Details of the Target

General Information of Target

Target ID LDTP10703
Target Name Leukocyte receptor cluster member 8 (LENG8)
Gene Name LENG8
Gene ID 114823
Synonyms
KIAA1932; Leukocyte receptor cluster member 8
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MALTLLEDWCKGMDMDPRKALLIVGIPMECSEVEIQDTVKAGLQPLCAYRVLGRMFRRED
NAKAVFIELADTVNYTTLPSHIPGKGGSWEVVVKPRNPDDEFLSRLNYFLKDEGRSMTDV
ARALGCCSLPAESLDAEVMPQVRSPPLEPPKESMWYRKLKVFSGTASPSPGEETFEDWLE
QVTEIMPIWQVSEVEKRRRLLESLRGPALSIMRVLQANNDSITVEQCLDALKQIFGDKED
FRASQFRFLQTSPKIGEKVSTFLLRLEPLLQKAVHKSPLSVRSTDMIRLKHLLARVAMTP
ALRGKLELLDQRGCPPNFLELMKLIRDEEEWENTEAVMKNKEKPSGRGRGASGRQARAEA
SVSAPQATVQARSFSDSSPQTIQGGLPPLVKRRRLLGSESTRGEDHGQATYPKAENQTPG
REGPQAAGEELGNEAGAGAMSHPKPWET
Target Bioclass
Other
Uniprot ID
Q96PV6
Ensemble ID
ENST00000326764.10
HGNC ID
HGNC:15500

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K318(6.51)  LDD0277  [1]
BTD
 Probe Info  		C695(0.83)  LDD2094  [2]
AHL-Pu-1
 Probe Info  		C529(2.61); C463(2.08)  LDD0169  [3]
DBIA
 Probe Info  		C643(7.24); C695(47.94); C566(6.18)  LDD0209  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C695(0.00); C643(0.00); C500(0.00); C600(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C695(0.00); C643(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C643(0.00); C500(0.00); C769(0.00); C695(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
NAIA_5
 Probe Info  		C500(0.00); C450(0.00)  LDD2224  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
IPM
 Probe Info  		C450(0.00); C584(0.00)  LDD0005  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [5]
AOyne
 Probe Info  		13.60  LDD0443  [11]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C085
 Probe Info  		7.36  LDD1777  [12]
C134
 Probe Info  		20.25  LDD1816  [12]
C135
 Probe Info  		10.85  LDD1817  [12]
C169
 Probe Info  		48.84  LDD1849  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C695(0.74)  LDD2117  [2]
 LDCM0025  4SU-RNA HEK-293T C529(3.43)  LDD0371  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C529(2.61); C463(2.08)  LDD0169  [3]
 LDCM0214  AC1 HEK-293T C643(1.14); C500(0.97); C600(0.97); C566(0.94)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C643(1.01); C500(0.96); C600(1.04); C566(0.97)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C643(0.97); C500(0.68); C600(0.99); C566(0.96)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C643(1.02); C500(1.00); C600(1.04); C566(0.98)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C450(1.07); C643(0.96); C500(0.96); C600(1.03)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C643(1.02); C500(1.10); C600(0.93); C566(0.95)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C643(0.97); C500(0.97); C600(1.00); C566(0.97)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C643(1.03); C500(0.85); C600(1.04); C566(0.91)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C643(1.15); C500(1.24); C600(1.02); C566(1.15)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C643(1.01); C500(0.91); C600(0.97); C566(0.97)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C643(1.01); C500(1.15); C600(1.09); C566(0.96)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C450(0.98); C643(0.90); C500(0.92); C600(0.90)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C450(0.86); C643(0.90); C500(0.88); C600(1.01)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C643(1.02); C500(0.90); C600(1.02); C566(0.97)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C450(1.03); C643(0.95); C500(0.99); C600(0.97)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C643(1.04); C500(1.12); C600(1.00); C566(0.91)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C643(0.96); C500(0.92); C600(0.92); C566(0.99)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C643(0.95); C500(0.79); C600(0.93); C566(1.03)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C643(0.99); C500(1.12); C600(1.01); C566(0.98)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C450(0.99); C643(0.99); C500(0.96); C600(1.10)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C643(0.98); C500(0.81); C600(0.98); C566(0.98)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C450(1.16); C643(0.91); C500(0.90); C600(1.07)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C643(1.04); C500(0.97); C600(0.94); C566(0.97)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C450(1.17); C643(0.89); C500(0.97); C600(1.10)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C643(1.03); C500(0.94); C600(0.88); C566(0.89)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C643(0.94); C500(1.00); C600(0.98); C566(0.97)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C643(0.92); C500(0.90); C600(0.98); C566(1.08)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C643(1.10); C500(1.02); C600(0.97); C566(0.92)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C450(1.03); C643(0.93); C500(1.04); C600(1.01)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C450(0.93); C643(0.96); C500(0.95); C600(1.01)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C643(0.96); C500(0.99); C600(0.91); C566(0.92)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C643(0.99); C500(0.97); C600(1.03); C566(0.93)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C450(1.00); C643(0.99); C500(1.02); C600(1.04)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C643(0.98); C500(0.95); C600(0.95); C566(0.86)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C643(1.05); C500(0.89); C600(1.05); C566(0.98)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C643(1.02); C500(0.75); C600(1.06); C566(0.95)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C643(1.03); C500(1.15); C600(1.04); C566(0.97)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C450(1.02); C643(0.91); C500(1.00); C600(0.96)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C450(0.98); C643(0.97); C500(0.98); C600(1.03)