Details of the Target

General Information of Target

Target ID LDTP05920
Target Name Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G)
Gene Name CAMK2G
Gene ID 818
Synonyms
CAMK; CAMK-II; CAMKG; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit gamma; CaMK-II subunit gamma; EC 2.7.11.17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLER
EARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQI
LESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGY
LSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDT
VTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKL
KGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPL
QTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKGRVPEGRSSRDRTAPSAGMQPQPSL
CSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFE
NLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDG
KWLNVHYHCSGAPAAPLQ
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
Subcellular location
Sarcoplasmic reticulum membrane
Function
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization. It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway.
Uniprot ID
Q13555
Ensemble ID
ENST00000305762.11
HGNC ID
HGNC:1463
ChEMBL ID
CHEMBL3829

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y231(20.00); Y517(11.98)  LDD0257  [2]
TH216
 Probe Info  		Y517(5.32)  LDD0259  [2]
DBIA
 Probe Info  		C273(4.05)  LDD3310  [3]
HPAP
 Probe Info  		3.00  LDD0062  [4]
ATP probe
 Probe Info  		K147(0.00); K43(0.00); K138(0.00); K227(0.00)  LDD0199  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C385(0.00); C273(0.00); C453(0.00); C290(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C273(0.00); C290(0.00); C549(0.00); C148(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C385(0.00); C273(0.00); C453(0.00); C290(0.00)  LDD0037  [6]
ATP probe
 Probe Info  		N.A.  LDD0035  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		C273(0.00); C7(0.00)  LDD0147  [8]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		C273(0.00); C148(0.00)  LDD0018  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
AOyne
 Probe Info  		14.50  LDD0443  [12]
NAIA_5
 Probe Info  		C273(0.00); C7(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		6.50  LDD1725  [14]
C055
 Probe Info  		11.88  LDD1752  [14]
C056
 Probe Info  		16.11  LDD1753  [14]
C063
 Probe Info  		11.08  LDD1760  [14]
C085
 Probe Info  		6.19  LDD1777  [14]
C159
 Probe Info  		12.21  LDD1839  [14]
C212
 Probe Info  		8.94  LDD1886  [14]
C216
 Probe Info  		6.54  LDD1890  [14]
C218
 Probe Info  		14.12  LDD1892  [14]
C280
 Probe Info  		15.35  LDD1950  [14]
C282
 Probe Info  		21.56  LDD1952  [14]
C284
 Probe Info  		55.72  LDD1954  [14]
C338
 Probe Info  		18.77  LDD2001  [14]
C403
 Probe Info  		16.68  LDD2061  [14]
FFF probe11
 Probe Info  		7.26  LDD0472  [15]
FFF probe13
 Probe Info  		9.91  LDD0476  [15]
FFF probe2
 Probe Info  		20.00  LDD0463  [15]
FFF probe3
 Probe Info  		20.00  LDD0465  [15]
FFF probe6
 Probe Info  		11.01  LDD0468  [15]
LD-F
 Probe Info  		L457(0.00); E461(0.00); S459(0.00)  LDD0015  [16]
OEA-DA
 Probe Info  		3.83  LDD0046  [17]
Probe 12
 Probe Info  		N.A.  LDD0420  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C290(1.10); C453(1.09); C385(0.87)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C290(1.00); C453(0.98); C385(0.98); C421(1.44)  LDD1508  [19]
 LDCM0226  AC11 HEK-293T C290(1.00); C453(0.96); C385(1.08)  LDD1509  [19]
 LDCM0237  AC12 HEK-293T C290(1.00); C453(1.00); C385(0.96)  LDD1510  [19]
 LDCM0259  AC14 HEK-293T C290(0.99); C453(0.96); C385(1.01); C421(0.95)  LDD1512  [19]
 LDCM0270  AC15 HEK-293T C290(1.11); C453(1.08); C385(1.08)  LDD1513  [19]
 LDCM0276  AC17 HEK-293T C290(1.03); C453(0.97); C385(1.04)  LDD1515  [19]
 LDCM0277  AC18 HEK-293T C290(1.01); C453(0.90); C385(0.98); C421(1.10)  LDD1516  [19]
 LDCM0278  AC19 HEK-293T C290(1.12); C453(0.85); C385(1.19)  LDD1517  [19]
 LDCM0279  AC2 HEK-293T C290(0.98); C453(0.96); C385(0.98); C421(1.22)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C290(1.02); C453(1.01); C385(1.07)  LDD1519  [19]
 LDCM0281  AC21 HEK-293T C290(1.01); C453(1.06); C385(0.96)  LDD1520  [19]
 LDCM0282  AC22 HEK-293T C290(1.05); C453(1.02); C385(0.99); C421(1.05)  LDD1521  [19]
 LDCM0283  AC23 HEK-293T C290(1.07); C453(1.20); C385(1.07)  LDD1522  [19]
 LDCM0284  AC24 HEK-293T C290(0.93); C453(1.06); C421(1.09)  LDD1523  [19]
