Details of the Target

General Information of Target

Target ID LDTP04463
Target Name H(+)/Cl(-) exchange transporter 7 (CLCN7)
Gene Name CLCN7
Gene ID 1186
Synonyms
H(+)/Cl(-) exchange transporter 7; Chloride channel 7 alpha subunit; Chloride channel protein 7; ClC-7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMS
SVELDDELLDPDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFR
TVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWA
TLNAAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVG
GLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAA
FGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINF
GRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV
AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHD
PPGSYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAI
WADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEG
LYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSDTASNHNG
FPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLGLVQRRLRLKDFRDAYPRFPP
IQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNRNQVVG
LVTRKDLARYRLGKRGLEELSLAQT
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Chloride channel (TC 2.A.49) family, ClC-7/CLCN7 subfamily
Subcellular location
Lysosome membrane
Function
Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.
TTD ID
T43531
Uniprot ID
P51798
DrugMap ID
TTST1AJ
Ensemble ID
ENST00000382745.9
HGNC ID
HGNC:2025

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P Deletion: p.Q321RfsTer3 DBIA    Probe Info 
A3KAW SNV: p.V772A DBIA    Probe Info 
DOTC24510 SNV: p.L23V DBIA    Probe Info 
HCC44 SNV: p.R157S DBIA    Probe Info 
HGC27 SNV: p.A548T DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.V189A DBIA    Probe Info 
LUDLU1 SNV: p.V474M DBIA    Probe Info 
MFE319 SNV: p.S11F DBIA    Probe Info 
NCIH716 SNV: p.Y790D; p.Y790Ter .
REH SNV: p.R26S DBIA    Probe Info 
SNGM SNV: p.P612L DBIA    Probe Info 
SW1271 SNV: p.K643R DBIA    Probe Info 
TOV21G SNV: p.S434Ter; p.Q439R DBIA    Probe Info 
TYKNU Deletion: p.R25_L37del DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K759(5.17)  LDD0277  [1]
IPM
 Probe Info  		C211(0.00); C637(0.00)  LDD0241  [2]
P11
 Probe Info  		20.00  LDD0201  [3]
BTD
 Probe Info  		C637(1.39)  LDD2099  [4]
Acrolein
 Probe Info  		N.A.  LDD0222  [5]
DBIA
 Probe Info  		C211(1.45)  LDD0080  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
W1
 Probe Info  		N.A.  LDD0236  [2]
PAL-AfBPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C010
 Probe Info  		6.02  LDD1719  [10]
C063
 Probe Info  		14.03  LDD1760  [10]
C064
 Probe Info  		9.25  LDD1761  [10]
C070
 Probe Info  		13.18  LDD1766  [10]
C071
 Probe Info  		10.20  LDD1767  [10]
C107
 Probe Info  		7.31  LDD1794  [10]
C112
 Probe Info  		20.82  LDD1799  [10]
C134
 Probe Info  		25.11  LDD1816  [10]
C140
 Probe Info  		9.99  LDD1822  [10]
C160
 Probe Info  		7.06  LDD1840  [10]
C161
 Probe Info  		17.75  LDD1841  [10]
C169
 Probe Info  		22.94  LDD1849  [10]
C170
 Probe Info  		9.99  LDD1850  [10]
C201
 Probe Info  		36.50  LDD1877  [10]
C219
 Probe Info  		5.50  LDD1893  [10]
C220
 Probe Info  		11.55  LDD1894  [10]
C225
 Probe Info  		10.63  LDD1898  [10]
C229
 Probe Info  		10.85  LDD1902  [10]
C231
 Probe Info  		13.93  LDD1904  [10]
C233
 Probe Info  		18.64  LDD1906  [10]
C240
 Probe Info  		8.34  LDD1913  [10]
C280
 Probe Info  		19.84  LDD1950  [10]
C282
 Probe Info  		22.16  LDD1952  [10]
C287
 Probe Info  		9.00  LDD1957  [10]
C288
 Probe Info  		9.13  LDD1958  [10]
C299
 Probe Info  		6.15  LDD1968  [10]
C310
 Probe Info  		10.56  LDD1977  [10]
C378
 Probe Info  		7.01  LDD2037  [10]
C380
 Probe Info  		9.85  LDD2039  [10]
VE-P
 Probe Info  		N.A.  LDD0396  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C637(0.89)  LDD2117  [4]
 LDCM0214  AC1 HCT 116 C211(0.95)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C211(1.10)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C211(0.77)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C211(0.82)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C211(0.78)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C211(0.66)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C211(0.68)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C211(0.68)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C211(0.68)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C211(0.67)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C211(0.89)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C211(0.91)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C211(1.17)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C211(0.83)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C211(0.80)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C211(0.66)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C211(1.00)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C211(0.81)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C211(0.81)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C211(0.89)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C211(0.90)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C211(0.97)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C211(0.88)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C211(1.19)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C211(0.87)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C211(0.99)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C211(0.97)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C211(0.99)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C211(1.01)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C211(0.98)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C211(0.84)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C211(0.87)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C211(1.10)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C211(1.19)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C211(1.05)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C211(1.15)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C211(1.27)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C211(1.11)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C211(1.05)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C211(1.08)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C211(1.07)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C211(1.07)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C211(0.97)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C211(1.05)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C211(1.05)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C211(1.02)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C211(1.01)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C211(1.27)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C211(0.98)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C211(1.11)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C211(0.96)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C211(1.07)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C211(1.06)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C211(1.03)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C211(1.05)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C211(1.17)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C211(1.13)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C211(1.10)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C211(1.02)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C211(0.98)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C211(0.96)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C211(1.00)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C211(1.05)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C211(0.91)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