Details of the Target

General Information of Target

Target ID LDTP01451
Target Name UBX domain-containing protein 7 (UBXN7)
Gene Name UBXN7
Gene ID 26043
Synonyms
KIAA0794; UBXD7; UBX domain-containing protein 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAHGGSAASSALKGLIQQFTTITGASESVGKHMLEACNNNLEMAVTMFLDGGGIAEEPS
TSSASVSTVRPHTEEEVRAPIPQKQEILVEPEPLFGAPKRRRPARSIFDGFRDFQTETIR
QEQELRNGGAIDKKLTTLADLFRPPIDLMHKGSFETAKECGQMQNKWLMINIQNVQDFAC
QCLNRDVWSNEAVKNIIREHFIFWQVYHDSEEGQRYIQFYKLGDFPYVSILDPRTGQKLV
EWHQLDVSSFLDQVTGFLGEHGQLDGLSSSPPKKCARSESLIDASEDSQLEAAIRASLQE
THFDSTQTKQDSRSDEESESELFSGSEEFISVCGSDEEEEVENLAKSRKSPHKDLGHRKE
ENRRPLTEPPVRTDPGTATNHQGLPAVDSEILEMPPEKADGVVEGIDVNGPKAQLMLRYP
DGKREQITLPEQAKLLALVKHVQSKGYPNERFELLTNFPRRKLSHLDYDITLQEAGLCPQ
ETVFVQERN
Target Bioclass
Other
Subcellular location
Nucleus
Function Ubiquitin-binding adapter that links a subset of NEDD8-associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates.
Uniprot ID
O94888
Ensemble ID
ENST00000296328.9
HGNC ID
HGNC:29119

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y227(20.00)  LDD0260  [2]
STPyne
 Probe Info  		K440(10.00)  LDD0277  [3]
IPM
 Probe Info  		N.A.  LDD0241  [4]
Probe 1
 Probe Info  		Y220(13.51)  LDD3495  [5]
BTD
 Probe Info  		C160(1.07)  LDD2125  [6]
AHL-Pu-1
 Probe Info  		C160(3.95)  LDD0168  [7]
HHS-475
 Probe Info  		Y207(0.66)  LDD0264  [8]
DBIA
 Probe Info  		C160(0.91)  LDD0078  [9]
5E-2FA
 Probe Info  		H4(0.00); H302(0.00)  LDD2235  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
HHS-482
 Probe Info  		Y207(1.23)  LDD2239  [16]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		8.69  LDD1711  [17]
C219
 Probe Info  		15.03  LDD1893  [17]
C220
 Probe Info  		22.47  LDD1894  [17]
C342
 Probe Info  		9.85  LDD2004  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C160(3.95)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C160(2.51)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C160(1.17)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C160(1.53)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C160(1.44)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C160(1.24)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C160(1.21)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C160(1.64)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C160(1.64)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C160(1.39)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C160(1.38)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C160(1.20)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C160(1.59)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C160(1.77)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C160(1.48)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C160(1.14)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C160(1.18)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C160(1.72)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C160(0.94); C180(0.94); C182(0.94)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C160(1.07); C180(1.11); C182(1.11)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C160(1.06); C180(1.16); C182(1.16)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C160(1.25); C180(1.17); C182(1.17)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C160(1.19); C180(0.96); C182(0.96)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C160(1.07); C180(1.05); C182(1.05)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C160(1.32); C180(1.16); C182(1.16)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C160(1.13)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C160(1.16); C180(0.95); C182(0.95)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C160(0.96); C180(0.87); C182(0.87)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C160(1.03); C180(1.16); C182(1.16)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C160(1.00); C180(0.97); C182(0.97)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C160(1.15); C180(0.94); C182(0.94)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C160(1.20); C180(0.98); C182(0.98)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C160(1.17); C180(1.09); C182(1.09)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C160(1.17); C180(1.01); C182(1.01)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C160(1.33)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C160(1.00)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C160(1.14)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C160(0.90)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C160(1.17)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C160(1.23)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C160(1.32)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C160(1.27)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C160(1.25)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C160(1.14)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C160(1.25)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C160(1.35)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C160(1.37)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C160(1.37)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C160(1.33)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C160(1.13)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C160(0.84)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C160(1.08)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C160(1.31)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C160(1.13)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C160(1.06)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C160(0.99)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C160(0.93)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C160(1.47)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C160(0.89)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C160(1.02)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C160(1.01)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C160(1.61)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C160(1.00)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C160(1.05)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C160(1.12)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C160(1.12)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C160(1.34)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C160(1.71)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C160(1.20)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C160(0.95)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C160(1.10)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C160(1.28)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C160(1.12)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C160(0.97)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C160(0.94)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C160(1.15)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C160(1.24)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C160(1.11)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C160(1.12)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C160(1.02)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C160(1.10)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C160(1.09)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C160(1.07)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C160(1.53)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C160(1.10)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C160(1.28)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C160(0.90)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C160(1.11)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C160(1.17)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C160(0.98)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C160(1.11)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C160(1.08)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C160(1.12)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C160(1.16)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