 LDCM0285  AC25 HEK-293T C290(1.04); C453(1.07); C385(0.87)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C290(1.02); C453(1.01); C385(1.07); C421(1.18)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C290(1.00); C453(0.94); C385(1.06)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C290(1.01); C453(1.05); C385(1.02)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C290(1.03); C453(0.94); C385(1.00)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C290(0.99); C453(0.86); C385(1.06)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C290(0.96); C453(1.13); C385(1.00); C421(0.91)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C290(1.13); C453(1.07); C385(1.15)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C290(0.99); C453(1.05); C421(0.92)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C290(0.99); C453(1.08); C385(0.99)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C290(0.99); C453(0.94); C385(0.94); C421(1.20)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C290(1.04); C453(0.88); C385(1.07)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C290(1.04); C453(1.17); C385(0.99)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C290(1.07); C453(0.93); C385(1.05)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C290(0.99); C453(0.90); C385(0.97); C421(0.98)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C290(1.02); C453(1.29); C385(1.12)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C290(0.99); C453(1.23); C385(0.92)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C290(1.08); C453(1.04); C421(1.04)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C290(1.15); C453(1.10); C385(1.09)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C290(1.00); C453(1.05); C385(1.07); C421(1.25)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C290(1.01); C453(0.97); C385(1.13)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C290(1.02); C453(0.89); C385(0.99)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C290(1.08); C453(0.97); C385(0.88)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C290(1.02); C453(0.93); C385(1.02); C421(1.01)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C290(1.09); C453(1.27); C385(1.01)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C290(1.08); C453(1.04); C421(1.13)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C290(1.04); C453(1.06); C385(0.98)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C290(1.09); C453(0.90); C385(0.94)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C290(0.98); C453(1.04); C385(0.98); C421(1.19)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C290(0.99); C453(1.03); C385(1.14)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C290(1.07); C453(0.99); C385(0.94)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C290(1.01); C453(1.03); C385(0.93)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C290(0.96); C453(1.06); C385(1.01); C421(0.81)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C290(1.07); C453(1.09); C385(1.01)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C290(1.01); C453(0.98); C421(1.12)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C290(1.09); C453(1.19); C385(1.06)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C290(1.03); C453(1.02); C385(0.97); C421(1.18)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C290(1.11); C453(1.01); C385(1.10)  LDD1561  [19]
 LDCM0323  AC6 HEK-293T C290(1.02); C453(1.05); C385(0.95); C421(0.80)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C290(1.04); C453(1.11); C385(0.90)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C290(1.00); C453(0.96); C385(0.92)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C290(0.97); C453(0.99); C385(0.95); C421(0.96)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C290(1.13); C453(1.08); C385(0.95)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C290(0.99); C453(1.01); C421(0.93)  LDD1567  [19]
 LDCM0334  AC7 HEK-293T C290(1.08); C453(1.09); C385(1.04)  LDD1568  [19]
 LDCM0345  AC8 HEK-293T C290(0.99); C453(0.97); C421(1.14)  LDD1569  [19]
 LDCM0248  AKOS034007472 HEK-293T C290(1.07); C453(0.93); C385(0.96)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C290(1.07); C453(1.18); C385(1.06)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C290(0.98); C453(0.99); C421(1.48)  LDD1514  [19]
 LDCM0156  Aniline NCI-H1299 11.90  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C273(0.93); C7(0.90)  LDD2227  [13]
