Details of the Target

General Information of Target

Target ID LDTP16107
Target Name TBC1 domain family member 13 (TBC1D13)
Gene Name TBC1D13
Gene ID 54662
Synonyms
TBC1 domain family member 13
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGFLHVGQDGLELPTSGDPPASASQSAGITGVSHRTQPPCFEGLTSKDLVREEKTRKRKR
KAKESGMALLQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDTSSKCM
MKMFSSTGQGNTEVVHTGTLQIHASHHIGDTCFQEIEKDIHDFVFQWQENETNGHEALMT
KTKKLMSSTERHDQRHAGNKPIKNELGSSFHSHLPEVHIFHPEGKIGNQVEKAINDAFSV
SASQRISCRPKTRISNKYRNNFLQSSLLTQKREVHTREKSFQRNESGKAFNGSSLLKKHQ
IIHLGDKQYKCDVCGKDFHQKRYLACHRCHTGENPYTCNECGKTFSHNSALLVHKAIHTG
EKPYKCNECGKVFNQQSNLARHHRVHTGEKPYKCEECDKVFSRKSHLERHRRIHTGEKPY
KCKVCDKAFRRDSHLAQHTVIHTGEKPYKCNECGKTFVQNSSLVMHKVIHTGEKRYKCNE
CGKVFNHKSNLACHRRLHTGEKPYKCNECGKVFNRKSNLERHHRLHTGKKS
Target Bioclass
Other
Subcellular location
Membrane
Function Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.
Uniprot ID
Q9NVG8
Ensemble ID
ENST00000223865.8
HGNC ID
HGNC:25571

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCLP1 SNV: p.E98G .
HCT15 SNV: p.W338Ter .
HEC1 SNV: p.R109W; p.P382T DBIA    Probe Info 
HEC1B SNV: p.R109W IA-alkyne    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
STPyne
 Probe Info  		K168(10.00); K392(1.49)  LDD0277  [3]
Sulforaphane-probe2
 Probe Info  		1.77  LDD0160  [4]
DA-P3
 Probe Info  		4.37  LDD0181  [5]
AHL-Pu-1
 Probe Info  		C387(2.16)  LDD0169  [6]
EA-probe
 Probe Info  		C145(0.79)  LDD2210  [7]
DBIA
 Probe Info  		C282(1.13)  LDD0078  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C145(0.00); C36(0.00); C131(0.00); C387(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C36(0.00); C282(0.00); C145(0.00); C131(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C145(0.00); C36(0.00); C131(0.00); C387(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		C145(0.00); C131(0.00); C387(0.00)  LDD0026  [10]
NAIA_4
 Probe Info  		C36(0.00); C131(0.00); C145(0.00); C387(0.00)  LDD2226  [11]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
WYneN
 Probe Info  		C387(0.00); C282(0.00); C36(0.00)  LDD0021  [12]
Compound 10
 Probe Info  		C282(0.00); C36(0.00)  LDD2216  [13]
Compound 11
 Probe Info  		C282(0.00); C36(0.00)  LDD2213  [13]
ENE
 Probe Info  		N.A.  LDD0006  [12]
IPM
 Probe Info  		C387(0.00); C282(0.00); C36(0.00)  LDD0005  [12]
VSF
 Probe Info  		C387(0.00); C282(0.00)  LDD0007  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
W1
 Probe Info  		C282(0.00); C36(0.00); C131(0.00)  LDD0236  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		22.01  LDD1752  [17]
C246
 Probe Info  		13.45  LDD1919  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C387(2.16)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C282(0.76)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C282(1.09)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C282(1.21)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C282(1.10)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C282(1.17)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C282(1.50)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C282(1.24)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C282(0.89)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C282(1.50)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C282(1.02)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C282(1.10)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C282(1.02)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C282(1.09)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C282(1.08)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C282(1.48)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C282(1.14)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C282(1.02); C36(0.53)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C282(1.14); C36(0.50)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C282(1.24); C36(0.53)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C282(1.22); C36(0.79)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C282(1.19); C36(0.60)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C282(1.01); C36(0.51)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C282(1.21); C36(0.59)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C282(1.09)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C282(1.26); C36(0.46)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C282(0.99); C36(0.52)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C282(1.20); C36(0.51)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C282(0.93); C36(0.60)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C282(0.99); C36(0.57)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C282(1.08); C36(0.56)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C282(1.10); C36(0.49)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C282(1.26); C36(0.58)  LDD0562  [8]
