Details of the Target

General Information of Target

Target ID LDTP02768
Target Name Ras-related C3 botulinum toxin substrate 2 (RAC2)
Gene Name RAC2
Gene ID 5880
Synonyms
Ras-related C3 botulinum toxin substrate 2; GX; Small G protein; p21-Rac2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAG
QEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLR
DDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQ
PTRQQKRACSLL
Target Bioclass
Enzyme
Family
Small GTPase superfamily, Rho family
Subcellular location
Cytoplasm
Function
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Uniprot ID
P15153
Ensemble ID
ENST00000249071.11
HGNC ID
HGNC:9802
ChEMBL ID
CHEMBL5581

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		100.00  LDD0242  [1]
TH211
 Probe Info  		Y139(20.00)  LDD0260  [2]
STPyne
 Probe Info  		K133(10.00); K147(8.58); K153(7.18); K96(10.00)  LDD0277  [3]
OPA-S-S-alkyne
 Probe Info  		K166(1.37)  LDD3494  [4]
JZ128-DTB
 Probe Info  		C157(0.00); C178(0.00)  LDD0462  [5]
THZ1-DTB
 Probe Info  		C157(1.10)  LDD0460  [5]
BTD
 Probe Info  		C178(1.35)  LDD1700  [6]
AHL-Pu-1
 Probe Info  		C157(2.70)  LDD0172  [7]
IPM
 Probe Info  		C178(34.40)  LDD1701  [6]
DBIA
 Probe Info  		C178(1.40)  LDD0078  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C178(0.00); C6(0.00); C105(0.00); C81(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C178(0.00); C105(0.00); C81(0.00)  LDD0036  [9]
IPIAA_H
 Probe Info  		C6(0.00); C81(0.00)  LDD0030  [10]
IPIAA_L
 Probe Info  		C178(0.00); C6(0.00); C157(0.00); C81(0.00)  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C178(0.00); C6(0.00); C105(0.00); C81(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
TFBX
 Probe Info  		C157(0.00); C178(0.00); C6(0.00)  LDD0027  [12]
Compound 10
 Probe Info  		C105(0.00); C178(0.00)  LDD2216  [13]
Compound 11
 Probe Info  		N.A.  LDD2213  [13]
NHS
 Probe Info  		K128(0.00); K166(0.00)  LDD0010  [14]
PF-06672131
 Probe Info  		N.A.  LDD0152  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
NAIA_5
 Probe Info  		C6(0.00); C157(0.00)  LDD2223  [11]
TPP-AC
 Probe Info  		N.A.  LDD0427  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C105(1.03)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C105(1.17); C178(0.99)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C178(0.93)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C178(1.39)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C105(0.55); C178(0.58)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C178(0.63)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C157(2.70)  LDD0172  [7]
 LDCM0214  AC1 HCT 116 C178(1.12)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C178(0.98)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C178(0.90)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C178(0.91)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C178(1.14)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C178(0.88)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C178(1.04)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C178(0.86)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C178(0.99)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C178(0.76)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C178(1.10)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C178(0.95)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C178(1.02)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C178(1.17)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C178(0.97)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C178(0.80)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C178(0.82)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C178(0.75)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C178(1.00)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C178(0.82)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C178(1.15)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C178(0.84)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C178(0.91)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C178(0.84)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C178(0.71)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C178(0.74)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C178(0.91)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C178(0.68)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C178(0.89)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C178(0.84)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C178(0.87)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C178(0.78)  LDD0562  [8]
 LDCM0259  AC14 HCT 116 C178(0.81)  LDD0576  [8]
 LDCM0263  AC143 HCT 116 C178(1.34)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C178(0.83)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C178(0.94)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C178(1.06)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C178(0.85)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C178(1.28)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C178(1.26)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C178(0.78)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C178(0.97)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C178(0.75)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C178(0.95)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C178(0.99)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C178(0.82)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C178(0.97)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C178(1.01)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C178(0.91)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C178(0.91)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C178(1.10)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C178(0.93)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C178(1.04)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C178(1.02)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C178(0.89)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C178(0.98)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C178(0.93)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C178(0.95)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C178(0.95)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C178(1.05)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C178(1.36)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C178(1.01)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C178(0.97)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C178(1.06)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C178(1.22)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C178(1.21)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C178(1.31)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C178(1.20)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C178(1.83)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C178(0.68)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C178(0.84)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C178(0.97)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C178(0.96)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C178(0.83)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C178(1.08)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C178(0.83)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C178(0.86)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C178(0.96)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C178(1.04)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C178(1.03)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C178(0.78)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C178(1.04)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C178(0.98)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C178(1.00)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C178(1.02)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C178(1.26)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C178(0.97)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C178(0.93)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C178(1.26)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C178(0.99)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C178