Details of the Target

General Information of Target

Target ID LDTP08016
Target Name Proton-coupled amino acid transporter 1 (SLC36A1)
Gene Name SLC36A1
Gene ID 206358
Synonyms
PAT1; Proton-coupled amino acid transporter 1; Proton/amino acid transporter 1; hPAT1; Solute carrier family 36 member 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTQRLRNEDYHDYSSTDVSPEESPSEGLNNLSSPGSYQRFGQSNSTTWFQTLIHLLKGN
IGTGLLGLPLAVKNAGIVMGPISLLIIGIVAVHCMGILVKCAHHFCRRLNKSFVDYGDTV
MYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFVFLADNFKQVIEAANGTTNNC
HNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIV
QRIPDPSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVT
ILYISLGCLGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIP
FFVSRAPEHCELVVDLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLE
VTTFYSEGMSPLTIFKDALISILGFVGFVVGTYEALYELIQPSNAPIFINSTCAFI
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Amino acid/polyamine transporter 2 family
Subcellular location
Cell membrane
Function
Electrogenic proton/amino acid symporter with selectivity for small apolar L-amino acids, their D-enantiomers and selected amino acid derivatives such as 4-aminobutanoate/GABA. May be involved in the efflux from the lysosomal compartment of neutral amino acids resulting from proteolysis. May play a role in specifying sites for exocytosis in neurons.
TTD ID
T31935
Uniprot ID
Q7Z2H8
DrugMap ID
TTUYIZW
Ensemble ID
ENST00000243389.8
HGNC ID
HGNC:18761
ChEMBL ID
CHEMBL1914279

