Details of the Target

General Information of Target

Target ID LDTP09632
Target Name tRNA-splicing endonuclease subunit Sen15 (TSEN15)
Gene Name TSEN15
Gene ID 116461
Synonyms
C1orf19; SEN15; tRNA-splicing endonuclease subunit Sen15; SEN15 homolog; HsSEN15; tRNA-intron endonuclease Sen15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEERGDSEPTPGCSGLGPGGVRGFGDGGGAPSWAPEDAWMGTHPKYLEMMELDIGDATQV
YVAFLVYLDLMESKSWHEVNCVGLPELQLICLVGTEIEGEGLQTVVPTPITASLSHNRIR
EILKASRKLQGDPDLPMSFTLAIVESDSTIVYYKLTDGFMLPDPQNISLRR
Target Bioclass
Other
Family
SEN15 family
Subcellular location
Nucleus
Function
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.
Uniprot ID
Q8WW01
Ensemble ID
ENST00000423085.7
HGNC ID
HGNC:16791

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.P164A DBIA    Probe Info 
NCIH2172 SNV: p.T111S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K124(10.00)  LDD0277  [2]
BTD
 Probe Info  		C13(0.74)  LDD2107  [3]
AHL-Pu-1
 Probe Info  		C13(2.32)  LDD0169  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
DBIA
 Probe Info  		C13(1.04)  LDD0531  [6]
W1
 Probe Info  		C13(0.61)  LDD0239  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
NAIA_5
 Probe Info  		N.A.  LDD2224  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
WYneO
 Probe Info  		N.A.  LDD0022  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
Compound 11
 Probe Info  		N.A.  LDD2213  [12]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		N.A.  LDD0005  [11]
VSF
 Probe Info  		N.A.  LDD0007  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [5]
AOyne
 Probe Info  		13.70  LDD0443  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C13(0.84)  LDD2142  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C13(1.00)  LDD2117  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C13(2.32)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C13(1.04)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C13(1.07)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C13(1.31)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C13(1.36)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C13(1.07)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C13(1.66)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C13(1.30)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C13(1.44)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C13(1.49)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C13(1.26)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C13(1.38)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C13(0.97)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C13(1.15)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C13(1.43)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C13(1.67)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C13(1.37)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C13(1.03)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C13(1.18)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C13(1.08)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C13(1.25)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C13(1.12)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C13(1.29)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C13(1.29)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C13(1.11)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C13(1.09)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C13(1.08)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C13(1.13)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C13(0.96)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C13(1.12)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C13(1.23)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C13(1.48)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C13(1.39)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C13(0.78)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C13(0.81)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C13(0.84)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C13(0.87)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C13(1.00)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C13(0.94)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C13(1.10)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C13(0.95)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C13(1.03)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C13(0.94)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C13(1.23)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C13(1.36)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C13(1.01)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C13(1.29)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C13(1.33)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C13(1.01)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C13(1.27)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C13(1.57)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C13(1.07)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C13(1.21)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C13(1.53)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C13(1.84)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C13(1.46)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C13(1.18)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C13(1.33)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C13(1.09)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C13(1.35)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C13(1.77)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C13(1.41)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C13(1.55)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C13(1.19)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C13(1.05)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C13(1.07)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C13(1.95)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C13(0.91)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C13(0.93)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C13(0.97)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C13(1.64)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C13(1.18)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C13(0.89)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C13(0.93)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C13(0.94)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C13(1.22)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C13(1.41)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C13(1.54)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C13(1.40)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C13(0.94)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C13(1.18)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C13(1.19)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C13(1.76)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C13(1.36)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C13(1.70)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C13(1.00)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C13(1.04)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C13(0.96)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C13(1.13)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C13(1.05)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C13(0.94)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C13(1.07)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C13(1.22)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C13(1.17)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C13(1.33)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C13(1.20)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C13(1.16)  LDD0624  [6]