 LDCM0246  AC128 HEK-293T C282(0.80); C131(0.81); C36(1.26)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C282(0.92); C131(0.75); C36(1.86)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C282(0.87); C131(0.95); C36(2.00)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C282(0.84); C131(1.04); C36(1.06)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C282(1.17); C131(0.76); C36(1.45)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C282(1.02); C131(1.01); C36(2.00)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C282(0.87); C131(0.99); C36(1.39)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C282(1.08); C131(1.03); C36(1.31)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C282(0.88); C131(1.04); C36(1.35)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C282(0.96); C131(0.73); C36(1.69)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C282(0.98); C131(0.86); C36(2.19)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C282(1.16); C131(0.82); C36(2.56)  LDD0856  [8]
 LDCM0259  AC14 HCT 116 C282(0.98)  LDD0576  [8]
 LDCM0260  AC140 HEK-293T C282(1.03); C131(0.92); C36(1.79)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C282(0.93); C131(0.87); C36(1.41)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C282(1.07); C131(0.88); C36(1.52)  LDD0860  [8]
 LDCM0263  AC143 HEK-293T C282(1.13); C131(0.96); C145(0.85); C36(1.18)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C282(1.21); C131(1.00); C145(0.92); C36(2.49)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C282(1.34); C131(1.02); C145(0.83); C36(1.56)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C282(1.18); C131(1.13); C145(0.81); C36(2.16)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C282(1.10); C131(1.00); C145(0.78); C36(1.43)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C282(1.14); C131(0.91); C145(0.70); C36(1.42)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C282(0.97); C131(0.94); C145(0.75); C36(1.08)  LDD0867  [8]
 LDCM0270  AC15 HCT 116 C282(1.04)  LDD0587  [8]
 LDCM0271  AC150 HEK-293T C282(1.04); C131(0.88); C145(0.76); C36(1.34)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C282(1.18); C131(1.03); C145(0.80); C36(1.30)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C282(1.02); C131(0.99); C145(0.74); C36(2.08)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C282(1.12); C131(0.99); C145(0.74); C36(2.12)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C282(0.99); C131(1.09); C145(0.86); C36(1.91)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C282(1.01); C131(0.96); C145(0.81); C36(1.57)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C282(1.19); C131(0.91); C145(0.84); C36(1.55)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C282(1.14); C131(1.20); C145(0.85); C36(2.10)  LDD2165  [8]
 LDCM0276  AC17 HCT 116 C282(0.99)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C282(1.00)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C282(1.06)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C282(0.95)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C282(0.96)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C282(0.94)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C282(0.92)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C282(0.93)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C282(1.17)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C282(0.67)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C282(0.70)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C282(0.73)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C282(0.68)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C282(0.74)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C282(0.84)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C282(0.85)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C282(0.68)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C282(0.66)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C282(0.74)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C282(0.95)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C282(0.85)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C282(0.85)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C282(1.02)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C282(0.95)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C282(1.61)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C282(0.80)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C282(1.29)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C282(1.04)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C282(1.22)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C282(1.13)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C282(1.26)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C282(1.16)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C282(1.15)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C282(1.06)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C282(1.01)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C282(1.05)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C282(0.91)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C282(0.94)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C282(0.95)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C282(0.97)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C282(1.06)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C282(0.83)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C282(1.36)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C282(1.16)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C282(0.99)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C282(0.99)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C282(1.00)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C282(1.23)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C282(1.25)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C282(0.89)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C282(1.17)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C282(1.35)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C282(1.20)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C282(1.04)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C282(0.93)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C282(1.17)  LDD0648  [8]
