(0.84)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C274(0.94); C333(0.92); C456(1.77); C461(1.16)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C274(1.11); C305(0.93); C333(1.04); C456(1.00)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C274(1.20); C305(1.00); C333(1.13); C456(0.99)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C274(1.33); C305(0.82); C333(1.25); C456(0.78)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C274(1.49); C305(0.52); C333(1.28); C456(0.79)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C274(1.10); C305(0.88); C333(1.10); C456(0.98)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C274(1.67); C305(0.47); C333(1.42); C456(0.61)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C274(1.44); C305(0.54); C333(1.24); C456(0.74)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C274(1.28); C305(0.82); C333(1.35); C456(0.75)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C274(1.21); C305(0.94); C333(1.15); C456(0.73)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C274(1.54); C305(1.01); C333(1.39); C456(1.20)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C274(1.17); C305(0.94); C333(1.27); C456(0.85)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C274(1.31); C305(0.70); C333(1.34); C456(0.83)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C274(1.15); C305(0.90); C333(1.13); C456(0.97)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C274(1.26); C305(0.64); C333(1.23); C456(0.76)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C274(1.30); C305(0.70); C333(1.32); C456(0.85)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C274(1.11); C305(1.12); C333(1.11); C456(1.18)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C274(1.06); C305(1.48); C333(1.16); C456(0.89)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C274(1.28); C305(0.99); C333(1.17); C456(1.12)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C274(1.57); C305(1.34); C333(1.19); C456(1.09)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C274(1.66); C305(1.06); C333(2.09); C456(0.49)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C274(1.11); C305(1.44); C333(1.01); C456(1.16)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C274(1.16); C305(1.44); C333(1.09); C456(1.04)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C274(1.72); C305(1.70); C333(1.45); C456(0.96)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C274(1.69); C305(1.42); C333(1.41); C456(1.06)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C274(2.22); C305(1.18); C333(1.84); C456(1.09)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C274(1.25); C305(1.33); C333(1.34); C456(1.16)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C274(1.09); C305(1.48); C333(1.03); C456(0.93)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C274(1.42); C305(1.58); C333(1.29); C456(1.18)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C274(1.66); C305(1.74); C333(1.35); C456(0.93)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C274(2.26); C305(1.43); C333(1.98); C456(0.94)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C274(1.38); C305(1.00); C333(1.34); C456(0.81)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C274(0.98); C305(0.81); C333(1.30); C456(0.65)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C274(1.19); C305(0.99); C333(1.11); C456(1.65)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C274(1.08); C305(1.17); C333(1.01); C456(1.27)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C274(1.10); C305(1.53); C333(0.91); C456(1.44)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C274(1.36); C305(1.13); C333(1.20); C456(0.96)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C274(1.63); C305(1.08); C333(1.23); C456(1.11)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C274(1.23); C305(1.21); C333(1.11); C456(1.46)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C274(1.40); C305(1.17); C333(1.19); C456(1.02)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C274(1.40); C305(1.32); C333(1.45); C456(1.15)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C274(1.50); C305(1.59); C333(1.34); C456(1.16)  LDD0811  [7]
 LDCM0634  CY-0357 Hep-G2 C333(1.03); C274(0.89)  LDD2228  [13]
 LDCM0495  E2913 HEK-293T C274(0.89); C333(1.09); C305(0.97); C441(0.98)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C4(2.41); C546(2.07)  LDD1702  [2]
 LDCM0625  F8 Ramos C441(0.85); C4(1.38); C333(0.96); 0.95  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C441(1.38); C4(2.45); C333(7.57); 2.43  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C441(2.03); C4(0.82); C333(0.72); 1.38  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C441(1.44); C4(8.91); C333(6.53); C274(1.02)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C441(0.87); C4(1.13); C333(1.21); 1.21  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C441(1.32); C4(1.01); C333(1.05); 1.67  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C441(2.01); C4(2.44); C333(6.33); C274(1.33)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C441(1.14); C4(1.85); C333(1.22); 1.05  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C441(1.27); C4(0.84); C333(1.24); C274(0.99)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C441(0.91); C4(0.81); C333(0.92); 1.41  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C441(1.38); C4(0.84); C333(0.82); 0.86  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C441(0.68); C4(2.28); C333(1.55); 1.18  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C441(0.98); C4(0.92); C333(1.14); 1.50  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C441(1.13); C4(19.63); C333(6.74); 2.07  LDD2201  [21]
 LDCM0468  Fragment33 HCT 116 C274(1.33); C305(0.67); C333(1.28); C456(0.99)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C441(0.46); C4(0.62); C333(1.52); 0.33  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C441(1.84); C4(4.25); C333(2.17); C274(1.31)  LDD2184  [21]
 LDCM0427  Fragment51 HCT 116 C274(2.16); C305(0.58); C333(1.67); C456(0.82)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C441(0.58); C4(1.34); C333(1.92); C274(1.16)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C441(0.52); C4(0.92); C333(1.19); 1.14  LDD2205  [21]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [6]
 LDCM0569  Fragment7 Ramos C441(1.48); C4(20.00); C333(9.91); 2.25  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C441(1.81); C333(8.74); C274(1.02); C546(0.46)  LDD2188  [21]
 LDCM0015  HNE MDA-MB-231 C441(0.87)  LDD0346  [21]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [4]
 LDCM0022  KB02 HCT 116 C333(2.18); C274(1.65)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C333(1.47); C274(1.12)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C333(1.47); C274(1.42)  LDD0082  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C4(0.44)  LDD2121  [2]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C4(1.58)  LDD2090  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C4(0.97)  LDD2093  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C305(1.24)  LDD2096  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C4(0.70); C333(0.95)  LDD2099  [2]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C4(0.63)  LDD2101  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C4(1.13)  LDD2105  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C4(0.81)  LDD2107  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C4(0.90)  LDD2111  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C4(2.65)  LDD2119  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C4(1.00)  LDD2120  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C4(0.74); C305(0.84); C333(2.68)  LDD2125  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C4(0.21)  LDD2126  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C4(1.05)  LDD2127  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C4(0.86)  LDD2134  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C4(0.66)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C4(1.22); C333(1.53)  LDD2136  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C4(2.18)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C4(0.77); C333(1.77)  LDD2140  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C4(1.03)  LDD2143  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C4(0.47)  LDD2150  [2]
 LDCM0627  NUDT7-COV-1 HEK-293T C4(0.48)  LDD2206  [22]
 LDCM0131  RA190 MM1.R C333(1.49)  LDD0304  [23]
 LDCM0003  Sulforaphane MCF-7 3.22  LDD0042  [5]
 LDCM0021  THZ1 HCT 116 C333(1.23); C274(0.97); C461(0.84)  LDD2173  [7]
 LDCM0112  W16 Hep-G2 C333(0.72); C4(1.35)  LDD0239  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tryptophan 2,3-dioxygenase (TDO2) Tryptophan 2,3-dioxygenase family P48775
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Optineurin (OPTN) . Q96CV9
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
6 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
23 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.