Details of the Target

General Information of Target

Target ID LDTP05049
Target Name Dynein light chain 1, cytoplasmic (DYNLL1)
Gene Name DYNLL1
Gene ID 8655
Synonyms
DLC1; DNCL1; DNCLC1; HDLC1; Dynein light chain 1, cytoplasmic; 8 kDa dynein light chain; DLC8; Dynein light chain LC8-type 1; Protein inhibitor of neuronal nitric oxide synthase; PIN
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGR
NFGSYVTHETKHFIYFYLGQVAILLFKSG
Target Bioclass
Other
Family
Dynein light chain family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.; Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.; Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.; Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1.
Uniprot ID
P63167
Ensemble ID
ENST00000242577.11
HGNC ID
HGNC:15476

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y50(5.48)  LDD0257  [3]
ONAyne
 Probe Info  		K36(0.79); K43(0.24)  LDD0274  [4]
OPA-S-S-alkyne
 Probe Info  		K49(2.52)  LDD3494  [5]
Probe 1
 Probe Info  		Y65(8.98)  LDD3495  [6]
DBIA
 Probe Info  		C24(2.05)  LDD3323  [7]
JZ128-DTB
 Probe Info  		C56(0.00); C24(0.00)  LDD0462  [8]
THZ1-DTB
 Probe Info  		C24(1.09)  LDD0460  [8]
BTD
 Probe Info  		C56(1.46)  LDD2090  [9]
Sulforaphane-probe2
 Probe Info  		1.66  LDD0160  [10]
EA-probe
 Probe Info  		C56(1.06); C56(0.96)  LDD2210  [11]
HHS-482
 Probe Info  		Y32(0.89)  LDD0285  [12]
HHS-475
 Probe Info  		Y65(0.72); Y32(1.11)  LDD0264  [13]
HHS-465
 Probe Info  		Y50(10.00)  LDD2237  [14]
5E-2FA
 Probe Info  		N.A.  LDD2235  [15]
ATP probe
 Probe Info  		K36(0.00); K9(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C56(0.00); C24(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [18]
Lodoacetamide azide
 Probe Info  		C56(0.00); C24(0.00)  LDD0037  [17]
JW-RF-010
 Probe Info  		C56(0.00); C24(0.00)  LDD0026  [19]
1d-yne
 Probe Info  		N.A.  LDD0356  [20]
ENE
 Probe Info  		N.A.  LDD0006  [21]
IPM
 Probe Info  		C24(0.00); C56(0.00)  LDD0005  [21]
NHS
 Probe Info  		N.A.  LDD0010  [21]
SF
 Probe Info  		K44(0.00); K36(0.00); Y32(0.00)  LDD0028  [22]
STPyne
 Probe Info  		K36(0.00); K9(0.00)  LDD0009  [21]
VSF
 Probe Info  		N.A.  LDD0007  [21]
Phosphinate-6
 Probe Info  		C24(0.00); C56(0.00)  LDD0018  [23]
1c-yne
 Probe Info  		K49(0.00); K9(0.00); K31(0.00)  LDD0228  [20]
Acrolein
 Probe Info  		C24(0.00); H41(0.00)  LDD0217  [24]
Methacrolein
 Probe Info  		C24(0.00); H41(0.00)  LDD0218  [24]
W1
 Probe Info  		C24(0.00); C56(0.00)  LDD0236  [25]
AOyne
 Probe Info  		15.00  LDD0443  [26]
NAIA_5
 Probe Info  		C56(0.00); C24(0.00)  LDD2223  [27]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		41.07  LDD1865  [28]
C191
 Probe Info  		36.76  LDD1868  [28]
C193
 Probe Info  		19.16  LDD1869  [28]
FFF probe13
 Probe Info  		6.35  LDD0475  [29]
FFF probe3
 Probe Info  		6.46  LDD0464  [29]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C56(0.88)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C56(1.12); C24(0.76)  LDD2112  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C56(0.88); C24(1.12)  LDD2117  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C56(0.59)  LDD2132  [9]