 LDCM0332  AC68 HEK-293T C282(0.95); C131(1.11); C145(0.91); C261(1.01)  LDD0930  [8]
 LDCM0333  AC69 HEK-293T C282(0.93); C131(1.17); C145(1.00); C261(0.98)  LDD0931  [8]
 LDCM0334  AC7 HCT 116 C282(1.21)  LDD0651  [8]
 LDCM0335  AC70 HEK-293T C282(0.95); C131(1.30); C145(0.84); C261(1.37)  LDD0933  [8]
 LDCM0336  AC71 HEK-293T C282(0.90); C131(1.30); C145(0.98); C261(1.06)  LDD0934  [8]
 LDCM0337  AC72 HEK-293T C282(1.03); C131(1.10); C145(0.88); C261(1.13)  LDD0935  [8]
 LDCM0338  AC73 HEK-293T C282(1.03); C131(1.19); C145(0.84); C261(1.13)  LDD0936  [8]
 LDCM0339  AC74 HEK-293T C282(0.77); C131(1.34); C145(0.75); C261(1.22)  LDD0937  [8]
 LDCM0340  AC75 HEK-293T C282(0.92); C131(1.29); C145(0.92); C261(1.34)  LDD0938  [8]
 LDCM0341  AC76 HEK-293T C282(0.93); C131(1.12); C145(0.94); C261(1.05)  LDD0939  [8]
 LDCM0342  AC77 HEK-293T C282(0.85); C131(1.22); C145(0.88); C261(1.28)  LDD0940  [8]
 LDCM0343  AC78 HEK-293T C282(0.89); C131(1.14); C145(0.96); C261(1.23)  LDD0941  [8]
 LDCM0344  AC79 HEK-293T C282(0.69); C131(1.23); C145(1.06); C261(1.06)  LDD0942  [8]
 LDCM0345  AC8 HCT 116 C282(1.23)  LDD0662  [8]
 LDCM0346  AC80 HEK-293T C282(0.86); C131(1.21); C145(0.87); C261(1.42)  LDD0944  [8]
 LDCM0347  AC81 HEK-293T C282(0.83); C131(1.24); C145(0.97); C261(1.32)  LDD0945  [8]
 LDCM0348  AC82 HEK-293T C282(0.89); C131(1.12); C145(0.82); C261(2.50)  LDD0946  [8]
 LDCM0349  AC83 HCT 116 C282(1.25); C36(1.66)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C282(1.28); C36(1.68)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C36(1.36); C282(1.40)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C36(1.24); C282(1.26)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C36(0.92); C282(0.99)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C282(1.04); C36(1.19)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C282(1.14); C36(1.31)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C36(0.74); C282(1.09)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C282(1.29); C36(1.85)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C282(1.29); C36(1.69)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C36(1.14); C282(1.28)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C36(1.16); C282(1.48)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C36(1.15); C282(1.24)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C36(1.20); C282(1.39)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C36(1.29); C282(1.40)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C282(0.94)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C282(1.26)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C282(1.03)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C282(0.99)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C282(1.32)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C282(1.13)  LDD0078  [8]
 LDCM0630  CCW28-3 231MFP C36(2.57); C282(1.53); C145(0.48)  LDD2214  [18]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C387(1.22)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C282(1.10)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C282(1.11)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C282(0.77)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C282(1.24)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C282(1.23)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C282(1.10)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C282(1.04)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C282(1.01)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C282(0.83)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C282(0.91)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C282(0.98)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C282(1.14)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C282(1.82)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C282(1.01)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C282(1.06)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C282(0.61)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C282(0.62)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C282(0.78)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C282(0.77)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C282(0.85)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C282(1.37)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C282(1.04)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C282(1.19)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C282(1.12)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C282(0.92)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C282(1.08)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C282(1.00)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C282(1.03)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C282(1.12)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C282(1.14)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C282(1.11)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C282(1.08)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C282(0.90)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C282(0.80)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C282(0.90)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C282(1.22)  LDD0719  [8]
