Details of the Target

General Information of Target

Target ID LDTP13834
Target Name Sodium-dependent multivitamin transporter (SLC5A6)
Gene Name SLC5A6
Gene ID 8884
Synonyms
SMVT; Sodium-dependent multivitamin transporter; Na(+)-dependent multivitamin transporter; hSMVT; Solute carrier family 5 member 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFG
LAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIK
IFEEEEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNL
LELLINIKAGTYLPQSYLIHEHMVITDRIENIDHLGFFIYRLCHDKETYKLQRRETIKGI
QKREASNCFAIRHFENKFAVETLICS
Target Type
Successful
Target Bioclass
Transporter and channel
Family
Sodium:solute symporter (SSF) (TC 2.A.21) family
Subcellular location
Cell membrane
Function
Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide. Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake. Required for biotin and pantothenate uptake in the intestine across the brush border membrane. Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin. Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier.
TTD ID
T62905
Uniprot ID
Q9Y289
DrugMap ID
TT61XTV
Ensemble ID
ENST00000310574.8
HGNC ID
HGNC:11041

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.98  LDD0402  [1]
FBPP2
 Probe Info  		2.20  LDD0318  [2]
CHEMBL5175495
 Probe Info  		9.06  LDD0196  [3]
Johansson_61
 Probe Info  		_(20.00)  LDD1487  [4]
DBIA
 Probe Info  		C628(0.87)  LDD0531  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
VSF
 Probe Info  		N.A.  LDD0007  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alk-rapa
 Probe Info  		3.56  LDD0213  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C628(0.87)  LDD0531  [5]
 LDCM0215  AC10 HEK-293T C628(1.36)  LDD0813  [5]
 LDCM0216  AC100 PaTu 8988t C577(1.09)  LDD1095  [5]
 LDCM0217  AC101 PaTu 8988t C577(1.05)  LDD1096  [5]
 LDCM0218  AC102 PaTu 8988t C577(1.10)  LDD1097  [5]
 LDCM0219  AC103 PaTu 8988t C577(0.91)  LDD1098  [5]
 LDCM0220  AC104 PaTu 8988t C577(0.98)  LDD1099  [5]
 LDCM0221  AC105 PaTu 8988t C577(0.90)  LDD1100  [5]
 LDCM0222  AC106 PaTu 8988t C577(1.01)  LDD1101  [5]
 LDCM0223  AC107 PaTu 8988t C577(0.76)  LDD1102  [5]
 LDCM0224  AC108 PaTu 8988t C577(0.99)  LDD1103  [5]
 LDCM0225  AC109 PaTu 8988t C577(0.91)  LDD1104  [5]
 LDCM0226  AC11 HEK-293T C628(1.47)  LDD0824  [5]
 LDCM0227  AC110 PaTu 8988t C577(1.18)  LDD1106  [5]
 LDCM0228  AC111 PaTu 8988t C577(1.10)  LDD1107  [5]
 LDCM0229  AC112 PaTu 8988t C577(1.08)  LDD1108  [5]
 LDCM0230  AC113 PaTu 8988t C577(0.99)  LDD1109  [5]
 LDCM0231  AC114 PaTu 8988t C577(0.90)  LDD1110  [5]
 LDCM0232  AC115 PaTu 8988t C577(0.85)  LDD1111  [5]
 LDCM0233  AC116 PaTu 8988t C577(0.94)  LDD1112  [5]
 LDCM0234  AC117 PaTu 8988t C577(0.91)  LDD1113  [5]
 LDCM0235  AC118 PaTu 8988t C577(0.93)  LDD1114  [5]
 LDCM0236  AC119 PaTu 8988t C577(1.00)  LDD1115  [5]
 LDCM0237  AC12 HEK-293T C628(1.06)  LDD0835  [5]
 LDCM0238  AC120 PaTu 8988t C577(0.92)  LDD1117  [5]
 LDCM0239  AC121 PaTu 8988t C577(0.94)  LDD1118  [5]
 LDCM0240  AC122 PaTu 8988t C577(1.10)  LDD1119  [5]
 LDCM0241  AC123 PaTu 8988t C577(1.04)  LDD1120  [5]
 LDCM0242  AC124 PaTu 8988t C577(1.04)  LDD1121  [5]
 LDCM0243  AC125 PaTu 8988t C577(1.00)  LDD1122  [5]
 LDCM0244  AC126 PaTu 8988t C577(0.90)  LDD1123  [5]
 LDCM0245  AC127 PaTu 8988t C577(0.93)  LDD1124  [5]
 LDCM0246  AC128 PaTu 8988t C577(0.90)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C577(0.95)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C577(0.92)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C577(0.86)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C577(0.93)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C577(0.87)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C577(0.80)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C577(0.91)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C577(0.81)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C577(0.81)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C577(0.91)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C577(0.91)  LDD1137  [5]