 LDCM0214  AC1 PaTu 8988t C24(0.52)  LDD1093  [30]
 LDCM0215  AC10 HEK-293T C56(1.08); C24(1.13)  LDD1508  [31]
 LDCM0226  AC11 HEK-293T C56(0.97); C24(1.10)  LDD1509  [31]
 LDCM0230  AC113 HEK-293T C56(1.54)  LDD0828  [30]
 LDCM0231  AC114 HEK-293T C56(1.50)  LDD0829  [30]
 LDCM0232  AC115 HEK-293T C56(1.42)  LDD0830  [30]
 LDCM0233  AC116 HEK-293T C56(1.37)  LDD0831  [30]
 LDCM0234  AC117 HEK-293T C56(1.22)  LDD0832  [30]
 LDCM0235  AC118 HEK-293T C56(1.54)  LDD0833  [30]
 LDCM0236  AC119 HEK-293T C56(1.27)  LDD0834  [30]
 LDCM0237  AC12 HEK-293T C56(0.94); C24(1.17)  LDD1510  [31]
 LDCM0238  AC120 HEK-293T C56(1.33)  LDD0836  [30]
 LDCM0239  AC121 HEK-293T C56(1.68)  LDD0837  [30]
 LDCM0240  AC122 HEK-293T C56(0.98)  LDD0838  [30]
 LDCM0241  AC123 HEK-293T C56(1.05)  LDD0839  [30]
 LDCM0242  AC124 HEK-293T C56(1.56)  LDD0840  [30]
 LDCM0243  AC125 HEK-293T C56(1.19)  LDD0841  [30]
 LDCM0244  AC126 HEK-293T C56(0.97)  LDD0842  [30]
 LDCM0245  AC127 HEK-293T C56(0.83)  LDD0843  [30]
 LDCM0259  AC14 HEK-293T C56(0.80); C24(1.12)  LDD1512  [31]
 LDCM0270  AC15 HEK-293T C56(1.07); C24(1.12)  LDD1513  [31]
 LDCM0276  AC17 HEK-293T C56(0.96); C24(1.11)  LDD1515  [31]
 LDCM0277  AC18 HEK-293T C56(1.27); C24(1.05)  LDD1516  [31]
 LDCM0278  AC19 HEK-293T C56(1.00); C24(1.40)  LDD1517  [31]
 LDCM0279  AC2 PaTu 8988t C24(0.79)  LDD1158  [30]
 LDCM0280  AC20 HEK-293T C56(1.05); C24(1.14)  LDD1519  [31]
 LDCM0281  AC21 HEK-293T C56(1.02); C24(1.08)  LDD1520  [31]
 LDCM0282  AC22 HEK-293T C56(0.96); C24(1.12)  LDD1521  [31]
 LDCM0283  AC23 HEK-293T C56(1.06); C24(1.09)  LDD1522  [31]
 LDCM0284  AC24 HEK-293T C56(1.04); C24(1.12)  LDD1523  [31]
 LDCM0285  AC25 HEK-293T C56(1.12); C24(1.11)  LDD1524  [31]
 LDCM0286  AC26 HEK-293T C56(0.92); C24(1.03)  LDD1525  [31]
 LDCM0287  AC27 HEK-293T C56(1.01); C24(1.12)  LDD1526  [31]
 LDCM0288  AC28 HEK-293T C56(1.16); C24(1.13)  LDD1527  [31]
 LDCM0289  AC29 HEK-293T C56(0.81); C24(1.14)  LDD1528  [31]
 LDCM0290  AC3 PaTu 8988t C24(0.73)  LDD1169  [30]
 LDCM0291  AC30 HEK-293T C56(0.97); C24(1.08)  LDD1530  [31]
 LDCM0292  AC31 HEK-293T C56(1.16); C24(1.13)  LDD1531  [31]
 LDCM0293  AC32 HEK-293T C56(1.12); C24(1.15)  LDD1532  [31]
 LDCM0294  AC33 HEK-293T C56(1.13); C24(1.13)  LDD1533  [31]
 LDCM0295  AC34 HEK-293T C56(0.99); C24(1.11)  LDD1534  [31]
 LDCM0296  AC35 HEK-293T C56(0.92); C24(1.11)  LDD1535  [31]
 LDCM0297  AC36 HEK-293T C56(1.25); C24(1.17)  LDD1536  [31]
 LDCM0298  AC37 HEK-293T C56(0.87); C24(1.01)  LDD1537  [31]
 LDCM0299  AC38 HEK-293T C56(1.00); C24(1.07)  LDD1538  [31]
 LDCM0300  AC39 HEK-293T C56(1.02); C24(1.17)  LDD1539  [31]
 LDCM0301  AC4 PaTu 8988t C24(0.83)  LDD1180  [30]
 LDCM0302  AC40 HEK-293T C56(0.98); C24(1.01)  LDD1541  [31]
 LDCM0303  AC41 HEK-293T C56(1.09); C24(1.05)  LDD1542  [31]
 LDCM0304  AC42 HEK-293T C56(1.07); C24(1.08)  LDD1543  [31]
 LDCM0305  AC43 HEK-293T C56(1.09); C24(1.13)  LDD1544  [31]
