Details of the Target

General Information of Target

Target ID LDTP02059
Target Name Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2)
Gene Name GNAI2
Gene ID 2771
Synonyms
GNAI2B; Guanine nucleotide-binding protein G(i) subunit alpha-2; Adenylate cyclase-inhibiting G alpha protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDG
YSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVL
PDDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRV
KTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEE
MNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITHSPLTICFPEYTGANKYDEA
ASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Target Bioclass
Other
Family
G-alpha family, G(i/o/t/z) subfamily
Subcellular location
Cytoplasm
Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.; [Isoform sGi2]: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool.
Uniprot ID
P04899
Ensemble ID
ENST00000266027.9
HGNC ID
HGNC:4385
ChEMBL ID
CHEMBL4105887

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.V234A DBIA    Probe Info 
CAL72 SNV: p.E64Ter DBIA    Probe Info 
CCK81 SNV: p.V180A DBIA    Probe Info 
COLO792 SNV: p.Q205R .
HT115 SNV: p.S47N DBIA    Probe Info 
HUPT4 SNV: p.R129Q DBIA    Probe Info 
JURKAT Insertion: p.N150KfsTer18 Compound 10    Probe Info 
REH SNV: p.I93F DBIA    Probe Info 
RL Deletion: p.K272del DBIA    Probe Info 
SNGM SNV: p.Q68Ter DBIA    Probe Info 
SUDHL4 Deletion: p.K272del DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y147(20.00); Y168(20.00); Y303(11.61); Y297(6.06)  LDD0260  [3]
STPyne
 Probe Info  		K17(8.09)  LDD0277  [4]
ONAyne
 Probe Info  		K272(5.56)  LDD0275  [4]
OPA-S-S-alkyne
 Probe Info  		K313(1.06); K29(1.82); K331(2.33)  LDD3494  [5]
Probe 1
 Probe Info  		Y61(16.23); Y155(69.13); Y297(24.22); Y303(20.63)  LDD3495  [6]
DBIA
 Probe Info  		C287(1.08); C255(1.90)  LDD3310  [7]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [8]
BTD
 Probe Info  		C287(0.96); C326(1.00); C352(0.75)  LDD2089  [9]
AHL-Pu-1
 Probe Info  		C352(2.17); C255(2.43); C140(3.31)  LDD0169  [10]
EA-probe
 Probe Info  		C112(0.99)  LDD2210  [11]
5E-2FA
 Probe Info  		H323(0.00); H281(0.00); H135(0.00); H189(0.00)  LDD2235  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C326(0.00); C66(0.00); C287(0.00); C255(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C326(0.00); C287(0.00); C112(0.00)  LDD0032  [14]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [15]
IPIAA_L
 Probe Info  		C66(0.00); C287(0.00); C326(0.00)  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C326(0.00); C66(0.00); C287(0.00); C255(0.00)  LDD0037  [13]
IPM
 Probe Info  		C66(0.00); C112(0.00); C352(0.00)  LDD0025  [16]
JW-RF-010
 Probe Info  		C112(0.00); C66(0.00)  LDD0026  [16]
NAIA_4
 Probe Info  		C66(0.00); C112(0.00); C140(0.00); C287(0.00)  LDD2226  [17]
TFBX
 Probe Info  		N.A.  LDD0027  [16]
WYneN
 Probe Info  		C255(0.00); C140(0.00)  LDD0021  [18]
Compound 10
 Probe Info  		C140(0.00); C287(0.00); C66(0.00)  LDD2216  [19]
PF-06672131
 Probe Info  		C255(0.00); C287(0.00)  LDD0017  [20]
Phosphinate-6
 Probe Info  		C112(0.00); C352(0.00)  LDD0018  [21]
Acrolein
 Probe Info  		C326(0.00); H57(0.00); H323(0.00); C255(0.00)  LDD0217  [22]
Cinnamaldehyde
 Probe Info  		C255(0.00); C66(0.00)  LDD0220  [22]
Crotonaldehyde
 Probe Info  		C326(0.00); C66(0.00); C255(0.00)  LDD0219  [22]
Methacrolein
 Probe Info  		C326(0.00); C66(0.00); C255(0.00)  LDD0218  [22]
AOyne
 Probe Info  		9.10  LDD0443  [23]
NAIA_5