 LDCM0259  AC14 HEK-293T C628(1.44)  LDD0857  [5]
 LDCM0260  AC140 PaTu 8988t C577(0.85)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C577(0.98)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C577(0.87)  LDD1141  [5]
 LDCM0263  AC143 PaTu 8988t C628(1.16)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C628(1.53)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C628(1.31)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C628(1.20)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C628(1.40)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C628(1.55)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C628(1.79)  LDD1148  [5]
 LDCM0270  AC15 HEK-293T C628(1.26)  LDD0868  [5]
 LDCM0271  AC150 PaTu 8988t C628(1.89)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C628(2.53)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C628(1.41)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C628(1.66)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C628(2.05)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C628(2.10)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C628(2.00)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C628(1.89)  LDD2169  [5]
 LDCM0276  AC17 HEK-293T C577(1.11)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C577(1.01)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C577(1.16)  LDD1517  [11]
 LDCM0279  AC2 HCT 116 C628(0.96)  LDD0596  [5]
 LDCM0280  AC20 HEK-293T C577(0.91)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C577(1.03)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C577(0.95)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C577(1.02)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C577(0.92)  LDD1523  [11]
 LDCM0285  AC25 HCT 116 C628(1.10)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C628(1.83)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C628(1.10)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C628(1.39)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C628(1.58)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C628(1.15)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C628(1.56)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C628(1.19)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C628(1.45)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C628(1.03)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C628(1.02)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C628(0.73)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C628(0.80)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C628(0.85)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C628(1.01)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C628(0.99)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C628(1.00)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C628(0.81)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C628(0.77)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C628(0.89)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C628(0.86)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C628(0.72)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C628(0.75)  LDD0624  [5]
 LDCM0308  AC46 PaTu 8988t C628(1.02)  LDD1187  [5]
 LDCM0309  AC47 PaTu 8988t C628(0.70)  LDD1188  [5]
 LDCM0310  AC48 PaTu 8988t C628(0.88)  LDD1189  [5]
 LDCM0311  AC49 PaTu 8988t C628(1.19)  LDD1190  [5]
 LDCM0312  AC5 HCT 116 C628(1.19)  LDD0629  [5]
 LDCM0313  AC50 PaTu 8988t C628(0.83)  LDD1192  [5]
 LDCM0314  AC51 PaTu 8988t C628(0.72)  LDD1193  [5]
 LDCM0315  AC52 PaTu 8988t C628(1.02)  LDD1194  [5]
 LDCM0316  AC53 PaTu 8988t C628(1.18)  LDD1195  [5]
 LDCM0317  AC54 PaTu 8988t C628(1.39)  LDD1196  [5]
 LDCM0318  AC55 PaTu 8988t C628(0.97)  LDD1197  [5]
 LDCM0319  AC56 PaTu 8988t C628(0.87)  LDD1198  [5]
 LDCM0320  AC57 HEK-293T C628(0.81)  LDD0918  [5]
 LDCM0321  AC58 HEK-293T C628(0.98)  LDD0919  [5]
 LDCM0322  AC59 HEK-293T C628(0.98)  LDD0920  [5]