 LDCM0306  AC44 HEK-293T C56(1.09); C24(1.14)  LDD1545  [31]
 LDCM0307  AC45 HEK-293T C56(0.84); C24(1.03)  LDD1546  [31]
 LDCM0308  AC46 HEK-293T C56(1.56)  LDD0906  [30]
 LDCM0309  AC47 HEK-293T C56(1.99)  LDD0907  [30]
 LDCM0310  AC48 HEK-293T C56(1.62)  LDD0908  [30]
 LDCM0311  AC49 HEK-293T C56(2.11)  LDD0909  [30]
 LDCM0312  AC5 PaTu 8988t C24(0.48)  LDD1191  [30]
 LDCM0313  AC50 HEK-293T C56(1.73)  LDD0911  [30]
 LDCM0314  AC51 HEK-293T C56(1.46)  LDD0912  [30]
 LDCM0315  AC52 HEK-293T C56(1.17)  LDD0913  [30]
 LDCM0316  AC53 HEK-293T C56(1.41)  LDD0914  [30]
 LDCM0317  AC54 HEK-293T C56(1.55)  LDD0915  [30]
 LDCM0318  AC55 HEK-293T C56(1.60)  LDD0916  [30]
 LDCM0319  AC56 HEK-293T C56(2.10)  LDD0917  [30]
 LDCM0320  AC57 HEK-293T C56(1.15); C24(1.17)  LDD1559  [31]
 LDCM0321  AC58 HEK-293T C56(1.07); C24(1.17)  LDD1560  [31]
 LDCM0322  AC59 HEK-293T C56(1.14); C24(1.23)  LDD1561  [31]
 LDCM0323  AC6 HEK-293T C56(1.09); C24(1.00)  LDD1562  [31]
 LDCM0324  AC60 HEK-293T C56(1.13); C24(1.16)  LDD1563  [31]
 LDCM0325  AC61 HEK-293T C56(0.93); C24(1.07)  LDD1564  [31]
 LDCM0326  AC62 HEK-293T C56(1.03); C24(1.15)  LDD1565  [31]
 LDCM0327  AC63 HEK-293T C56(1.08); C24(1.09)  LDD1566  [31]
 LDCM0328  AC64 HEK-293T C56(1.32); C24(1.08)  LDD1567  [31]
 LDCM0334  AC7 HEK-293T C56(1.03); C24(1.07)  LDD1568  [31]
 LDCM0345  AC8 HEK-293T C56(1.22); C24(1.00)  LDD1569  [31]
 LDCM0349  AC83 HEK-293T C56(0.93)  LDD0947  [30]
 LDCM0350  AC84 HEK-293T C56(1.21)  LDD0948  [30]
 LDCM0351  AC85 HEK-293T C56(1.42)  LDD0949  [30]
 LDCM0352  AC86 HEK-293T C56(1.49)  LDD0950  [30]
 LDCM0353  AC87 HEK-293T C56(1.08)  LDD0951  [30]
 LDCM0354  AC88 HEK-293T C56(1.00)  LDD0952  [30]
 LDCM0355  AC89 HEK-293T C56(0.99)  LDD0953  [30]
 LDCM0357  AC90 HEK-293T C56(1.00)  LDD0955  [30]
 LDCM0358  AC91 HEK-293T C56(1.49)  LDD0956  [30]
 LDCM0359  AC92 HEK-293T C56(1.11)  LDD0957  [30]
 LDCM0360  AC93 HEK-293T C56(0.96)  LDD0958  [30]
 LDCM0361  AC94 HEK-293T C56(0.85)  LDD0959  [30]
 LDCM0362  AC95 HEK-293T C56(1.04)  LDD0960  [30]
 LDCM0363  AC96 HEK-293T C56(1.59)  LDD0961  [30]
 LDCM0364  AC97 HEK-293T C56(0.95)  LDD0962  [30]
 LDCM0520  AKOS000195272 MDA-MB-231 C24(0.70)  LDD2113  [9]
 LDCM0248  AKOS034007472 HEK-293T C56(0.80); C24(1.02)  LDD1511  [31]
 LDCM0356  AKOS034007680 HEK-293T C56(0.97); C24(1.13)  LDD1570  [31]
 LDCM0275  AKOS034007705 HEK-293T C56(0.90); C24(1.04)  LDD1514  [31]
 LDCM0156  Aniline NCI-H1299 13.67  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C56(1.21)  LDD2171  [30]
 LDCM0108  Chloroacetamide HeLa C24(0.00); H41(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C56(0.51)  LDD2227  [27]
 LDCM0367  CL1 PaTu 8988t C24(1.16)  LDD1246  [30]
 LDCM0368  CL10 PaTu 8988t C24(0.56)  LDD1247  [30]
 LDCM0369  CL100 PaTu 8988t C24(0.85)  LDD1248  [30]
 LDCM0370  CL101 HEK-293T C56(1.20); C24(1.11)  LDD1574  [31]
 LDCM0371  CL102 HEK-293T C56(1.06); C24(1.00)  LDD1575  [31]
 LDCM0372  CL103 HEK-293T C56(0.87); C24(1.15)  LDD1576  [31]
