Details of the Target

General Information of Target

Target ID LDTP04885
Target Name Protein S100-A10 (S100A10)
Gene Name S100A10
Gene ID 6281
Synonyms
ANX2LG; CAL1L; CLP11; Protein S100-A10; Calpactin I light chain; Calpactin-1 light chain; Cellular ligand of annexin II; S100 calcium-binding protein A10; p10 protein; p11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSQMEHAMETMMFTFHKFAGDKGYLTKEDLRVLMEKEFPGFLENQKDPLAVDKIMKDLD
QCRDGKVGFQSFFSLIAGLTIACNDYFVVHMKQKGKK
Target Bioclass
Transporter and channel
Family
S-100 family
Function
Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.
Uniprot ID
P60903
Ensemble ID
ENST00000368809.1
HGNC ID
HGNC:10487

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
P2
 Probe Info  		2.98  LDD0449  [2]
P3
 Probe Info  		3.34  LDD0450  [2]
P8
 Probe Info  		7.38  LDD0451  [2]
ONAyne
 Probe Info  		K18(0.08); K23(0.73); K28(0.25); K37(0.57)  LDD0274  [3]
BTD
 Probe Info  		C62(12.34)  LDD1699  [4]
AZ-9
 Probe Info  		E44(10.00)  LDD2209  [5]
OPA-S-S-alkyne
 Probe Info  		K57(2.66); K28(5.79)  LDD3494  [6]
AHL-Pu-1
 Probe Info  		C62(4.27)  LDD0171  [7]
DBIA
 Probe Info  		C62(5.94)  LDD0209  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [10]
ATP probe
 Probe Info  		N.A.  LDD0035  [11]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
ENE
 Probe Info  		N.A.  LDD0006  [13]
IPM
 Probe Info  		N.A.  LDD0147  [14]
NHS
 Probe Info  		N.A.  LDD0010  [13]
STPyne
 Probe Info  		N.A.  LDD0009  [13]
TFBX
 Probe Info  		N.A.  LDD0148  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
AOyne
 Probe Info  		15.00  LDD0443  [17]
NAIA_5
 Probe Info  		C83(0.00); C62(0.00)  LDD2223  [12]
HHS-475
 Probe Info  		Y25(0.80)  LDD2238  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C62(0.92)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C62(1.01)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C62(0.74)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C62(1.21)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C62(0.62)  LDD2103  [4]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C62(0.58)  LDD2132  [4]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C62(0.78)  LDD2131  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C62(4.27)  LDD0171  [7]
 LDCM0545  Acetamide MDA-MB-231 C62(0.46)  LDD2138  [4]
 LDCM0156  Aniline NCI-H1299 13.04  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C62(0.49)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C62(1.51); C62(0.94); C62(0.78)  LDD2227  [12]
 LDCM0634  CY-0357 Hep-G2 C62(1.69)  LDD2228  [12]
 LDCM0625  F8 Ramos C62(0.10)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C62(2.47)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C62(20.00)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C62(0.45)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C62(1.25)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C62(1.00)  LDD2193  [19]
 LDCM0580  Fragment21 Ramos C62(1.36)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C62(1.99)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C62(1.08)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C62(0.74)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C62(1.54)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C62(1.08)  LDD2200  [19]
 LDCM0468  Fragment33 Ramos C62(1.66)  LDD2202  [19]
 LDCM0596  Fragment38 Ramos C62(1.76)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C62(0.78)  LDD2184  [19]
 LDCM0610  Fragment52 Ramos C62(2.76)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C62(1.28)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C62(0.71)  LDD2186  [19]
 LDCM0015  HNE MDA-MB-231 C62(0.99)  LDD0346  [19]
 LDCM0022  KB02 22RV1 C62(1.53)  LDD2243  [20]
 LDCM0023  KB03 Jurkat C62(5.94)  LDD0209  [8]
 LDCM0024  KB05 COLO792 C62(3.03)  LDD3310  [20]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C62(0.98)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C62(0.63)  LDD2121  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C62(0.62)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C62(1.33)  LDD2090  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C62(0.72)  LDD2092  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C62(0.66)  LDD2093  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C62(1.37)  LDD2094  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C62(0.66)  LDD2096  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C62(0.61)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C62(0.85)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C62(0.95)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C62(1.11)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C62(0.55)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C62(0.80)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C62(0.99)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C62(0.95)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C62(0.89)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C62(0.99)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C62(0.92)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C62(1.93)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C62(1.25)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C62(0.72)  LDD2114  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C62(0.34)  LDD2115  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C62(0.52)  LDD2116  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C62(0.61)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C62(2.62)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C62(0.90)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C62(0.71)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C62(0.90)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C62(0.81)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C62(0.57)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C62(0.81)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C62(0.93)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C62(0.88)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C62(0.49)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C62(0.33)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C62(0.77)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C62(1.13)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C62(0.98)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C62(1.43)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C62(0.70)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C62(0.86)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C62(1.08)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C62(4.04)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C62(9.95)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C62(0.96)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C62(3.42)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C62(0.46)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C62(0.71)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C62(0.57)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C62(0.66)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C62(1.63)  LDD2153  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C62(0.80)  LDD2206  [21]
 LDCM0628  OTUB2-COV-1 HEK-293T C62(0.68)  LDD2207  [21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Helicase-like transcription factor (HLTF) SNF2/RAD54 helicase family Q14527
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A2 (ANXA2) Annexin family P07355
Transient receptor potential cation channel subfamily M member 4 (TRPM4) Transient receptor (TC 1.A.4) family Q8TD43
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-C chemokine receptor type 10 (CCR10) G-protein coupled receptor 1 family P46092
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nanos homolog 2 (NANOS2) Nanos family P60321
Protein S100-A3 (S100A3) S-100 family P33764
Protein S100-Z (S100Z) S-100 family Q8WXG8
Neuroblast differentiation-associated protein AHNAK (AHNAK) . Q09666

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phenethyl Isothiocyanate Small molecular drug DB12695

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
21 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.