C160(0.95)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C160(0.98)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C160(1.05)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C160(1.27)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C160(1.07)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C160(1.02)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C160(1.14)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C160(1.24)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C160(1.24)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C160(1.28)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C160(1.07)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C160(1.16)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C160(1.12)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C160(1.08)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C160(1.19)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C160(1.40)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C160(1.27)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C160(1.33)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C160(1.37)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C160(1.27)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C160(1.12)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C160(1.24)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C160(1.36)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C160(1.24)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C160(1.31)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C160(1.32)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C160(1.37)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C160(1.62)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C160(0.99); C180(1.09); C182(1.09)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C180(0.88); C182(0.88); C160(0.93)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C160(1.14)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C180(1.04); C182(1.04); C160(1.09)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C180(0.91); C182(0.91); C160(0.98)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C180(0.98); C182(0.98); C160(1.10)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C180(1.09); C182(1.09); C160(1.20)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C180(0.99); C182(0.99); C160(1.26)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C180(1.10); C182(1.10); C160(1.38)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C160(1.14); C180(1.18); C182(1.18)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C180(1.00); C182(1.00); C160(1.35)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C180(0.79); C182(0.79); C160(0.97)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C160(0.96); C180(0.97); C182(0.97)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C160(1.41)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C180(0.95); C182(0.95); C160(0.99)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C180(0.50); C182(0.50); C160(1.12)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C180(1.24); C182(1.24); C160(1.69)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C160(1.58)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C160(1.44)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C160(1.18)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C160(1.21)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C160(1.04)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C160(1.15)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C160(1.27)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C160(1.07)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C160(1.51)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C160(1.42)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C160(1.09)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C160(1.10)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C160(1.02)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C160(1.18)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C160(1.32)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C160(1.89)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C160(1.08)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C160(1.09)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C160(1.33)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C160(1.55)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 12.16  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C160(0.91)  LDD0078  [9]
 LDCM0367  CL1 HCT 116 C160(0.74); C180(0.99); C182(0.99)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C160(1.02); C180(1.04); C182(1.04)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C160(1.18)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C160(1.38)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C160(0.93)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C160(0.97)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C160(1.19)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C160(1.12)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C160(1.62)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C160(1.45)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C160(1.25)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C160(1.07)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C160(1.02); C180(1.27); C182(1.27)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C160(1.34)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C160(1.02)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C160(1.02)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C160(1.30)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C160(1.17)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C160(1.09)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C160(1.03)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C160(1.32)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C160(1.15)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C160(1.14)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C180(1.20); C182(1.20); C160(1.38)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C160(1.41)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C160(0.95)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C160(1.13)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C160(1.04)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C160(1.11)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C160(1.00)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C160(1.02)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C160(1.12)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C160(1.42)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C160(0.97); C180(1.11); C182(1.11)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C160(0.85); C180(0.99); C182(0.99)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C160(0.96); C180(1.00); C182(1.00)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C160(0.99)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C160(0.95)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C160(0.98)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C160(0.99)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C180(0.94); C182(0.94); C160(1.08)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C160(1.00)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C160(1.08)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C160(1.30)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C160(0.96)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C160(1.21)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C160(1.13)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C160(1.01)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C160(0.99)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C160(1.03)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C160(1.10)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C160(0.80); C180(0.94); C182(0.94)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