Details of the Target

General Information of Target

Target ID LDTP10530
Target Name Beta-1,3-galactosyltransferase 6 (B3GALT6)
Gene Name B3GALT6
Gene ID 126792
Synonyms
Beta-1,3-galactosyltransferase 6; Beta-1,3-GalTase 6; Beta3Gal-T6; Beta3GalT6; EC 2.4.1.134; GAG GalTII; Galactosyltransferase II; Galactosylxylosylprotein 3-beta-galactosyltransferase; UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLHCEVEVISRHLPALGLRNRGKGVRAVLSLCQQTSRSQPPVRAFLLISTLKDKRGTRY
ELRENIEQFFTKFVDEGKATVRLKEPPVDICLSKAISSSLKGFLSAMRLAHRGCNVDTPV
STLTPVKTSEFENFKTKMVITSKKDYPLSKNFPYSLEHLQTSYCGLVRVDMRMLCLKSLR
KLDLSHNHIKKLPATIGDLIHLQELNLNDNHLESFSVALCHSTLQKSLRSLDLSKNKIKA
LPVQFCQLQELKNLKLDDNELIQFPCKIGQLINLRFLSAARNKLPFLPSEFRNLSLEYLD
LFGNTFEQPKVLPVIKLQAPLTLLESSARTILHNRIPYGSHIIPFHLCQDLDTAKICVCG
RFCLNSFIQGTTTMNLHSVAHTVVLVDNLGGTEAPIISYFCSLGCYVNSSDMLK
Target Bioclass
Enzyme
Family
Glycosyltransferase 31 family
Subcellular location
Golgi apparatus, Golgi stack membrane
Function
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues.
Uniprot ID
Q96L58
Ensemble ID
ENST00000379198.5
HGNC ID
HGNC:17978