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.Y14N .
Ishikawa (Heraklio) 02 ER SNV: p.L439P .
JHH7 SNV: p.I415T .
LNCaP clone FGC SNV: p.I358V .
MOLT4 SNV: p.E184K .
NCIH1975 SNV: p.A410T .
NCIH23 SNV: p.Y122D .
OCUM1 SNV: p.Y347C .
SW1783 SNV: p.A265V .
TOV21G SNV: p.L324F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C370(0.75)  LDD1507  [1]
PAL-AfBPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C060
 Probe Info  		5.70  LDD1757  [2]
C063
 Probe Info  		13.93  LDD1760  [2]
C064
 Probe Info  		6.19  LDD1761  [2]
C067
 Probe Info  		5.35  LDD1763  [2]
C070
 Probe Info  		16.56  LDD1766  [2]
C091
 Probe Info  		14.52  LDD1782  [2]
C106
 Probe Info  		16.68  LDD1793  [2]
C107
 Probe Info  		8.82  LDD1794  [2]
C112
 Probe Info  		22.63  LDD1799  [2]
C115
 Probe Info  		7.57  LDD1802  [2]
C134
 Probe Info  		47.18  LDD1816  [2]
C135
 Probe Info  		24.59  LDD1817  [2]
C139
 Probe Info  		17.51  LDD1821  [2]
C140
 Probe Info  		12.55  LDD1822  [2]
C159
 Probe Info  		9.25  LDD1839  [2]
C160
 Probe Info  		13.09  LDD1840  [2]
C161
 Probe Info  		23.10  LDD1841  [2]
C183
 Probe Info  		5.70  LDD1861  [2]
C186
 Probe Info  		11.47  LDD1864  [2]
C219
 Probe Info  		9.45  LDD1893  [2]
C220
 Probe Info  		18.64  LDD1894  [2]
C229
 Probe Info  		7.84  LDD1902  [2]
C231
 Probe Info  		17.75  LDD1904  [2]
C233
 Probe Info  		21.86  LDD1906  [2]
C239
 Probe Info  		8.17  LDD1912  [2]
C293
 Probe Info  		17.88  LDD1963  [2]
C310
 Probe Info  		11.55  LDD1977  [2]
C314
 Probe Info  		14.72  LDD1981  [2]
C413
 Probe Info  		20.53  LDD2069  [2]
C414
 Probe Info  		5.24  LDD2070  [2]
C425
 Probe Info  		5.35  LDD2080  [2]
C429
 Probe Info  		14.12  LDD2084  [2]
C433
 Probe Info  		14.22  LDD2088  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C370(0.75)  LDD1507  [1]
 LDCM0259  AC14 HEK-293T C129(1.62)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C129(1.14); C106(1.05)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C370(0.69)  LDD1515  [1]
 LDCM0282  AC22 HEK-293T C129(1.51)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C129(1.18); C106(1.08)  LDD1522  [1]
 LDCM0284  AC24 HEK-293T C129(1.19)  LDD1523  [1]
 LDCM0285  AC25 HEK-293T C370(0.87)  LDD1524  [1]
 LDCM0291  AC30 HEK-293T C129(1.01)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C129(0.93); C106(1.01)  LDD1531  [1]
 LDCM0293  AC32 HEK-293T C129(0.98)  LDD1532  [1]
 LDCM0294  AC33 HEK-293T C370(0.77)  LDD1533  [1]
 LDCM0299  AC38 HEK-293T C129(1.06)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C129(0.93); C106(1.01)  LDD1539  [1]
 LDCM0302  AC40 HEK-293T C129(0.94)  LDD1541  [1]
 LDCM0303  AC41 HEK-293T C370(0.77)  LDD1542  [1]
 LDCM0308  AC46 HEK-293T C129(1.07)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C129(1.65); C106(0.97)  LDD1548  [1]
 LDCM0310  AC48 HEK-293T C129(1.26)  LDD1549  [1]
 LDCM0311  AC49 HEK-293T C370(0.78)  LDD1550  [1]
 LDCM0317  AC54 HEK-293T C129(1.17)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C129(1.01); C106(1.09)  LDD1557  [1]
 LDCM0319  AC56 HEK-293T C129(1.45)  LDD1558  [1]
 LDCM0320  AC57 HEK-293T C370(0.93)  LDD1559  [1]
 LDCM0323  AC6 HEK-293T C129(1.16)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C129(1.13)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C129(1.06); C106(1.02)  LDD1566  [1]
 LDCM0328  AC64 HEK-293T C129(1.32)  LDD1567  [1]
 LDCM0334  AC7 HEK-293T C129(0.79); C106(0.91)  LDD1568  [1]
 LDCM0345  AC8 HEK-293T C129(1.32)  LDD1569  [1]
 LDCM0356  AKOS034007680 HEK-293T C370(0.87)  LDD1570  [1]
 LDCM0275  AKOS034007705 HEK-293T C129(1.32)  LDD1514  [1]
 LDCM0368  CL10 HEK-293T C129(1.46)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C129(2.02); C106(1.02)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C129(1.06); C106(1.02)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C129(0.94); C106(1.00)  LDD1581  [1]
 LDCM0379  CL11 HEK-293T C129(1.21); C106(1.46)  LDD1583  [1]
 LDCM0382  CL112 HEK-293T C129(1.50); C106(0.99)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C129(1.51); C106(1.10)  LDD1590  [1]
 LDCM0390  CL12 HEK-293T C129(1.67)  LDD1594  [1]
 LDCM0391  CL120 HEK-293T C129(1.16); C106(1.05)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C129(1.07); C106(1.14)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C129(1.08); C106(0.97)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C129(1.21); C106(1.21)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C370(0.83)  LDD1608  [1]
 LDCM0410  CL22 HEK-293T C129(1.50)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C129(1.14); C106(1.55)  LDD1615  [1]
 LDCM0412  CL24 HEK-293T C129(1.07)  LDD1616  [1]
 LDCM0416  CL28 HEK-293T C129(1.15); C106(1.25)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C370(0.72)  LDD1621  [1]
 LDCM0423  CL34 HEK-293T C129(1.58)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C129(1.17); C106(1.48)  LDD1628  [1]
 LDCM0425  CL36 HEK-293T C129(1.11)  LDD1629  [1]
 LDCM0429  CL4 HEK-293T C129(1.71); C106(1.17)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C129(2.03); C106(1.23)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C370(0.88)  LDD1635  [1]
 LDCM0436  CL46 HEK-293T C129(1.39)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C129(1.03); C106(1.51)  LDD1641  [1]
 LDCM0438  CL48 HEK-293T C129(1.84)  LDD1642  [1]
 LDCM0440  CL5 HEK-293T C370(0.92)  LDD1644  [1]
 LDCM0443  CL52 HEK-293T C129(0.96); C106(1.13)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C370(0.85)  LDD1647  [1]
 LDCM0449  CL58 HEK-293T C129(1.52)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C129(0.86); C106(1.50)  LDD1653  [1]
 LDCM0452  CL60 HEK-293T C129(1.12)  LDD1655  [1]
 LDCM0456  CL64 HEK-293T C129(1.39); C106(1.19)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C370(0.72)  LDD1660  [1]
 LDCM0463  CL70 HEK-293T C129(1.26)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C129(1.99); C106(1.46)  LDD1667  [1]
 LDCM0465  CL72 HEK-293T C129(1.14)  LDD1668  [1]
 LDCM0469  CL76 HEK-293T C129(1.49); C106(1.08)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C370(0.66)  LDD1673  [1]
 LDCM0476  CL82 HEK-293T C129(1.28)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C129(1.25); C106(1.30)  LDD1680  [1]
 LDCM0478  CL84 HEK-293T C129(1.10)  LDD1681  [1]
 LDCM0482  CL88 HEK-293T C129(1.15); C106(1.02)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C370(0.88)  LDD1686  [1]
 LDCM0489  CL94 HEK-293T C129(1.39)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C129(1.17); C106(1.43)  LDD1693  [1]
 LDCM0491  CL96 HEK-293T C129(1.14)  LDD1694  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067

The Drug(s) Related To This Target

Approved
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Gamma-aminobutyric Acid Small molecular drug DB02530
Glycine Small molecular drug DB00145
Methotrexate Small molecular drug DB00563
Taurine Small molecular drug DB01956
Vigabatrin Small molecular drug DB01080
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
5-hydroxy-l-tryptophan Small molecular drug D09BNS
Alanine Small molecular drug DB00160
Indole-3-propionic Acid Small molecular drug D00ZYK
Spaglumic Acid . DB08835

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587