(0.87)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C178(0.98)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C178(1.05)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C178(1.01)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C178(1.04)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C178(1.13)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C178(1.02)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C178(1.26)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C178(1.13)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C178(1.18)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C178(1.30)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C178(1.36)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C178(1.28)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C178(1.09)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C178(1.14)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C178(0.83)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C178(0.70)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C178(0.87)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C178(0.95)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C178(0.97)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C178(1.20)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C178(0.97)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C178(0.91)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C178(1.17)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C178(1.00)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C178(0.82)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C178(0.98)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C178(1.05)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C178(0.99)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C178(0.94)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C178(1.02)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C178(1.03)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C178(1.33)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C178(1.30)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C178(1.35)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C178(1.27)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C178(1.46)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C178(1.38)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C178(1.27)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C178(1.43)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C178(1.39)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C178(1.50)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C178(1.32)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C178(1.36)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C178(1.48)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C178(1.44)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C178(1.55)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C178(1.00)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C178(0.81)  LDD0683  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C178(1.02)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C178(0.95)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C178(1.03)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C178(0.93)  LDD0592  [8]
 LDCM0020  ARS-1620 HCC44 C178(1.40)  LDD0078  [8]
 LDCM0498  BS-3668 MDA-MB-231 C105(1.03); C178(0.43)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C157(2.36)  LDD2214  [18]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0367  CL1 HCT 116 C178(1.12)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C178(1.27)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C178(1.06)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C178(0.78)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C178(0.71)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C178(0.89)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C178(0.87)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C178(1.01)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C178(1.06)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C178(0.88)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C178(0.96)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C178(1.07)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C178(0.88)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C178(0.89)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C178(1.05)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C178(1.01)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C178(1.04)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C178(1.19)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C178(1.01)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C178(1.41)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C178(0.74)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C178(0.73)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C178(1.10)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C178(1.13)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C178(0.93)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C178(1.16)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C178(1.03)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C178(1.00)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C178(1.08)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C178(1.12)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C178(1.33)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C178(1.35)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C178(1.14)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C178(1.53)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C178(1.47)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C178(1.05)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C178(1.47)  LDD0720  [8]
 LDCM0407  CL2 HCT 116 C178(1.19)  LDD0724  [8]
 LDCM0418  CL3 HCT 116 C178(1.15)  LDD0735  [8]
 LDCM0420  CL31 HCT 116 C178(1.06)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C178(1.26)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C178(1.26)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C178(1.06)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C178(1.21)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C178(1.00)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C178(1.33)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C178(1.13)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C178(0.97)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C178(1.09)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C178(1.08)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C178(1.07)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C178(1.21)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C178(1.25)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C178(1.20)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C178(1.02)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C178(1.51)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C178(1.14)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C178(1.14)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C178(1.21)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C178(1.15)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C178(1.10)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C178(1.39)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C178(1.01)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C178(1.04)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C178(1.15)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C178(1.41)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C178(1.05)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C178(1.21)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C178(1.22)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C178(1.49)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C178(1.16)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C178(1.14)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C178(1.15)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C178(1.12)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C178(1.11)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C178(1.06)