 LDCM0323  AC6 HEK-293T C628(1.13)  LDD0921  [5]
 LDCM0324  AC60 HEK-293T C628(0.83)  LDD0922  [5]
 LDCM0325  AC61 HEK-293T C628(0.90)  LDD0923  [5]
 LDCM0326  AC62 HEK-293T C628(0.99)  LDD0924  [5]
 LDCM0327  AC63 HEK-293T C628(1.61)  LDD0925  [5]
 LDCM0328  AC64 HEK-293T C628(1.24)  LDD0926  [5]
 LDCM0329  AC65 HEK-293T C628(0.89)  LDD0927  [5]
 LDCM0330  AC66 HEK-293T C628(1.14)  LDD0928  [5]
 LDCM0331  AC67 HEK-293T C628(1.14)  LDD0929  [5]
 LDCM0332  AC68 HCT 116 C628(0.91)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C628(0.79)  LDD0650  [5]
 LDCM0334  AC7 HEK-293T C628(1.25)  LDD0932  [5]
 LDCM0335  AC70 HCT 116 C628(1.03)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C628(0.84)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C628(0.93)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C628(0.96)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C628(0.81)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C628(0.92)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C628(0.75)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C628(0.84)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C628(0.87)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C628(0.94)  LDD0661  [5]
 LDCM0345  AC8 HEK-293T C628(1.27)  LDD0943  [5]
 LDCM0346  AC80 HCT 116 C628(0.74)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C628(0.92)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C628(0.77)  LDD0665  [5]
 LDCM0349  AC83 PaTu 8988t C628(0.70); C577(0.86)  LDD1228  [5]
 LDCM0350  AC84 PaTu 8988t C628(0.83); C577(0.99)  LDD1229  [5]
 LDCM0351  AC85 PaTu 8988t C628(0.62); C577(0.88)  LDD1230  [5]
 LDCM0352  AC86 PaTu 8988t C628(0.80); C577(0.96)  LDD1231  [5]
 LDCM0353  AC87 PaTu 8988t C628(0.96); C577(0.89)  LDD1232  [5]
 LDCM0354  AC88 PaTu 8988t C628(0.79); C577(0.95)  LDD1233  [5]
 LDCM0355  AC89 PaTu 8988t C628(0.70); C577(1.11)  LDD1234  [5]
 LDCM0357  AC90 PaTu 8988t C628(0.75); C577(1.08)  LDD1236  [5]
 LDCM0358  AC91 PaTu 8988t C628(0.94); C577(0.90)  LDD1237  [5]
 LDCM0359  AC92 PaTu 8988t C628(0.82); C577(1.02)  LDD1238  [5]
 LDCM0360  AC93 PaTu 8988t C628(0.59); C577(0.84)  LDD1239  [5]
 LDCM0361  AC94 PaTu 8988t C628(0.70); C577(0.97)  LDD1240  [5]
 LDCM0362  AC95 PaTu 8988t C628(0.74); C577(0.92)  LDD1241  [5]
 LDCM0363  AC96 PaTu 8988t C628(0.84); C577(0.98)  LDD1242  [5]
 LDCM0364  AC97 PaTu 8988t C628(0.68); C577(1.17)  LDD1243  [5]
 LDCM0365  AC98 PaTu 8988t C577(1.04)  LDD1244  [5]
 LDCM0366  AC99 PaTu 8988t C577(0.98)  LDD1245  [5]
 LDCM0248  AKOS034007472 HEK-293T C628(1.38)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C628(1.39)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C628(1.08)  LDD0873  [5]
 LDCM0156  Aniline NCI-H1299 12.27  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C628(0.98)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C628(0.82)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C628(0.85)  LDD0686  [5]
 LDCM0370  CL101 HEK-293T C628(1.24)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C628(1.81)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C628(1.45)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C628(1.39)  LDD0971  [5]
 LDCM0374  CL105 HEK-293T C577(1.16)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C577(1.32)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C577(0.93)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C577(1.02); C628(1.17)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C577(1.57)  LDD1582  [11]
 LDCM0379  CL11 HCT 116 C628(0.82)  LDD0696  [5]
 LDCM0380  CL110 HEK-293T C577(2.04)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C577(1.26)  LDD1585  [11]
 LDCM0382  CL112 HCT 116 C628(1.10)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C628(1.58)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C628(1.26)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C628(1.08)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C628(0.91)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C628(0.93)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C628(0.89)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C628(0.80)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C628(0.70)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C628(0.93)  LDD0708  [5]
