Details of the Target

General Information of Target

Target ID LDTP10749
Target Name Exportin-6 (XPO6)
Gene Name XPO6
Gene ID 23214
Synonyms
KIAA0370; RANBP20; Exportin-6; Exp6; Ran-binding protein 20
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
PPPGAHLYEELGDSSILFLLYHFQQSRGNNSVSEDRKHQQVVMPFSSNTIEAHKSAHVDG
SLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTNSDISQRTDFVDPFSPKIQAKS
KSLRGPREKIQRLWSQSVSLPRRLMRKVPNRPEIIDLQQWQGTRQKAENENTGICTNKRG
SSNPLLTTEEANLTEKEEIRQGETLMIEGTEQLKSLSSDSSFCFPRPHFSFSTLPTVSRT
VELKSEPNVISSPAECSLELSPSRPCVLHSSLSRRETPICMLPIETERNIFENFAHPPNI
SPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIPLPLPPPTFFPLSV
STSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVKCTTNLMPAEKIKS
SMTQLSTTTVCKTDPQREPKGILRHVKNLAELEKSVANMYSQIEKNYLRTNVSELQTMCP
SEVTNMEITSEQNKGSLNNIVEGTEKQSHSQSTSL
Target Bioclass
Other
Family
Exportin family
Subcellular location
Nucleus
Function Mediates the nuclear export of actin and profilin-actin complexes in somatic cells.
Uniprot ID
Q96QU8
Ensemble ID
ENST00000304658.10
HGNC ID
HGNC:19733

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ETK1 SNV: p.A709V DBIA    Probe Info 
HCT116 SNV: p.S695N DBIA    Probe Info 
HDMYZ SNV: p.S598F DBIA    Probe Info 
HEC1 SNV: p.R644Q DBIA    Probe Info 
HT115 SNV: p.R1109H .
LS123 SNV: p.S295R DBIA    Probe Info 
MOLT4 SNV: p.L11F IA-alkyne    Probe Info 
NCIH358 SNV: p.Q637H DBIA    Probe Info 
NCIH716 SNV: p.S295R .
SHP77 SNV: p.D283Y DBIA    Probe Info 
SISO SNV: p.Q483H DBIA    Probe Info 
SNGM SNV: p.V325A DBIA    Probe Info 
SSP25 SNV: p.A709V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y104(10.70)  LDD0257  [1]
STPyne
 Probe Info  		K717(2.52); K891(10.00)  LDD0277  [2]
ONAyne
 Probe Info  		K439(10.00)  LDD0275  [2]
m-APA
 Probe Info  		11.78  LDD0403  [3]
BTD
 Probe Info  		C723(1.21)  LDD1700  [4]
AHL-Pu-1
 Probe Info  		C22(2.62)  LDD0168  [5]
DBIA
 Probe Info  		C299(1.32); C547(0.89)  LDD0078  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C22(0.00); C315(0.00); C547(0.00); C299(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C22(0.00); C315(0.00); C324(0.00); C723(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C315(0.00); C299(0.00); C324(0.00); C159(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
IPM
 Probe Info  		C886(0.00); C315(0.00); C22(0.00); C723(0.00)  LDD0005  [10]
SF
 Probe Info  		N.A.  LDD0028  [11]
TFBX
 Probe Info  		C324(0.00); C547(0.00); C723(0.00); C159(0.00)  LDD0148  [12]
VSF
 Probe Info  		C159(0.00); C886(0.00)  LDD0007  [10]
Acrolein
 Probe Info  		C22(0.00); C159(0.00); C547(0.00); C282(0.00)  LDD0217  [13]
Methacrolein
 Probe Info  		C159(0.00); C547(0.00)  LDD0218  [13]
W1
 Probe Info  		N.A.  LDD0236  [14]
AOyne
 Probe Info  		15.00  LDD0443  [15]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe2
 Probe Info  		20.00  LDD0463  [16]
JN0003
 Probe Info  		20.00  LDD0469  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C723(0.96)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C723(1.32)  LDD2152  [4]
 LDCM0025  4SU-RNA HEK-293T C22(2.62)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C324(2.13)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C159(1.44); C299(1.10); C324(1.10); C547(1.08)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C159(1.23); C299(1.27); C324(1.23); C547(1.18)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C159(0.79); C299(0.92); C324(1.00); C547(1.21)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C159(0.90); C299(0.98); C324(0.93); C547(0.96)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C159(0.83); C299(0.98); C324(1.11); C547(0.86)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C159(0.85); C299(1.18); C324(0.95); C547(1.01)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C159(0.90); C299(0.93); C324(0.85); C547(0.83)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C159(1.01); C299(1.03); C324(1.04); C547(0.96)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C159(0.97); C299(1.00); C324(1.05); C547(1.07)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C159(0.94); C299(1.07); C324(0.91); C547(0.88)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C159(0.97); C299(0.87); C324(0.95); C547(1.12)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C159(0.72); C299(0.79); C324(1.04); C547(1.00)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C159(0.96); C299(1.30); C324(0.97); C547(1.08)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C159(0.96); C299(0.97); C324(1.07); C547(1.05)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C159(0.90); C299(0.91); C324(1.16); C547(0.99)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C159(0.94); C299(1.07); C324(0.87); C547(1.04)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C159(1.07); C299(1.03); C547(1.00); C723(0.85)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C159(0.87); C299(0.98); C547(1.08); C723(0.91)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C159(0.87); C299(0.91); C547(1.16); C723(0.96)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C159(0.82); C299(1.09); C547(1.10); C723(0.99)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C159(1.20); C299(1.16); C547(1.01); C723(0.95)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C159(0.99); C299(1.13); C547(1.10); C723(0.99)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C159(0.86); C299(1.31); C547(1.04); C723(0.90)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C159(0.83); C299(1.16); C324(0.86); C547(0.98)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C159(0.93); C299(1.21); C547(1.02); C723(1.02)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C159(0.93); C299(1.54); C547(1.13); C723(0.93)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C159(0.89); C299(1.17); C547(1.07); C723(0.87)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C159(0.99); C299(1.59); C547(1.02); C723(0.93)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C159(0.86); C299(1.41); C547(0.95); C723(1.05)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C159(1.17); C299(1.34); C547(1.00); C723(1.03)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C159(1.19); C299(1.16); C547(1.13); C723(1.06)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C159(1.09); C299(1.24); C547(1.07); C723(0.92)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C159(1.92); C299(1.07); C547(1.31); C723(0.76)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C159(1.21); C299(0.94); C547(1.06); C723(0.72)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C159(1.60); C299(1.07); C547(1.31); C723(0.79)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C159(1.09); C299(0.88); C547(1.02); C723(0.73)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C159(1.20); C299(1.10); C547(1.16); C723(0.86)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C159(1.58); C299(0.99); C547(1.18); C723(0.71)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C159(1.45); C299(1.35); C547(1.31); C723(0.78)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C159(1.49); C299(1.30); C547(1.27); C723(0.90)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C159(1.49); C299(0.95); C547(1.17); C723(0.79)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C159(1.37); C299(1.04); C547(1.21); C723(0.79)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C159(1.80); C299(1.31); C547(1.27); C723(0.86)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C159(1.34); C299(1.23); C547(1.20); C723(0.90)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C159(0.89); C299(1.19); C324(1.07); C547(0.98)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C159(1.87); C299(1.44); C547(1.39); C723(0.97)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C159(1.56); C299(1.36); C547(1.28); C723(0.83)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C159(1.44); C299(1.00); C547(1.14); C723(0.88)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C886(0.74); C547(0.82); C723(0.87); C159(1.10)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C886(0.71); C723(0.98); C159(1.00); C547(1.05)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C886(0.97); C723(1.03); C547(1.10); C299(1.21)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C886(0.96); C547(1.03); C723(1.21); C159(1.32)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C547(0.79); C886(0.89); C723(1.07); C159(1.17)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C547(0.86); C886(1.07); C723(1.29); C299(1.56)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C547(0.84); C886(0.94); C723(1.08); C159(1.51)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C723(0.87); C324(0.93); C547(0.99); C159(1.03)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C886(0.81); C723(0.97); C299(1.17); C159(1.26)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C886(0.80); C547(0.95); C723(0.98); C299(1.20)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C547(0.74); C886(0.85); C723(1.03); C299(1.43)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C547(1.00); C886(1.01); C723(1.38); C299(1.65)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C159(1.31); C299(1.31); C547(0.87); C723(0.94)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C159(1.37); C299(1.42); C547(0.80); C723(1.05)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C159(1.00); C299(1.13); C547(0.85); C723(1.04)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C159(1.26); C299(0.89); C547(0.97); C723(0.96)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C324(1.01); C723(1.06); C547(1.08); C159(1.17)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C723(0.94); C324(0.99); C547(1.04); C159(1.11)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C723(0.92); C159(1.02); C299(1.06); C324(1.07)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C723(0.80); C547(0.99); C299(1.15); C324(1.27)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C723(1.05); C324(1.07); C299(1.08); C159(1.09)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C159(1.00); C547(1.03); C324(1.05); C299(1.18)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C324(0.99); C299(1.12); C723(1.16); C547(1.19)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C324(0.96); C547(1.10); C299(1.12); C723(1.14)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C723(0.92); C159(0.94); C324(1.00); C299(1.02)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C723(0.98); C547(1.02); C886(1.07); C159(1.09)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C723(1.15); C299(1.20); C547(1.22); C159(1.41)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C723(0.98); C159(1.15); C886(1.16); C299(1.19)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C723(0.93); C159(1.15); C299(1.36); C547(1.39)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C723(0.96); C547(1.15); C299(1.22); C159(1.26)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C723(1.03); C547(1.04); C324(1.09); C159(1.29)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C723(1.01); C159(1.04); C547(1.29); C299(1.30)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C723(0.97); C547(1.13); C299(1.25); C886(1.39)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C723(1.00); C159(1.26); C886(1.28); C547(1.33)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C723(0.93); C547(1.17); C159(1.32); C299(1.39)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C723(1.02); C547(1.08); C159(1.15); C299(1.57)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C547(0.88); C723(0.93); C299(1.06); C159(1.14)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C723(0.85); C159(0.87); C547(1.00); C299(1.21)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C299(0.93); C723(0.95); C159(0.96); C547(1.02)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C547(0.97); C723(0.98); C299(1.00); C159(1.19)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C723(1.04); C299(1.07); C547(1.13); C159(1.30)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C723(0.97); C547(1.15); C324(1.20); C299(1.35)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C723(0.87); C159(1.00); C299(1.08); C547(1.08)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C723(0.92); C159(1.09); C547(1.16); C299(1.26)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C723(0.93); C159(1.02); C547(1.09); C299(1.25)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C159(0.98); C723(1.09); C299(1.13); C547(1.22)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C159(0.94); C723(1.03); C547(1.10); C299(1.13)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C723(0.92); C547(1.23); C159(1.25); C299(1.30)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C299(0.98); C723(1.09); C547(1.22); C159(1.30)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C723(1.03); C299(1.09); C159(1.15); C547(1.17)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C299(0.99); C547(1.14); C159(1.23); C723(1.37)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C723(1.07); C547(1.18); C299(1.26); C159(1.33)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C723(0.98); C547(1.17); C159(1.21); C299(1.35)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C723(0.99); C547(1.11); C159(1.25); C299(1.30)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C299(0.82); C723(1.07); C159(1.08); C547(1.13)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C299(1.04); C159(1.07); C547(1.17); C723(1.19)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C723(0.90); C547(1.10); C159(1.23); C299(1.33)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C723(0.98); C299(1.13); C159(1.15); C547(1.21)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C723(0.97); C159(1.18); C547(1.28); C299(1.38)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C547(1.21); C723(1.25); C159(1.27); C299(1.58)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C159(1.07); C723(1.14); C324(1.17); C299(1.18)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C324(0.92); C723(0.98); C159(1.10); C547(1.26)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C324(0.99); C547(1.16); C723(1.21); C159(1.22)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C723(0.97); C159(0.98); C547(1.05); C324(1.22)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C324(0.91); C723(1.02); C547(1.09); C159(1.15)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C324(0.97); C547(1.03); C159(1.04); C723(1.14)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C723(1.08); C547(1.17); C299(1.22); C324(1.25)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C324(0.68); C723(0.97); C547(1.08); C299(1.13)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C324(0.98); C723(1.18); C299(1.21); C547(1.24)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C324(1.09); C159(1.29); C723(1.31); C299(1.38)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C324(0.72); C547(1.14); C299(1.23); C159(1.34)