Details of the Target

General Information of Target

Target ID LDTP07109
Target Name ATP-binding cassette sub-family C member 10 (ABCC10)
Gene Name ABCC10
Gene ID 89845
Synonyms
MRP7; SIMRP7; ATP-binding cassette sub-family C member 10; EC 7.6.2.2; EC 7.6.2.3; Multidrug resistance-associated protein 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERLLAQLCGSSAAWPLPLWEGDTTGHCFTQLVLSALPHALLAVLSACYLGTPRSPDYIL
PCSPGWRLRLAASFLLSVFPLLDLLPVALPPGAGPGPIGLEVLAGCVAAVAWISHSLALW
VLAHSPHGHSRGPLALALVALLPAPALVLTVLWHCQRGTLLPPLLPGPMARLCLLILQLA
ALLAYALGWAAPGGPREPWAQEPLLPEDQEPEVAEDGESWLSRFSYAWLAPLLARGACGE
LRQPQDICRLPHRLQPTYLARVFQAHWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGF
SGPLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVL
NILYCKALQLGPSRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVG
VAFVGGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQA
LGARVEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVFTA
LALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDPPAEPSTVLEL
HGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVR
GLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVG
EKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLL
CTHRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPKAWAENGQESDSATAQSVQNP
EKTKEGLEEEQSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRN
AADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNG
SSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATP
TGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYH
VQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRC
QFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSG
LVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLP
NALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLR
SQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMGGLDGELGEGGR
SLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRL
NTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQGVPASLGGP
Target Bioclass
Enzyme
Family
ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Subcellular location
Cell membrane
Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel. Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP.
Uniprot ID
Q5T3U5
Ensemble ID
ENST00000244533.7
HGNC ID
HGNC:52
ChEMBL ID
CHEMBL2073687

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
42MGBA SNV: p.R570W .
A375 SNV: p.A88P .
AN3CA SNV: p.R1086M .
HCT15 SNV: p.L363M; p.W556C .
HT SNV: p.V351A .
IGROV1 Deletion: p.G1245AfsTer22 .
JM1 SNV: p.L1392V .
KYSE510 SNV: p.P808S .
MCC13 SNV: p.S942F
Substitution: p.G188R		 .
SKMEL2 SNV: p.K744N .
SKMEL3 SNV: p.L1005M .
SNU1 Deletion: p.G1245AfsTer22 .
SUPT1 SNV: p.Y508C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
AHL-Pu-1
 Probe Info  		C1425(2.75)  LDD0170  [2]
DBIA
 Probe Info  		C248(1.55)  LDD0531  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
AOyne
 Probe Info  		13.50  LDD0443  [5]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C355
 Probe Info  		24.59  LDD2016  [6]
C356
 Probe Info  		10.34  LDD2017  [6]
C357
 Probe Info  		6.19  LDD2018  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C1425(2.75)  LDD0170  [2]
 LDCM0026  4SU-RNA+native RNA DM93 C1425(2.92)  LDD0171  [2]
 LDCM0214  AC1 HCT 116 C248(1.55)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C475(0.79)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C475(0.68)  LDD0543  [3]
 LDCM0237  AC12 HCT 116 C475(0.78)  LDD0554  [3]
 LDCM0259  AC14 HCT 116 C475(0.76)  LDD0576  [3]
 LDCM0263  AC143 HCT 116 C248(1.64)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C248(1.63)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C248(1.36)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C248(1.21)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C248(1.23)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C248(1.13)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C248(1.04)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C475(0.71)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C248(1.50)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C248(1.21)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C248(1.28)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C248(1.32)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C248(1.20)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C248(1.60)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C248(1.49)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C248(1.07)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C248(0.99); C475(1.29)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C475(0.77); C248(1.60)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C475(0.69); C248(1.00)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C248(0.86)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C475(0.88); C248(1.10)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C475(0.84); C248(1.46)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C475(0.85); C248(1.05)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C475(0.81); C248(1.02)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C475(1.05); C248(1.09)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C248(1.02)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C248(0.80)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C248(0.69)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C248(0.91)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C248(0.93)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C248(1.23)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C248(0.94)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C248(0.80)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C248(0.86)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C248(0.84)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C248(0.75)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C238(0.94); C1391(1.11); C62(0.97)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C238(1.11); C248(1.09); C1391(1.05); C62(0.83)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C238(1.01); C248(1.01); C1391(1.22); C702(1.01)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C238(0.98); C1391(1.20); C62(0.72)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C238(1.04); C248(1.10); C1391(0.93); C702(0.94)  LDD1539  [7]
 LDCM0301  AC4 HCT 116 C248(1.37)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C238(1.03); C248(1.03); C1391(1.12)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C238(1.06); C1391(1.06); C702(0.92)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C238(1.09); C248(1.14); C1391(1.03); C702(1.18)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C238(0.97); C1391(1.13); C62(1.05)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C238(1.06); C248(1.18); C1391(1.04); C62(0.85)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C238(1.01); C248(1.02); C1391(1.09); C702(1.06)  LDD1546  [7]