C160(0.96)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C160(1.00)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C160(0.96)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C160(0.99)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C160(1.04)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C160(1.13)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C160(1.13)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C160(1.12)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C160(1.15)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C160(0.82); C180(0.97); C182(0.97)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C160(1.11)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C160(1.01)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C160(1.40)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C160(1.15)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C160(1.03)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C160(1.08)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C160(0.93)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C160(0.84)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C160(0.99)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C160(1.03)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C160(0.93); C180(1.13); C182(1.13)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C160(0.84)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C160(1.10)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C160(0.90)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C160(0.82)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C160(0.93)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C160(0.85)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C160(1.08)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C160(0.77)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C160(0.80)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C160(0.88)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C160(0.96); C180(0.98); C182(0.98)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C160(0.94)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C160(0.96)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C160(0.94)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C160(1.20)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C160(1.29)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C160(1.03)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C160(1.40)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C160(1.46)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C160(1.07)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C160(0.93)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C160(1.02); C180(1.25); C182(1.25)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C160(1.07)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C160(1.15)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C160(0.96)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C160(1.18)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C160(1.12)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C160(1.01); C180(2.56); C182(2.56)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C160(1.09); C180(0.57); C182(0.57)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C160(1.03); C180(1.01); C182(1.01)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C160(1.10); C180(1.28); C182(1.28)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C160(1.42); C180(1.32); C182(1.32)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C160(1.21); C180(0.79); C182(0.79)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C160(1.17); C180(1.46); C182(1.46)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C160(1.24); C180(0.96); C182(0.96)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C160(0.98); C180(1.49); C182(1.49)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C160(1.02); C180(2.18); C182(2.18)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C160(0.98); C180(0.99); C182(0.99)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C160(1.04); C180(1.05); C182(1.05)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C160(1.00); C180(1.28); C182(1.28)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C160(1.03); C180(2.61); C182(2.61)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C160(1.17); C180(1.26); C182(1.26)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C160(1.04); C180(1.11); C182(1.11)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C160(1.04); C180(1.09); C182(1.09)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C160(1.14)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C160(1.16)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C160(0.99)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C160(1.03)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C160(1.17)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C160(1.17)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C160(1.20)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C160(1.20)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C160(1.22)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C160(1.13); C478(1.04); C180(1.20)  LDD1698  [18]
 LDCM0625  F8 Ramos C160(1.08)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C160(1.01)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C160(2.95)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C160(0.97)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C160(1.54)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C160(0.70)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C160(0.88)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C160(0.79)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C160(0.39)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C160(0.95)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C160(0.72)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C160(1.34)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C160(1.32)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C160(0.97)  LDD2201  [19]
 LDCM0468  Fragment33 HCT 116 C160(1.47)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C160(1.36)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C160(0.85)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C160(1.42)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C160(1.09)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C160(1.57)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C160(0.73)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C160(0.73)  LDD2188  [19]
 LDCM0116  HHS-0101 DM93 Y207(0.66)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y207(0.67)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y207(0.79)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y207(0.74)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y207(0.66)  LDD0268  [8]
 LDCM0022  KB02 HEK-293T C478(0.94); C180(0.98)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C478(0.98); C180(0.86)  LDD1497  [18]
 LDCM0024  KB05 MEL182 C160(2.32)  LDD3317  [20]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C160(1.07)  LDD2125  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Cullin-1 (CUL1) Cullin family Q13616
Cullin-2 (CUL2) Cullin family Q13617
Cullin-3 (CUL3) Cullin family Q13618
Cullin-4A (CUL4A) Cullin family Q13619
Cullin-4B (CUL4B) Cullin family Q13620
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
E3 ubiquitin-protein ligase TRIM62 (TRIM62) TRIM/RBCC family Q9BVG3
E3 ubiquitin-protein ligase TRIM8 (TRIM8) TRIM/RBCC family Q9BZR9
E3 ubiquitin-protein ligase ZNRF1 (ZNRF1) . Q8ND25
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Homeobox protein MOX-1 (MEOX1) . P50221
Hypoxia-inducible factor 1-alpha (HIF1A) . Q16665
Paired box protein Pax-5 (PAX5) . Q02548
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
NEDD8 (NEDD8) Ubiquitin family Q15843
C-type lectin domain family 19 member A (CLEC19A) . Q6UXS0
DAZ-associated protein 2 (DAZAP2) . Q15038
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840