 LDCM0367  CL1 HEK-293T C290(1.02); C453(1.10); C385(1.19)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C290(0.85); C453(0.76); C385(0.85); C421(1.04)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C290(1.02); C453(0.89)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C290(0.97); C453(1.11); C385(1.13)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C290(0.97); C453(0.64)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C290(1.00); C453(1.39); C385(1.03)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C290(0.98); C453(1.00)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C290(1.00); C453(1.08); C385(1.05)  LDD1578  [19]
 LDCM0375  CL106 HEK-293T C290(0.98); C453(0.77)  LDD1579  [19]
 LDCM0376  CL107 HEK-293T C290(1.03); C453(0.99); C385(1.03)  LDD1580  [19]
 LDCM0377  CL108 HEK-293T C290(1.04); C453(0.94)  LDD1581  [19]
 LDCM0378  CL109 HEK-293T C290(1.11); C453(1.02); C385(1.00)  LDD1582  [19]
 LDCM0379  CL11 HEK-293T C290(1.08); C453(0.99); C385(0.99)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C290(0.93); C453(0.75)  LDD1584  [19]
 LDCM0381  CL111 HEK-293T C290(0.96); C453(1.08); C385(0.97)  LDD1585  [19]
 LDCM0382  CL112 HEK-293T C290(1.04); C453(0.87)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C290(1.01); C453(1.11); C385(1.14)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C290(0.88); C453(0.74)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C290(0.98); C453(1.18); C385(0.96)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C290(0.98); C453(0.92)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C290(1.04); C453(1.18); C385(1.12)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C290(0.99); C453(0.81)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C290(1.00); C453(0.90); C385(1.02)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C290(1.13); C453(0.94); C421(1.26)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C290(1.00); C453(0.95)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C290(1.06); C453(1.09); C385(1.16)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C290(0.99); C453(1.02)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C290(0.95); C453(0.86); C385(0.97)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C290(0.92); C453(0.87)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C290(1.01); C453(1.22); C385(0.94)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C290(0.97); C453(0.76)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C290(1.03); C453(0.94); C385(1.02)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C290(1.02); C453(0.97)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C290(1.00); C453(1.12); C385(1.26)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C290(0.96); C453(0.78)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C290(1.06); C453(1.08); C385(1.04)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C290(1.02); C453(1.04)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C290(1.15); C453(0.98); C385(1.02)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C290(1.07); C453(0.96); C385(1.01); C421(1.17)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C290(1.07); C453(1.06); C385(1.24)  LDD1610  [19]
 LDCM0407  CL2 HEK-293T C290(0.94); C453(0.69)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C290(1.08); C453(1.05); C385(1.02)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C290(1.15); C453(0.83); C385(0.78)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C290(0.93); C453(1.02); C385(1.06); C421(0.99)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C290(1.19); C453(1.17); C385(1.04)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C290(1.04); C453(1.07); C421(1.47)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C290(1.08); C453(1.00); C385(1.00)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C290(0.95); C453(0.99)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C290(0.98); C453(0.99); C385(0.91)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C290(0.97); C453(1.00)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C290(1.20); C453(0.97); C385(1.04)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C290(1.03); C453(1.21); C385(1.09)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C290(1.04); C453(1.04); C385(0.99); C421(1.07)  LDD1623  [19]
 LDCM0420  CL31 HEK-293T C290(1.02); C453(1.00); C385(1.21)  LDD1624  [19]
 LDCM0421  CL32 HEK-293T C290(1.03); C453(0.82); C385(1.00)  LDD1625  [19]
 LDCM0422  CL33 HEK-293T C290(1.06); C453(0.90); C385(0.92)  LDD1626  [19]
 LDCM0423  CL34 HEK-293T C290(1.00); C453(0.83); C385(0.96); C421(0.82)  LDD1627  [19]
 LDCM0424  CL35 HEK-293T C290(1.05); C453(1.13); C385(1.07)  LDD1628  [19]