 LDCM0392  CL121 PaTu 8988t C628(1.15)  LDD1271  [5]
 LDCM0393  CL122 PaTu 8988t C628(1.16)  LDD1272  [5]
 LDCM0394  CL123 PaTu 8988t C628(0.75)  LDD1273  [5]
 LDCM0395  CL124 PaTu 8988t C628(0.91)  LDD1274  [5]
 LDCM0396  CL125 HEK-293T C628(1.00)  LDD0994  [5]
 LDCM0397  CL126 HEK-293T C628(0.72)  LDD0995  [5]
 LDCM0398  CL127 HEK-293T C628(1.36)  LDD0996  [5]
 LDCM0399  CL128 HEK-293T C628(1.09)  LDD0997  [5]
 LDCM0400  CL13 HCT 116 C628(0.79)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C628(0.83)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C628(0.91)  LDD0719  [5]
 LDCM0403  CL16 HEK-293T C628(1.04)  LDD1001  [5]
 LDCM0404  CL17 HEK-293T C628(1.78)  LDD1002  [5]
 LDCM0405  CL18 HEK-293T C628(1.43)  LDD1003  [5]
 LDCM0406  CL19 HEK-293T C628(1.55)  LDD1004  [5]
 LDCM0407  CL2 HCT 116 C628(1.01)  LDD0724  [5]
 LDCM0408  CL20 HEK-293T C628(1.29)  LDD1006  [5]
 LDCM0409  CL21 HEK-293T C628(1.49)  LDD1007  [5]
 LDCM0410  CL22 HEK-293T C628(1.51)  LDD1008  [5]
 LDCM0411  CL23 HEK-293T C628(1.46)  LDD1009  [5]
 LDCM0412  CL24 HEK-293T C628(1.72)  LDD1010  [5]
 LDCM0413  CL25 HEK-293T C628(1.54)  LDD1011  [5]
 LDCM0414  CL26 HEK-293T C628(0.86)  LDD1012  [5]
 LDCM0415  CL27 HEK-293T C628(2.06)  LDD1013  [5]
 LDCM0416  CL28 HEK-293T C628(1.64)  LDD1014  [5]
 LDCM0417  CL29 HEK-293T C628(1.14)  LDD1015  [5]
 LDCM0418  CL3 HCT 116 C628(0.73)  LDD0735  [5]
 LDCM0419  CL30 HEK-293T C628(1.29)  LDD1017  [5]
 LDCM0420  CL31 PaTu 8988t C628(1.68)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C628(1.57)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C628(1.44)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C628(1.63)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C628(1.73)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C628(1.99)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C628(1.78)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C628(1.31)  LDD1307  [5]
 LDCM0429  CL4 HCT 116 C628(1.03)  LDD0746  [5]
 LDCM0430  CL40 PaTu 8988t C628(1.32)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C628(1.48)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C628(2.54)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C628(3.13)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C628(1.46)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C628(1.84)  LDD1314  [5]
 LDCM0436  CL46 HEK-293T C577(1.03)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C577(0.96)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C577(0.98)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C577(1.05)  LDD1643  [11]
 LDCM0440  CL5 HCT 116 C628(0.72)  LDD0757  [5]
 LDCM0441  CL50 HEK-293T C577(2.03)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C577(1.04); C628(1.40)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C577(1.88)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C577(2.01)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C577(0.95)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C577(0.97)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C577(1.44)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C577(1.07)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C577(1.02)  LDD1653  [11]
 LDCM0451  CL6 HCT 116 C628(0.91)  LDD0768  [5]
 LDCM0452  CL60 HEK-293T C577(0.95)  LDD1655  [11]
 LDCM0453  CL61 PaTu 8988t C577(1.08)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C577(1.02)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C577(1.18)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C577(1.31)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C577(1.21)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C577(1.15)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C577(1.17)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C577(0.88)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C577(1.33)  LDD1340  [5]
