Details of the Target

General Information of Target

Target ID LDTP04090
Target Name Transcriptional regulator ATRX (ATRX)
Gene Name ATRX
Gene ID 546
Synonyms
RAD54L; XH2; Transcriptional regulator ATRX; EC 3.6.4.12; ATP-dependent helicase ATRX; X-linked helicase II; X-linked nuclear protein; XNP; Znf-HX
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTAEPMSESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENS
KEEGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQS
LPKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGEDGLHGIVSCTACGQQVNH
FQKDSIYRHPSLQVLICKNCFKYYMSDDISRDSDGMDEQCRWCAEGGNLICCDFCHNAFC
KKCILRNLGRKELSTIMDENNQWYCYICHPEPLLDLVTACNSVFENLEQLLQQNKKKIKV
DSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKLI
ETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAM
DAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPT
EEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQS
SVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKELYVKLTPVSLSNSPI
KGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEESDLRRSPRVK
TTPLRRPTETNPVTSNSDEECNETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSK
QSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRK
RKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKR
IPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTT
IMELRDRLPKKQQASASTDGVDKLSGKEESFTSLEVRKVAETKEKSKHLKTKTCKKVQDG
LSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLP
EREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDK
KSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNL
SSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADI
TSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDD
DDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQV
NSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSE
DSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKS
NSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEE
EERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMVIKL
KPHQVDGVQFMWDCCCESVKKTKKSPGSGCILAHCMGLGKTLQVVSFLHTVLLCDKLDFS
TALVVCPLNTALNWMNEFEKWQEGLKDDEKLEVSELATVKRPQERSYMLQRWQEDGGVMI
IGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRS
RRRIILTGTPLQNNLIEYHCMVNFIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVM
KKRAHILYEMLAGCVQRKDYTALTKFLPPKHEYVLAVRMTSIQCKLYQYYLDHLTGVGNN
SEGGRGKAGAKLFQDFQMLSRIWTHPWCLQLDYISKENKGYFDEDSMDEFIASDSDETSM
SLSSDDYTKKKKKGKKGKKDSSSSGSGSDNDVEVIKVWNSRSRGGGEGNVDETGNNPSVS
LKLEESKATSSSNPSSPAPDWYKDFVTDADAEVLEHSGKMVLLFEILRMAEEIGDKVLVF
SQSLISLDLIEDFLELASREKTEDKDKPLIYKGEGKWLRNIDYYRLDGSTTAQSRKKWAE
EFNDETNVRGRLFIISTKAGSLGINLVAANRVIIFDASWNPSYDIQSIFRVYRFGQTKPV
YVYRFLAQGTMEDKIYDRQVTKQSLSFRVVDQQQVERHFTMNELTELYTFEPDLLDDPNS
EKKKKRDTPMLPKDTILAELLQIHKEHIVGYHEHDSLLDHKEEEELTEEERKAAWAEYEA
EKKGLTMRFNIPTGTNLPPVSFNSQTPYIPFNLGALSAMSNQQLEDLINQGREKVVEATN
SVTAVRIQPLEDIISAVWKENMNLSEAQVQALALSRQASQELDVKRREAIYNDVLTKQQM
LISCVQRILMNRRLQQQYNQQQQQQMTYQQATLGHLMMPKPPNLIMNPSNYQQIDMRGMY
QPVAGGMQPPPLQRAPPPMRSKNPGPSQGKSM
Target Bioclass
Enzyme
Family
SNF2/RAD54 helicase family
Subcellular location
Nucleus
Function
Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomeres. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting; according to a report, it is not sufficient to decrease chromatin condensation at telomeres nor to increase expression of telomeric RNA in fibroblasts. May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as a negative regulator of chromatin incorporation of transcriptionally repressive histone MACROH2A1, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes.