 LDCM0373  CL104 HEK-293T C56(1.14); C24(1.08)  LDD1577  [31]
 LDCM0374  CL105 HEK-293T C56(1.31); C24(1.10)  LDD1578  [31]
 LDCM0375  CL106 HEK-293T C56(1.08); C24(1.05)  LDD1579  [31]
 LDCM0376  CL107 HEK-293T C56(0.98); C24(1.15)  LDD1580  [31]
 LDCM0377  CL108 HEK-293T C56(1.19); C24(1.17)  LDD1581  [31]
 LDCM0378  CL109 HEK-293T C56(1.32); C24(1.06)  LDD1582  [31]
 LDCM0379  CL11 PaTu 8988t C24(0.91)  LDD1258  [30]
 LDCM0380  CL110 HEK-293T C56(1.11); C24(0.96)  LDD1584  [31]
 LDCM0381  CL111 HEK-293T C56(1.04); C24(1.09)  LDD1585  [31]
 LDCM0382  CL112 HEK-293T C56(1.03); C24(1.08)  LDD1586  [31]
 LDCM0383  CL113 HEK-293T C56(1.26); C24(1.14)  LDD1587  [31]
 LDCM0384  CL114 HEK-293T C56(1.27); C24(0.93)  LDD1588  [31]
 LDCM0385  CL115 HEK-293T C56(1.06); C24(1.07)  LDD1589  [31]
 LDCM0386  CL116 HEK-293T C56(1.20); C24(1.16)  LDD1590  [31]
 LDCM0387  CL117 HEK-293T C56(1.28); C24(1.13)  LDD1591  [31]
 LDCM0388  CL118 HEK-293T C56(1.05); C24(1.12)  LDD1592  [31]
 LDCM0389  CL119 HEK-293T C56(0.98); C24(1.13)  LDD1593  [31]
 LDCM0390  CL12 PaTu 8988t C24(0.86)  LDD1269  [30]
 LDCM0391  CL120 HEK-293T C56(1.09); C24(1.18)  LDD1595  [31]
 LDCM0392  CL121 HEK-293T C56(1.50)  LDD0990  [30]
 LDCM0393  CL122 HEK-293T C56(1.14)  LDD0991  [30]
 LDCM0394  CL123 HEK-293T C56(1.29)  LDD0992  [30]
 LDCM0395  CL124 HEK-293T C56(1.51)  LDD0993  [30]
 LDCM0396  CL125 HEK-293T C56(1.54); C24(1.20)  LDD1600  [31]
 LDCM0397  CL126 HEK-293T C56(1.17); C24(1.04)  LDD1601  [31]
 LDCM0398  CL127 HEK-293T C56(1.22); C24(1.12)  LDD1602  [31]
 LDCM0399  CL128 HEK-293T C56(1.42); C24(1.12)  LDD1603  [31]
 LDCM0400  CL13 PaTu 8988t C24(0.28)  LDD1279  [30]
 LDCM0401  CL14 PaTu 8988t C24(0.22)  LDD1280  [30]
 LDCM0402  CL15 PaTu 8988t C24(0.68)  LDD1281  [30]
 LDCM0403  CL16 PaTu 8988t C24(0.21)  LDD1282  [30]
 LDCM0404  CL17 PaTu 8988t C24(0.20)  LDD1283  [30]
 LDCM0405  CL18 PaTu 8988t C24(0.17)  LDD1284  [30]
 LDCM0406  CL19 PaTu 8988t C24(0.16)  LDD1285  [30]
 LDCM0407  CL2 PaTu 8988t C24(0.84)  LDD1286  [30]
 LDCM0408  CL20 PaTu 8988t C24(0.08)  LDD1287  [30]
 LDCM0409  CL21 PaTu 8988t C24(0.05)  LDD1288  [30]
 LDCM0410  CL22 PaTu 8988t C24(0.11)  LDD1289  [30]
 LDCM0411  CL23 PaTu 8988t C24(0.11)  LDD1290  [30]
 LDCM0412  CL24 PaTu 8988t C24(0.30)  LDD1291  [30]
 LDCM0413  CL25 PaTu 8988t C24(0.26)  LDD1292  [30]
 LDCM0414  CL26 PaTu 8988t C24(0.10)  LDD1293  [30]
 LDCM0415  CL27 PaTu 8988t C24(0.22)  LDD1294  [30]
 LDCM0416  CL28 PaTu 8988t C24(0.07)  LDD1295  [30]
 LDCM0417  CL29 PaTu 8988t C24(0.06)  LDD1296  [30]
 LDCM0418  CL3 PaTu 8988t C24(1.00)  LDD1297  [30]
 LDCM0419  CL30 PaTu 8988t C24(0.23)  LDD1298  [30]
 LDCM0420  CL31 HEK-293T C56(0.76)  LDD1018  [30]
 LDCM0421  CL32 HEK-293T C56(0.55)  LDD1019  [30]
 LDCM0422  CL33 HEK-293T C56(0.57)  LDD1020  [30]
 LDCM0423  CL34 HEK-293T C56(0.83)  LDD1021  [30]
 LDCM0424  CL35 HEK-293T C56(0.86)  LDD1022  [30]
 LDCM0425  CL36 HEK-293T C56(0.72)  LDD1023  [30]
 LDCM0426  CL37 HEK-293T C56(0.79)  LDD1024  [30]