 Probe Info  		C326(0.00); C66(0.00); C255(0.00); C140(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C232
 Probe Info  		33.82  LDD1905  [24]
FFF probe13
 Probe Info  		20.00  LDD0475  [25]
FFF probe3
 Probe Info  		20.00  LDD0464  [25]
STS-1
 Probe Info  		N.A.  LDD0136  [26]
STS-2
 Probe Info  		N.A.  LDD0139  [26]
VE-P
 Probe Info  		N.A.  LDD0396  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C287(0.53); C66(0.85)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C287(0.73); C66(0.96)  LDD2112  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C287(1.44); C66(1.61); C140(1.25)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C326(1.80)  LDD2152  [9]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C287(1.01)  LDD2103  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C326(1.19); C66(1.31)  LDD2131  [9]
 LDCM0025  4SU-RNA HEK-293T C112(3.94)  LDD0172  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C352(2.17); C255(2.43); C140(3.31)  LDD0169  [10]
 LDCM0214  AC1 HEK-293T C255(0.89); C287(0.82); C112(0.95)  LDD1507  [28]
 LDCM0215  AC10 HEK-293T C66(1.20); C255(1.03); C287(1.02); C112(1.02)  LDD1508  [28]
 LDCM0226  AC11 HEK-293T C66(1.10); C255(1.17); C287(1.08); C112(0.95)  LDD1509  [28]
 LDCM0237  AC12 HEK-293T C66(0.99); C255(1.08); C287(1.07); C112(1.07)  LDD1510  [28]
 LDCM0259  AC14 HEK-293T C66(0.93); C255(1.08); C287(1.07); C112(1.05)  LDD1512  [28]
 LDCM0270  AC15 HEK-293T C255(1.04); C287(1.06); C112(1.08); C326(1.04)  LDD1513  [28]
 LDCM0276  AC17 HEK-293T C255(0.94); C287(0.90); C112(1.01)  LDD1515  [28]
 LDCM0277  AC18 HEK-293T C66(1.03); C255(1.04); C287(1.03); C112(1.00)  LDD1516  [28]
 LDCM0278  AC19 HEK-293T C66(1.03); C255(1.04); C287(1.14); C112(1.01)  LDD1517  [28]
 LDCM0279  AC2 HEK-293T C66(0.67); C255(1.02); C287(1.05); C112(1.03)  LDD1518  [28]
 LDCM0280  AC20 HEK-293T C66(1.00); C255(1.07); C287(1.06); C112(1.03)  LDD1519  [28]
 LDCM0281  AC21 HEK-293T C255(0.98); C287(1.01); C112(1.03); C326(0.95)  LDD1520  [28]
 LDCM0282  AC22 HEK-293T C66(0.81); C255(0.92); C287(1.17); C112(1.07)  LDD1521  [28]
 LDCM0283  AC23 HEK-293T C255(1.06); C287(1.08); C112(1.05); C326(1.05)  LDD1522  [28]
 LDCM0284  AC24 HEK-293T C255(1.00); C287(1.02); C112(0.95); C326(1.08)  LDD1523  [28]
 LDCM0285  AC25 HEK-293T C255(0.96); C287(0.89); C112(0.94)  LDD1524  [28]
 LDCM0286  AC26 HEK-293T C66(0.81); C255(0.97); C287(1.02); C112(1.03)  LDD1525  [28]
 LDCM0287  AC27 HEK-293T C66(0.89); C255(1.09); C287(1.04); C112(0.97)  LDD1526  [28]
 LDCM0288  AC28 HEK-293T C66(1.03); C255(1.03); C287(1.06); C112(1.01)  LDD1527  [28]
 LDCM0289  AC29 HEK-293T C255(1.01); C287(0.93); C112(1.05); C326(1.03)  LDD1528  [28]
 LDCM0290  AC3 HEK-293T C66(0.96); C255(1.11); C287(1.01); C112(1.06)  LDD1529  [28]
 LDCM0291  AC30 HEK-293T C66(0.97); C255(1.02); C287(0.97); C112(1.02)  LDD1530  [28]
 LDCM0292  AC31 HEK-293T C255(1.00); C287(1.10); C112(0.97); C326(1.03)  LDD1531  [28]
 LDCM0293  AC32 HEK-293T C255(1.09); C287(1.18); C112(0.99); C326(1.07)  LDD1532  [28]
 LDCM0294  AC33 HEK-293T C255(0.83); C287(0.94); C112(0.97)  LDD1533  [28]
 LDCM0295  AC34 HEK-293T C66(0.79); C255(1.04); C287(1.06); C112(1.08)  LDD1534  [28]
 LDCM0296  AC35 HEK-293T C66(0.96); C255(1.19); C287(1.04); C112(0.93)  LDD1535  [28]
 LDCM0297  AC36 HEK-293T C66(1.05); C255(1.07); C287(0.93); C112(1.02)  LDD1536  [28]
 LDCM0298  AC37 HEK-293T C255(0.95); C287(1.02); C112(1.03); C326(1.03)  LDD1537  [28]
 LDCM0299  AC38 HEK-293T C66(0.84); C255(0.98); C287(1.11); C112(1.12)  LDD1538  [28]