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C324(0.99); C547(1.21); C159(1.42); C299(1.44)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C324(0.86); C723(0.94); C159(1.00); C547(1.06)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C324(0.80); C547(1.04); C159(1.08); C299(1.17)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C723(0.86); C159(0.98); C547(1.01); C324(1.05)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C324(0.83); C547(1.06); C723(1.16); C159(1.27)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C324(0.81); C159(1.04); C547(1.09); C299(1.14)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C324(0.92); C723(0.97); C159(1.04); C547(1.11)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C324(0.88); C723(0.96); C159(1.38); C547(1.40)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C324(0.87); C723(1.13); C159(1.51); C547(1.62)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C324(0.92); C723(1.02); C159(1.54); C547(1.77)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C324(0.87); C723(1.10); C547(1.11); C159(1.21)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C324(0.84); C723(1.00); C159(1.14); C547(1.17)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C324(0.83); C723(1.12); C159(1.14); C547(1.20)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C324(0.98); C547(1.04); C723(1.06); C159(1.11)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C547(0.92); C723(0.96); C324(0.97); C159(0.98)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C324(0.88); C723(0.95); C159(1.11); C547(1.14)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C324(0.84); C159(0.97); C547(1.07); C723(1.20)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C324(0.77); C723(1.03); C547(1.50); C159(1.57)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C723(0.77); C159(1.11); C547(1.25); C299(1.44)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C723(0.86); C159(1.13); C547(1.29); C299(1.36)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C159(0.70); C723(0.85); C547(1.20); C299(1.21)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C159(0.79); C723(0.87); C299(1.07); C547(1.32)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C299(0.84); C159(0.95); C723(1.04); C547(1.23)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C159(0.71); C299(0.88); C723(1.10); C547(1.21)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C159(0.92); C723(0.98); C299(1.03); C547(1.41)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C299(0.75); C723(0.95); C547(1.13); C159(1.86)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C723(0.95); C159(1.04); C547(1.51); C299(1.56)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C159(0.94); C723(1.00); C299(1.35); C547(1.42)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C159(0.84); C723(0.87); C299(1.06); C547(1.23)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C159(0.89); C299(1.02); C547(1.08); C723(1.16)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C159(0.74); C299(0.87); C723(0.94); C547(1.25)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C159(1.03); C723(1.10); C299(1.12); C547(1.37)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C723(0.92); C159(0.96); C299(1.13); C547(1.39)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C324(0.86); C723(1.07); C547(1.10); C159(1.19)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C159(0.73); C299(0.88); C324(0.98); C723(1.03)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C159(0.96); C299(1.02); C324(1.03); C547(1.07)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C723(0.95); C159(0.97); C547(0.97); C324(1.12)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C723(1.08); C159(1.14); C324(1.18); C547(1.18)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 11.78  LDD0403  [3]
 LDCM0020  ARS-1620 HCC44 C299(1.32); C547(0.89)  LDD0078  [6]
 LDCM0108  Chloroacetamide HeLa C22(0.00); C159(0.00); C282(0.00); C547(0.00)  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C299(0.45)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C886(0.68); C159(1.02); C299(1.11); C723(1.13)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C886(0.66); C159(0.94); C547(1.13); C723(1.13)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C723(0.92); C324(0.98); C547(1.05); C159(1.13)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C723(0.81); C159(0.86); C547(0.92); C324(1.20)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C723(0.89); C547(0.90); C324(0.93); C159(0.97)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C723(0.85); C547(0.91); C159(0.97); C324(1.01)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C723(0.85); C547(0.97); C159(1.03); C324(1.10)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C324(0.89); C547(1.11); C723(1.14); C159(1.21)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C324(0.94); C723(1.15); C547(1.21); C159(1.42)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C324