Details of the Target

General Information of Target

Target ID LDTP01638
Target Name YEATS domain-containing protein 4 (YEATS4)
Gene Name YEATS4
Gene ID 8089
Synonyms
GAS41; YEATS domain-containing protein 4; Glioma-amplified sequence 41; Gas41; NuMA-binding protein 1; NuBI-1; NuBI1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMS
AYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKL
FQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTR
EKLEAAKKKTSFEIAELKERLKASRETINCLKNEIRKLEEDDQAKDI
Target Bioclass
Other
Subcellular location
Nucleus
Function
Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac). Also able to recognize and bind crotonylated histone H3. May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo. Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z. H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell.
Uniprot ID
O95619
Ensemble ID
ENST00000247843.7
HGNC ID
HGNC:24859
ChEMBL ID
CHEMBL4296266

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C210(1.40)  LDD2090  [2]
AHL-Pu-1
 Probe Info  		C210(2.08)  LDD0172  [3]
DBIA
 Probe Info  		C210(1.82)  LDD0080  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
ENE
 Probe Info  		N.A.  LDD0006  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
W1
 Probe Info  		N.A.  LDD0236  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C052
 Probe Info  		5.24  LDD1750  [13]
C107
 Probe Info  		8.34  LDD1794  [13]
C229
 Probe Info  		11.31  LDD1902  [13]
C233
 Probe Info  		15.24  LDD1906  [13]
C234
 Probe Info  		5.70  LDD1907  [13]
C339
 Probe Info  		5.86  LDD2002  [13]
C420
 Probe Info  		10.06  LDD2075  [13]
C433
 Probe Info  		8.57  LDD2088  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C210(2.08)  LDD0172  [3]
 LDCM0214  AC1 PaTu 8988t C210(0.87)  LDD1093  [4]
 LDCM0215  AC10 HEK-293T C210(0.86)  LDD0813  [4]
 LDCM0216  AC100 HCT 116 C210(1.17)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C210(1.14)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C210(0.99)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C210(1.36)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C210(1.11)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C210(1.09)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C210(1.17)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C210(1.16)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C210(1.17)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C210(1.12)  LDD0542  [4]
 LDCM0226  AC11 HEK-293T C210(0.82)  LDD0824  [4]
 LDCM0227  AC110 HCT 116 C210(1.24)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C210(1.19)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C210(1.45)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C210(0.91)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C210(1.13)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C210(1.55)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C210(1.64)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C210(1.36)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C210(1.37)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C210(1.57)  LDD0553  [4]
 LDCM0237  AC12 HEK-293T C210(0.83)  LDD0835  [4]
 LDCM0238  AC120 HCT 116 C210(1.20)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C210(1.34)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C210(1.63)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C210(1.05)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C210(1.03)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C210(1.19)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C210(1.62)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C210(1.66)  LDD0562  [4]
 LDCM0259  AC14 HEK-293T C210(0.99)  LDD0857  [4]
 LDCM0263  AC143 HCT 116 C210(1.02)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C210(0.81)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C210(0.90)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C210(0.92)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C210(1.10)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C210(1.09)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C210(1.25)  LDD0586  [4]
 LDCM0270  AC15 HEK-293T C210(0.93)  LDD0868  [4]
 LDCM0271  AC150 HCT 116 C210(1.18)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C210(0.80)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C210(0.81)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C210(0.92)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C210(1.00)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C210(0.80)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C210(0.93)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C210(0.99)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C210(1.00)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C210(0.82)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C210(0.87)  LDD0595  [4]
 LDCM0279  AC2 PaTu 8988t C210(0.70)  LDD1158  [4]
 LDCM0280  AC20 HCT 116 C210(0.95)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C210(0.86)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C210(0.94)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C210(1.02)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C210(1.02)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C210(2.76)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C210(1.17)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C210(1.34)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C210(1.73)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C210(1.57)  LDD0606  [4]
 LDCM0290  AC3 PaTu 8988t C210(0.78)  LDD1169  [4]
 LDCM0291  AC30 HCT 116 C210(1.51)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C210(1.46)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C210(2.17)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C210(1.86)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C210(1.36)  LDD0612  [4]
 LDCM0296  AC35 HEK-293T C210(1.07)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C210(0.94)  LDD1536  [14]
 LDCM0299  AC38 HEK-293T C210(0.95)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C210(1.01)  LDD1539  [14]
 LDCM0301  AC4 PaTu 8988t C210(0.70)  LDD1180  [4]
 LDCM0302  AC40 HEK-293T C210(1.06)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C210(0.97)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C210(1.07)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C210(1.12)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C210(0.95)  LDD1545  [14]