C211(1.11)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C211(1.19)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C211(1.14)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C211(0.96)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C211(1.03)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C211(1.06)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C211(0.98)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C211(1.05)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C211(1.13)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C211(1.00)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C211(0.99)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C211(0.89)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C211(0.98)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C211(0.88)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C211(1.05)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C211(0.78)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C211(0.91)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C211(0.83)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C211(0.95)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C211(0.87)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C211(1.00)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C211(1.12)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C211(1.34)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C211(0.99)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C211(0.85)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C211(1.08)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C211(1.02)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C211(0.82)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C211(0.98)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C211(0.76)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C211(0.85)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C211(0.84)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C211(0.91)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C211(0.99)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C211(1.09)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C211(0.91)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C211(1.13)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C211(0.90)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C211(1.09)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C211(1.01)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C211(0.91)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C211(0.90)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C211(0.89)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C211(0.88)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C211(0.97)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C211(1.00)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C211(1.09)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C211(1.05)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C211(1.05)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C211(0.98)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C211(1.02)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C211(1.01)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C211(1.00)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C211(0.95)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C211(0.96)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C211(0.97)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C211(0.89)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C211(0.86)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C211(1.24)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C211(0.94)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C211(1.11)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C211(0.98)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C211(0.91)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C211(0.96)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C211(0.84)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C211(0.89)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C211(0.78)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C211(0.92)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C211(0.98)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C211(1.16)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C211(0.91)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C211(1.04)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C211(0.90)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C211(0.85)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C211(0.86)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C211(0.94)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C211(0.94)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C211(1.00)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C211(0.92)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C211(0.87)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C211(1.08)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C211(0.81)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C211(0.93)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C211(0.91)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C211(0.95)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C211(0.99)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C211(0.91)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C211(0.87)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C211(0.64)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C211(0.84)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C211(1.17)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C211(1.18)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C211(1.09)  LDD0592  [6]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0367  CL1 HCT 116 C211(1.11)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C211(0.93)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C211(1.08)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C211(1.16)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C211(1.42)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C211(1.37)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C211(1.28)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C211(1.27)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C211(1.18)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C211(1.00)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C211(1.13)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C211(1.15)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C211(1.12)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C211(1.18)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C211(1.18)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C211(0.99)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C211(0.86)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C211(0.92)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C211(0.94)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C211(0.88)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C211(0.87)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C211(0.91)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C211(0.80)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C211(0.84)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C211(0.84)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C211(0.86)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C211(0.94)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C211(1.00)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C211(0.91)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C211(1.01)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C211(1.11)