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C643(1.01); C500(1.00); C600(1.01); C566(1.02)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C450(0.84); C643(1.00); C500(0.86); C600(0.97)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C643(0.93); C500(0.93); C600(0.96); C566(0.84)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C450(0.88); C643(0.96); C500(0.97); C600(0.95)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C643(1.01); C500(1.01); C600(1.02); C566(0.98)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C643(0.94); C500(1.00); C600(0.95); C566(0.97)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C643(1.03); C500(1.22); C600(1.08); C566(0.95)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C450(0.88); C643(0.92); C500(0.97); C600(0.96)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C450(1.00); C643(0.93); C500(1.01); C600(1.00)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C643(1.09); C500(1.08); C600(1.01); C566(0.97)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C450(0.83); C643(1.00); C500(0.94); C600(1.09)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C643(1.02); C500(1.05); C600(0.98); C566(0.93)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C643(0.96); C500(0.91); C600(0.98); C566(1.00)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C643(0.93); C500(0.89); C600(0.99); C566(0.99)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C450(0.91); C643(0.96); C500(0.89); C600(0.99)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C643(1.09); C500(0.90); C600(0.96); C566(0.99)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C450(0.97); C643(0.98); C500(0.93); C600(0.98)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C450(1.13); C643(0.96); C500(0.95); C600(1.07)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C643(1.04); C500(1.04); C600(1.09); C566(0.95)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C450(0.89); C643(0.98); C500(0.96); C600(1.00)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C643(1.04); C500(1.07); C600(0.96); C566(1.02)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C450(1.04); C643(1.03); C500(0.85); C600(0.98)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C450(0.86); C643(0.95); C500(1.01); C600(0.94)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C643(0.99); C500(1.07); C600(1.01); C566(0.95)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C450(0.95); C643(1.00); C500(0.96); C600(1.05)  LDD1514  [13]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0632  CL-Sc Hep-G2 C450(20.00); C450(0.95)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C450(0.94); C643(1.05); C500(0.97); C600(1.02)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C450(1.28); C643(1.27); C500(0.98); C600(0.78)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C643(1.06); C500(1.02); C600(0.96); C566(1.01)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C450(0.83); C643(0.95); C500(1.04); C600(0.91)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C643(0.98); C500(0.94); C600(1.10); C566(0.93)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C450(0.87); C643(0.94); C500(0.91); C600(0.90)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C643(0.93); C500(0.91); C600(1.01); C566(1.03)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C450(0.76); C643(1.01); C500(0.95); C600(0.95)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C643(0.90); C500(1.00); C600(1.09); C566(0.94)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C450(1.06); C643(0.94); C500(1.00); C600(1.00)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C643(1.02); C500(1.12); C600(0.98); C566(0.98)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C450(0.79); C643(0.98); C500(1.01); C600(0.98)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C643(1.03); C500(1.10); C600(1.13); C566(1.03)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C643(1.06); C500(1.01); C600(0.99); C566(0.98)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C450(0.83); C643(1.03); C500(0.95); C600(0.93)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C643(0.98); C500(0.92); C600(1.08); C566(0.99)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C450(0.95); C643(1.01); C500(1.07); C600(0.92)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C643(0.97); C500(1.05); C600(0.95); C566(0.90)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C450(1.12); C643(0.94); C500(1.04); C600(0.98)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C643(1.00); C500(0.95); C600(0.92); C566(1.04)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C450(0.62); C643(0.96); C500(0.99); C600(1.01)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C643(0.97); C500(1.06); C600(1.06); C566(0.96)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C450(1.18); C643(0.90); C500(1.09); C600(0.92)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C450(1.08); C643(1.04); C500(0.94); C600(1.10)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C643(0.94); C500(1.07); C600(0.94); C566(1.04)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C450(0.84); C643(0.96); C500(1.05); C600(1.02)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C643(0.91); C500(1.01); C600(1.10); C566(0.95)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C450(0.72); C643(1.08); C500(0.96); C600(0.86)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C643(0.95); C500(1.01); C600(0.96); C566(1.06)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C450(0.71); C643(0.98); C500(1.08); C600(1.10)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C643(0.97); C500(0.95); C600(1.11); C566(0.93)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C450(0.76); C643(0.95); C500(0.98); C600(0.92)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C643(0.97); C500(0.96); C600(0.93); C566(1.06)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C450(0.90); C643(1.06); C500(1.25); C600