Details of the Target

General Information of Target

Target ID LDTP14189
Target Name UbiA prenyltransferase domain-containing protein 1 (UBIAD1)
Gene Name UBIAD1
Gene ID 29914
Synonyms
TERE1; UbiA prenyltransferase domain-containing protein 1; EC 2.5.1.-; EC 2.5.1.39; Transitional epithelial response protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPSLLNWRRVSSFTGPVPRARHGHRAVAIRELMIIFGGGNEGIADELHVYNTATNQWF
LPAVRGDIPPGCAAHGFVCDGTRILVFGGMVEYGRYSNELYELQASRWLWKKVKPHPPPS
GLPPCPRLGHSFSLYGNKCYLFGGLANESEDSNNNVPRYLNDFYELELQHGSGVVGWSIP
VTKGVVPSPRESHTAVIYCKKDSGSPKMYVFGGMCGARLDDLWQLDLETMSWSKPETKGT
VPLPRSLHTASVIGNKMYIFGGWVPHKGENTETSPHDCEWRCTSSFSYLNLDTTEWTTLV
SDSQEDKKNSRPRPRAGHCAVAIGTRLYFWSGRDGYKKALNSQVCCKDLWYLDTEKPPAP
SQVQLIKATTNSFHVKWDEVSTVEGYLLQLSTDLPYQAASSDSSAAPNMQGVRMDPHRQG
SNNIVPNSINDTINSTKTEQPATKETSMKNKPDFKALTDSNAILYPSLASNASNHNSHVV
DMLRKNEGPHTSANVGVLSSCLDVRTVIPETSVSSTVSSTQTMVTQQTIKTESSSTNGAV
VKDETSLTTFSTKSEVDETYALPATKISRVETHATATPFSKETPSNPVATVKAGERQWCD
VGIFKNNTALVSQFYLLPKGKQSISKVGNADVPDYSLLKKQDLVPGTGYRFRVAAINGCG
IGPFSKISEFKTCIPGFPGAPSAVRISKNVEGIHLSWEPPTSPSGNILEYSAYLAIRTAQ
IQDNPSQLVFMRIYCGLKTSCIVTAGQLANAHIDYTSRPAIVFRISAKNEKGYGPATQVR
WLQGNNKKAPLN
Target Bioclass
Enzyme
Family
UbiA prenyltransferase family
Subcellular location
Endoplasmic reticulum membrane
Function
Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress.
Uniprot ID
Q9Y5Z9
Ensemble ID
ENST00000376804.2
HGNC ID
HGNC:30791

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.F294V .
KASUMI2 SNV: p.L188P .
LNCaP clone FGC Deletion: p.L221SfsTer136 .
NCIH196 SNV: p.V216I .
REH SNV: p.T18I .
TCCSUP SNV: p.Q299E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
STPyne
 Probe Info  		K307(10.00)  LDD0277  [2]
BTD
 Probe Info  		C31(0.92)  LDD2100  [3]
DBIA
 Probe Info  		C31(7.76)  LDD0209  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
AOyne
 Probe Info  		15.00  LDD0443  [7]
NAIA_5
 Probe Info  		C31(0.00); C46(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		12.82  LDD1752  [9]
C056
 Probe Info  		25.99  LDD1753  [9]
C153
 Probe Info  		29.24  LDD1834  [9]
C169
 Probe Info  		30.27  LDD1849  [9]
C178
 Probe Info  		17.03  LDD1857  [9]
C246
 Probe Info  		15.89  LDD1919  [9]
C287
 Probe Info  		9.38  LDD1957  [9]
C289
 Probe Info  		29.24  LDD1959  [9]
C355
 Probe Info  		39.40  LDD2016  [9]
C356
 Probe Info  		10.78  LDD2017  [9]
C357
 Probe Info  		9.19  LDD2018  [9]
C388
 Probe Info  		37.79  LDD2047  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C31(1.36)  LDD0531  [10]
 LDCM0215  AC10 HEK-293T C31(1.04); C46(1.04)  LDD1508  [11]
 LDCM0216  AC100 HCT 116 C31(0.79)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C31(0.89)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C31(0.83)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C31(1.40)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C31(0.90)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C31(0.76)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C31(0.94)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C31(0.59)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C31(1.42)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C31(0.98)  LDD0542  [10]
 LDCM0226  AC11 HEK-293T C31(0.97); C46(0.85)  LDD1509  [11]
 LDCM0227  AC110 HCT 116 C31(1.71)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C31(1.57)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C31(0.65)  LDD0546  [10]
 LDCM0237  AC12 HEK-293T C31(0.92); C46(1.00)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C31(0.95); C46(1.00); C87(1.28)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C31(0.94); C46(1.11); C87(0.92)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C31(1.02); C46(1.10)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C31(1.04); C46(0.77)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C31(1.08); C46(0.92)  LDD1517  [11]
 LDCM0279  AC2 HCT 116 C31(1.27)  LDD0596  [10]
 LDCM0280  AC20 HEK-293T C31(1.02); C46(0.92)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C31(1.03); C46(0.98); C87(1.08)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C31(0.90); C46(1.03); C87(1.07)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C31(0.87); C46(0.98); C87(1.06)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C31(1.01); C46(1.19); C87(1.08)  LDD1523  [11]