(1.02); C723(1.08); C547(1.22); C159(1.38)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C324(1.03); C723(1.15); C547(1.16); C159(1.35)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C547(1.01); C159(1.05); C324(1.07); C723(1.20)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C886(0.60); C159(1.01); C299(1.11); C547(1.14)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C159(0.98); C324(1.04); C547(1.06); C723(1.20)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C159(1.06); C723(1.09); C324(1.17); C299(1.24)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C723(1.00); C547(1.05); C159(1.12); C299(1.17)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C723(1.00); C159(1.09); C547(1.09); C886(1.31)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C723(0.95); C547(1.11); C159(1.19); C299(1.42)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C723(0.91); C159(0.99); C547(1.01); C299(1.28)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C723(1.02); C159(1.12); C547(1.14); C299(1.26)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C159(1.10); C723(1.20); C299(1.33); C547(1.44)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C723(0.97); C547(1.07); C159(1.11); C299(1.12)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C159(1.01); C723(1.05); C547(1.10); C299(1.20)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C886(0.75); C547(1.15); C159(1.17); C299(1.18)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C299(1.07); C723(1.08); C159(1.08); C547(1.12)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C299(0.97); C547(0.99); C723(0.99); C159(1.07)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C723(0.87); C547(1.07); C159(1.10); C299(1.12)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C723(0.93); C159(1.02); C547(1.03); C299(1.24)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C159(1.12); C547(1.18); C723(1.33); C299(1.39)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C159(0.97); C547(0.99); C723(1.03); C299(1.10)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C159(0.88); C723(0.94); C547(0.98); C324(1.01)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C324(0.77); C159(0.99); C723(1.07); C547(1.11)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C324(0.92); C547(1.04); C299(1.24); C159(1.29)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C886(0.68); C159(1.03); C547(1.09); C299(1.21)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C886(0.67); C159(0.93); C547(1.02); C723(1.06)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C886(0.49); C723(1.19); C547(1.19); C159(1.21)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C324(0.68); C299(0.99); C547(1.19); C159(1.25)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C324(0.85); C723(1.00); C299(1.07); C159(1.08)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C299(0.94); C324(1.05); C159(1.19); C547(1.28)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C299(1.10); C324(1.28); C547(1.28); C159(1.28)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C886(0.58); C159(1.01); C299(1.02); C723(1.03)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C299(1.11); C547(1.15); C159(1.20); C324(1.26)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C547(1.07); C299(1.19); C159(1.31); C723(1.67)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C547(1.05); C723(1.21); C159(1.32); C299(1.40)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C324(1.07); C299(1.10); C547(1.13); C159(1.19)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C159(1.34); C299(1.10); C324(1.76); C547(1.12)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C159(1.20); C299(1.30); C324(1.95); C547(1.21)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C159(1.06); C299(1.01); C324(0.94); C547(1.38)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C159(1.17); C299(1.03); C324(1.06); C547(1.11)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C159(1.26); C299(0.98); C324(1.36); C547(1.16)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C159(1.13); C299(1.06); C324(1.02); C547(1.32)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C159(0.96); C299(0.97); C547(0.96); C723(1.08)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C159(1.11); C299(0.97); C324(0.92); C547(1.54)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C159(0.99); C299(1.20); C324(1.05); C547(1.03)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C159(1.01); C299(1.39); C324(0.81); C547(1.00)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C159(0.95); C299(1.26); C324(0.96); C547(0.95)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C159(1.04); C299(1.48); C324(1.09); C547(1.17)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C159(1.16); C299(1.52); C324(1.02); C547(1.16)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C159(1.11); C299(1.37); C324(0.99); C547(1.03)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C159(1.33); C299(1.54); C324(