(1.03)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C643(0.92); C500(1.00); C600(1.15); C566(0.94)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C450(1.00); C643(1.13); C500(1.04); C600(0.89)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C643(1.16); C500(0.87); C600(0.98); C566(1.05)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C643(1.13); C500(1.01); C600(0.97); C566(0.90)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C643(0.97); C500(0.93); C600(1.09); C566(0.87)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C643(1.06); C500(1.05); C600(1.07); C566(0.98)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C643(1.00); C500(1.03); C600(1.08); C566(0.97)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C643(1.14); C500(1.17); C600(1.19); C566(1.09)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C450(0.93); C643(1.06); C500(0.91); C600(1.12)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C450(1.08); C643(1.00); C500(1.09); C600(0.72)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C643(1.15); C500(0.91); C600(1.09); C566(1.12)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C450(1.08); C643(1.07); C500(0.99); C600(1.06)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C450(0.65); C643(0.98); C500(1.03); C600(0.97)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C643(0.99); C500(1.17); C600(1.06); C566(1.00)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C450(0.97); C643(1.01); C500(1.11); C600(0.92)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C643(1.02); C500(0.89); C600(1.07); C566(0.98)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C643(1.02); C500(0.95); C600(1.05); C566(0.93)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C450(0.99); C643(0.97); C500(0.94); C600(0.88)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C643(1.02); C500(0.99); C600(1.00); C566(0.92)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C643(0.93); C500(0.93); C600(1.08); C566(1.00)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C643(1.06); C500(1.03); C600(1.15); C566(1.01)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C450(0.91); C643(1.06); C500(1.00); C600(1.15)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C450(1.01); C643(1.10); C500(0.98); C600(0.73)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C643(0.95); C500(1.11); C600(1.25); C566(1.09)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C450(1.09); C643(1.13); C500(0.94); C600(1.13)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C450(0.68); C643(1.04); C500(1.04); C600(0.98)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C450(1.06); C643(0.90); C500(1.06); C600(1.00)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C643(1.09); C500(0.97); C600(0.99); C566(1.05)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C643(0.98); C500(0.92); C600(0.96); C566(1.07)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C643(1.09); C500(0.96); C600(0.94); C566(0.95)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C643(1.00); C500(1.08); C600(1.11); C566(0.96)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C643(1.01); C500(0.88); C600(1.09); C566(0.94)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C643(1.08); C500(1.28); C600(1.10); C566(1.04)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C450(0.88); C643(0.94); C500(0.95); C600(1.05)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C450(0.85); C643(1.14); C500(1.10); C600(0.71)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C643(1.01); C500(1.10); C600(1.17); C566(1.04)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C450(1.00); C643(1.11); C500(0.92); C600(1.05)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C450(0.70); C643(0.96); C500(0.90); C600(1.01)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C643(1.14); C500(0.87); C600(0.97); C566(0.98)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C643(0.91); C500(1.07); C600(1.14); C566(0.91)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C643(0.96); C500(0.92); C600(0.95); C566(1.01)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C643(1.01); C500(1.12); C600(1.00); C566(0.92)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C643(1.01); C500(1.07); C600(1.01); C566(0.89)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C643(0.96); C500(0.72); C600(1.08); C566(0.98)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C643(1.08); C500(1.11); C600(0.99); C566(1.00)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C450(0.99); C643(1.05); C500(1.04); C600(1.10)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C450(0.95); C643(1.08); C500(0.97); C600(0.74)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C643(1.01); C500(0.95); C600(1.15); C566(1.06)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C643(1.10); C500(1.04); C600(1.12); C566(0.91)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C450(1.02); C643(1.10); C500(0.93); C600(1.08)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C450(0.78); C643(0.97); C500(0.98); C600(1.02)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C643(0.87); C500(1.00); C600(1.06); C566(0.93)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C450(0.83); C643(0.96); C500(1.01); C600(0.90)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C643(1.14); C500(1.05); C600(1.00); C566(0.99)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C643(1.06); C500(1.00); C600(1.01); C566(0.87)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C643(1.03); C500(0.86); C600(1.03); C566(0.93)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C643(0.99); C500(1.03); C600(1.08); C566(1.02)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C643(1.08); C500(1.09); C600(1.13); C566(1.04)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C450(0.88); C643(1.01); C500(1.03); C600(1.05)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C643(1.00); C500(0.