 LDCM0285  AC25 HCT 116 C31(0.59)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C31(1.14)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C31(0.77)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C31(2.01)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C31(1.24)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C31(1.36)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C31(1.08)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C31(0.96)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C31(1.37)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C31(0.51)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C31(0.31)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C31(0.85)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C31(0.81)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C31(1.17)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C31(1.37)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C31(1.28)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C31(1.73)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C31(1.65)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C31(0.85)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C31(1.23)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C31(1.53)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C31(0.91)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C31(1.02)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C31(1.00)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C31(0.99)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C31(1.16)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C31(0.98)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C31(1.57)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C31(1.15)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C31(0.91)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C31(1.08)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C31(0.94)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C31(1.18)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C31(1.04)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C31(1.39)  LDD0636  [10]
 LDCM0320  AC57 HEK-293T C31(1.15); C46(1.00)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C31(1.04); C46(1.07)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C31(1.10); C46(1.04)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C31(0.93); C46(1.07); C87(1.06)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C31(1.08); C46(1.05)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C31(1.11); C46(1.15); C87(1.04)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C31(0.92); C46(1.07); C87(1.10)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C31(1.08); C46(1.02); C87(1.23)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C31(1.12); C46(1.05); C87(0.81)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C31(0.98); C46(1.00); C87(0.91)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C31(1.02); C46(1.06); C87(0.75)  LDD1569  [11]
 LDCM0365  AC98 HCT 116 C31(1.25)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C31(0.68)  LDD0683  [10]
 LDCM0248  AKOS034007472 HEK-293T C31(1.02); C46(1.06); C87(1.04)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C31(1.01); C46(0.99)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C31(1.02); C46(1.24); C87(1.04)  LDD1514  [11]
 LDCM0367  CL1 PaTu 8988t C31(0.97)  LDD1246  [10]
 LDCM0368  CL10 PaTu 8988t C31(0.98)  LDD1247  [10]
 LDCM0369  CL100 HCT 116 C31(1.23)  LDD0686  [10]
 LDCM0370  CL101 HEK-293T C31(1.07); C46(1.01)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C31(1.09); C46(1.19); C87(0.85)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C31(1.00); C46(1.03)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C31(0.98); C46(0.98); C87(0.85)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C31(0.99); C46(0.84)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C31(0.97); C46(1.11); C87(0.83)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C31(0.99); C46(0.97)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C31(1.08); C46(1.04); C87(0.82)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C31(0.97); C46(1.29)  LDD1582  [11]
 LDCM0379  CL11 PaTu 8988t C31(1.18)  LDD1258  [10]
 LDCM0380  CL110 HEK-293T C31(1.03); C46(1.06); C87(1.21)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C31(1.05); C46(0.97)  LDD1585  [11]
 LDCM0382  CL112 HCT 116 C31(0.51)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C31(0.51)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C31(0.81)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C31(1.33)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C31(0.53)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C31(2.15)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C31(1.06)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C31(1.10)  LDD0706  [10]
 LDCM0390  CL12 PaTu 8988t C31(1.45)  LDD1269  [10]