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C178(1.12)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C178(1.12)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C178(1.12)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C178(1.25)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C178(1.27)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C178(1.34)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C178(1.15)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C178(1.27)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C178(1.27)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C178(1.17)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C178(1.18)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C178(1.10)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C178(1.12)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C178(1.32)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C178(1.15)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C178(0.99)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C178(1.07)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C178(1.29)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C178(1.08)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C178(1.15)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C178(1.12)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C178(1.17)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C178(1.00)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C178(1.03)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C178(1.15)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C178(1.25)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C178(0.98)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C178(1.03)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C178(0.81)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C178(1.32)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C178(1.44)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C178(0.91)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C178(1.12)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C178(1.48)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C178(1.20)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C178(0.97)  LDD0811  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C178(10.26); C105(6.69)  LDD1702  [6]
 LDCM0625  F8 Ramos C178(0.57); C157(0.59); C105(8.56)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C178(1.18); C157(0.57); C105(1.44)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C178(0.02); C157(0.02); C105(0.06)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C178(1.12); C157(0.80); C105(1.05)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C178(0.85); C157(0.53); C105(0.46)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C178(0.77); C157(0.73); C105(1.10)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C178(1.05); C157(0.85); C105(3.38)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C178(0.72); C157(0.69); C105(0.40)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C178(1.61); C157(0.49); C105(0.94)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C178(0.67); C157(0.61); C105(1.13)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C178(1.34); C157(7.44); C105(0.54)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C178(1.09); C157(0.55); C105(0.46)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C178(0.92); C157(0.76); C105(0.89)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C178(1.15); C157(0.46); C105(1.23)  LDD2201  [19]
 LDCM0468  Fragment33 HCT 116 C178(1.31)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C178(1.08); C157(0.40); C105(2.00)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C178(1.05); C157(0.90); C105(1.10)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C178(1.25)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C178(1.16); C157(0.61); C105(0.73)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C178(1.06); C157(0.85); C105(0.17)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C178(0.92); C157(0.79); C105(0.85)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C178(1.28); C157(1.09); C105(0.58)  LDD2188  [19]
 LDCM0015  HNE MDA-MB-231 C178(1.00); C157(0.91)  LDD0346  [19]
 LDCM0107  IAA HeLa N.A.  LDD0221  [16]
 LDCM0179  JZ128 PC-3 C157(0.00); C178(0.00)  LDD0462  [5]
 LDCM0022  KB02 Ramos C178(1.09); C157(0.50); C105(0.73)  LDD2182  [19]
 LDCM0023  KB03 MDA-MB-231 C178(34.40)  LDD1701  [6]
 LDCM0024  KB05 G361 C178(3.99); C176(1.43)  LDD3311  [20]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C178(0.60)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0224  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C178(0.53)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C178(1.86)  LDD2090  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C178(0.98)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C105(0.89)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C105(0.45)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C105(1.02); C178(1.05)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C105(1.10)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C105(1.12); C178(1.21)  LDD2099  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C178(1.36)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C105(0.97)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C105(1.18); C178(1.36)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C105(1.07); C178(0.86)  LDD2107  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C105(0.97); C178(0.80)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C178(0.89)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C105(0.75)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C105(0.65)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C105(0.79)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C105(0.91); C178(0.38)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C178(2.25)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C105(0.70); C178(0.93)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C105(1.00); C178(0.23)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C105(1.11); C178(0.87)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C105(0.92); C178(0.31)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C105(0.98); C178(0.74)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C105(1.00); C178(0.45)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C178(0.90)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C105(0.78); C178(0.98)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C105(1.21); C178(0.81)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C178(0.72)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C105(0.43); C178(0.65)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C178(0.95)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C178(1.11)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C105(1.02); C178(0.83)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C178(1.35)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C105(0.80); C178(0.62)  LDD2140  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C105(0.86); C178(1.04)  LDD2143  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C105(0.95); C178(0.89)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C178(3.90)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C105(0.63); C178(0.60)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C105(0.84); C178(0.38)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C105(0.99); C178(0.41)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C105(0.80)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C178(1.27)  LDD2153  [6]
 LDCM0131  RA190 MM1.R C178(1.12)  LDD0304  [21]
 LDCM0021  THZ1 HeLa S3 C157(1.10)  LDD0460  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phospholipase D2 (PLD2) Phospholipase D family O14939
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor alpha-induced protein 8-like protein 2 (TNFAIP8L2) TNFAIP8 family Q6P589
Arfaptin-2 (ARFIP2) . P53365

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dextromethorphan Small molecular drug DB00514

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
18 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.