 LDCM0308  AC46 HEK-293T C13(0.92)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C13(1.09)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C13(1.04)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C13(0.98)  LDD0909  [6]
 LDCM0312  AC5 HCT 116 C13(0.94)  LDD0629  [6]
 LDCM0313  AC50 HEK-293T C13(1.08)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C13(1.12)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C13(1.08)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C13(1.33)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C13(1.16)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C13(1.38)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C13(0.99)  LDD0917  [6]
 LDCM0320  AC57 HCT 116 C13(1.67)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C13(1.65)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C13(1.70)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C13(1.32)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C13(1.68)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C13(1.36)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C13(1.82)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C13(1.56)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C13(1.76)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C13(1.63)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C13(1.46)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C13(2.04)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C13(1.30)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C13(1.50)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C13(1.08)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C13(1.81)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C13(1.32)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C13(1.47)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C13(2.08)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C13(2.01)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C13(2.19)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C13(1.54)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C13(1.41)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C13(1.29)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C13(1.39)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C13(1.39)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C13(1.51)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C13(1.51)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C13(2.67)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C13(1.52)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C13(1.56)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C13(1.36)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C13(1.37)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C13(1.23)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C13(1.29)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C13(1.41)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C13(1.16)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C13(1.43)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C13(1.51)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C13(1.20)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C13(1.11)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C13(1.26)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C13(1.10)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C13(1.62)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C13(1.70)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C13(1.29)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C13(1.11)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C13(1.17)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C13(1.58)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 14.49  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0367  CL1 HEK-293T C13(1.05)  LDD0965  [6]
 LDCM0368  CL10 HEK-293T C13(1.02)  LDD0966  [6]
 LDCM0369  CL100 HCT 116 C13(1.12)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C13(1.08)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C13(1.09)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C13(1.80)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C13(1.07)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C13(1.36)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C13(1.50)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C13(1.34)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C13(1.17)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C13(1.12)  LDD0695  [6]
 LDCM0379  CL11 HEK-293T C13(0.91)  LDD0977  [6]
 LDCM0380  CL110 HCT 116 C13(1.59)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C13(1.20)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C13(1.13)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C13(1.47)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C13(1.71)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C13(1.12)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C13(1.15)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C13(1.06)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C13(1.17)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C13(1.13)  LDD0706  [6]
 LDCM0390  CL12 HEK-293T C13(1.01)  LDD0988  [6]
 LDCM0391  CL120 HCT 116 C13(1.20)  LDD0708  [6]
 LDCM0392  CL121 HEK-293T C13(1.30)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C13(1.15)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C13(1.41)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C13(1.02)  LDD0993  [6]
 LDCM0396  CL125 HCT 116 C13(1.15)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C13(1.12)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C13(1.33)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C13(1.79)  LDD0716  [6]
 LDCM0400  CL13 HEK-293T C13(0.96)  LDD0998  [6]
 LDCM0401  CL14 HEK-293T C13(1.11)  LDD0999  [6]
 LDCM0402  CL15 HEK-293T C13(1.19)  LDD1000  [6]
 LDCM0403  CL16 HCT 116 C13(1.38)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C13(1.07)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C13(1.25)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C13(1.12)  LDD0723  [6]
 LDCM0407  CL2 HEK-293T C13(1.01)  LDD1005  [6]
 LDCM0408  CL20 HCT 116 C13(1.30)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C13(1.76)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C13(2.02)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C13(1.28)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C13(1.27)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C13(1.93)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C13(1.40)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C13(1.34)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C13(1.31)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C13(1.33)  LDD0734  [6]
 LDCM0418  CL3 HEK-293T C13(0.97)  LDD1016  [6]
 LDCM0419  CL30 HCT 116 C13(1.17)  LDD0736  [6]