Uniprot ID
P46100
Ensemble ID
ENST00000373344.11
HGNC ID
HGNC:886

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.E1413D DBIA    Probe Info 
CAL27 SNV: p.S510F DBIA    Probe Info 
CCK81 SNV: p.H2252R; p.Q2421Ter DBIA    Probe Info 
HCC1395 SNV: p.K1175E DBIA    Probe Info 
HCT116 Deletion: p.T1529del DBIA    Probe Info 
HCT15 SNV: p.L629R DBIA    Probe Info 
HEC1B Insertion: p.N114KfsTer2
SNV: p.M860T		 IA-alkyne    Probe Info 
HT115 SNV: p.K869N; p.R1138I DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.R1339M DBIA    Probe Info 
JEKO1 SNV: p.R246C DBIA    Probe Info 
LNCaP clone FGC Deletion: p.E2265del DBIA    Probe Info 
LS123 SNV: p.K778E DBIA    Probe Info 
MCC13 SNV: p.G1042E; p.E1391K DBIA    Probe Info 
NCIH1155 SNV: p.E649K DBIA    Probe Info 
NCIH446 SNV: p.K688N DBIA    Probe Info 
P31FUJ Deletion: p.D1940IfsTer15 DBIA    Probe Info 
SKMEL2 SNV: p.L2056I DBIA    Probe Info 
SNGM Insertion: p.T1582NfsTer19 DBIA    Probe Info 
SW1271 Substitution: p.T2007L DBIA    Probe Info 
SW756 SNV: p.L195F .
TE10 SNV: p.T172I DBIA    Probe Info 
TYKNU SNV: p.I2390V DBIA    Probe Info 
U87MG SNV: p.N564S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K396(7.14)  LDD0277  [2]
BTD
 Probe Info  		C450(0.75)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C605(2.13)  LDD0171  [4]
DBIA
 Probe Info  		C231(1.30); C232(1.30); C1122(1.28); C605(1.13)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C605(0.00); C1888(0.00); C197(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C605(0.00); C197(0.00); C1814(0.00); C1718(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C1718(0.00); C627(0.00); C618(0.00); C197(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		C450(0.00); C618(0.00)  LDD0005  [9]
VSF
 Probe Info  		N.A.  LDD0007  [9]
YN-1
 Probe Info  		N.A.  LDD0446  [10]
Phosphinate-6
 Probe Info  		C1074(0.00); C324(0.00); C450(0.00)  LDD0018  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C433
 Probe Info  		5.62  LDD2088  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C450(0.70)  LDD2142  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C450(0.92)  LDD2152  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C450(0.94)  LDD2103  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C605(2.13)  LDD0171  [4]
 LDCM0214  AC1 HCT 116 C220(0.97); C171(1.09); C174(1.09); C1789(1.24)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C220(1.26); C171(1.15); C174(1.15); C1789(1.33)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C220(0.84); C171(0.92); C174(0.92); C1789(1.09)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C220(1.09); C171(0.81); C174(0.81); C1789(1.16)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C220(0.91); C171(0.88); C174(0.88); C1789(1.06)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C220(0.98); C171(1.06); C174(1.06); C1789(1.17)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C220(0.97); C171(0.75); C174(0.75); C1789(1.04)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C220(2.12); C171(1.06); C174(1.06); C1789(1.14)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C220(1.18); C171(1.06); C174(1.06); C1789(1.22)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C220(1.22); C171(1.21); C174(1.21); C1789(1.08)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C220(0.89); C171(0.81); C174(0.81); C1789(1.11)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C220(0.96); C171(0.72); C174(0.72); C1789(1.01)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C220(1.36); C171(1.24); C174(1.24); C1789(1.26)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C220(0.92); C171(0.69); C174(0.69); C1789(1.23)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C220(0.97); C171(0.74); C174(0.74); C1789(1.10)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C220(0.90); C171(0.90); C174(0.90); C1789(1.00)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C220(1.10); C171(0.86); C174(0.86); C1789(0.89)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C220(1.25); C171(0.93); C174(0.93); C1789(0.94)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C220(1.08); C171(1.17); C174(1.17); C1789(0.89)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C220(1.36); C171(1.10); C174(1.10); C1789(0.88)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C220(1.14); C171(0.89); C174(0.89); C1789(0.95)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C220(1.07); C171(1.01); C174(1.01); C1789(0.96)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C220(1.18); C171(1.01); C174(1.01); C1789(0.90)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C220(1.09); C171(1.19); C174(1.19); C1789(1.08)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C220(0.90); C171(1.53); C174(1.53); C1789(0.97)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C220(1.02); C171(1.17); C174(1.17); C1789(0.83)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C220(1.33); C171(1.07); C174(1.07); C1789(0.96)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C220(0.93); C171(0.86); C174(0.86); C1789(0.80)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C220(1.23); C171(1.08); C174(1.08); C1789(0.88)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C220(1.36); C171(1.23); C174(1.23); C1789(1.12)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C220(1.30); C171(1.18); C174(1.18); C1789(1.07)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C220(1.38); C171(1.01); C174(1.01); C1789(0.90)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C220(1.18); C171(1.19); C