78); C600(1.08); C566(1.01)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C450(0.99); C643(1.10); C500(1.02); C600(0.77)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C643(0.98); C500(1.05); C600(1.10); C566(1.00)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C450(1.18); C643(1.08); C500(1.00); C600(1.06)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C450(0.67); C643(0.98); C500(1.00); C600(0.99)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C643(0.93); C500(0.96); C600(1.04); C566(0.92)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C643(0.97); C500(0.92); C600(0.99); C566(1.08)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C643(1.15); C500(1.00); C600(0.94); C566(0.96)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C643(1.03); C500(0.98); C600(1.08); C566(0.90)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C643(0.94); C500(1.25); C600(1.10); C566(0.99)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C643(1.39); C500(0.96); C600(1.12); C566(1.06)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C643(1.01); C500(1.16); C600(1.08); C566(1.06)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C450(0.92); C643(0.98); C500(1.03); C600(1.10)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C450(0.86); C643(1.06); C500(0.97); C600(0.84)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C643(1.01); C500(1.04); C600(1.02); C566(1.03)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C450(0.99); C643(0.96); C500(1.08); C600(1.15)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C450(0.67); C643(0.99); C500(1.02); C600(1.07)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C643(0.90); C500(1.04); C600(1.14); C566(1.01)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C450(0.66); C643(0.96); C500(0.95); C600(0.98)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C643(0.95); C500(0.89); C600(0.96); C566(1.01)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C643(0.99); C500(1.11); C600(0.91); C566(0.98)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C450(1.03); C643(1.12); C500(1.00); C600(1.07)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C643(1.26); C500(0.92); C600(1.12); C566(0.92)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C643(0.88); C500(0.85); C600(1.05); C566(1.00)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C643(1.08); C500(1.01); C600(1.06); C566(0.94)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C450(0.86); C643(0.98); C500(0.99); C600(1.13)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C450(1.05); C643(1.01); C500(0.90); C600(0.86)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C643(1.41); C500(0.97); C600(0.97); C566(0.93)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C450(0.70); C643(1.03); C500(0.92); C600(1.14)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C450(0.76); C643(0.99); C500(1.02); C600(0.97)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C643(0.95); C500(1.01); C600(1.07); C566(0.96)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C450(1.17); C643(0.95); C500(0.92); C600(0.89)  LDD1697  [13]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C547(5.23)  LDD0513  [14]
 LDCM0495  E2913 HEK-293T C450(1.01); C643(0.98); C500(0.97); C600(0.98)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C695(3.59); C643(1.93)  LDD1702  [2]
 LDCM0468  Fragment33 HEK-293T C450(0.96); C643(1.05); C500(0.98); C600(0.93)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C643(0.92); C500(1.01); C600(1.03); C566(0.98)  LDD1631  [13]
 LDCM0022  KB02 HEK-293T C643(1.00); C500(0.87); C600(0.98); C566(1.02)  LDD1492  [13]
 LDCM0023  KB03 Jurkat C643(7.24); C695(47.94); C566(6.18)  LDD0209  [4]
 LDCM0024  KB05 G361 C695(2.28); C566(3.52)  LDD3311  [15]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C695(0.83)  LDD2094  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C584(1.36)  LDD2099  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C695(0.63)  LDD2125  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C695(0.97)  LDD2136  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C643(0.57)  LDD2150  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Integrator complex subunit 11 (INTS11) RNA-metabolizing metallo-beta-lactamase-like family Q5TA45
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Transport and Golgi organization protein 1 homolog (MIA3) MIA/OTOR family Q5JRA6
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MSX-2 (MSX2) Msh homeobox family P35548
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
HMG domain-containing protein 4 (HMGXB4) . Q9UGU5
Other
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cilia- and flagella-associated protein 53 (CFAP53) CFAP53 family Q96M91
Conserved oligomeric Golgi complex subunit 2 (COG2) COG2 family Q14746
PCI domain-containing protein 2 (PCID2) CSN12 family Q5JVF3
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
Protein INCA1 (INCA1) INCA family Q0VD86
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
MAPK-interacting and spindle-stabilizing protein-like (MAPK1IP1L) MISS family Q8NDC0
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
Nuclear cap-binding protein subunit 3 (NCBP3) NCBP3 family Q53F19
U1 small nuclear ribonucleoprotein A (SNRPA) RRM U1 A/B'' family P09012
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
BAG family molecular chaperone regulator 3 (BAG3) . O95817
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Genetic suppressor element 1 (GSE1) . Q14687
Heterogeneous nuclear ribonucleoprotein M (HNRNPM) . P52272
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Period circadian protein homolog 2 (PER2) . O15055
Protein TFG (TFG) . Q92734
Suppressor of cytokine signaling 7 (SOCS7) . O14512
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
Uncharacterized protein C10orf55 (C10orf55) . Q5SWW7

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840