Details of the Target

General Information of Target

Target ID LDTP14278
Target Name Sulfide:quinone oxidoreductase, mitochondrial (SQOR)
Gene Name SQOR
Gene ID 58472
Synonyms
SQRDL; Sulfide:quinone oxidoreductase, mitochondrial; SQOR; EC 1.8.5.8; Sulfide dehydrogenase-like; Sulfide quinone oxidoreductase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGGLWRPGWRCVPFCGWRWIHPGSPTRAAERVEPFLRPEWSGTGGAERGLRWLGTWKRCS
LRARHPALQPPRRPKSSNPFTRAQEEERRRQNKTTLTYVAAVAVGMLGASYAAVPLYRLY
CQTTGLGGSAVAGHASDKIENMVPVKDRIIKISFNADVHASLQWNFRPQQTEIYVVPGET
ALAFYRAKNPTDKPVIGISTYNIVPFEAGQYFNKIQCFCFEEQRLNPQEEVDMPVFFYID
PEFAEDPRMIKVDLITLSYTFFEAKEGHKLPVPGYN
Target Bioclass
Enzyme
Family
SQRD family
Subcellular location
Mitochondrion
Function
Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione.
Uniprot ID
Q9Y6N5
Ensemble ID
ENST00000260324.12
HGNC ID
HGNC:20390
ChEMBL ID
CHEMBL4523512