174(1.19); C1789(1.69)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C220(0.80); C171(0.74); C174(0.74); C1789(1.30)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C220(1.01); C171(0.86); C174(0.86); C1789(1.13)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C220(0.90); C171(0.72); C174(0.72); C1789(1.47)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C220(0.87); C171(0.72); C174(0.72); C1789(1.00)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C220(1.17); C171(0.98); C174(0.98); C1789(1.29)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C220(1.12); C171(0.92); C174(0.92); C1789(1.52)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C220(1.11); C171(0.71); C174(0.71); C1789(1.45)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C220(0.88); C171(0.92); C174(0.92); C1789(1.39)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C220(0.87); C171(0.86); C174(0.86); C1789(1.09)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C220(1.10); C171(0.79); C174(0.79); C1789(1.24)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C220(1.05); C171(0.77); C174(0.77); C1789(1.15)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C220(1.25); C171(1.07); C174(1.07); C1789(1.26)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C220(1.34); C171(0.87); C174(0.87); C1789(1.06)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C220(0.97); C171(0.83); C174(0.83); C1789(1.38)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C220(0.73); C171(0.67); C174(0.67); C1789(1.01)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C220(1.08); C1574(1.06); C1575(1.06); C1576(1.06)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C1814(0.81); C220(0.92); C324(1.02); C1789(1.04)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C1574(0.88); C1575(0.88); C1576(0.88); C1814(0.94)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C1814(0.96); C1574(1.06); C1575(1.06); C1576(1.06)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C1574(0.88); C1575(0.88); C1576(0.88); C2404(0.98)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C1814(0.94); C324(1.02); C223(1.13); C231(1.13)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C1814(0.85); C1574(1.02); C1575(1.02); C1576(1.02)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C2404(0.85); C220(1.08); C1844(1.17); C223(1.17)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C1814(0.89); C171(0.96); C174(0.96); C2404(1.06)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C1844(0.83); C220(0.90); C1814(0.92); C1574(0.95)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C1814(0.94); C1844(0.99); C1789(1.01); C1574(1.03)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C1814(0.96); C223(1.02); C231(1.02); C1574(1.04)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C220(1.01); C1574(1.06); C1575(1.06); C1576(1.06)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C220(0.97); C1574(0.89); C1575(0.89); C1576(0.89)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C220(0.73); C1574(1.07); C1575(1.07); C1576(1.07)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C220(0.84); C1574(0.93); C1575(0.93); C1576(0.93)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C171(0.76); C174(0.76); C235(0.79); C223(0.87)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C171(0.79); C174(0.79); C220(0.93); C1814(0.98)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C171(0.41); C174(0.41); C1814(0.93); C2404(0.99)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C335(0.50); C232(0.66); C2404(0.82); C223(0.98)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C171(0.71); C174(0.71); C235(0.82); C223(0.89)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C171(0.70); C174(0.70); C1814(0.89); C220(0.90)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C171(0.40); C174(0.40); C220(0.80); C235(0.88)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C171(0.52); C174(0.52); C235(0.76); C223(0.80)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C171(0.79); C174(0.79); C220(0.79); C1814(0.89)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C335(0.72); C1814(0.79); C1574(0.85); C1575(0.85)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C335(0.75); C1814(0.84); C1574(0.86); C1575(0.86)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C335(0.80); C1574(0.86); C1575(0.86); C1576(0.86)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C335(0.87); C232(0.90); C1814(0.90); C1574(0.91)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C335(0.82); C1814(0.93); C2404(1.11); C1574(1.12)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C335(0.43); C232(0.64); C2404(0.84); C171(0.98)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C1814(0.94); C1574(1.06); C1575(1.06); C1576(1.06)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C335(0.61); C1574(0.78); C1575(0.78); C1576(0.78)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C335(0.69); C1814(1.05); C1574(1.06); C1575(1.06)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C171(0.94); C174(0.94); C1574(0.98); C1575(0.98)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C1574(1.00); C1575(1.00); C1576(1.00); C171(1.05)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C324(0.68); C220(0.78); C2404(0.83); C171(0.86)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C324(0.78); C1814(0.84); C171(0.95); C174(0.95)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C1574(0.81); C1575(0.81); C1576(0.81); C324(0.82)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C324(0.56); C1