 LDCM0403  CL16 HEK-293T C282(0.92); C131(1.16); C204(1.06); C36(1.07)  LDD1001  [8]
 LDCM0404  CL17 HCT 116 C282(1.29)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C282(0.97)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C282(0.93)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C282(0.87)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C282(1.23)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C282(1.47)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C282(0.96)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C282(1.19)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C282(0.92)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C282(1.05)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C282(1.07)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C282(0.89)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C282(0.96)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C282(1.07)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C282(0.93)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C282(1.02)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C282(1.03); C36(0.98)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C282(1.20); C36(1.00)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C282(5.15); C36(1.20)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C282(1.72); C36(1.31)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C282(1.69); C36(1.13)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C282(1.36); C36(1.12)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C282(1.81); C36(1.18)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C282(2.71); C36(1.10)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C282(0.99)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C282(1.22); C36(1.08)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C282(1.25); C36(1.03)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C282(2.69); C36(1.09)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C282(1.67); C36(1.13)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C282(2.47); C36(1.14)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C282(2.18); C36(1.27)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C36(0.91)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C36(0.71)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C36(0.63)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C36(0.66)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C282(0.75)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C36(0.92)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C36(0.94)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C36(0.64)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C36(0.79)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C36(0.72)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C36(0.45)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C36(0.82)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C36(1.03)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C36(0.77)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C36(0.72)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C282(0.79)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C36(1.10)  LDD0769  [8]
 LDCM0453  CL61 HEK-293T C282(1.04); C131(1.15); C36(1.44)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C282(1.46); C131(0.83); C36(1.09)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C282(1.06); C131(1.20); C36(0.98)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C282(1.19); C131(1.05); C36(1.38)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C282(0.88); C131(0.96); C36(1.11)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C282(1.02); C131(1.01); C36(0.93)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C282(0.92); C131(1.07); C36(1.03)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C282(1.37); C131(1.02); C36(1.18)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C282(1.12); C131(0.92); C36(1.23)  LDD1059  [8]
 LDCM0462  CL7 HCT 116 C282(0.97)  LDD0779  [8]
 LDCM0463  CL70 HEK-293T C282(1.05); C131(1.02); C36(0.86)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C282(1.47); C131(0.93); C36(0.82)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C282(1.05); C131(1.16); C36(1.32)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C282(1.42); C131(0.92); C36(1.23)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C282(1.53); C131(0.98); C36(1.42)  LDD1065  [8]
 LDCM0469  CL76 HEK-293T C282(0.95); C131(0.78); C261(0.93); C36(0.94)  LDD1067  [8]