 LDCM0391  CL120 HCT 116 C31(1.17)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C31(0.85)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C31(1.28)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C31(1.15)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C31(1.30)  LDD0712  [10]
 LDCM0396  CL125 HEK-293T C31(1.58); C46(1.04)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C31(1.24); C46(1.13); C87(0.99)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C31(1.13); C46(0.96)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C31(1.14); C46(1.08); C87(0.89)  LDD1603  [11]
 LDCM0400  CL13 PaTu 8988t C31(1.35)  LDD1279  [10]
 LDCM0401  CL14 PaTu 8988t C31(1.14)  LDD1280  [10]
 LDCM0402  CL15 PaTu 8988t C31(1.04)  LDD1281  [10]
 LDCM0403  CL16 HCT 116 C31(0.85)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C31(0.84)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C31(1.18)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C31(1.32)  LDD0723  [10]
 LDCM0407  CL2 PaTu 8988t C31(1.14)  LDD1286  [10]
 LDCM0408  CL20 HCT 116 C31(1.06)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C31(1.57)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C31(1.96)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C31(1.06)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C31(1.28)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C31(1.23)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C31(1.08)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C31(1.35)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C31(1.40)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C31(1.33)  LDD0734  [10]
 LDCM0418  CL3 PaTu 8988t C31(1.15)  LDD1297  [10]
 LDCM0419  CL30 HCT 116 C31(1.01)  LDD0736  [10]
 LDCM0420  CL31 PaTu 8988t C31(1.21)  LDD1299  [10]
 LDCM0421  CL32 PaTu 8988t C31(1.97)  LDD1300  [10]
 LDCM0422  CL33 PaTu 8988t C31(1.62)  LDD1301  [10]
 LDCM0423  CL34 PaTu 8988t C31(2.13)  LDD1302  [10]
 LDCM0424  CL35 PaTu 8988t C31(1.79)  LDD1303  [10]
 LDCM0425  CL36 PaTu 8988t C31(1.73)  LDD1304  [10]
 LDCM0426  CL37 PaTu 8988t C31(2.76)  LDD1305  [10]
 LDCM0428  CL39 PaTu 8988t C31(1.60)  LDD1307  [10]
 LDCM0429  CL4 PaTu 8988t C31(0.86)  LDD1308  [10]
 LDCM0430  CL40 PaTu 8988t C31(1.44)  LDD1309  [10]
 LDCM0431  CL41 PaTu 8988t C31(1.91)  LDD1310  [10]
 LDCM0432  CL42 PaTu 8988t C31(2.24)  LDD1311  [10]
 LDCM0433  CL43 PaTu 8988t C31(3.07)  LDD1312  [10]
 LDCM0434  CL44 PaTu 8988t C31(1.89)  LDD1313  [10]
 LDCM0435  CL45 PaTu 8988t C31(1.54)  LDD1314  [10]
 LDCM0436  CL46 HCT 116 C31(1.02)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C31(1.05)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C31(1.13)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C31(1.17)  LDD0756  [10]
 LDCM0440  CL5 PaTu 8988t C31(1.23)  LDD1319  [10]
 LDCM0441  CL50 HCT 116 C31(0.87)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C31(1.08)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C31(1.18)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C31(0.71)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C31(0.84)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C31(1.24)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C31(0.98)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C31(0.90)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C31(1.09)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C31(1.54)  LDD0767  [10]
 LDCM0451  CL6 PaTu 8988t C31(0.95)  LDD1330  [10]
 LDCM0452  CL60 HCT 116 C31(0.99)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C31(1.58)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C31(1.38)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C31(1.22)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C31(2.14)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C31(0.80)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C31(1.67)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C31(0.53)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C31(0.58)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C31(0.89)  LDD0778  [10]
 LDCM0462  CL7 PaTu 8988t C31(1.21)  LDD1341  [10]
 LDCM0463  CL70 HCT 116 C31(0.97)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C31(0.81)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C31(0.60)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C31(0.80)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C31(0.78)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C31(0.60)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C31(0.24)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C31(0.31)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C31(0.76)  LDD0789  [10]
 LDCM0473  CL8 PaTu 8988t C31(1.40)  LDD1352  [10]