574(0.86); C1575(0.86); C1576(0.86)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C324(0.82); C1574(0.82); C1575(0.82); C1576(0.82)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C335(0.30); C232(0.56); C2404(0.78); C223(0.91)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C171(0.92); C174(0.92); C1574(0.94); C1575(0.94)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C324(0.75); C1574(0.75); C1575(0.75); C1576(0.75)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C1574(0.85); C1575(0.85); C1576(0.85); C1814(1.04)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C324(0.75); C1574(0.94); C1575(0.94); C1576(0.94)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C324(0.72); C220(0.92); C1574(0.95); C1575(0.95)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C1574(0.79); C1575(0.79); C1576(0.79); C171(0.95)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C324(0.87); C1814(0.93); C1789(0.99); C2404(1.08)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C324(0.85); C1814(0.96); C1789(1.00); C2404(1.05)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C324(0.84); C1814(0.90); C171(1.01); C174(1.01)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C324(1.16); C171(1.25); C174(1.25); C1814(1.35)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C335(0.32); C232(0.61); C2404(0.83); C223(0.85)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C324(0.95); C171(1.05); C174(1.05); C1789(1.14)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C1814(0.85); C1789(0.96); C171(0.99); C174(0.99)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C1814(0.95); C220(1.01); C171(1.02); C174(1.02)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C171(0.99); C174(0.99); C324(1.01); C2404(1.02)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C324(0.77); C171(0.99); C174(0.99); C1814(1.06)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C171(0.98); C174(0.98); C2404(1.23); C324(1.32)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C171(0.99); C174(0.99); C1814(1.47); C2404(1.59)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C2404(0.79); C232(0.84); C231(0.84); C240(0.91)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C1574(0.89); C1575(0.89); C1576(0.89); C2404(0.91)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C324(0.77); C1574(0.86); C1575(0.86); C1576(0.86)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C2404(0.91); C223(1.07); C240(1.07); C1814(1.07)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C1574(0.79); C1575(0.79); C1576(0.79); C2404(0.97)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C324(0.63); C232(0.79); C2404(0.84); C240(1.03)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C1574(0.84); C1575(0.84); C1576(0.84); C232(0.85)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C324(0.67); C231(0.79); C232(0.80); C1574(0.85)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C232(0.89); C2404(1.00); C324(1.00); C240(1.01)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C324(0.85); C232(0.90); C231(0.94); C2404(0.95)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C324(0.89); C232(0.97); C2404(1.00); C1574(1.00)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C231(0.68); C223(0.83); C240(0.85); C232(0.86)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C1789(0.81); C1814(0.93); C223(1.05); C220(1.06)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C1574(0.64); C1789(0.79); C220(0.85); C1575(0.95)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C324(0.74); C2404(0.81); C171(1.03); C174(1.03)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C220(0.72); C232(0.76); C240(0.76); C223(0.80)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C1574(0.60); C220(0.77); C1789(0.89); C1575(0.90)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C1574(0.78); C1789(0.79); C171(0.83); C174(0.83)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C1789(0.86); C171(1.00); C174(1.00); C220(1.22)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C1789(1.00); C220(1.01); C171(1.02); C174(1.02)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C1789(0.91); C220(0.95); C223(1.02); C171(1.05)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C1574(0.80); C1789(0.89); C171(0.93); C174(0.93)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C1789(0.84); C223(0.92); C231(0.96); C220(0.97)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C220(0.74); C1574(0.82); C1789(0.87); C1814(0.95)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C1574(0.65); C220(0.84); C1789(0.93); C171(0.96)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C324(0.78); C2404(0.92); C171(1.16); C174(1.16)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C220(0.84); C1574(0.98); C171(1.00); C174(1.00)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C220(0.77); C1814(0.82); C1789(0.92); C171(0.95)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C1789(0.84); C171(0.97); C174(0.97); C220(1.01)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C232(0.94); C1844(0.95); C324(0.96); C1814(0.97)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C232(0.85); C1814(0.93); C240(0.99); C1844(1.00)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C1814(0.82); C1844(0.84); C232(0.85); C240(0.85)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C232(0.68); C1814(0.79); C240(0.92); C1844(0.96)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C1814(0.88); C232(0.89); C2404(0.92); C240(0.93)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C231(