 LDCM0470  CL77 HEK-293T C282(1.01); C131(1.03); C261(1.16); C36(1.41)  LDD1068  [8]
 LDCM0471  CL78 HEK-293T C282(0.88); C131(2.07); C261(0.89); C36(1.03)  LDD1069  [8]
 LDCM0472  CL79 HEK-293T C282(1.14); C131(1.20); C261(1.40); C36(1.09)  LDD1070  [8]
 LDCM0473  CL8 HCT 116 C282(1.02)  LDD0790  [8]
 LDCM0474  CL80 HEK-293T C282(1.03); C131(0.77); C261(0.85); C36(1.06)  LDD1072  [8]
 LDCM0475  CL81 HEK-293T C282(1.01); C131(1.14); C261(1.25); C36(0.93)  LDD1073  [8]
 LDCM0476  CL82 HEK-293T C282(1.00); C131(0.81); C261(1.32); C36(0.89)  LDD1074  [8]
 LDCM0477  CL83 HEK-293T C282(0.86); C131(0.73); C261(1.47); C36(0.98)  LDD1075  [8]
 LDCM0478  CL84 HEK-293T C282(0.79); C131(0.47); C261(0.93); C36(1.45)  LDD1076  [8]
 LDCM0479  CL85 HEK-293T C282(0.99); C131(0.84); C261(0.96); C36(1.15)  LDD1077  [8]
 LDCM0480  CL86 HEK-293T C282(1.06); C131(0.82); C261(1.07); C36(1.21)  LDD1078  [8]
 LDCM0481  CL87 HEK-293T C282(1.02); C131(0.84); C261(1.00); C36(1.51)  LDD1079  [8]
 LDCM0482  CL88 HEK-293T C282(1.06); C131(0.60); C261(1.26); C36(1.51)  LDD1080  [8]
 LDCM0483  CL89 HEK-293T C282(0.92); C131(1.60); C261(1.02); C36(1.03)  LDD1081  [8]
 LDCM0484  CL9 HCT 116 C282(0.95)  LDD0801  [8]
 LDCM0485  CL90 HEK-293T C282(1.11); C131(0.63); C261(1.42); C36(1.51)  LDD1083  [8]
 LDCM0486  CL91 HCT 116 C282(1.27)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C282(1.29)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C282(0.86)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C282(0.81)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C282(1.16)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C282(1.07)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C282(1.16)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C282(0.98)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C282(0.86)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C282(0.90); C36(1.07); C131(0.96); C145(0.84)  LDD1698  [19]
 LDCM0175  Ethacrynic acid HeLa C145(0.79)  LDD2210  [7]
 LDCM0625  F8 Ramos C36(1.18); C282(1.56); C387(0.87)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C36(3.05); C131(0.71); C282(9.11); C387(6.09)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C36(0.29); C282(20.00); C387(0.55)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C36(0.84); C131(0.62); C282(1.58); C387(1.36)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C36(0.95); C282(0.90); C387(0.94); C145(0.43)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C36(0.74); C282(0.63); C387(1.32); C145(1.39)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C36(1.02); C131(0.51); C282(7.06); C387(2.80)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C36(0.88); C131(0.54); C282(0.87); C387(0.99)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C36(0.95); C282(1.15); C387(1.63); C145(1.13)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C36(0.73); C131(1.83); C282(0.77); C387(0.74)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C36(1.06); C131(0.81); C282(0.87); C387(0.81)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C36(1.31); C282(1.99); C387(1.05); C145(0.96)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C36(0.80); C282(0.77); C387(0.96); C145(1.08)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C36(1.58); C282(3.25); C387(1.38); C145(0.89)  LDD2201  [20]
 LDCM0468  Fragment33 HEK-293T C282(1.20); C131(1.05); C36(1.26)  LDD1066  [8]
 LDCM0596  Fragment38 Ramos C36(0.60); C131(1.82); C282(0.86); C387(0.96)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C36(1.13); C282(1.77); C387(0.85); C145(1.50)  LDD2184  [20]
 LDCM0427  Fragment51 HCT 116 C282(2.15); C36(1.46)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C36(0.84); C131(0.84); C282(0.89); C387(1.08)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C36(0.92); C131(1.30); C282(0.86); C387(1.30)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C36(4.86); C387(2.39); C145(2.89)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C36(1.82); C131(0.45); C282(13.60); C387(1.50)  LDD2188  [20]
 LDCM0015  HNE MDA-MB-231 C387(1.01)  LDD0346  [20]
 LDCM0022  KB02 HCT 116 C387(2.90); C282(6.84)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C387(1.33); C282(1.47)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C387(1.77); C282(1.56)  LDD0082  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C387(0.85); C282(0.57); C36(0.28)  LDD2206  [21]
 LDCM0628  OTUB2-COV-1 HEK-293T C36(1.03); C282(0.67); C36(0.67); C387(0.27)  LDD2207  [21]
 LDCM0029  Quercetin HEK-293T 4.37  LDD0181  [5]
 LDCM0131  RA190 MM1.R C282(1.55); C36(1.05)  LDD0304  [22]
 LDCM0003  Sulforaphane MDA-MB-231 1.77  LDD0160  [4]
 LDCM0112  W16 Hep-G2 C282(0.65); C36(0.68)  LDD0239  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-4 complex accessory subunit Tepsin (TEPSIN) . Q96N21
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 618 (ZNF618) Krueppel C2H2-type zinc-finger protein family Q5T7W0
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Perilipin-3 (PLIN3) Perilipin family O60664
Speedy protein E4 (SPDYE4) Speedy/Ringo family A6NLX3
Rho guanine nucleotide exchange factor 5 (ARHGEF5) . Q12774

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
22 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.