 LDCM0428  CL39 HEK-293T C56(0.82)  LDD1026  [30]
 LDCM0429  CL4 PaTu 8988t C24(1.11)  LDD1308  [30]
 LDCM0430  CL40 HEK-293T C56(0.66)  LDD1028  [30]
 LDCM0431  CL41 HEK-293T C56(0.87)  LDD1029  [30]
 LDCM0432  CL42 HEK-293T C56(0.98)  LDD1030  [30]
 LDCM0433  CL43 HEK-293T C56(0.58)  LDD1031  [30]
 LDCM0434  CL44 HEK-293T C56(1.00)  LDD1032  [30]
 LDCM0435  CL45 HEK-293T C56(0.56)  LDD1033  [30]
 LDCM0436  CL46 HEK-293T C56(0.15); C24(1.13)  LDD1640  [31]
 LDCM0437  CL47 HEK-293T C56(0.21); C24(1.03)  LDD1641  [31]
 LDCM0438  CL48 HEK-293T C56(0.13); C24(1.07)  LDD1642  [31]
 LDCM0439  CL49 HEK-293T C56(1.24); C24(1.09)  LDD1643  [31]
 LDCM0440  CL5 PaTu 8988t C24(0.43)  LDD1319  [30]
 LDCM0441  CL50 HEK-293T C56(0.93); C24(1.00)  LDD1645  [31]
 LDCM0443  CL52 HEK-293T C56(0.75); C24(1.05)  LDD1646  [31]
 LDCM0444  CL53 HEK-293T C56(0.57); C24(1.01)  LDD1647  [31]
 LDCM0445  CL54 HEK-293T C56(0.55); C24(1.00)  LDD1648  [31]
 LDCM0446  CL55 HEK-293T C56(0.27); C24(1.11)  LDD1649  [31]
 LDCM0447  CL56 HEK-293T C56(0.18); C24(1.05)  LDD1650  [31]
 LDCM0448  CL57 HEK-293T C56(0.12); C24(0.97)  LDD1651  [31]
 LDCM0449  CL58 HEK-293T C56(0.15); C24(1.11)  LDD1652  [31]
 LDCM0450  CL59 HEK-293T C56(0.24); C24(1.15)  LDD1653  [31]
 LDCM0451  CL6 PaTu 8988t C24(0.55)  LDD1330  [30]
 LDCM0452  CL60 HEK-293T C56(0.11); C24(0.99)  LDD1655  [31]
 LDCM0453  CL61 HEK-293T C56(1.25); C24(1.03)  LDD1656  [31]
 LDCM0454  CL62 HEK-293T C56(1.10); C24(1.10)  LDD1657  [31]
 LDCM0455  CL63 HEK-293T C56(0.92); C24(1.13)  LDD1658  [31]
 LDCM0456  CL64 HEK-293T C56(0.95); C24(1.00)  LDD1659  [31]
 LDCM0457  CL65 HEK-293T C56(0.67); C24(1.16)  LDD1660  [31]
 LDCM0458  CL66 HEK-293T C56(0.52); C24(1.06)  LDD1661  [31]
 LDCM0459  CL67 HEK-293T C56(0.37); C24(1.14)  LDD1662  [31]
 LDCM0460  CL68 HEK-293T C56(0.20); C24(1.03)  LDD1663  [31]
 LDCM0461  CL69 HEK-293T C56(0.15); C24(1.02)  LDD1664  [31]
 LDCM0462  CL7 PaTu 8988t C24(0.41)  LDD1341  [30]
 LDCM0463  CL70 HEK-293T C56(0.18); C24(1.04)  LDD1666  [31]
 LDCM0464  CL71 HEK-293T C56(0.27); C24(1.04)  LDD1667  [31]
 LDCM0465  CL72 HEK-293T C56(0.13); C24(1.19)  LDD1668  [31]
 LDCM0466  CL73 HEK-293T C56(1.23); C24(0.98)  LDD1669  [31]
 LDCM0467  CL74 HEK-293T C56(1.20); C24(1.04)  LDD1670  [31]
 LDCM0469  CL76 HEK-293T C56(0.95); C24(1.10)  LDD1672  [31]
 LDCM0470  CL77 HEK-293T C56(0.80); C24(1.00)  LDD1673  [31]
 LDCM0471  CL78 HEK-293T C56(0.52); C24(1.09)  LDD1674  [31]
 LDCM0472  CL79 HEK-293T C56(0.43); C24(1.11)  LDD1675  [31]
 LDCM0473  CL8 PaTu 8988t C24(0.67)  LDD1352  [30]
 LDCM0474  CL80 HEK-293T C56(0.27); C24(1.05)  LDD1677  [31]
 LDCM0475  CL81 HEK-293T C56(0.15); C24(1.06)  LDD1678  [31]
 LDCM0476  CL82 HEK-293T C56(0.23); C24(1.14)  LDD1679  [31]
 LDCM0477  CL83 HEK-293T C56(0.35); C24(1.03)  LDD1680  [31]
 LDCM0478  CL84 HEK-293T C56(0.23); C24(0.97)  LDD1681  [31]
 LDCM0479  CL85 HEK-293T C56(1.50); C24(1.11)  LDD1682  [31]
 LDCM0480  CL86 HEK-293T C56(1.14); C24(1.02)  LDD1683  [31]
 LDCM0481  CL87 HEK-293T C56(1.11); C24(1.07)  LDD1684  [31]