0.68); C240(0.75); C324(0.76); C232(0.83)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C232(0.73); C240(0.76); C231(0.79); C1814(0.88)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C232(0.62); C240(0.75); C1814(0.82); C231(0.89)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C232(0.59); C240(0.80); C235(0.91); C1814(0.94)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C235(0.84); C1814(0.86); C232(0.86); C1844(0.91)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C1814(0.78); C232(0.87); C324(0.87); C240(1.02)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C232(0.79); C240(0.81); C231(0.84); C223(0.92)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C231(0.65); C240(0.68); C232(0.71); C1814(0.81)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C235(0.82); C232(0.91); C223(0.92); C240(0.97)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C232(0.73); C1814(0.81); C240(0.87); C231(1.01)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C171(0.65); C174(0.65); C2404(0.99); C223(1.23)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C220(0.81); C324(0.96); C171(0.97); C174(0.97)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C450(0.26)  LDD2138  [3]
 LDCM0248  AKOS034007472 HCT 116 C220(1.24); C171(1.01); C174(1.01); C1789(1.19)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C324(0.85); C2404(1.04); C1844(1.13); C220(1.17)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C2404(0.81); C223(1.38); C240(1.38); C171(1.48)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.44  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C231(1.30); C232(1.30); C1122(1.28); C605(1.13)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C450(20.00); C1760(20.00); C1074(1.88); C450(1.18)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C220(0.73); C171(0.87); C174(0.87); C1789(1.17)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C1574(1.01); C1576(1.01); C171(1.06); C174(1.06)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C335(0.65); C232(0.72); C2404(0.83); C223(0.92)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C2404(0.80); C324(1.04); C1814(1.15); C335(1.16)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C2404(0.82); C324(0.88); C1844(1.03); C1789(1.03)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C2404(0.81); C324(0.87); C220(0.95); C1844(1.02)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C2404(0.68); C324(0.84); C171(1.02); C174(1.02)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C171(0.80); C174(0.80); C235(0.81); C223(0.86)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C235(0.85); C223(0.93); C171(1.12); C174(1.12)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C171(0.47); C174(0.47); C235(0.87); C1814(0.94)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C171(0.79); C174(0.79); C223(0.93); C235(0.97)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C171(0.57); C174(0.57); C1814(0.91); C235(0.97)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C324(1.02); C1789(1.10); C1574(1.16); C1576(1.16)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C171(0.57); C174(0.57); C235(0.67); C223(0.90)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C171(0.51); C174(0.51); C220(0.87); C231(0.95)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C232(0.80); C335(0.88); C1814(0.89); C1574(0.94)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C335(0.87); C1814(0.99); C1574(1.03); C1575(1.03)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C335(0.72); C1574(0.84); C1575(0.84); C1576(0.84)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C232(0.99); C1574(1.00); C1575(1.00); C1576(1.00)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C1574(0.70); C1575(0.70); C1576(0.70); C232(0.88)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C1574(1.16); C1575(1.16); C1576(1.16); C171(1.17)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C220(0.90); C2404(0.93); C171(0.99); C174(0.99)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C324(0.67); C1814(0.94); C1574(0.98); C1575(0.98)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C1789(1.17); C171(1.18); C174(1.18); C220(1.18)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C324(0.71); C1574(0.84); C1575(0.84); C1576(0.84)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C1789(0.94); C1814(0.96); C324(1.01); C171(1.10)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C324(0.81); C2404(0.97); C1789(0.98); C171(1.05)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C171(0.94); C174(0.94); C1814(0.97); C324(1.09)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C171(1.08); C174(1.08); C1814(1.09); C324(1.22)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C231(0.62); C324(0.67); C240(0.81); C223(0.84)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C1574(0.80); C1575(0.80); C1576(0.80); C324(0.91)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C324(0.47); C171(0.96); C174(0.96); C1574(0.96)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C231(0.64); C240(0.81); C223(0.81); C324(0.89)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C324(1.15); C1789(1.19); C1574(1.22); C1576(1.22)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C171(0.91); C174(0.91); C220(0.94); C324(0.95)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C324(1.12); C1574(1.19); C1576(1.19); C220(1.22)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C231(0.72); C223(0.91); C240(1.09); C220(1.11)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C1789(