 LDCM0300  AC39 HEK-293T C255(1.05); C287(1.07); C112(0.99); C326(1.17)  LDD1539  [28]
 LDCM0301  AC4 HEK-293T C66(1.06); C255(1.17); C287(1.00); C112(1.15)  LDD1540  [28]
 LDCM0302  AC40 HEK-293T C255(1.09); C287(1.07); C112(1.07); C326(1.10)  LDD1541  [28]
 LDCM0303  AC41 HEK-293T C255(0.91); C287(0.86); C112(0.93)  LDD1542  [28]
 LDCM0304  AC42 HEK-293T C66(1.12); C255(1.08); C287(0.99); C112(1.10)  LDD1543  [28]
 LDCM0305  AC43 HEK-293T C66(1.38); C255(1.18); C287(1.09); C112(0.96)  LDD1544  [28]
 LDCM0306  AC44 HEK-293T C66(1.03); C255(1.30); C287(1.03); C112(1.21)  LDD1545  [28]
 LDCM0307  AC45 HEK-293T C255(0.98); C287(0.97); C112(1.03); C326(1.00)  LDD1546  [28]
 LDCM0308  AC46 HEK-293T C66(1.10); C255(1.06); C287(1.16); C112(0.98)  LDD1547  [28]
 LDCM0309  AC47 HEK-293T C255(1.00); C287(1.15); C112(1.05); C326(1.18)  LDD1548  [28]
 LDCM0310  AC48 HEK-293T C255(1.01); C287(1.13); C112(0.94); C326(1.03)  LDD1549  [28]
 LDCM0311  AC49 HEK-293T C255(0.89); C287(0.91); C112(0.99)  LDD1550  [28]
 LDCM0312  AC5 HEK-293T C255(1.02); C287(1.02); C112(1.00); C326(1.00)  LDD1551  [28]
 LDCM0313  AC50 HEK-293T C66(0.71); C255(1.07); C287(0.99); C112(0.95)  LDD1552  [28]
 LDCM0314  AC51 HEK-293T C66(1.09); C255(1.13); C287(1.10); C112(0.88)  LDD1553  [28]
 LDCM0315  AC52 HEK-293T C66(1.02); C255(1.01); C287(1.03); C112(1.07)  LDD1554  [28]
 LDCM0316  AC53 HEK-293T C255(0.88); C287(0.95); C112(1.05); C326(0.99)  LDD1555  [28]
 LDCM0317  AC54 HEK-293T C66(1.04); C255(0.99); C287(1.12); C112(1.07)  LDD1556  [28]
 LDCM0318  AC55 HEK-293T C255(0.98); C287(1.06); C112(1.02); C326(1.09)  LDD1557  [28]
 LDCM0319  AC56 HEK-293T C255(1.03); C287(0.98); C112(1.02); C326(0.99)  LDD1558  [28]
 LDCM0320  AC57 HEK-293T C255(0.89); C287(0.89); C112(1.05)  LDD1559  [28]
 LDCM0321  AC58 HEK-293T C66(0.75); C255(1.17); C287(1.02); C112(0.99)  LDD1560  [28]
 LDCM0322  AC59 HEK-293T C66(1.21); C255(1.14); C287(1.11); C112(0.98)  LDD1561  [28]
 LDCM0323  AC6 HEK-293T C66(1.01); C255(1.11); C287(1.05); C112(1.09)  LDD1562  [28]
 LDCM0324  AC60 HEK-293T C66(1.06); C255(1.00); C287(0.98); C112(1.00)  LDD1563  [28]
 LDCM0325  AC61 HEK-293T C255(0.98); C287(0.95); C112(1.13); C326(0.94)  LDD1564  [28]
 LDCM0326  AC62 HEK-293T C66(1.12); C255(1.09); C287(1.11); C112(1.07)  LDD1565  [28]
 LDCM0327  AC63 HEK-293T C255(1.03); C287(1.08); C112(1.10); C326(1.16)  LDD1566  [28]
 LDCM0328  AC64 HEK-293T C255(0.98); C287(1.09); C112(1.02); C326(0.98)  LDD1567  [28]
 LDCM0334  AC7 HEK-293T C255(1.09); C287(1.24); C112(0.98); C326(1.09)  LDD1568  [28]
 LDCM0345  AC8 HEK-293T C255(1.05); C287(1.09); C112(1.04); C326(1.05)  LDD1569  [28]
 LDCM0520  AKOS000195272 MDA-MB-231 C287(0.96)  LDD2113  [9]
 LDCM0248  AKOS034007472 HEK-293T C255(1.03); C287(0.99); C112(1.07); C326(0.97)  LDD1511  [28]
 LDCM0356  AKOS034007680 HEK-293T C255(0.91); C287(0.96); C112(1.03)  LDD1570  [28]
 LDCM0275  AKOS034007705 HEK-293T C255(1.06); C287(0.99); C112(0.99); C326(1.01)  LDD1514  [28]
 LDCM0156  Aniline NCI-H1299 12.99  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C66(1.13); C352(0.79)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa C326(0.00); H189(0.00); C255(0.00); H323(0.00)  LDD0222  [22]
 LDCM0367  CL1 HEK-293T C255(1.00); C287(1.12); C112(0.98); C326(0.96)  LDD1571  [28]
 LDCM0368  CL10 HEK-293T C66(1.06); C255(1.31); C287(1.22); C112(0.96)  LDD1572  [28]
 LDCM0369  CL100 HEK-293T C255(1.07); C287(0.90); C112(1.18); C326(0.98)  LDD1573  [28]
 LDCM0370  CL101 HEK-293T C255(1.01); C287(1.12); C112(1.02); C326(1.01)  LDD1574  [28]