 LDCM0482  CL88 HEK-293T C56(0.97); C24(1.10)  LDD1685  [31]
 LDCM0483  CL89 HEK-293T C56(0.90); C24(1.14)  LDD1686  [31]
 LDCM0484  CL9 PaTu 8988t C24(0.50)  LDD1363  [30]
 LDCM0485  CL90 HEK-293T C56(0.91); C24(0.97)  LDD1688  [31]
 LDCM0486  CL91 PaTu 8988t C24(0.85)  LDD1365  [30]
 LDCM0487  CL92 PaTu 8988t C24(0.70)  LDD1366  [30]
 LDCM0488  CL93 PaTu 8988t C24(0.67)  LDD1367  [30]
 LDCM0489  CL94 PaTu 8988t C24(0.83)  LDD1368  [30]
 LDCM0490  CL95 PaTu 8988t C24(0.45)  LDD1369  [30]
 LDCM0491  CL96 PaTu 8988t C24(0.67)  LDD1370  [30]
 LDCM0492  CL97 PaTu 8988t C24(0.93)  LDD1371  [30]
 LDCM0493  CL98 PaTu 8988t C24(0.60)  LDD1372  [30]
 LDCM0494  CL99 PaTu 8988t C24(0.66)  LDD1373  [30]
 LDCM0634  CY-0357 Hep-G2 C56(0.83)  LDD2228  [27]
 LDCM0495  E2913 HEK-293T C56(0.81); C24(1.09)  LDD1698  [31]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C56(3.25)  LDD1702  [9]
 LDCM0175  Ethacrynic acid HeLa C56(1.06); C56(0.96)  LDD2210  [11]
 LDCM0625  F8 Ramos C56(2.35); C24(0.96)  LDD2187  [32]
 LDCM0572  Fragment10 Ramos C56(1.65); C24(1.02)  LDD2189  [32]
 LDCM0573  Fragment11 Ramos C56(0.00)  LDD2190  [32]
 LDCM0574  Fragment12 Ramos C56(3.15); C24(1.38)  LDD2191  [32]
 LDCM0575  Fragment13 Ramos C56(0.90); C24(1.09)  LDD2192  [32]
 LDCM0576  Fragment14 Ramos C56(2.87); C24(1.54)  LDD2193  [32]
 LDCM0579  Fragment20 Ramos C56(3.31); C24(1.38)  LDD2194  [32]
 LDCM0580  Fragment21 Ramos C56(0.99); C24(1.03)  LDD2195  [32]
 LDCM0582  Fragment23 Ramos C56(1.47); C24(1.59)  LDD2196  [32]
 LDCM0578  Fragment27 Ramos C56(0.94); C24(0.97)  LDD2197  [32]
 LDCM0586  Fragment28 Ramos C56(0.91); C24(0.61)  LDD2198  [32]
 LDCM0588  Fragment30 Ramos C56(1.26); C24(1.28)  LDD2199  [32]
 LDCM0589  Fragment31 Ramos C56(1.25); C24(1.23)  LDD2200  [32]
 LDCM0590  Fragment32 Ramos C56(1.53); C24(0.97)  LDD2201  [32]
 LDCM0468  Fragment33 HEK-293T C56(0.93); C24(1.09)  LDD1671  [31]
 LDCM0596  Fragment38 Ramos C56(1.56); C24(0.62)  LDD2203  [32]
 LDCM0566  Fragment4 Ramos C56(2.23); C24(0.76)  LDD2184  [32]
 LDCM0427  Fragment51 HEK-293T C56(2.08)  LDD1025  [30]
 LDCM0610  Fragment52 Ramos C56(1.89); C24(1.20)  LDD2204  [32]
 LDCM0614  Fragment56 Ramos C56(0.88); C24(0.92)  LDD2205  [32]
 LDCM0569  Fragment7 Ramos C56(2.40); C24(0.79)  LDD2186  [32]
 LDCM0571  Fragment9 Ramos C56(3.16); C24(1.29)  LDD2188  [32]
 LDCM0116  HHS-0101 DM93 Y65(0.72); Y32(1.11)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y65(0.53); Y32(0.81)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y65(0.69); Y32(0.93)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y65(0.78); Y32(0.82)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y65(0.56); Y32(1.70)  LDD0268  [13]
 LDCM0015  HNE MDA-MB-231 C56(1.13)  LDD0346  [32]
 LDCM0107  IAA HeLa C24(0.00); H41(0.00)  LDD0221  [24]