 LDCM0425  CL36 HEK-293T C290(0.99); C453(0.98); C421(0.78)  LDD1629  [19]
 LDCM0426  CL37 HEK-293T C290(1.03); C453(0.94); C385(0.93)  LDD1630  [19]
 LDCM0428  CL39 HEK-293T C290(0.99); C453(1.00); C385(0.99)  LDD1632  [19]
 LDCM0429  CL4 HEK-293T C290(1.04); C453(0.93)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C290(1.05); C453(0.92)  LDD1634  [19]
 LDCM0431  CL41 HEK-293T C290(1.02); C453(0.98); C385(0.98)  LDD1635  [19]
 LDCM0432  CL42 HEK-293T C290(1.06); C453(1.05); C385(0.97); C421(1.21)  LDD1636  [19]
 LDCM0433  CL43 HEK-293T C290(1.03); C453(0.94); C385(1.07)  LDD1637  [19]
 LDCM0434  CL44 HEK-293T C290(1.07); C453(0.57); C385(1.00)  LDD1638  [19]
 LDCM0435  CL45 HEK-293T C290(1.05); C453(0.84); C385(0.94)  LDD1639  [19]
 LDCM0436  CL46 HEK-293T C290(1.02); C453(0.89); C385(0.98); C421(0.86)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C290(1.19); C453(1.16); C385(1.15)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C290(1.04); C453(1.06); C421(0.98)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C290(0.99); C453(1.17); C385(1.13)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C290(1.07); C453(0.99); C385(1.09)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C290(0.94); C453(0.80)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C290(0.98); C453(0.98)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C290(1.10); C453(0.87); C385(0.91)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C290(0.91); C453(0.98); C385(0.97); C421(1.17)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C290(1.07); C453(0.96); C385(1.15)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C290(1.07); C453(0.76); C385(0.93)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C290(1.05); C453(0.90); C385(0.91)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C290(1.10); C453(0.95); C385(1.01); C421(0.95)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C290(1.17); C453(1.23); C385(0.97)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C290(1.02); C453(0.84); C385(0.89); C421(1.24)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C290(1.09); C453(0.93); C421(1.06)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C290(0.98); C453(1.03); C385(1.06)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C290(0.91); C453(0.99)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C290(0.93); C453(1.38); C385(1.04)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C290(1.04); C453(0.94)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C290(1.01); C453(0.99); C385(0.95)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C290(1.01); C453(0.98); C385(1.06); C421(1.36)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C290(1.09); C453(0.99); C385(1.25)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C290(1.07); C453(0.75); C385(0.98)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C290(1.03); C453(1.01); C385(0.94)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C290(1.01); C453(0.92); C385(1.07)  LDD1665  [19]
 LDCM0463  CL70 HEK-293T C290(1.06); C453(0.89); C385(1.03); C421(0.88)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C290(1.19); C453(1.22); C385(1.16)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C290(1.07); C453(0.96); C421(0.78)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C290(0.95); C453(1.04); C385(1.03)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C290(0.97); C453(1.07)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C290(1.03); C453(0.95)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C290(1.09); C453(0.81); C385(0.92)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C290(1.04); C453(0.86); C385(0.94); C421(1.34)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C290(1.05); C453(0.90); C385(1.15)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C290(0.91); C453(0.90); C385(0.74)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C290(1.03); C453(0.84); C385(0.99)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C290(1.14); C453(1.01); C385(0.95)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C290(0.97); C453(0.88); C385(1.02); C421(1.07)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C290(1.02); C453(0.89); C385(0.97)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C290(1.12); C453(0.95); C421(0.91)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C290(1.14); C453(1.22); C385(0.95)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C290(1.01); C453(0.82)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