 LDCM0371  CL102 HEK-293T C66(1.21); C255(1.02); C287(0.98); C112(0.93)  LDD1575  [28]
 LDCM0372  CL103 HEK-293T C255(0.98); C287(0.97); C112(0.96); C326(1.00)  LDD1576  [28]
 LDCM0373  CL104 HEK-293T C255(1.05); C287(0.93); C112(0.97); C326(1.02)  LDD1577  [28]
 LDCM0374  CL105 HEK-293T C255(0.96); C287(1.16); C112(1.01); C326(1.08)  LDD1578  [28]
 LDCM0375  CL106 HEK-293T C66(1.29); C255(0.90); C287(1.00); C112(0.93)  LDD1579  [28]
 LDCM0376  CL107 HEK-293T C255(0.98); C287(1.00); C112(0.94); C326(1.02)  LDD1580  [28]
 LDCM0377  CL108 HEK-293T C255(0.95); C287(0.88); C112(0.99); C326(0.95)  LDD1581  [28]
 LDCM0378  CL109 HEK-293T C255(1.02); C287(0.89); C112(0.91); C326(0.98)  LDD1582  [28]
 LDCM0379  CL11 HEK-293T C255(1.27); C287(1.32); C112(1.13); C326(1.29)  LDD1583  [28]
 LDCM0380  CL110 HEK-293T C66(1.12); C255(0.97); C287(0.98); C112(1.00)  LDD1584  [28]
 LDCM0381  CL111 HEK-293T C255(0.96); C287(1.01); C112(0.92); C326(1.00)  LDD1585  [28]
 LDCM0382  CL112 HEK-293T C255(0.97); C287(0.98); C112(1.14); C326(1.00)  LDD1586  [28]
 LDCM0383  CL113 HEK-293T C255(0.98); C287(0.93); C112(0.97); C326(0.93)  LDD1587  [28]
 LDCM0384  CL114 HEK-293T C66(0.92); C255(1.01); C287(1.01); C112(0.99)  LDD1588  [28]
 LDCM0385  CL115 HEK-293T C255(0.95); C287(1.01); C112(0.94); C326(1.04)  LDD1589  [28]
 LDCM0386  CL116 HEK-293T C255(1.02); C287(0.84); C112(0.95); C326(0.96)  LDD1590  [28]
 LDCM0387  CL117 HEK-293T C255(0.98); C287(1.14); C112(0.91); C326(1.00)  LDD1591  [28]
 LDCM0388  CL118 HEK-293T C66(1.61); C255(0.94); C287(1.06); C112(1.05)  LDD1592  [28]
 LDCM0389  CL119 HEK-293T C255(0.97); C287(0.99); C112(0.94); C326(1.06)  LDD1593  [28]
 LDCM0390  CL12 HEK-293T C255(1.35); C287(1.50); C112(1.03); C326(1.22)  LDD1594  [28]
 LDCM0391  CL120 HEK-293T C255(1.03); C287(1.00); C112(1.05); C326(1.02)  LDD1595  [28]
 LDCM0392  CL121 HEK-293T C255(0.97); C287(1.01); C112(1.06); C326(0.98)  LDD1596  [28]
 LDCM0393  CL122 HEK-293T C66(1.05); C255(0.95); C287(1.01); C112(1.03)  LDD1597  [28]
 LDCM0394  CL123 HEK-293T C255(0.97); C287(0.99); C112(1.01); C326(1.00)  LDD1598  [28]
 LDCM0395  CL124 HEK-293T C255(0.98); C287(0.83); C112(1.04); C326(1.06)  LDD1599  [28]
 LDCM0396  CL125 HEK-293T C255(1.02); C287(0.98); C112(1.03); C326(0.83)  LDD1600  [28]
 LDCM0397  CL126 HEK-293T C66(1.14); C255(1.08); C287(1.09); C112(1.06)  LDD1601  [28]
 LDCM0398  CL127 HEK-293T C255(1.05); C287(1.03); C112(1.03); C326(0.90)  LDD1602  [28]
 LDCM0399  CL128 HEK-293T C255(1.02); C287(0.89); C112(1.18); C326(0.97)  LDD1603  [28]
 LDCM0400  CL13 HEK-293T C255(0.98); C287(1.02); C112(0.97); C326(0.89)  LDD1604  [28]
 LDCM0401  CL14 HEK-293T C66(1.25); C255(1.04); C287(1.15); C112(1.02)  LDD1605  [28]
 LDCM0402  CL15 HEK-293T C255(0.96); C287(0.89); C112(1.01); C326(0.96)  LDD1606  [28]
 LDCM0403  CL16 HEK-293T C255(1.02); C287(1.13); C112(1.06); C326(0.95)  LDD1607  [28]
 LDCM0404  CL17 HEK-293T C255(0.96); C287(0.79); C112(1.01)  LDD1608  [28]
 LDCM0405  CL18 HEK-293T C66(1.30); C255(1.18); C287(1.13); C112(1.05)  LDD1609  [28]
 LDCM0406  CL19 HEK-293T C66(1.27); C255(1.40); C287(1.11); C112(0.94)  LDD1610  [28]
 LDCM0407  CL2 HEK-293T C66(0.97); C255(1.03); C287(1.08); C112(0.98)  LDD1611  [28]
 LDCM0408  CL20 HEK-293T C66(1.18); C255(1.36); C287(1.19); C112(1.11)  LDD1612  [28]
 LDCM0409  CL21 HEK-293T C255(1.04); C287(1.28); C112(0.97); C326(1.12)  LDD1613  [28]
 LDCM0410  CL22 HEK-293T C66(1.23); C255(1.16); C287(1.28); C112(1.16)  LDD1614  [28]