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y434(13.70); Y242(10.20)  LDD0260  [1]
STPyne
 Probe Info  		K173(8.50); K177(5.44); K207(5.65); K241(5.56)  LDD0277  [2]
ONAyne
 Probe Info  		K115(7.14); K371(5.63)  LDD0275  [2]
IPM
 Probe Info  		C201(0.00); C127(0.00)  LDD0241  [3]
m-APA
 Probe Info  		11.33  LDD0403  [4]
BTD
 Probe Info  		C127(0.64)  LDD2117  [5]
AHL-Pu-1
 Probe Info  		C201(3.20)  LDD0170  [6]
DBIA
 Probe Info  		C379(0.82)  LDD0533  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C201(0.00); C379(0.00); C337(0.00); C127(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C379(0.00); C337(0.00); C201(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C379(0.00); C127(0.00); C337(0.00)  LDD0037  [8]
ATP probe
 Probe Info  		K173(0.00); K344(0.00)  LDD0035  [9]
NAIA_4
 Probe Info  		C201(0.00); C337(0.00); C379(0.00)  LDD2226  [10]
WYneN
 Probe Info  		C337(0.00); C201(0.00)  LDD0021  [11]
WYneO
 Probe Info  		C337(0.00); C201(0.00)  LDD0022  [11]
PF-06672131
 Probe Info  		N.A.  LDD0152  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
NAIA_5
 Probe Info  		C201(0.00); C379(0.00); C337(0.00); C127(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		5.74  LDD1725  [14]
C056
 Probe Info  		23.43  LDD1753  [14]
C091
 Probe Info  		15.03  LDD1782  [14]
C092
 Probe Info  		21.86  LDD1783  [14]
C094
 Probe Info  		33.82  LDD1785  [14]
C158
 Probe Info  		8.94  LDD1838  [14]
C159
 Probe Info  		8.69  LDD1839  [14]
C160
 Probe Info  		8.00  LDD1840  [14]
C161
 Probe Info  		15.35  LDD1841  [14]
C289
 Probe Info  		26.72  LDD1959  [14]
VE-P
 Probe Info  		N.A.  LDD0396  [15]
DA-2
 Probe Info  		N.A.  LDD0072  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C127(0.64)  LDD2117  [5]
 LDCM0025  4SU-RNA DM93 C201(3.20)  LDD0170  [6]
 LDCM0214  AC1 HEK-293T C127(1.04)  LDD1507  [17]
 LDCM0216  AC100 HCT 116 C379(0.82)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C379(1.10)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C379(0.96)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C379(1.03)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C379(0.85)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C379(0.95)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C379(0.97)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C379(0.82)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C379(0.93)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C379(1.03)  LDD0542  [7]
 LDCM0227  AC110 HCT 116 C379(0.95)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C379(1.15)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C379(1.00)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C379(0.72)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C379(0.84)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C379(0.86)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C379(0.91)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C379(1.09)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C379(0.81)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C379(0.81)  LDD0553  [7]
 LDCM0237  AC12 HEK-293T C337(1.09)  LDD1510  [17]
 LDCM0238  AC120 HCT 116 C379(0.83)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C379(1.05)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C379(0.87)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C379(0.95)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C379(0.88)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C379(0.85)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C379(0.94)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C379(0.84)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C379(1.01)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C379(0.98)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C379(0.90)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C379(1.17)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C379(1.02)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C379(1.00)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C379(1.20)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C379(1.00)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C379(1.09)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C379(1.05)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C379(1.35)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C379(1.23)  LDD0575  [7]
 LDCM0260  AC140 HCT 116 C379(1.41)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C379(1.27)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C379(1.10)  LDD0579  [7]
 LDCM0276  AC17 HEK-293T C127(0.98)  LDD1515  [17]
 LDCM0280  AC20 HEK-293T C337(1.32)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C127(1.05)  LDD1520  [17]
 LDCM0285  AC25 HEK-293T C127(1.03)  LDD1524  [17]
 LDCM0288  AC28 HEK-293T C337(1.23)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C127(1.04)  LDD1528  [17]
 LDCM0294  AC33 HEK-293T C127(1.08)  LDD1533  [17]
 LDCM0296  AC35 HCT 116 C379(0.95)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C379(1.03)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C379(0.91)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C379(1.18)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C379(1.03)  LDD0617  [7]
 LDCM0301  AC4 HEK-293T C337(1.24)  LDD1540  [17]
 LDCM0302  AC40 HCT 116 C379(0.96)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C379(0.88)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C379(0.94)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C379(1.04)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C379(0.79)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C379(0.83)  LDD0624  [7]
 LDCM0311  AC49 HEK-293T C127(1.16)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C127(1.04)  LDD1551  [17]
 LDCM0315  AC52 HEK-293T C337(1.00)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C127(1.13)  LDD1555  [17]
 LDCM0320  AC57 HEK-293T C127(1.00)  LDD1559  [17]
 LDCM0324  AC60 HEK-293T C337(1.19)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C127(1.05)  LDD1564  [17]
 LDCM0365  AC98 HCT 116 C379(0.99)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C379(0.90)  LDD0683  [7]
 LDCM0248  AKOS034007472 HEK-293T C127(1.08)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C127(1.11)  LDD1570  [17]
 LDCM0156  Aniline NCI-H1299 11.33  LDD0403  [4]
 LDCM0020  ARS-1620 HCC44 C201(1.14); C379(0.83)  LDD2171  [7]
 LDCM0108  Chloroacetamide HeLa C337(0.00); C127(0.00)  LDD0222  [13]
 LDCM0371  CL102 HEK-293T C127(1.03)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C127(0.99)  LDD1576  [17]
 LDCM0375  CL106 HEK-293T C127(1.08)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C127(0.99)  LDD1580  [17]
 LDCM0380  CL110 HEK-293T C127(0.98)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C127(1.08)  LDD1585  [17]
 LDCM0384  CL114 HEK-293T C127(1.07)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C127(0.97)  LDD1589  [17]
 LDCM0387  CL117 HCT 116 C379(0.94)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C379(0.91)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C379(0.92)  LDD0706  [7]
 LDCM0391  CL120 HCT 116 C379(1.07)  LDD0708  [7]
 LDCM0393  CL122 HEK-293T C127(1.05)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C127(1.08)  LDD1598  [17]
 LDCM0397  CL126 HEK-293T C127(0.97)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C127(0.99)  LDD1602  [17]
 LDCM0401  CL14 HEK-293T C127(1.03)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C127(1.10)  LDD1606  [17]
 LDCM0404  CL17 HEK-293T C127(1.12)  LDD1608  [17]
 LDCM0407  CL2 HEK-293T C127(1.00)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C337(1.46)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C127(1.10)  LDD1613  [17]
 LDCM0414  CL26 HEK-293T C127(1.04)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C127(0.98)  LDD1619  [17]
 LDCM0417  CL29 HEK-293T C127(1.01)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C127(1.07)  LDD1622  [17]
 LDCM0420  CL31 HCT 116 C379(1.15)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C379(0.96)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C379(0.94)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C379(0.84)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C379(1.09)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C379(1.22)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C379(1.18)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C379(1.00)  LDD0745  [7]
 LDCM0430  CL40 HCT 116 C379(1.19)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C379(1.11)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C379(1.35)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C379(0.87)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C379(0.87)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C379(1.06)  LDD0752  [7]
 LDCM0440  CL5 HEK-293T C127(0.93)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C127(1.09)  LDD1645  [17]
 LDCM0444  CL53 HEK-293T C127(1.12)  LDD1647  [17]
 LDCM0447  CL56 HEK-293T C337(1.43)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C127(1.16)  LDD1651  [17]
 LDCM0453  CL61 HCT 116 C379(0.92)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C379(1.05)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C379(1.51)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C379(0.80)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C379(1.08)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C379(0.81)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C379(1.23)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C379(1.33)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C379(1.28)  LDD0778  [7]
 LDCM0463  CL70 HCT 116 C379(1.02)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C379(1.11)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C379(1.02)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C379(1.30)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C379(1.34)  LDD0784  [7]
 LDCM0470  CL77 HEK-293T C127(1.04)  LDD1673  [17]
 LDCM0473  CL8 HEK-293T C337(2.26)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C337(0.98)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C127(1.18)  LDD1678  [17]
 LDCM0480  CL86 HEK-293T C127(0.89)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C127(0.88)  LDD1684  [17]
 LDCM0483  CL89 HEK-293T C127(1.03)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C127(1.10)  LDD1687  [17]
 LDCM0487  CL92 HEK-293T C337(1.12)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C127(1.12)  LDD1691  [17]
 LDCM0493  CL98 HEK-293T C127(1.03)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C127(0.94)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C127(1.00)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C201(4.84)  LDD1702  [5]
 LDCM0468  Fragment33 HCT 116 C379(0.83)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C379(1.43)  LDD0744  [7]
 LDCM0015  HNE MDA-MB-231 C337(1.11)  LDD0346  [18]
 LDCM0107  IAA HeLa N.A.  LDD0221  [13]
 LDCM0022  KB02 T cell C379(6.36)  LDD1703  [19]
 LDCM0023  KB03 769-P C127(1.48)  LDD2663  [20]
 LDCM0024  KB05 G361 C201(2.34)  LDD3311  [20]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C127(1.24)  LDD2137  [5]
 LDCM0021  THZ1 HCT 116 C201(1.14); C379(0.83)  LDD2173  [7]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
16 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840