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C211(1.09)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C211(1.00)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C211(0.93)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C211(1.10)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C211(1.01)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C211(0.89)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C211(1.14)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C211(1.02)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C211(0.89)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C211(1.03)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C211(0.89)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C211(1.04)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C211(0.94)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C211(0.87)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C211(0.98)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C211(1.03)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C211(0.87)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C211(0.93)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C211(0.93)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C211(1.02)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C211(0.88)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C211(1.02)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C211(1.36)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C211(0.96)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C211(1.08)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C211(1.13)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C211(1.04)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C211(1.05)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C211(0.93)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C211(0.91)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C211(1.10)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C211(1.12)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C211(1.07)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C211(0.98)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C211(0.97)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C211(1.19)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C211(1.46)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C211(1.11)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C211(1.03)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C211(1.07)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C211(1.24)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C211(0.92)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C211(1.04)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C211(1.19)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C211(1.04)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C211(1.01)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C211(1.18)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C211(1.03)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C211(0.98)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C211(1.24)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C211(1.11)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C211(1.10)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C211(1.01)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C211(1.14)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C211(1.09)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C211(1.13)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C211(1.29)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C211(1.17)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C211(1.10)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C211(1.18)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C211(1.07)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C211(1.04)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C211(1.20)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C211(0.93)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C211(1.16)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C211(1.12)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C211(0.94)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C211(1.16)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C211(1.05)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C211(1.06)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C211(1.03)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C211(0.97)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C211(0.99)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C211(0.85)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C211(1.03)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C211(1.07)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C211(1.14)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C211(1.09)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C211(0.97)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C211(0.94)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C211(0.93)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C211(1.00)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C211(1.03)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C211(1.03)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C211(0.78)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C211(1.38)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C211(0.87)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C211(0.87)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C211(1.01)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C211(1.14)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C211(1.12)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C211(1.11)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C211(1.17)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C211(1.01)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C211(0.95)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C637(1.08); C211(0.85)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C211(21.83); C637(0.64)  LDD1702  [4]
 LDCM0468  Fragment33 HCT 116 C211(1.12)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C211(1.13)  LDD0744  [6]
 LDCM0022  KB02 HCT 116 C211(1.45)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C211(1.81)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C211(1.20)  LDD0082  [6]
 LDCM0109  NEM HeLa N.A.  LDD0227  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C637(1.39)  LDD2099  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C637(1.06)  LDD2136  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C637(1.13)  LDD2144  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-coupled neutral amino acid transporter 7 (SLC38A7) Amino acid/polyamine transporter 2 family Q9NVC3
mRNA export factor GLE1 (GLE1) GLE1 family Q53GS7
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Osteopetrosis-associated transmembrane protein 1 (OSTM1) OSTM1 family Q86WC4
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Transmembrane protein 179B (TMEM179B) TMEM179 family Q7Z7N9
Guided entry of tail-anchored proteins factor 1 (GET1) WRB/GET1 family O00258
Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1) . Q9Y5Y7
Solute carrier family 66 member 2 (SLC66A2) . Q8N2U9
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ganglioside-induced differentiation-associated protein 1 (GDAP1) GST superfamily Q8TB36
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dids Small molecular drug D0PW7B
Diphenylamine-2-carboxylic Acid Small molecular drug D03APP
Gtpgammas Small molecular drug D0Z4AU
Nppb Small molecular drug D08DQL
Ns5818 Small molecular drug D00UTF
Sits Small molecular drug D0A2UX

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402