 LDCM0411  CL23 HEK-293T C255(1.32); C287(1.49); C112(1.13); C326(1.32)  LDD1615  [28]
 LDCM0412  CL24 HEK-293T C255(1.23); C287(1.40); C112(1.05); C326(1.19)  LDD1616  [28]
 LDCM0413  CL25 HEK-293T C255(1.00); C287(0.98); C112(1.00); C326(0.86)  LDD1617  [28]
 LDCM0414  CL26 HEK-293T C66(1.62); C255(0.97); C287(1.00); C112(0.88)  LDD1618  [28]
 LDCM0415  CL27 HEK-293T C255(0.93); C287(1.06); C112(0.91); C326(0.89)  LDD1619  [28]
 LDCM0416  CL28 HEK-293T C255(1.04); C287(0.92); C112(1.02); C326(0.88)  LDD1620  [28]
 LDCM0417  CL29 HEK-293T C255(1.00); C287(0.86); C112(0.99)  LDD1621  [28]
 LDCM0418  CL3 HEK-293T C255(0.98); C287(1.10); C112(0.95); C326(1.09)  LDD1622  [28]
 LDCM0419  CL30 HEK-293T C66(0.78); C255(0.91); C287(1.06); C112(1.06)  LDD1623  [28]
 LDCM0420  CL31 HEK-293T C66(0.96); C255(1.14); C287(1.06); C112(0.93)  LDD1624  [28]
 LDCM0421  CL32 HEK-293T C66(1.19); C255(1.15); C287(1.05); C112(1.12)  LDD1625  [28]
 LDCM0422  CL33 HEK-293T C255(1.34); C287(1.30); C112(0.81); C326(0.91)  LDD1626  [28]
 LDCM0423  CL34 HEK-293T C66(1.27); C255(1.24); C287(1.22); C112(1.00)  LDD1627  [28]
 LDCM0424  CL35 HEK-293T C255(1.30); C287(1.61); C112(1.04); C326(1.32)  LDD1628  [28]
 LDCM0425  CL36 HEK-293T C255(1.28); C287(1.37); C112(1.01); C326(1.22)  LDD1629  [28]
 LDCM0426  CL37 HEK-293T C255(1.09); C287(0.99); C112(1.00); C326(0.95)  LDD1630  [28]
 LDCM0428  CL39 HEK-293T C255(0.99); C287(1.04); C112(1.11); C326(0.97)  LDD1632  [28]
 LDCM0429  CL4 HEK-293T C255(1.12); C287(1.00); C112(1.00); C326(0.94)  LDD1633  [28]
 LDCM0430  CL40 HEK-293T C255(1.00); C287(0.97); C112(1.06); C326(0.94)  LDD1634  [28]
 LDCM0431  CL41 HEK-293T C255(0.92); C287(0.90); C112(1.00)  LDD1635  [28]
 LDCM0432  CL42 HEK-293T C66(0.94); C255(1.11); C287(1.14); C112(1.04)  LDD1636  [28]
 LDCM0433  CL43 HEK-293T C66(1.03); C255(1.17); C287(1.10); C112(1.03)  LDD1637  [28]
 LDCM0434  CL44 HEK-293T C66(1.05); C255(1.24); C287(1.09); C112(1.09)  LDD1638  [28]
 LDCM0435  CL45 HEK-293T C255(1.07); C287(1.08); C112(1.09); C326(1.05)  LDD1639  [28]
 LDCM0436  CL46 HEK-293T C66(0.94); C255(1.19); C287(1.27); C112(1.15)  LDD1640  [28]
 LDCM0437  CL47 HEK-293T C255(1.30); C287(1.29); C112(1.03); C326(1.30)  LDD1641  [28]
 LDCM0438  CL48 HEK-293T C255(1.30); C287(1.34); C112(1.04); C326(1.15)  LDD1642  [28]
 LDCM0439  CL49 HEK-293T C255(1.04); C287(1.19); C112(1.04); C326(0.85)  LDD1643  [28]
 LDCM0440  CL5 HEK-293T C255(0.94); C287(0.85); C112(1.01)  LDD1644  [28]
 LDCM0441  CL50 HEK-293T C66(1.20); C255(1.03); C287(1.07); C112(1.06)  LDD1645  [28]
 LDCM0443  CL52 HEK-293T C255(0.97); C287(0.91); C112(1.14); C326(1.09)  LDD1646  [28]
 LDCM0444  CL53 HEK-293T C255(0.99); C287(0.89); C112(0.97)  LDD1647  [28]
 LDCM0445  CL54 HEK-293T C66(1.15); C255(1.23); C287(1.00); C112(1.02)  LDD1648  [28]
 LDCM0446  CL55 HEK-293T C66(1.20); C255(1.35); C287(1.05); C112(1.04)  LDD1649  [28]
 LDCM0447  CL56 HEK-293T C66(1.14); C255(1.48); C287(1.12); C112(1.15)  LDD1650  [28]
 LDCM0448  CL57 HEK-293T C255(1.13); C287(1.12); C112(1.08); C326(1.02)  LDD1651  [28]
 LDCM0449  CL58 HEK-293T C66(1.17); C255(1.25); C287(1.30); C112(1.09)  LDD1652  [28]
 LDCM0450  CL59 HEK-293T C255(1.22); C287(1.40); C112(1.03); C326(1.38)  LDD1653  [28]
 LDCM0451  CL6 HEK-293T C66(0.99); C255(1.07); C287(1.12); C112(0.98)  LDD1654  [28]
 LDCM0452  CL60 HEK-293T C255(1.25); C287(1.45); C112(0.97); C326(1.21)  LDD1655  [28]
 LDCM0453  CL61 HEK-293T C255(1.01); C287(1.08); C112(1.10); C326(0.88)  LDD1656  [28]