 LDCM0308  AC46 HCT 116 C210(1.60)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C210(1.23)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C210(1.30)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C210(1.42)  LDD0628  [4]
 LDCM0312  AC5 PaTu 8988t C210(0.80)  LDD1191  [4]
 LDCM0313  AC50 HCT 116 C210(1.41)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C210(1.47)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C210(1.40)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C210(1.10)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C210(1.51)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C210(0.99)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C210(1.23)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C210(0.85)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C210(0.76)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C210(1.11)  LDD0639  [4]
 LDCM0323  AC6 HEK-293T C210(1.04)  LDD0921  [4]
 LDCM0324  AC60 HCT 116 C210(1.03)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C210(0.84)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C210(0.98)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C210(1.32)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C210(1.32)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C210(0.95)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C210(0.84)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C210(0.95)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C210(0.80)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C210(0.75)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C210(0.90)  LDD0932  [4]
 LDCM0335  AC70 HCT 116 C210(0.81)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C210(0.73)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C210(1.05)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C210(1.13)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C210(0.89)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C210(0.88)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C210(0.96)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C210(0.98)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C210(0.93)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C210(0.98)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C210(0.85)  LDD0943  [4]
 LDCM0346  AC80 HCT 116 C210(1.19)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C210(0.83)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C210(0.95)  LDD0665  [4]
 LDCM0365  AC98 HCT 116 C210(1.19)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C210(1.05)  LDD0683  [4]
 LDCM0248  AKOS034007472 HEK-293T C210(0.97)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C210(0.88)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C210(0.96)  LDD0873  [4]
 LDCM0156  Aniline NCI-H1299 10.64  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 HEK-293T C210(1.07)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C210(0.88)  LDD1572  [14]
 LDCM0369  CL100 PaTu 8988t C210(0.61)  LDD1248  [4]
 LDCM0370  CL101 HEK-293T C210(1.25)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C210(1.05)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C210(0.93)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C210(1.00)  LDD0971  [4]
 LDCM0374  CL105 HCT 116 C210(0.95)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C210(0.81)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C210(0.89)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C210(0.94)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C210(1.01)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C210(0.94)  LDD1583  [14]
 LDCM0380  CL110 HCT 116 C210(0.86)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C210(1.01)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C210(1.50)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C210(2.13)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C210(2.34)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C210(2.27)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C210(1.71)  LDD0703  [4]
 LDCM0387  CL117 HEK-293T C210(1.04)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C210(1.10)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C210(0.88)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C210(1.11)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C210(0.91)  LDD1595  [14]
 LDCM0392  CL121 HCT 116 C210(1.21)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C210(1.24)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C210(1.38)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C210(1.43)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C210(1.00)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C210(0.75)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C210(0.86)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C210(0.75)  LDD0716  [4]
 LDCM0400  CL13 HEK-293T C210(1.15)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C210(1.03)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C210(0.78)  LDD1606  [14]
 LDCM0403  CL16 HCT 116 C210(1.18)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C210(0.86)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C210(1.14)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C210(0.93)  LDD0723  [4]
 LDCM0407  CL2 HEK-293T C210(1.06)  LDD1611  [14]
 LDCM0408  CL20 HCT 116 C210(1.04)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C210(0.94)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C210(1.08)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C210(1.09)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C210(1.08)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C210(1.21)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C210(1.33)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C210(0.98)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C210(1.06)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C210(1.00)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C210(0.89)  LDD1622  [14]
 LDCM0419  CL30 HCT 116 C210(1.06)  LDD0736  [4]
 LDCM0420  CL31 HEK-293T C210(0.98)  LDD1018  [4]
 LDCM0421  CL32 HCT 116 C210(1.10)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C210(0.99)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C210(0.95)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C210(0.97)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C210(0.85)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C210(1.03)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C210(1.07)  LDD0745  [4]