 LDCM0308  AC46 HCT 116 C475(1.00)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C475(0.87)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C475(1.05)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C475(0.96)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C248(1.11)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C475(0.92)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C475(1.04)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C475(0.79)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C475(0.66)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C475(0.78)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C475(1.49)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C475(0.85)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C475(1.23)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C475(1.13)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C475(1.36)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C475(0.88)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C475(1.15)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C475(1.15)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C475(1.23)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C475(1.11)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C475(1.66)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C475(2.06)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C475(1.67)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C475(2.03)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C475(0.58); C248(0.62)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C475(0.61); C248(0.87)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C475(0.88)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C248(0.66); C475(1.29)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C475(0.97); C248(1.54)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C248(0.96); C475(1.08)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C248(0.95); C475(1.08)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C475(0.82); C248(0.83)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C475(0.74); C248(0.80)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C475(0.76); C248(0.84)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C475(0.76); C248(0.84)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C248(0.68); C475(1.06)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C475(0.70); C248(1.32)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C475(0.89)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C248(0.82); C475(0.97)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C475(0.78); C248(1.66)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C475(0.73); C248(0.76)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C248(1.03); C475(1.15)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C248(1.03); C475(1.19)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C248(1.08); C475(1.09)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C248(0.99); C475(1.29)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C475(0.92); C248(1.08)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C248(0.94); C475(1.08)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C248(1.02); C475(1.05)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C248(1.11); C475(1.25)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C248(1.06); C475(1.11)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C475(1.17); C248(1.17)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C248(1.05); C475(1.12)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C248(1.03); C475(1.30)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C248(1.06); C475(1.21)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C248(1.10); C475(1.33)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C248(1.06); C475(1.12)  LDD0681  [3]
 LDCM0248  AKOS034007472 HCT 116 C475(0.78)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C475(0.86)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C475(0.86)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C248(0.84)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C248(1.06)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C248(1.14)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C475(0.78)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C475(0.73)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C475(0.78)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C475(0.85)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C475(1.20); C248(1.23)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C475(0.95); C248(1.10)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C475(1.13); C248(1.42)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C248(1.00); C475(1.11)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C475(0.91); C248(1.17)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C248(0.94)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C475(1.04); C248(1.16)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C475(0.93); C248(1.16)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C248(1.22)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C248(1.05)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C248(1.08)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C248(1.56)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C248(0.82)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C238(1.09); C248(0.97); C1391(1.00)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C238(1.12); C248(1.19); C1391(1.03); C702(0.98)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C238(1.08); C248(1.03); C1391(0.99)  LDD1593  [7]
 LDCM0390  CL12 HCT 116 C248(0.98)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C238(0.98); C248(1.05); C1391(1.03); C702(1.02)  LDD1595  [7]
 LDCM0392  CL121 HCT 116 C475(1.16)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C475(0.97)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C475(0.74)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C475(0.90)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C475(1.06)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C475(1.03)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C475(0.91)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C475(1.48)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C248(1.01)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C248(1.03)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C248(1.00)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C248(0.83)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C248(0.91)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C248(0.77)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C248(0.84)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C248(1.27)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C248(0.76)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C248(0.98)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C248(0.94)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C248(0.74)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C248(0.78)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C248(0.94)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C248(0.84)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C248(0.76)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C248(0.75)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C248(0.91)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C248(0.90)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C248(0.90)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C238(0.91); C1391(1.18); C62(1.00)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C238(1.13); C248(0.85); C1391(0.98); C62(0.95)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C238(2.03); C248(1.34); C1391(1.27); C702(0.75)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C238(1.09); C1391(1.14); C62(0.74)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C238(1.01); C248(0.97); C1391(0.89); C702(0.99)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C238(1.13); C248(1.19); C1391(1.15)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C238(1.03); C248(1.00); C1391(1.22)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C238(1.06); C248(1.12); C1391(1.09)  LDD1632  [7]