 LDCM0454  CL62 HEK-293T C66(1.36); C255(0.97); C287(1.01); C112(1.09)  LDD1657  [28]
 LDCM0455  CL63 HEK-293T C255(0.96); C287(1.08); C112(0.95); C326(0.97)  LDD1658  [28]
 LDCM0456  CL64 HEK-293T C255(1.04); C287(0.87); C112(1.19); C326(1.06)  LDD1659  [28]
 LDCM0457  CL65 HEK-293T C255(0.90); C287(0.86); C112(1.00)  LDD1660  [28]
 LDCM0458  CL66 HEK-293T C66(1.30); C255(1.07); C287(1.04); C112(0.98)  LDD1661  [28]
 LDCM0459  CL67 HEK-293T C66(1.23); C255(1.12); C287(1.09); C112(0.94)  LDD1662  [28]
 LDCM0460  CL68 HEK-293T C66(1.10); C255(1.16); C287(1.11); C112(1.11)  LDD1663  [28]
 LDCM0461  CL69 HEK-293T C255(1.10); C287(1.18); C112(1.00); C326(0.98)  LDD1664  [28]
 LDCM0462  CL7 HEK-293T C66(1.11); C255(1.26); C287(1.06); C112(1.02)  LDD1665  [28]
 LDCM0463  CL70 HEK-293T C66(1.08); C255(1.22); C287(1.27); C112(1.09)  LDD1666  [28]
 LDCM0464  CL71 HEK-293T C255(1.17); C287(1.34); C112(0.96); C326(1.25)  LDD1667  [28]
 LDCM0465  CL72 HEK-293T C255(1.26); C287(1.21); C112(0.93); C326(1.16)  LDD1668  [28]
 LDCM0466  CL73 HEK-293T C255(1.06); C287(1.07); C112(0.91); C326(0.96)  LDD1669  [28]
 LDCM0467  CL74 HEK-293T C66(1.35); C255(1.02); C287(1.06); C112(1.00)  LDD1670  [28]
 LDCM0469  CL76 HEK-293T C255(1.07); C287(1.02); C112(1.01); C326(0.97)  LDD1672  [28]
 LDCM0470  CL77 HEK-293T C255(0.97); C287(0.51); C112(0.90)  LDD1673  [28]
 LDCM0471  CL78 HEK-293T C66(0.83); C255(1.16); C287(1.07); C112(1.04)  LDD1674  [28]
 LDCM0472  CL79 HEK-293T C66(1.36); C255(1.38); C287(1.07); C112(1.07)  LDD1675  [28]
 LDCM0473  CL8 HEK-293T C66(1.03); C255(1.18); C287(1.07); C112(0.84)  LDD1676  [28]
 LDCM0474  CL80 HEK-293T C66(1.15); C255(1.28); C287(1.11); C112(1.10)  LDD1677  [28]
 LDCM0475  CL81 HEK-293T C255(0.98); C287(1.12); C112(0.97); C326(0.97)  LDD1678  [28]
 LDCM0476  CL82 HEK-293T C66(1.09); C255(1.21); C287(1.26); C112(1.04)  LDD1679  [28]
 LDCM0477  CL83 HEK-293T C255(1.24); C287(1.40); C112(1.08); C326(1.13)  LDD1680  [28]
 LDCM0478  CL84 HEK-293T C255(1.22); C287(1.42); C112(0.87); C326(1.13)  LDD1681  [28]
 LDCM0479  CL85 HEK-293T C255(1.03); C287(1.07); C112(0.98); C326(0.88)  LDD1682  [28]
 LDCM0480  CL86 HEK-293T C66(1.67); C255(1.03); C287(1.06); C112(1.00)  LDD1683  [28]
 LDCM0481  CL87 HEK-293T C255(1.05); C287(1.06); C112(1.01); C326(0.88)  LDD1684  [28]
 LDCM0482  CL88 HEK-293T C255(1.05); C287(1.06); C112(0.95); C326(0.93)  LDD1685  [28]
 LDCM0483  CL89 HEK-293T C255(1.04); C287(0.86); C112(1.01)  LDD1686  [28]
 LDCM0484  CL9 HEK-293T C255(1.13); C287(1.27); C112(1.03); C326(1.08)  LDD1687  [28]
 LDCM0485  CL90 HEK-293T C66(0.77); C255(1.39); C287(1.07); C112(1.02)  LDD1688  [28]
 LDCM0486  CL91 HEK-293T C66(1.07); C255(1.20); C287(1.07); C112(0.94)  LDD1689  [28]
 LDCM0487  CL92 HEK-293T C66(1.12); C255(1.30); C287(1.10); C112(1.06)  LDD1690  [28]
 LDCM0488  CL93 HEK-293T C255(1.10); C287(1.03); C112(1.00); C326(1.02)  LDD1691  [28]
 LDCM0489  CL94 HEK-293T C66(1.01); C255(1.17); C287(1.18); C112(1.23)  LDD1692  [28]
 LDCM0490  CL95 HEK-293T C255(1.33); C287(1.18); C112(1.18); C326(1.36)  LDD1693  [28]
 LDCM0491  CL96 HEK-293T C255(1.35); C287(1.29); C112(0.96); C326(1.02)  LDD1694  [28]
 LDCM0492  CL97 HEK-293T C255(1.03); C287(1.00); C112(0.95); C326(0.88)  LDD1695  [28]
 LDCM0493  CL98 HEK-293T C66(1.29); C255(1.03); C287(0.87); C112(1.05)  LDD1696  [28]
 LDCM0494  CL99 HEK-293T C255(0.90); C287(1.07); C112(0.97); C326(0.98)  LDD1697  [28]
 LDCM0634  CY-0357 Hep-G2 C112(1.77)  LDD2228  [17]