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C271(6.63)  LDD3310  [1]
BTD
 Probe Info  		C271(0.84)  LDD2120  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		7.89  LDD1728  [7]
C056
 Probe Info  		17.75  LDD1753  [7]
C134
 Probe Info  		20.97  LDD1816  [7]
C161
 Probe Info  		10.70  LDD1841  [7]
C169
 Probe Info  		23.43  LDD1849  [7]
C293
 Probe Info  		15.89  LDD1963  [7]
C355
 Probe Info  		31.34  LDD2016  [7]
C356
 Probe Info  		8.28  LDD2017  [7]
C357
 Probe Info  		5.70  LDD2018  [7]
C362
 Probe Info  		29.04  LDD2023  [7]
C388
 Probe Info  		41.64  LDD2047  [7]
C390
 Probe Info  		26.17  LDD2049  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C271(1.24); C32(1.01)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C32(1.09)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C32(1.32)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C32(0.98)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C271(1.09)  LDD1512  [8]
 LDCM0270  AC15 HEK-293T C32(1.03)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C271(1.22); C32(0.84)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C32(1.02)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C32(1.11)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C32(0.95)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C32(0.88)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C271(0.90); C32(0.97)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C271(1.01)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C32(0.89)  LDD1522  [8]
 LDCM0285  AC25 HEK-293T C271(1.19); C32(0.89)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C32(0.86)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C32(1.16)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C32(1.00)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C271(1.02); C32(1.11)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C32(1.05)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C271(1.04)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C32(0.81)  LDD1531  [8]
 LDCM0294  AC33 HEK-293T C271(1.09); C32(1.00)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C32(1.05)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C32(1.16)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C32(0.88)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C271(1.11); C32(1.05)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C271(0.94)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C32(1.05)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C32(0.88)  LDD1540  [8]
 LDCM0303  AC41 HEK-293T C271(1.10); C32(1.01)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C32(0.98)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C32(1.04)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C32(1.08)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C271(0.98); C32(1.03)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C271(0.96)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C32(1.22)  LDD1548  [8]
 LDCM0311  AC49 HEK-293T C271(1.13); C32(0.95)  LDD1550  [8]
 LDCM0312  AC5 HEK-293T C271(1.06); C32(0.94)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C32(0.96)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C32(1.17)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C32(1.05)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C271(0.96); C32(1.03)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C271(1.03)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C32(0.94)  LDD1557  [8]
 LDCM0320  AC57 HEK-293T C271(1.11); C32(0.85)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C32(1.00)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C32(1.13)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C271(1.06)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C32(0.90)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C271(1.09); C32(0.89)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C271(1.07)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C32(0.86)  LDD1566  [8]
 LDCM0334  AC7 HEK-293T C32(1.06)  LDD1568  [8]
 LDCM0248  AKOS034007472 HEK-293T C271(1.06); C32(0.91)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C271(1.06); C32(0.90)  LDD1570  [8]
 LDCM0367  CL1 HEK-293T C271(1.15)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C271(1.47)  LDD1572  [8]
 LDCM0369  CL100 HEK-293T C271(1.32)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C271(1.15)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C271(1.03)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C271(1.10)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C271(1.26)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C271(1.27)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C271(0.95)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C271(1.02)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C271(1.02)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C271(1.11)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C32(0.99)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C271(1.12)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C271(1.23)  LDD1585  [8]
 LDCM0382  CL112 HEK-293T C271(1.35)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C271(1.04)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C271(1.43)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C271(1.06)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C271(1.48)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C271(1.18)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C271(1.04)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C271(1.08)  LDD1593  [8]
 LDCM0391  CL120 HEK-293T C271(1.74)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C271(1.04)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C271(1.04)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C271(1.20)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C271(1.37)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C271(1.01)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C271(1.21)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C271(1.11)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C271(0.99)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C271(1.29)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C271(1.25)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C271(1.20)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C271(1.35)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C271(1.45); C32(1.02)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C32(0.97)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C32(1.10)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C271(0.92)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C32(1.05)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C271(1.20); C32(1.25)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C271(1.08)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C32(1.07)  LDD1615  [8]
 LDCM0413  CL25 HEK-293T C271(1.16)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C271(1.20)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C271(1.00)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C271(1.13)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C271(1.12); C32(1.04)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C271(1.06)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C32(0.95)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C32(1.22)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C32(1.06)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C271(1.11); C32(1.22)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C271(0.96)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C32(1.24)  LDD1628  [8]
 LDCM0426  CL37 HEK-293T C271(1.15)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C271(1.21)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C271(1.39)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C271(1.33)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C271(1.02); C32(0.98)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C32(0.90)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C32(1.17)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C32(1.10)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C271(1.15); C32(1.08)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C271(1.20)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C32(0.92)  LDD1641  [8]
 LDCM0439  CL49 HEK-293T C271(1.14)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C271(1.19); C32(1.00)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C271(1.15)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C271(1.34)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C271(1.15); C32(0.92)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C32(1.36)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C32(1.26)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C32(0.92)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C271(1.19); C32(1.10)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C271(1.06)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C32(1.05)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C32(1.13)  LDD1654  [8]
 LDCM0453  CL61 HEK-293T C271(1.02)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C271(1.03)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C271(1.04)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C271(1.44)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C271(1.27); C32(1.08)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C32(0.93)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C32(1.04)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C32(1.03)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C271(1.13); C32(1.19)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C32(1.11)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C271(1.02)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C32(1.18)  LDD1667  [8]
 LDCM0466  CL73 HEK-293T C271(1.15)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C271(0.98)  LDD1670  [8]
 LDCM0469  CL76 HEK-293T C271(1.47)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C271(1.30); C32(0.98)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C32(0.89)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C32(1.15)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C32(1.21)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C32(1.14)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C271(1.21); C32(1.06)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C271(0.97)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C32(1.25)  LDD1680  [8]
 LDCM0479  CL85 HEK-293T C271(1.06)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C271(1.02)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C271(1.13)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C271(1.19)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C271(1.12); C32(0.82)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C271(1.17); C32(1.13)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C32(1.37)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C32(1.23)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C32(1.06)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C271(1.00); C32(1.01)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C271(1.12)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C32(0.99)  LDD1693  [8]
 LDCM0492  CL97 HEK-293T C271(1.19)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C271(1.12)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C271(1.13)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C271(1.21)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C271(1.00)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C271(1.01)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C32(0.83)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C32(0.99)  LDD1497  [8]
 LDCM0024  KB05 COLO792 C271(6.63)  LDD3310  [1]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C271(0.84)  LDD2120  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402