 LDCM0420  CL31 HEK-293T C13(1.05)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C13(1.15)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C13(1.22)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C13(1.49)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C13(1.30)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C13(1.12)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C13(1.17)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C13(1.46)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C13(1.26)  LDD1027  [6]
 LDCM0430  CL40 HEK-293T C13(1.43)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C13(1.16)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C13(1.20)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C13(1.22)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C13(1.30)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C13(1.28)  LDD1033  [6]
 LDCM0436  CL46 HCT 116 C13(0.89)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C13(0.85)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C13(0.88)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C13(0.94)  LDD0756  [6]
 LDCM0440  CL5 HEK-293T C13(1.12)  LDD1038  [6]
 LDCM0441  CL50 HCT 116 C13(0.86)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C13(0.96)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C13(0.90)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C13(0.94)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C13(0.89)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C13(0.83)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C13(0.91)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C13(0.90)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C13(0.87)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C13(0.99)  LDD0767  [6]
 LDCM0451  CL6 HEK-293T C13(1.28)  LDD1049  [6]
 LDCM0452  CL60 HCT 116 C13(1.02)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C13(0.97)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C13(1.02)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C13(1.18)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C13(1.37)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C13(1.07)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C13(1.61)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C13(1.25)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C13(1.17)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C13(1.08)  LDD0778  [6]
 LDCM0462  CL7 HEK-293T C13(0.85)  LDD1060  [6]
 LDCM0463  CL70 HCT 116 C13(1.15)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C13(1.19)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C13(1.09)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C13(1.20)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C13(1.20)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C13(1.00)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C13(1.14)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C13(1.09)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C13(0.96)  LDD0789  [6]
 LDCM0473  CL8 HEK-293T C13(1.50)  LDD1071  [6]
 LDCM0474  CL80 HCT 116 C13(0.93)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C13(0.91)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C13(0.82)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C13(0.88)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C13(1.09)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C13(1.02)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C13(1.00)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C13(0.91)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C13(0.93)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C13(0.98)  LDD0800  [6]
 LDCM0484  CL9 HEK-293T C13(1.18)  LDD1082  [6]
 LDCM0485  CL90 HCT 116 C13(1.02)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C13(1.17)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C13(1.06)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C13(1.04)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C13(1.04)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C13(1.08)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C13(1.02)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C13(1.03)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C13(1.29)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C13(1.05)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C13(1.13)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C13(1.04)  LDD1702  [3]
 LDCM0625  F8 Ramos C13(1.20)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C13(1.73)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C13(1.41)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C13(1.01)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C13(0.94)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C13(0.64)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C13(1.00)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C13(0.99)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C13(0.99)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C13(0.94)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C13(0.50)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C13(1.19)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C13(0.86)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C13(1.66)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C13(1.13)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C13(0.99)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C13(1.19)  LDD2184  [16]
 LDCM0427  Fragment51 HEK-293T C13(1.02)  LDD1025  [6]
 LDCM0610  Fragment52 Ramos C13(1.07)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C13(1.22)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C13(1.47)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C13(1.28)  LDD2188  [16]
 LDCM0015  HNE MDA-MB-231 C13(1.02)  LDD0346  [16]
 LDCM0022  KB02 HEK-293T C13(0.93)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C13(1.13)  LDD1497  [15]
 LDCM0024  KB05 COLO792 C13(2.21)  LDD3310  [17]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C13(0.74)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C13(0.84)  LDD2108  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C13(0.60)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C13(0.73)  LDD2141  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C13(0.86)  LDD2206  [18]
 LDCM0628  OTUB2-COV-1 HEK-293T C13(1.09); C13(0.77)  LDD2207  [18]
 LDCM0131  RA190 MM1.R C13(1.19)  LDD0304  [19]
 LDCM0112  W16 Hep-G2 C13(0.61)  LDD0239  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerase II subunit RPB7 (POLR2G) Eukaryotic RPB7/RPC8 RNA polymerase subunit family P62487
Pyridoxal phosphate phosphatase PHOSPHO2 (PHOSPHO2) PHOSPHO family Q8TCD6
Testis-specific serine/threonine-protein kinase 2 (TSSK2) CAMK Ser/Thr protein kinase family Q96PF2
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein 554 (ZNF554) Krueppel C2H2-type zinc-finger protein family Q86TJ5
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Protein INCA1 (INCA1) INCA family Q0VD86
Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1) LRIF1 family Q5T3J3
Meiosis-specific protein MEI4 (MEI4) MEI4L family A8MW99
Dynein axonemal assembly factor 6 (DNAAF6) PIH1 family Q9NQM4
Protein TASOR 2 (TASOR2) TASOR family Q5VWN6
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
Heat shock factor 2-binding protein (HSF2BP) . O75031
Mirror-image polydactyly gene 1 protein (MIPOL1) . Q8TD10
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.