 LDCM0462  CL7 HCT 116 C628(1.12)  LDD0779  [5]
 LDCM0463  CL70 PaTu 8988t C577(1.03)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C577(1.15)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C577(0.97)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C577(1.39)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C577(1.22)  LDD1346  [5]
 LDCM0469  CL76 HEK-293T C628(1.04)  LDD1067  [5]
 LDCM0470  CL77 HEK-293T C628(0.91)  LDD1068  [5]
 LDCM0471  CL78 HEK-293T C628(1.11)  LDD1069  [5]
 LDCM0472  CL79 HEK-293T C628(1.09)  LDD1070  [5]
 LDCM0473  CL8 HCT 116 C628(0.98)  LDD0790  [5]
 LDCM0474  CL80 HEK-293T C628(0.87)  LDD1072  [5]
 LDCM0475  CL81 HEK-293T C628(0.89)  LDD1073  [5]
 LDCM0476  CL82 HEK-293T C628(0.79)  LDD1074  [5]
 LDCM0477  CL83 HEK-293T C628(1.25)  LDD1075  [5]
 LDCM0478  CL84 HEK-293T C628(1.22)  LDD1076  [5]
 LDCM0479  CL85 HEK-293T C628(1.04)  LDD1077  [5]
 LDCM0480  CL86 HEK-293T C628(1.01)  LDD1078  [5]
 LDCM0481  CL87 HEK-293T C628(0.98)  LDD1079  [5]
 LDCM0482  CL88 HEK-293T C628(1.06)  LDD1080  [5]
 LDCM0483  CL89 HEK-293T C628(1.43)  LDD1081  [5]
 LDCM0484  CL9 HCT 116 C628(0.95)  LDD0801  [5]
 LDCM0485  CL90 HEK-293T C628(1.01)  LDD1083  [5]
 LDCM0486  CL91 HCT 116 C628(1.27)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C628(0.89)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C628(0.85)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C628(0.70)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C628(1.03)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C628(1.11)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C628(1.26)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C628(1.19)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C628(1.10)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C577(1.02)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C577(36.15)  LDD1702  [12]
 LDCM0625  F8 Ramos C577(1.22)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C577(3.58)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C577(1.11)  LDD2190  [13]
 LDCM0575  Fragment13 Ramos C577(1.45)  LDD2192  [13]
 LDCM0580  Fragment21 Ramos C577(1.46)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C577(0.95)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C577(0.89)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C577(1.20)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C577(1.59)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C577(2.46)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C577(4.50)  LDD2201  [13]
 LDCM0468  Fragment33 PaTu 8988t C577(1.22)  LDD1347  [5]
 LDCM0596  Fragment38 Ramos C577(2.81)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C577(5.07)  LDD2184  [13]
 LDCM0427  Fragment51 PaTu 8988t C628(2.12)  LDD1306  [5]
 LDCM0610  Fragment52 Ramos C577(2.44)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C577(1.17)  LDD2205  [13]
 LDCM0615  Fragment63-R Jurkat _(20.00)  LDD1487  [4]
 LDCM0569  Fragment7 Ramos C577(3.94)  LDD2186  [13]
 LDCM0015  HNE MDA-MB-231 C577(1.13)  LDD0346  [13]
 LDCM0022  KB02 HEK-293T C577(0.73)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C577(0.85)  LDD1497  [11]
 LDCM0024  KB05 SK-MEL-28 C577(10.90)  LDD3427  [14]
 LDCM0628  OTUB2-COV-1 HEK-293T C577(0.76)  LDD2207  [15]
 LDCM0131  RA190 MM1.R C628(1.38)  LDD0304  [16]
 LDCM0090  Rapamycin JHH-7 3.56  LDD0213  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PDZ domain-containing protein 11 (PDZD11) . Q5EBL8

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Biotin Small molecular drug DB00121
Lipoic Acid Small molecular drug DB00166
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gabapentin Enacarbil Small molecular drug D05KBU

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
16 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.