 LDCM0429  CL4 HEK-293T C210(0.82)  LDD1633  [14]
 LDCM0430  CL40 HCT 116 C210(0.98)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C210(0.95)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C210(0.93)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C210(0.96)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C210(0.86)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C210(0.86)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C210(0.90)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C210(0.88)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C210(1.00)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C210(0.90)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C210(0.91)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C210(1.08)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C210(1.21)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C210(0.93)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C210(1.05)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C210(1.00)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C210(0.90)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C210(0.95)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C210(1.02)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C210(1.03)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C210(0.98)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C210(0.88)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C210(1.00)  LDD1050  [4]
 LDCM0453  CL61 HCT 116 C210(0.79)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C210(1.23)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C210(1.01)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C210(0.74)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C210(0.80)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C210(1.20)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C210(1.00)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C210(1.77)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C210(1.09)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C210(1.06)  LDD1665  [14]
 LDCM0463  CL70 HCT 116 C210(0.98)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C210(0.88)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C210(1.14)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C210(0.96)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C210(1.02)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C210(1.06)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C210(1.18)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C210(1.20)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C210(1.09)  LDD0789  [4]
 LDCM0473  CL8 HEK-293T C210(0.71)  LDD1676  [14]
 LDCM0474  CL80 HCT 116 C210(0.99)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C210(0.98)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C210(0.95)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C210(0.86)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C210(1.12)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C210(1.17)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C210(1.16)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C210(0.85)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C210(0.92)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C210(0.99)  LDD0800  [4]
 LDCM0485  CL90 HCT 116 C210(0.89)  LDD0802  [4]
 LDCM0486  CL91 PaTu 8988t C210(0.55)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C210(0.51)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C210(0.66)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C210(0.57)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C210(0.66)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C210(0.55)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C210(0.56)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C210(0.66)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C210(0.61)  LDD1373  [4]
 LDCM0495  E2913 HEK-293T C210(0.95)  LDD1698  [14]
 LDCM0625  F8 Ramos C210(1.27)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C210(2.00)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C210(4.06)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C210(1.13)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C210(1.01)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C210(1.13)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C210(1.11)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C210(1.17)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C210(0.96)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C210(0.96)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C210(0.83)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C210(1.39)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C210(0.95)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C210(1.60)  LDD2201  [15]
 LDCM0468  Fragment33 HCT 116 C210(1.15)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C210(1.01)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C210(0.92)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C210(1.01)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C210(1.05)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C210(1.44)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C210(1.10)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C210(1.25)  LDD2188  [15]
 LDCM0022  KB02 HCT 116 C210(1.82)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C210(1.16)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C210(1.51)  LDD0082  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C210(1.40)  LDD2090  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C210(1.06)  LDD2099  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C210(1.13)  LDD2104  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C210(0.93)  LDD2120  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C210(0.84)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C210(0.89)  LDD2127  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C210(0.81)  LDD2143  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C210(1.79)  LDD2153  [2]
 LDCM0131  RA190 MM1.R C210(1.14)  LDD0304  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ankyrin repeat and protein kinase domain-containing protein 1 (ANKK1) TKL Ser/Thr protein kinase family Q8NFD2
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transforming acidic coiled-coil-containing protein 1 (TACC1) TACC family O75410

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.