 LDCM0474  CL80 HCT 116 C31(1.13)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C31(0.82)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C31(1.65)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C31(0.73)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C31(1.25)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C31(0.79)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C31(0.69)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C31(0.88)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C31(0.42)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C31(0.63)  LDD0800  [10]
 LDCM0484  CL9 PaTu 8988t C31(1.07)  LDD1363  [10]
 LDCM0485  CL90 HCT 116 C31(0.29)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C31(1.27)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C31(1.47)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C31(1.22)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C31(1.43)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C31(1.29)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C31(1.21)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C31(1.16)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C31(1.30)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C31(1.25)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C31(0.99); C46(1.08)  LDD1698  [11]
 LDCM0625  F8 Ramos C31(1.86)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C31(2.46)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C31(0.13)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C31(1.13)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C31(0.95)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C31(1.00)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C31(1.23)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C31(0.92)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C31(0.80)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C31(1.20)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C31(0.87)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C31(1.34)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C31(1.00)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C31(3.29)  LDD2201  [12]
 LDCM0468  Fragment33 HCT 116 C31(1.23)  LDD0785  [10]
 LDCM0596  Fragment38 Ramos C31(1.56)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C31(1.36)  LDD2184  [12]
 LDCM0427  Fragment51 PaTu 8988t C31(1.76)  LDD1306  [10]
 LDCM0610  Fragment52 Ramos C31(1.24)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C31(1.35)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C31(1.24)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C31(2.88)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C31(0.95)  LDD1492  [11]
 LDCM0023  KB03 Jurkat C31(7.76)  LDD0209  [4]
 LDCM0024  KB05 HEK-293T C31(0.96)  LDD1502  [11]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C31(0.92)  LDD2100  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C31(1.28)  LDD2207  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
rRNA methyltransferase 3, mitochondrial (MRM3) RNA methyltransferase TrmH family Q9HC36
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
NADH-cytochrome b5 reductase 3 (CYB5R3) Flavoprotein pyridine nucleotide cytochrome reductase family P00387
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) HIBADH-related family P31937
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) HMG-CoA reductase family P04035
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Sterol O-acyltransferase 1 (SOAT1) Membrane-bound acyltransferase family P35610
Phosphatase and actin regulator 3 (PHACTR3) Phosphatase and actin regulator family Q96KR7
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (PIGP) PIGP family P57054
GTPase HRas (HRAS) Ras family P01112
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Solute carrier family 7 member 14 (SLC7A14) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family Q8TBB6
Claudin-7 (CLDN7) Claudin family O95471
G protein-activated inward rectifier potassium channel 2 (KCNJ6) Inward rectifier-type potassium channel family P48051
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Synaptotagmin-1 (SYT1) Synaptotagmin family P21579
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 139 (TMEM139) . Q8IV31
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myeloid cell surface antigen CD33 (CD33) SIGLEC (sialic acid binding Ig-like lectin) family P20138
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein EVI2A (EVI2A) EVI2A family P22794
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Tomoregulin-2 (TMEFF2) Tomoregulin family Q9UIK5
Bcl-2-interacting killer (BIK) . Q13323
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phylloquinone Small molecular drug DB01022

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.