 LDCM0495  E2913 HEK-293T C255(0.98); C287(1.05); C112(0.97); C326(1.03)  LDD1698  [28]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C66(2.42); C112(2.10)  LDD1702  [9]
 LDCM0175  Ethacrynic acid HeLa C112(0.99)  LDD2210  [11]
 LDCM0625  F8 Ramos C352(1.30); C140(0.53); C326(0.76); C66(1.45)  LDD2187  [29]
 LDCM0572  Fragment10 Ramos C352(0.96); C140(0.78); C326(0.93); C66(0.48)  LDD2189  [29]
 LDCM0573  Fragment11 Ramos C352(0.25); C140(0.15); C326(1.18); C66(0.72)  LDD2190  [29]
 LDCM0574  Fragment12 Ramos C352(0.84); C140(0.92); C326(3.53); C66(0.33)  LDD2191  [29]
 LDCM0575  Fragment13 Ramos C352(0.99); C140(1.08); C326(1.22); C66(0.50)  LDD2192  [29]
 LDCM0576  Fragment14 Ramos C352(1.14); C140(0.80); C326(1.26); C66(0.94)  LDD2193  [29]
 LDCM0579  Fragment20 Ramos C352(0.83); C140(0.83); C326(2.21); C66(0.23)  LDD2194  [29]
 LDCM0580  Fragment21 Ramos C352(0.90); C140(1.27); C326(1.25); C66(0.47)  LDD2195  [29]
 LDCM0582  Fragment23 Ramos C352(1.21); C140(0.92); C326(1.70); C66(0.29)  LDD2196  [29]
 LDCM0578  Fragment27 Ramos C352(0.84); C140(1.20); C326(1.16); C66(0.54)  LDD2197  [29]
 LDCM0586  Fragment28 Ramos C352(0.78); C140(0.86); C326(1.35); C66(0.88)  LDD2198  [29]
 LDCM0588  Fragment30 Ramos C352(1.15); C140(1.03); C326(1.69); C66(0.56)  LDD2199  [29]
 LDCM0589  Fragment31 Ramos C352(0.89); C140(1.30); C326(1.41); C66(0.64)  LDD2200  [29]
 LDCM0590  Fragment32 Ramos C352(0.92); C140(0.75); C326(1.11); C66(0.30)  LDD2201  [29]
 LDCM0468  Fragment33 HEK-293T C255(0.94); C287(1.06); C112(0.92); C326(0.91)  LDD1671  [28]
 LDCM0596  Fragment38 Ramos C352(0.73); C140(0.94); C326(2.17); C66(0.69)  LDD2203  [29]
 LDCM0566  Fragment4 Ramos C352(0.85); C140(0.73); C326(0.52); C66(0.95)  LDD2184  [29]
 LDCM0427  Fragment51 HEK-293T C66(1.09); C255(1.03); C287(1.05); C112(1.01)  LDD1631  [28]
 LDCM0610  Fragment52 Ramos C352(0.93); C140(1.12); C326(1.32); C66(0.70)  LDD2204  [29]
 LDCM0614  Fragment56 Ramos C352(1.20); C140(1.01); C326(1.39); C66(0.64)  LDD2205  [29]
 LDCM0569  Fragment7 Ramos C352(0.95); C140(0.76); C326(0.25); C66(0.77)  LDD2186  [29]
 LDCM0571  Fragment9 Ramos C352(0.94); C140(0.64); C326(0.91); C66(0.30)  LDD2188  [29]
 LDCM0015  HNE MDA-MB-231 C112(0.98)  LDD0346  [29]
 LDCM0107  IAA HeLa H323(0.00); C326(0.00); H57(0.00); H189(0.00)  LDD0221  [22]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [8]
 LDCM0022  KB02 HEK-293T C66(0.98); C326(0.94); C140(1.02); C255(0.85)  LDD1492  [28]
 LDCM0023  KB03 HEK-293T C66(1.04); C326(0.86); C140(0.98); C255(0.97)  LDD1497  [28]
 LDCM0024  KB05 COLO792 C287(1.08); C255(1.90)  LDD3310  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C287(0.68)  LDD2102  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C66(1.05)  LDD2121  [9]
 LDCM0109  NEM HeLa H189(0.00); H323(0.00); H57(0.00); H245(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C287(0.96); C326(1.00); C352(0.75)  LDD2089  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C287(0.79)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C326(1.32)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C287(1.01)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C287(0.39); C326(0.21)  LDD2096  [9]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C326(1.31); C255(0.89)  LDD2097  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C287(0.91); C326(1.05); C66(0.96); C140(0.98)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C287(1.25); C66(2.09); C352(1.02)  LDD2099  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C287(0.89)  LDD2101  