Details of the Target

General Information of Target

Target ID LDTP04946
Target Name Ubiquitin-fold modifier 1 (UFM1)
Gene Name UFM1
Gene ID 51569
Synonyms
C13orf20; Ubiquitin-fold modifier 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKVSFKITLTSDPRLPYKVLSVPESTPFTAVLKFAAEEFKVPAATSAIITNDGIGINPA
QTAGNVFLKHGSELRIIPRDRVGSC
Target Bioclass
Other
Family
UFM1 family
Subcellular location
Nucleus
Function
Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. Ufmylation of TRIP4 regulates nuclear receptors-mediated transcription.
Uniprot ID
P61960
Ensemble ID
ENST00000239878.9
HGNC ID
HGNC:20597

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y18(7.57)  LDD0260  [1]
STPyne
 Probe Info  		K19(8.99)  LDD0277  [2]
AZ-9
 Probe Info  		E25(10.00)  LDD2209  [3]
HHS-482
 Probe Info  		Y18(1.15)  LDD0285  [4]
HHS-475
 Probe Info  		Y18(0.75)  LDD0264  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
HHS-465
 Probe Info  		K19(0.00); Y18(0.00)  LDD2240  [7]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C135
 Probe Info  		11.08  LDD1817  [8]
C139
 Probe Info  		11.39  LDD1821  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0116  HHS-0101 DM93 Y18(0.75)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y18(1.46)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y18(0.35)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y18(0.81)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y18(1.09)  LDD0268  [5]
 LDCM0123  JWB131 DM93 Y18(1.15)  LDD0285  [4]
 LDCM0124  JWB142 DM93 Y18(1.30)  LDD0286  [4]
 LDCM0125  JWB146 DM93 Y18(1.05)  LDD0287  [4]
 LDCM0126  JWB150 DM93 Y18(5.00)  LDD0288  [4]
 LDCM0127  JWB152 DM93 Y18(2.73)  LDD0289  [4]
 LDCM0128  JWB198 DM93 Y18(2.34)  LDD0290  [4]
 LDCM0129  JWB202 DM93 Y18(0.98)  LDD0291  [4]
 LDCM0130  JWB211 DM93 Y18(1.45)  LDD0292  [4]
 LDCM0109  NEM HeLa N.A.  LDD0229  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin-like modifier-activating enzyme 5 (UBA5) Ubiquitin-activating E1 family Q9GZZ9
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
BTB/POZ domain-containing protein KCTD21 (KCTD21) . Q4G0X4

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587