 LDCM0123  JWB131 DM93 Y32(0.89)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y32(0.91)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y32(0.90)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y32(6.57)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y32(2.84)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y32(3.09)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y32(0.85)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y32(1.14)  LDD0292  [12]
 LDCM0179  JZ128 PC-3 C56(0.00); C24(0.00)  LDD0462  [8]
 LDCM0022  KB02 HEK-293T C56(1.20); C24(0.96)  LDD1492  [31]
 LDCM0023  KB03 HEK-293T C56(0.95); C24(1.07)  LDD1497  [31]
 LDCM0024  KB05 SKMEL24 C24(2.05)  LDD3323  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C56(0.96)  LDD2102  [9]
 LDCM0109  NEM HeLa N.A.  LDD0223  [24]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C56(1.46)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C56(0.84)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C56(1.26)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C56(1.32)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C56(0.32)  LDD2096  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C56(1.67)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C56(0.82); C24(1.25)  LDD2099  [9]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C56(1.32)  LDD2100  [9]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C56(0.81)  LDD2104  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C56(1.48)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C56(0.75)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C56(0.94); C24(1.14)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C56(1.25)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C56(0.84); C24(1.18)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C56(1.73)  LDD2110  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C56(0.91)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C56(0.61)  LDD2114  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C56(0.42); C24(0.48)  LDD2115  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C24(2.46)  LDD2119  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C56(0.67)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C56(1.05); C24(1.13)  LDD2123  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C56(0.99); C24(0.97)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C56(0.50)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C56(1.05); C24(1.33)  LDD2127  [9]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C56(0.71)  LDD2128  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C56(1.02)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C56(0.61)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C56(1.17)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C56(1.21)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C56(1.34); C24(1.61)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C56(0.82); C24(1.20)  LDD2137  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C56(0.84); C24(0.89)  LDD2140  [9]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C56(1.07)  LDD2141  