C290(0.88); C453(0.97); C385(1.04)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C290(1.02); C453(0.96)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C290(1.14); C453(0.94); C385(0.97)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C290(1.06); C453(0.87); C385(0.81)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C290(0.95); C453(0.80); C385(0.77); C421(1.19)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C290(1.07); C453(0.99); C385(1.06)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C290(0.96); C453(1.01); C385(0.95)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C290(1.05); C453(0.84); C385(0.92)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C290(1.02); C453(0.94); C385(0.97); C421(1.10)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C290(1.03); C453(1.04); C385(0.92)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C290(1.15); C453(0.95); C421(1.17)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C290(1.06); C453(1.10); C385(1.04)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C290(0.99); C453(1.03)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C290(0.98); C453(1.44); C385(0.98)  LDD1697  [19]
 LDCM0165  Compound 9 HL-60 N.A.  LDD0420  [18]
 LDCM0495  E2913 HEK-293T C290(0.94); C453(0.92); C385(0.98)  LDD1698  [19]
 LDCM0625  F8 Ramos C148(0.89); C273(1.66)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C148(0.95)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C148(13.18); C273(15.81)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C148(0.78)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C148(0.93); C273(1.04)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C273(0.76)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C273(0.82)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C273(0.89)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C148(1.03); C273(0.98)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C273(2.02)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C148(0.42); C273(1.74)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C148(1.04); C273(0.87)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C148(0.75); C273(0.81)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C148(0.91)  LDD2201  [20]
 LDCM0468  Fragment33 HEK-293T C290(0.95); C453(0.92); C385(1.03)  LDD1671  [19]
 LDCM0596  Fragment38 Ramos C148(1.54)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C273(4.20)  LDD2184  [20]
 LDCM0427  Fragment51 HEK-293T C290(0.98); C453(1.06)  LDD1631  [19]
 LDCM0614  Fragment56 Ramos C148(1.62)  LDD2205  [20]
 LDCM0571  Fragment9 Ramos C148(1.06)  LDD2188  [20]
 LDCM0022  KB02 HEK-293T C385(0.97); C290(0.91); C421(1.35); C453(1.15)  LDD1492  [19]
 LDCM0023  KB03 Jurkat C290(20.00)  LDD0315  [21]
 LDCM0024  KB05 COLO792 C273(4.05)  LDD3310  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C7(0.66)  LDD2206  [22]
 LDCM0628  OTUB2-COV-1 HEK-293T C7(0.76)  LDD2207  [22]
 LDCM0014  Panhematin HEK-293T 3.00  LDD0062  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (DUS1L) Dus family Q6P1R4
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) CAMK Ser/Thr protein kinase family Q13557
Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G) CAMK Ser/Thr protein kinase family Q13555
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Nuclear RNA export factor 1 (NXF1) NXF family Q9UBU9
Transportin-3 (TNPO3) . Q9Y5L0
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 19-3 (KRTAP19-3) KRTAP type 19 family Q7Z4W3
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64
Large ribosomal subunit protein uL11m (MRPL11) Universal ribosomal protein uL11 family Q9Y3B7
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Nuclear transport factor 2 (NUTF2) . P61970
Spermatid perinuclear RNA-binding protein (STRBP) . Q96SI9
Tetratricopeptide repeat protein 5 (TTC5) . Q8N0Z6

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bosutinib Small molecular drug DB06616
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-tert-butyl-3-(3-methylbenzyl)-1h-pyrazolo[34-d]Pyrimidin-4-amine . DB08699

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
17 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
18 A Photoaffinity Displacement Assay and Probes to Study the Cyclin-Dependent Kinase Family. Angew Chem Int Ed Engl. 2019 Nov 25;58(48):17322-17327. doi: 10.1002/anie.201906321. Epub 2019 Oct 31.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
22 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.