 LDCM0429  CL4 HCT 116 C248(1.03)  LDD0746  [3]
 LDCM0430  CL40 HEK-293T C238(0.87); C248(1.01); C1391(0.99); C702(1.07)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C238(1.15); C1391(1.05); C702(1.18)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C238(1.08); C248(1.17); C1391(1.05); C702(0.89)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C238(1.01); C1391(1.17); C62(1.08)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C238(1.15); C248(0.85); C1391(1.00); C62(1.03)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C238(1.23); C248(1.06); C1391(1.08); C702(1.03)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C238(1.14); C1391(1.18); C62(0.73)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C238(1.04); C248(1.05); C1391(1.03); C702(0.91)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C238(1.18); C248(1.17); C1391(1.06)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C238(1.13); C248(0.92); C1391(1.08)  LDD1643  [7]
 LDCM0440  CL5 HCT 116 C248(0.91)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C238(1.04); C248(1.29); C1391(1.22); C702(1.05)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C238(1.13); C248(0.89); C1391(0.95); C702(0.86)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C238(1.24); C1391(1.22); C702(1.03)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C238(1.43); C248(1.60); C1391(1.11); C702(1.09)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C238(1.05); C1391(1.22); C62(1.08)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C238(1.19); C248(0.88); C1391(0.98); C62(1.16)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C238(1.35); C248(1.15); C1391(0.96); C702(0.94)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C238(1.09); C1391(1.17); C62(0.78)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C238(1.14); C248(1.07); C1391(1.17); C702(1.06)  LDD1653  [7]
 LDCM0451  CL6 HCT 116 C248(1.04)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C238(1.14); C248(1.15); C1391(1.05)  LDD1655  [7]
 LDCM0453  CL61 HCT 116 C248(0.97)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C248(0.79)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C248(1.12)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C248(0.87)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C248(0.92)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C248(0.91)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C248(0.84)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C248(0.75)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C248(1.00)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C248(0.94)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C248(1.24)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C248(1.00)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C248(0.74)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C248(0.79)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C248(1.20)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C238(0.99); C248(0.93); C1391(0.89); C702(1.20)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C238(1.25); C1391(1.11); C702(0.88)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C238(1.07); C248(1.14); C1391(1.08); C702(1.06)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C238(0.89); C1391(1.30); C62(0.84)  LDD1675  [7]
 LDCM0473  CL8 HCT 116 C248(0.96)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C238(1.03); C248(0.99); C1391(1.06); C62(0.88)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C238(1.03); C248(1.17); C1391(1.23); C702(1.07)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C238(1.19); C1391(1.12); C62(0.72)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C238(1.18); C248(0.99); C1391(0.97); C702(0.87)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C238(1.23); C248(1.06); C1391(1.24)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C238(1.20); C248(1.11); C1391(1.28)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C238(1.02); C248(1.21); C1391(1.04); C702(1.03)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C238(1.02); C248(1.07); C1391(1.06)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C238(1.03); C248(0.95); C1391(1.11); C702(1.05)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C238(1.00); C1391(1.15); C702(1.08)  LDD1686  [7]
 LDCM0484  CL9 HCT 116 C248(1.09)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C238(2.14); C248(2.59); C1391(1.34); C702(1.36)  LDD1688  [7]
 LDCM0486  CL91 HCT 116 C248(1.14)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C248(1.29)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C248(1.18)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C248(1.10)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C248(1.23)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C248(1.24)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C248(1.37)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C248(1.23)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C248(1.02)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C238(1.10); C248(0.98); C1391(1.19)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C248(0.80)  LDD0785  [3]
 LDCM0427  Fragment51 HEK-293T C238(1.03); C248(1.06); C1391(0.92); C702(1.02)  LDD1631  [7]
 LDCM0022  KB02 COLO-792 C781(2.09)  LDD2306  [8]
 LDCM0023  KB03 AN3-CA C365(1.38)  LDD2681  [8]
 LDCM0024  KB05 HMCB C365(1.53)  LDD3312  [8]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 20 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cyclosporine Protein/peptide DB00091
Cytarabine Small molecular drug DB00987
Daunorubicin Small molecular drug DB00694
Docetaxel Small molecular drug DB01248
Doxorubicin Small molecular drug DB00997
Estradiol Small molecular drug DB00783
Estradiol Acetate Small molecular drug DB13952
Estradiol Cypionate Small molecular drug DB13954
Estradiol Valerate Small molecular drug DB13956
Etoposide Small molecular drug DB00773
Gemcitabine Small molecular drug DB00441
Methotrexate Small molecular drug DB00563
Paclitaxel Small molecular drug DB01229
Sildenafil Small molecular drug DB00203
Taurocholic Acid Small molecular drug DB04348
Tenofovir Disoproxil Small molecular drug DB00300
Verapamil Small molecular drug DB00661
Vincristine Small molecular drug DB00541
Estradiol Benzoate . DB13953
Estradiol Dienanthate . DB13955

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840