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C56(0.66)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C56(1.04)  LDD2144  [9]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C56(1.64)  LDD2145  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C56(0.97); C24(0.86)  LDD2146  [9]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C56(0.90)  LDD2147  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C56(0.48); C24(0.48)  LDD2148  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C56(0.51)  LDD2151  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C56(2.41)  LDD2153  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C56(0.99)  LDD2206  [33]
 LDCM0628  OTUB2-COV-1 HEK-293T C56(1.47); C24(1.05); C56(1.04); C56(0.98)  LDD2207  [33]
 LDCM0131  RA190 MM1.R C24(1.13)  LDD0304  [34]
 LDCM0003  Sulforaphane MDA-MB-231 1.66  LDD0160  [10]
 LDCM0021  THZ1 HeLa S3 C24(1.09)  LDD0460  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myocardial zonula adherens protein (MYZAP) MYZAP family P0CAP1
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Serine/threonine-protein kinase Nek9 (NEK9) NEK Ser/Thr protein kinase family Q8TD19
Serine/threonine-protein kinase PAK 1 (PAK1) STE Ser/Thr protein kinase family Q13153
Septin-4 (SEPTIN4) Septin GTPase family O43236
Guanine nucleotide-binding protein-like 3-like protein (GNL3L) TRAFAC class YlqF/YawG GTPase family Q9NVN8
OTU domain-containing protein 6A (OTUD6A) . Q7L8S5
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Small ribosomal subunit protein RACK1 (RACK1) WD repeat G protein beta family P63244
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 710 (ZNF710) Krueppel C2H2-type zinc-finger protein family Q8N1W2
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
THAP domain-containing protein 10 (THAP10) . Q9P2Z0
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Olfactory receptor 7C2 (OR7C2) G-protein coupled receptor 1 family O60412
Other
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Bcl-2-modifying factor (BMF) Bcl-2 family Q96LC9
Dynactin subunit 5 (DCTN5) Dynactin subunits 5/6 family Q9BTE1
Dynein axonemal light chain 4 (DNAL4) Dynein light chain family O96015
Protein FAM153A (FAM153A) FAM153 family Q9UHL3
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Gephyrin (GPHN) MoaB/Mog family; MoeA family Q9NQX3
Ciliary microtubule associated protein 1A (CIMAP1A) ODF3 family Q96PU9
cAMP-dependent protein kinase inhibitor alpha (PKIA) PKI family P61925
cAMP-dependent protein kinase inhibitor gamma (PKIG) PKI family Q9Y2B9
Developmental pluripotency-associated protein 3 (DPPA3) . Q6W0C5
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
MORN repeat-containing protein 3 (MORN3) . Q6PF18
Protein FAM117B (FAM117B) . Q6P1L5
Regulator of DNA class I crossover intermediates 1 (REDIC1) . Q86WS4
Sperm mitochondrial-associated cysteine-rich protein (SMCP) . P49901
Uncharacterized protein C14orf119 (C14orf119) . Q9NWQ9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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