1.13); C547(1.20)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C159(1.14); C299(1.48); C324(1.11); C547(1.25)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C159(0.90); C299(1.11); C547(1.02); C723(1.15)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C159(1.07); C299(1.38); C324(1.10); C547(1.09)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C159(0.95); C299(1.30); C324(1.00); C547(1.13)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C159(1.37); C299(2.03); C324(1.03); C547(1.45)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C159(1.15); C299(1.45); C324(1.16); C547(1.22)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C159(1.15); C299(1.53); C324(1.09); C547(1.21)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C159(1.17); C299(1.64); C324(0.94); C547(1.22)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C159(0.82); C299(0.85); C324(0.99); C547(1.08)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C159(1.31); C299(0.89); C324(0.89); C547(0.96)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C159(0.82); C299(0.84); C324(0.87); C547(0.97)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C159(0.99); C299(0.89); C324(0.99); C547(1.06)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C159(1.09); C299(1.02); C547(0.97); C723(1.07)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C159(1.16); C299(0.95); C324(1.21); C547(1.00)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C159(1.15); C299(0.90); C324(1.07); C547(1.06)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C159(1.60); C299(0.83); C324(1.02); C547(1.09)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C159(0.93); C299(0.84); C324(0.84); C547(0.84)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C159(1.20); C299(0.90); C324(0.87); C547(1.04)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C159(1.00); C299(0.81); C324(1.00); C547(0.91)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C159(1.07); C299(0.96); C324(0.93); C547(0.98)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C159(1.27); C299(0.81); C324(0.84); C547(0.91)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C159(1.35); C299(0.89); C324(0.86); C547(1.02)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C159(1.43); C299(0.96); C324(0.94); C547(1.01)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C159(0.99); C299(1.08); C547(1.04); C723(1.17)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C159(1.18); C299(0.96); C324(0.91); C547(1.11)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C159(1.94); C299(1.04); C324(0.98); C547(1.14)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C159(1.06); C299(1.04); C324(0.74); C547(1.18)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C159(1.20); C299(1.03); C324(0.78); C547(1.12)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C159(1.47); C299(1.18); C324(0.94); C547(1.21)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C159(1.30); C299(1.09); C324(0.98); C547(1.44)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C159(2.01); C299(1.26); C324(0.93); C547(1.44)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C159(1.79); C299(1.12); C324(0.91); C547(1.23)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C159(1.29); C299(1.14); C324(0.92); C547(1.10)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C159(1.19); C299(1.15); C324(1.06); C547(1.17)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C159(0.92); C299(1.17); C547(1.21); C723(1.62)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C159(1.55); C299(1.01); C324(1.06); C547(1.10)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C159(1.26); C299(1.09); C324(0.99); C547(1.16)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C159(1.05); C299(1.03); C324(1.18); C547(1.21)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C159(1.10); C299(1.16); C324(1.00); C547(1.02)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C159(1.88); C299(1.10); C324(0.95); C547(1.18)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C299(1.11); C324(1.10); C547(0.81); C723(0.92)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C299(0.93); C324(1.15); C547(0.88); C723(1.00)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C299(1.07); C324(1.26); C547(0.90); C723(0.94)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C299(1.09); C324(1.22); C547(1.05); C723(1.05)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C159(1.07); C299(2.00); C547(1.05); C723(1.16)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C299(1.14); C324(1.05); C547(1.02); C723(1.05)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C299(1.15); C324(1.16); C547(0.98); C723(1.16)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C299(1.41); C324(1.30); C547(0.96); C723(1.08)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C299(1.20); C324(1.49); C547(0.95); C723(1.14)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C299(1.55); C324(1.71); C547(0.97); C723(1.06)