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C255(0.74)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C287(1.20); C326(0.91); C255(1.09)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C287(0.48); C66(0.93)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C287(1.05); C66(1.58)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C287(0.57)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C287(0.95); C326(1.03); C66(1.20); C255(0.54)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C287(0.71); C255(1.00)  LDD2110  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C287(0.54)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C287(0.47); C326(0.47); C255(0.49)  LDD2115  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C287(0.84)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C287(1.00); C326(0.33)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C287(1.28); C66(2.43)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C287(0.75)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C326(0.27)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C287(1.11); C66(1.40); C140(1.13)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C287(0.72); C326(0.28)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C287(1.17); C66(1.28); C140(0.96)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C326(0.22)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C287(0.95); C66(2.48)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C287(0.95)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C287(1.24)  LDD2129  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C287(0.57)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C287(1.43)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C287(1.81); C66(1.81); C140(1.34)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C287(0.98); C66(1.84); C140(0.85)  LDD2137  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C66(1.21)  LDD2140  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C287(0.75); C326(1.08)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C66(1.76)  LDD2144  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C287(1.85)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C287(1.01)  LDD2146  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C326(1.57)  LDD2147  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C287(0.84); C326(0.34)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C326(0.81); C66(0.99)  LDD2150  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C287(1.29); C255(1.05)  LDD2153  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C112(0.72)  LDD2206  [30]
 LDCM0628  OTUB2-COV-1 HEK-293T C112(2.39)  LDD2207  [30]
 LDCM0131  RA190 MM1.R C112(1.18); C287(1.06); C66(0.77)  LDD0304  [31]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-X-C chemokine receptor type 5 (CXCR5) G-protein coupled receptor 1 family P32302
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Neutrophil cytosol factor 2 (NCF2) NCF2/NOXA1 family P19878
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
G-protein-signaling modulator 3 (GPSM3) . Q9Y4H4
Neutrophil cytosol factor 1 (NCF1) . P14598
Purkinje cell protein 2 homolog (PCP2) . Q8IVA1

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
20 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
27 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
28 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
29 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
31 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.