0.82); C171(0.96); C174(0.96); C220(1.03)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C1789(0.84); C220(1.28); C335(1.29); C171(1.32)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C1789(0.87); C223(1.15); C231(1.15); C220(1.24)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C220(0.66); C324(0.83); C171(0.89); C174(0.89)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C1789(0.77); C223(1.20); C231(1.20); C335(1.31)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C1789(0.74); C223(0.87); C231(0.87); C171(1.29)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C1789(0.79); C223(1.27); C231(1.27); C220(2.10)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C223(0.69); C231(0.69); C1789(0.93); C220(1.24)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C1789(0.99); C223(1.50); C231(1.50); C335(1.51)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C220(1.48); C171(1.36); C174(1.36); C1789(1.04)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C220(1.15); C171(1.42); C174(1.42); C1789(0.93)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C220(1.47); C171(1.26); C174(1.26); C1789(0.92)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C220(1.40); C171(1.81); C174(1.81); C1789(0.79)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C220(1.55); C171(1.48); C174(1.48); C1789(0.80)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C220(0.75); C1574(1.07); C1576(1.07); C171(0.90)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C220(1.20); C171(1.25); C174(1.25); C1789(0.98)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C220(0.91); C171(0.92); C174(0.92); C1789(0.82)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C220(0.93); C171(1.15); C174(1.15); C1789(1.41)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C220(0.84); C171(0.81); C174(0.81); C1789(0.93)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C220(1.30); C171(1.05); C174(1.05); C1789(1.34)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C220(1.19); C171(1.04); C174(1.04); C1789(1.22)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C220(1.13); C171(0.89); C174(0.89); C1789(1.04)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C220(1.27); C171(1.01); C174(1.01); C1789(1.14)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C220(1.06); C171(1.08); C174(1.08); C1789(1.08)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C220(0.90); C1574(0.93); C1576(0.93); C171(1.19)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C220(1.10); C171(0.99); C174(0.99); C1789(1.08)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C220(1.04); C171(1.03); C174(1.03); C1789(1.25)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C220(1.47); C171(1.18); C174(1.18); C1789(1.47)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C220(1.15); C171(1.15); C174(1.15); C1789(1.34)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C220(0.95); C171(1.07); C174(1.07); C1789(1.17)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C220(1.10); C171(1.27); C174(1.27); C1789(1.25)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C220(0.89); C1574(0.72); C1575(0.72); C1576(0.72)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C220(0.96); C1574(0.73); C1575(0.72); C1576(0.73)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C220(1.18); C1574(0.73); C1575(0.74); C1576(0.73)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C220(1.05); C1574(0.95); C1575(0.95); C1576(0.95)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C220(1.05); C1574(1.02); C1576(1.02); C171(1.02)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C220(1.16); C1574(0.84); C1575(0.82); C1576(0.84)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C220(1.26); C1574(0.83); C1575(0.79); C1576(0.83)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C220(1.24); C1574(0.91); C1575(0.90); C1576(0.91)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C220(1.03); C1574(0.95); C1575(0.91); C1576(0.95)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C220(0.74); C1574(0.76); C1575(0.78); C1576(0.76)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C220(0.83); C1574(0.83); C1575(0.82); C1576(0.83)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C220(0.91); C1574(0.90); C1575(0.89); C1576(0.90)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C220(1.11); C1574(0.80); C1575(0.79); C1576(0.80)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C220(1.15); C1574(0.89); C1575(0.88); C1576(0.89)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C220(0.99); C1574(0.96); C1575(0.97); C1576(0.96)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C220(0.88); C1574(1.06); C1576(1.06); C171(1.04)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C220(1.06); C1574(0.97); C1575(0.98); C1576(0.97)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C220(0.88); C171(0.93); C174(0.93); C1789(1.26)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C220(0.94); C171(0.86); C174(0.86); C1789(1.19)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C220(1.23); C171(0.96); C174(0.96); C1789(1.24)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C220(1.14); C171(1.00); C174(1.00); C1789(1.32)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C220(1.07); C171(1.00); C174(1.00); C1789(1.21)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C220(1.32); C171(1.19); C174(1.19); C1789(1.35)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C220(1.29); C171(1.07); C174(1.07); C1789(1.34)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C220(1.05); C171(1.04); C174(1.04); C1789(1.12)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C220(1.33); C171(1.01); C174(1.01); C1789(1.17)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C220(1.20); C1574(1.06); C1576(1.06); C171(1.13)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C220(1.15); C171(0.99); C174(0.99); C1789(1.28)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C220(1.23); C171(0.95); C174(0.95); C1789(1.35)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C220(0.88); C171(1.05); C174(1.05); C1789(1.44)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C220(0.91); C171(0.94); C174(0.94); C1789(1.22)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C220(1.10); C171(1.03); C174(1.03); C1789(1.28)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C220(1.08); C171(0.86); C174(0.86); C1789(0.84)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C220(0.99); C171(0.83); C174(0.83); C1789(0.70)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C220(1.10); C171(0.93); C174(0.93); C1789(0.71)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C220(1.75); C171(0.93); C174(0.93); C1789(0.95)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C220(1.34); C1574(1.31); C1576(1.31); C171(1.24)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C220(1.20); C171(0.93); C174(0.93); C1789(0.90)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C220(1.59); C171(0.88); C174(0.88); C1789(0.73)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C220(1.81); C171(1.08); C174(1.08); C1789(0.93)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C220(1.28); C171(0.99); C174(0.99); C1789(0.70)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C220(1.57); C171(1.14); C174(1.14); C1789(0.90)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C220(1.17); C171(0.84); C174(0.84); C1789(0.77)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C220(0.87); C171(0.86); C174(0.86); C1789(0.69)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C220(1.07); C171(0.96); C174(0.96); C1789(0.79)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C220(1.09); C171(0.94); C174(0.94); C1789(0.79)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C220(1.95); C171(1.32); C174(1.32); C1789(0.86)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C220(0.98); C1574(1.19); C1576(1.19); C171(1.04)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C220(0.72); C171(0.64); C174(0.64); C1789(0.59)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C220(1.05); C171(0.99); C174(0.99); C1789(1.29)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C220(0.97); C171(0.89); C174(0.89); C1789(1.07)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C220(1.07); C171(0.95); C174(0.95); C1789(1.16)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C220(1.35); C171(1.06); C174(1.06); C1789(1.15)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C220(1.01); C171(0.91); C174(0.91); C1789(1.18)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C220(0.94); C171(1.06); C174(1.06); C1789(1.10)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C220(1.14); C171(1.09); C174(1.09); C1789(1.16)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C220(1.10); C171(1.05); C174(1.05); C1789(1.24)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C220(1.04); C171(1.04); C174(1.04); C1789(1.29)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C605(0.75)  LDD2228  [7]
 LDCM0495  E2913 HEK-293T C605(0.94); C1844(1.21); C1026(0.94); C2404(1.19)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C618(1.26); C450(1.20)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C220(0.93); C171(0.96); C174(0.96); C1789(1.27)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C220(1.37); C171(1.36); C174(1.36); C1789(1.39)  LDD0744  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C223(3.59); C231(3.59); C2404(2.11); C335(2.70)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C223(8.48); C231(8.48); C2404(2.38); C335(1.77)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C223(2.25); C231(2.25); C2404(1.99); C335(1.90)  LDD0082  [5]
 LDCM0109  NEM HeLa N.A.  LDD0225  [12]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C450(0.84)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C450(0.99)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C450(1.05)  LDD2094  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C450(0.73)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C450(0.69)  LDD2099  [3]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C450(1.14)  LDD2116  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C450(1.03)  LDD2118  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C450(1.22)  LDD2122  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C450(1.01)  LDD2124  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C450(0.98)  LDD2128  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C450(0.75)  LDD1700  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C450(1.08)  LDD2143  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C450(0.55)  LDD2150  [3]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C450(1.62)  LDD2153  [3]
 LDCM0021  THZ1 HCT 116 C1590(1.13); C1595(1.13); C223(1.05); C235(1.05)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase EZH2 (EZH2) Histone-lysine methyltransferase family Q15910
DNA repair protein RAD50 (RAD50) SMC family Q92878
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Chromobox protein homolog 5 (CBX5) . P45973

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402