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C299(1.01); C324(1.27); C547(0.87); C723(1.06)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C299(1.15); C324(1.01); C547(0.82); C723(1.07)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C299(1.13); C324(1.43); C547(1.02); C723(1.09)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C299(1.10); C324(1.46); C547(0.84); C723(1.21)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C299(1.40); C324(1.46); C547(0.88); C723(1.11)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C159(1.10); C299(1.38); C547(1.27); C723(1.14)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C299(0.90); C324(1.05); C547(1.34); C723(1.12)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C159(1.46); C299(1.27); C324(1.20); C547(1.00)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C159(1.29); C299(1.20); C324(1.14); C547(1.00)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C159(1.20); C299(1.19); C324(1.14); C547(1.00)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C159(1.21); C299(1.55); C324(1.22); C547(0.97)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C159(1.63); C299(1.31); C324(1.13); C547(0.94)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C159(1.17); C299(1.39); C324(1.12); C547(1.07)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C159(1.34); C299(1.10); C324(1.25); C547(0.97)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C159(1.50); C299(1.19); C324(1.14); C547(1.08)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C159(1.30); C299(1.23); C324(1.19); C547(1.07)  LDD0811  [6]
 LDCM0185  Compound 17 HEK-293T 6.04  LDD0512  [16]
 LDCM0495  E2913 HEK-293T C723(0.91); C547(0.95); C1114(0.95); C324(1.05)  LDD1698  [17]
 LDCM0625  F8 Ramos C723(1.01); C159(0.97); C1114(0.73); C886(1.96)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C723(3.65); C159(3.86)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C723(3.00); C159(20.00); C22(0.09)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C723(3.80)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C723(0.72); C159(1.07); C1114(0.89); C299(1.53)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C159(1.58); C22(3.88)  LDD2193  [18]
 LDCM0580  Fragment21 Ramos C723(1.04); C159(1.18); C1114(1.09); C299(1.15)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C723(0.89); C159(0.73); C1114(0.96); C299(0.59)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C723(0.66); C159(0.86); C1114(0.86); C299(0.84)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C723(0.60); C159(0.80); C1114(0.74); C299(1.21)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C723(0.67); C159(1.49); C1114(0.88); C299(1.56)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C723(0.91); C159(1.19); C1114(0.82); C299(2.03)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C723(1.92); C159(7.28)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C159(1.34); C299(1.06); C324(0.87); C547(1.15)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C723(0.57); C159(1.20); C1114(2.40); C299(1.79)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C723(4.13); C886(3.02)  LDD2184  [18]
 LDCM0427  Fragment51 HCT 116 C159(1.24); C299(1.59); C324(1.39); C547(1.27)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C723(0.55); C159(1.18)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C723(0.61); C159(1.27); C1114(0.95); C299(2.04)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C22(0.83)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C159(8.49)  LDD2188  [18]
 LDCM0022  KB02 HCT 116 C299(4.35)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C299(2.65)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C299(20.00)  LDD0082  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C886(1.17)  LDD2092  [4]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C886(1.08)  LDD2094  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C886(1.81)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C723(1.36); C547(0.55)  LDD2099  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C886(0.90)  LDD2105  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C723(0.96)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C723(0.66)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C723(1.02)  LDD2111  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C723(0.84)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C723(0.80)  LDD2125  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C723(0.91)  LDD2135  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C723(1.21)  LDD1700  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C723(1.01)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C723(0.78); C552(0.65)  LDD2146  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C886(2.76)  LDD2153  [4]
 LDCM0628  OTUB2-COV-1 HEK-293T C324(0.29)  LDD2207  [19]
 LDCM0021  THZ1 HCT 116 C299(1.00); C159(1.21); C547(1.32)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.